Large Receptor Reserve for Cannabinoid Actions in the Central
... The actions of cannabinoids, such as D9-tetrahydrocannabinol, in the brain appear to be mediated predominately through a single type of receptor, termed the CB1 receptor (Herkenham et al., 1990; Matsuda et al., 1990). A second type of cannabinoid receptor, termed the CB2 receptor, is found mainly ou ...
... The actions of cannabinoids, such as D9-tetrahydrocannabinol, in the brain appear to be mediated predominately through a single type of receptor, termed the CB1 receptor (Herkenham et al., 1990; Matsuda et al., 1990). A second type of cannabinoid receptor, termed the CB2 receptor, is found mainly ou ...
(4)CCF DRUGS
... Electrical effects result from two actions that are dose-dependent: • Direct action on myocardial cells (↓ of Na+/K+ATPase → Na+/Ca+ entrapment inside cell→ Tachyarrhythmogenic activity • Indirect action by parasympathetic stimulation (due to ↓ of Na+/K+ATPase of Neuronal cells→nodal tissue depola ...
... Electrical effects result from two actions that are dose-dependent: • Direct action on myocardial cells (↓ of Na+/K+ATPase → Na+/Ca+ entrapment inside cell→ Tachyarrhythmogenic activity • Indirect action by parasympathetic stimulation (due to ↓ of Na+/K+ATPase of Neuronal cells→nodal tissue depola ...
drug dosage and therapy
... performed in caring for sick and injured patients. The appropriate drug given in the correct dosage will very often hasten a patient's recovery. On the other hand, an inappropriate drug or dosage may worsen a patient's condition or even result in his death. The enlisted person charged with the admin ...
... performed in caring for sick and injured patients. The appropriate drug given in the correct dosage will very often hasten a patient's recovery. On the other hand, an inappropriate drug or dosage may worsen a patient's condition or even result in his death. The enlisted person charged with the admin ...
Psychotropic Medications Metabolized by Cytochromes P450 (CYP
... placenta and Consists of more than 50 isoforms. Cytochromes P450 (CYPs) are major source of catalytic activity for drug oxidation [1-3]. CYP2D6 is a member of the cytochrome P450 super family. It plays a primary role in the metabolism of more than 70 substrate medications, belonging to classes such ...
... placenta and Consists of more than 50 isoforms. Cytochromes P450 (CYPs) are major source of catalytic activity for drug oxidation [1-3]. CYP2D6 is a member of the cytochrome P450 super family. It plays a primary role in the metabolism of more than 70 substrate medications, belonging to classes such ...
Cannabidiol as a Potential Treatment for Anxiety Disorders
... Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effect ...
... Cannabis sativa, a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effect ...
Information Sheet Nitrous Oxide
... but its dissociative effects are probably caused by preventing the normal action of the NMDA receptor4. Long term effects/known harms: Regular use can lead to red blood cell problems that could result in anaemia. There is a risk of vitamin D deficiency and a link with mood swings and depression. The ...
... but its dissociative effects are probably caused by preventing the normal action of the NMDA receptor4. Long term effects/known harms: Regular use can lead to red blood cell problems that could result in anaemia. There is a risk of vitamin D deficiency and a link with mood swings and depression. The ...
FORMULATION AND EVALUATION OF THERMOSENSITIVE IN SITU GEL OF SALBUTAMOL
... undergoes significant degradation in gastrointestinal tract or metabolized via liver in high degree and gives undesirably slow effects13. For this parenteral route is preferred but it is undesirable or impractical if drug is intended for the treatment of chronic disease, so alternative route is pref ...
... undergoes significant degradation in gastrointestinal tract or metabolized via liver in high degree and gives undesirably slow effects13. For this parenteral route is preferred but it is undesirable or impractical if drug is intended for the treatment of chronic disease, so alternative route is pref ...
Committee on Drugs 1997;99;918 DOI: 10.1542/peds.99.6.918
... agents (hydrocodone or hydromorphone) for codeine and may be more addictive than codeine.2,3 In addition, many of these cough products are elixirs, which may contain up to 25% alcohol by volume.3 The over-the-counter availability of numerous cough and cold preparations promotes the perception that s ...
... agents (hydrocodone or hydromorphone) for codeine and may be more addictive than codeine.2,3 In addition, many of these cough products are elixirs, which may contain up to 25% alcohol by volume.3 The over-the-counter availability of numerous cough and cold preparations promotes the perception that s ...
Additivity Versus Synergy: A Theoretical Analysis of - Area-c54
... RESULTS: Drugs that compete for a single receptor, and that similarly affect the receptor, must be additive in their effects. Receptors that bind suppressors in serial circuits, or enhancers in parallel circuits, increase the apparent potency of the drugs and the steepness of the concentration versu ...
... RESULTS: Drugs that compete for a single receptor, and that similarly affect the receptor, must be additive in their effects. Receptors that bind suppressors in serial circuits, or enhancers in parallel circuits, increase the apparent potency of the drugs and the steepness of the concentration versu ...
Management of Medication Induced Xerostomia An Evidence Based
... trials that yielded unanimous CTF PHC scores of A-I. Furthermore, the xerostomic drugs prescribed in all three studies were of a psychiatric nature (major depressive disorder and/or psychoses). In general, acute administration of 10 mg yohimbine yielded a significant increase of NSFR. 12,13 However, ...
... trials that yielded unanimous CTF PHC scores of A-I. Furthermore, the xerostomic drugs prescribed in all three studies were of a psychiatric nature (major depressive disorder and/or psychoses). In general, acute administration of 10 mg yohimbine yielded a significant increase of NSFR. 12,13 However, ...
mechanisms of la toxicity
... The clinical presentation of LAST is typically a biphasic one, involving the CNS and CVS; by initially causing excitation and then depression. The reason for this is that these two organ systems are especially sensitive to electrophysiological changes; and are also most vulnerable to hypoxia due to ...
... The clinical presentation of LAST is typically a biphasic one, involving the CNS and CVS; by initially causing excitation and then depression. The reason for this is that these two organ systems are especially sensitive to electrophysiological changes; and are also most vulnerable to hypoxia due to ...
Age-related differences in reporting of drug
... We hypothesized that mitochondrial dysfunction could be more common in drugs associated with pediatric hepatotoxicity (due to inborn mitochondrial genetic defects), and that drugs of highly lipophilicity, dose, high first pass clearance, biliary excretion, or which inhibit bile acid efflux (e.g. thr ...
... We hypothesized that mitochondrial dysfunction could be more common in drugs associated with pediatric hepatotoxicity (due to inborn mitochondrial genetic defects), and that drugs of highly lipophilicity, dose, high first pass clearance, biliary excretion, or which inhibit bile acid efflux (e.g. thr ...
Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine
... ParaA and tacrine are structurally similar, and both substances are anticholinesterase agents. It is also possible that they could similarly modify nAChR responses. This view is supported by the observation that tacrine shortens the open time of nAChR, meaning that it is an open channel blocker [20] ...
... ParaA and tacrine are structurally similar, and both substances are anticholinesterase agents. It is also possible that they could similarly modify nAChR responses. This view is supported by the observation that tacrine shortens the open time of nAChR, meaning that it is an open channel blocker [20] ...
Sample pages 1 PDF
... pharmacokinetics – the study of time-dependent drug movement into, around and out of the body. ...
... pharmacokinetics – the study of time-dependent drug movement into, around and out of the body. ...
Marijuana: Impact on the Developing Adolescent Brain
... WWI (2 yrs.) 116,516 WWII (5 yrs.) 405,399 Vietnam (20 yrs.) 58,209 Addiction kills more people in 1 year than 27 years of WWI, WWII & Vietnam ...
... WWI (2 yrs.) 116,516 WWII (5 yrs.) 405,399 Vietnam (20 yrs.) 58,209 Addiction kills more people in 1 year than 27 years of WWI, WWII & Vietnam ...
Marijuana - Destiny High School
... Marijuana Marijuana is considered a possible gateway drug, a drug that may lead the user to try other, more dangerous drugs. Studies have shown that a teen who uses marijuana is 15 times more likely to use cocaine than a teen who has never used marijuana. ...
... Marijuana Marijuana is considered a possible gateway drug, a drug that may lead the user to try other, more dangerous drugs. Studies have shown that a teen who uses marijuana is 15 times more likely to use cocaine than a teen who has never used marijuana. ...
... This potent broad spectrum antibiotic is reserved for use in serious infections where other less dangerous agents have not worked. It penetrates into the CNS well and can be used for meningitis. The danger relates to the risk of serious and fatal blood dyscrasias (aplastic anemia, thrombocytopenia, ...
PDF Format - Indian Pediatrics
... Justification: The indications and doses of most drugs used for heart ailments in children are extrapolated from data in adult patients. Separate guidelines are needed for neonates, infants and children because of the differences in underlying heart diseases and metabolic clearance of some of these ...
... Justification: The indications and doses of most drugs used for heart ailments in children are extrapolated from data in adult patients. Separate guidelines are needed for neonates, infants and children because of the differences in underlying heart diseases and metabolic clearance of some of these ...
What is Cipro - Public Health
... unlikely, if it occurs at all. Therefore, there is no need to treat contacts of persons ill with anthrax, such as household contacts, friends, or coworkers, unless they also were also exposed to the same source of infection. Should I ask my doctor to write a prescription for Cipro in case it's neede ...
... unlikely, if it occurs at all. Therefore, there is no need to treat contacts of persons ill with anthrax, such as household contacts, friends, or coworkers, unless they also were also exposed to the same source of infection. Should I ask my doctor to write a prescription for Cipro in case it's neede ...
Full text in pdf format
... arthropods. Ingestion of high doses causes ovigerous American lobsters Homarus americanus to molt before their eggs hatch. To determine the effect of repeated exposure to doses at or below the noobserved-effect level (NOEL) of a single exposure (NOEL: 0.12 µg g–1), ovigerous lobsters were given eith ...
... arthropods. Ingestion of high doses causes ovigerous American lobsters Homarus americanus to molt before their eggs hatch. To determine the effect of repeated exposure to doses at or below the noobserved-effect level (NOEL) of a single exposure (NOEL: 0.12 µg g–1), ovigerous lobsters were given eith ...
Fact Sheet: Fentanyl and Synthetic Opioids
... widely, but generally doses fall within 5-200 milligrams.viii Many synthetic opioids are unapproved and have very little available research on their effects in humans. What is known about some of the fentanyl analogues and other opiate-like NPS is that many are highly potent, with effects active at ...
... widely, but generally doses fall within 5-200 milligrams.viii Many synthetic opioids are unapproved and have very little available research on their effects in humans. What is known about some of the fentanyl analogues and other opiate-like NPS is that many are highly potent, with effects active at ...
![Nefazodone in the rat: mimicry and antagonism of [À]-DOM](http://s1.studyres.com/store/data/007839591_1-ac381daefe7f911d421bf0a90c9e2846-300x300.png)
Nefazodone in the rat: mimicry and antagonism of [À]-DOM
... The continued widespread illicit use of hallucinogens (Johnston, 1997; Leshner, 1999) coupled with the fact that the SSRIs are the most widely prescribed psychoactive drugs in the world (Gram, 1994; Pincus et al., 1998) makes it likely that co-ingestion of these agents represents a common phenomenon ...
... The continued widespread illicit use of hallucinogens (Johnston, 1997; Leshner, 1999) coupled with the fact that the SSRIs are the most widely prescribed psychoactive drugs in the world (Gram, 1994; Pincus et al., 1998) makes it likely that co-ingestion of these agents represents a common phenomenon ...
Eliot Gardner, Ph.D. - Nysam
... and URB602 study Compare the peripheral antinociceptive effects of 2-AG, JZL184, URB602 and their combination in the formalin test Study the mechanisms by which JZL184 and URB602 produce their effects using specific CB1 and CB2 receptor antagonists ...
... and URB602 study Compare the peripheral antinociceptive effects of 2-AG, JZL184, URB602 and their combination in the formalin test Study the mechanisms by which JZL184 and URB602 produce their effects using specific CB1 and CB2 receptor antagonists ...
Adverse Effects of Antiepileptic Drugs
... tients occurs with the use of chloramphenicol in the newborn or tetracycline in infants and children. In contrast, adults have greater toxicity from aminoglycosides. The adverse effects of AEDs also vary with age. The growth effects of AEDs are important in children but not in adults. Elderly patien ...
... tients occurs with the use of chloramphenicol in the newborn or tetracycline in infants and children. In contrast, adults have greater toxicity from aminoglycosides. The adverse effects of AEDs also vary with age. The growth effects of AEDs are important in children but not in adults. Elderly patien ...
Title to be Placed Here
... of REM sleep to remission from untreated depression was studied over a 5-month period in 20 depressed and 10 control volunteers 60% of the depressed were in remission at the end of the study 64% of the variance in remission could be accounted for by 4 variables: – The initial level of self-reported ...
... of REM sleep to remission from untreated depression was studied over a 5-month period in 20 depressed and 10 control volunteers 60% of the depressed were in remission at the end of the study 64% of the variance in remission could be accounted for by 4 variables: – The initial level of self-reported ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.