Research Article PRELIMINARY PHYTOCHEMICAL ANALYSIS, HPTLC STUDIES AND ANTIPYRETIC ACTIVITY HELICTERES ISORA
... active site of cyclooxygenase. During fever, arachidonic acid synthesis may be inhibited by antipyretics. Most of the currently available antipyretics inhibit both cyclooxygenase1 and cyclooxygenase 2 (COX‐1 and COX‐2, respectively), inhibiting the synthesis of pros ...
... active site of cyclooxygenase. During fever, arachidonic acid synthesis may be inhibited by antipyretics. Most of the currently available antipyretics inhibit both cyclooxygenase1 and cyclooxygenase 2 (COX‐1 and COX‐2, respectively), inhibiting the synthesis of pros ...
ANNONA SQUAMOSA INDUCED GASTRIC ULCER IN ALBINO RATS. Full Proceeding Paper
... Peptic ulcer is a major health hazard both in terms of morbidity and mortality. It occurs due to imbalance between offensive versus impaired mucosal resistance. As an alternative to allopathic therapeutics, scientific research on plants used in traditional medicine is receiving growing interest as a ...
... Peptic ulcer is a major health hazard both in terms of morbidity and mortality. It occurs due to imbalance between offensive versus impaired mucosal resistance. As an alternative to allopathic therapeutics, scientific research on plants used in traditional medicine is receiving growing interest as a ...
Case Studies - Richman Chemical Inc.
... found it satisfactory. • No FDA requirement for safety testing. • In September, 1937, Massengill sent 633 shipments to 2/3 of the country. Richman Chemical Inc. www.richmanchemical.com ...
... found it satisfactory. • No FDA requirement for safety testing. • In September, 1937, Massengill sent 633 shipments to 2/3 of the country. Richman Chemical Inc. www.richmanchemical.com ...
Pharmacokinetics
... single dose or 50% of usual oral dosage. Child: >12yr PO 2-3mcg/kg/day, 6-12yr PO 45mcg/kg/day; 1-5yr PO 5-6 mcg/kg/day, 6-12mos PO 6-8 mcg/kg/day, up to 6mos PO 810 mcg/kg/day – all children's as single dose am; myxedema coma- Adult: IV 200-500 mcg, may increase by 100-300mcg after 24 hr; use oral ...
... single dose or 50% of usual oral dosage. Child: >12yr PO 2-3mcg/kg/day, 6-12yr PO 45mcg/kg/day; 1-5yr PO 5-6 mcg/kg/day, 6-12mos PO 6-8 mcg/kg/day, up to 6mos PO 810 mcg/kg/day – all children's as single dose am; myxedema coma- Adult: IV 200-500 mcg, may increase by 100-300mcg after 24 hr; use oral ...
poly(lactic-co-glycolic acid) based drug delivery devices
... Poly(D,L-lactide-co-glycolide) (PLGA) is the most frequently used biodegradable polymer for developing nano/ microparticles encapsulating therapeutic drugs in controlled release (CR) applications. PLGA based drug delivery devices have several advantages over the conventional devices. One of the adva ...
... Poly(D,L-lactide-co-glycolide) (PLGA) is the most frequently used biodegradable polymer for developing nano/ microparticles encapsulating therapeutic drugs in controlled release (CR) applications. PLGA based drug delivery devices have several advantages over the conventional devices. One of the adva ...
Determining the subjective and physiological effects
... Heart rate, diastolic and systolic blood pressure were measured by a Microlife Automatic Blood Pressure Monitor A100 Plus, which has been validated and determined as suitable for clinical use by the British Hypertension Society (http://www.bhsoc.org/blood_pressure_list.stm). Body temperature of the ...
... Heart rate, diastolic and systolic blood pressure were measured by a Microlife Automatic Blood Pressure Monitor A100 Plus, which has been validated and determined as suitable for clinical use by the British Hypertension Society (http://www.bhsoc.org/blood_pressure_list.stm). Body temperature of the ...
Evaluating Drugs Used To Treat: Constipation
... different types. Saline laxatives are magnesiumbased drugs and are best known as “milk of magnesia.” Others contain sodium phosphate or “phosphor-soda”. They draw water into the colon and soften the stool. But restrictions apply to their use. Extended use of saline laxatives can lead to electrolyte ...
... different types. Saline laxatives are magnesiumbased drugs and are best known as “milk of magnesia.” Others contain sodium phosphate or “phosphor-soda”. They draw water into the colon and soften the stool. But restrictions apply to their use. Extended use of saline laxatives can lead to electrolyte ...
pharmaceuticals: restrictions in use and availability
... effective date on which the regulation came into force; a summary of regulatory measures taken by governments; brief explanatory comments where necessary; and legal and bibliographical references. While the information cannot be regarded as exhaustive, either in terms of products or regulatory measu ...
... effective date on which the regulation came into force; a summary of regulatory measures taken by governments; brief explanatory comments where necessary; and legal and bibliographical references. While the information cannot be regarded as exhaustive, either in terms of products or regulatory measu ...
DISSOLUTION PROFILING OF BILAYERED CONVENTIONAL RELEASE PARACETAMOL AND
... follows rpm 100, temperature 37.5°C, bath volume 1000 mL and sampling interval are 5, 10, 15, 30, 45, 60, 120, 180, 240, ...
... follows rpm 100, temperature 37.5°C, bath volume 1000 mL and sampling interval are 5, 10, 15, 30, 45, 60, 120, 180, 240, ...
Low potential of dobutamine and dopexamine to block intestinal
... translocation, and eventually give rise to multiple organ failure (8, 9). A well-established action of the older catecholamines epinephrine and norepinephrine on the gut, which may limit their therapeutic usefulness, is the inhibition of propulsive intestinal motility (10 –13). This effect is primar ...
... translocation, and eventually give rise to multiple organ failure (8, 9). A well-established action of the older catecholamines epinephrine and norepinephrine on the gut, which may limit their therapeutic usefulness, is the inhibition of propulsive intestinal motility (10 –13). This effect is primar ...
Alcohol and Other Drugs: A Handbook for Health Professionals
... This Handbook has been produced with a very broad target audience in mind. Largely it will cater for the professional alcohol and other drugs needs of non-specialist medical practitioners and nurses. But it is also designed to be a useful practical tool for a wide range of other health and human ser ...
... This Handbook has been produced with a very broad target audience in mind. Largely it will cater for the professional alcohol and other drugs needs of non-specialist medical practitioners and nurses. But it is also designed to be a useful practical tool for a wide range of other health and human ser ...
Meperidine - Home - KSU Faculty Member websites
... Effects of meperidine: • The effects of meperidine are felt 10-15 minutes after ingestion and typically last anywhere from 2-4 hours. • mepiridine effects are very similar to morphine, with sedation, respiratory depression and euphoria less intense than that of morphine. • nausea and vomiting are c ...
... Effects of meperidine: • The effects of meperidine are felt 10-15 minutes after ingestion and typically last anywhere from 2-4 hours. • mepiridine effects are very similar to morphine, with sedation, respiratory depression and euphoria less intense than that of morphine. • nausea and vomiting are c ...
... prime spectrum remedy. It has an outstanding antibacterial efficacy against most gram-negative and gram-positive bacteria9. Pefloxacin is a bactericidal compound, this action results from interference with the activity of DNA gyrase and topoisomerase IV, which are important for the transcription and ...
DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF ROSIGLITAZONE MALEATE IN
... good agreement with label claim. The methods were validated statistically and by recovery studies.The proposed method can be used for routine QC analysis. Keywords: UV Spectrophotometry, Derivative spectroscopy, Rosiglitazone Maleate, Pharmaceutical formulation ...
... good agreement with label claim. The methods were validated statistically and by recovery studies.The proposed method can be used for routine QC analysis. Keywords: UV Spectrophotometry, Derivative spectroscopy, Rosiglitazone Maleate, Pharmaceutical formulation ...
What is the first choice antidepressant for patients with renal
... based on a study of 12 patients with end stage renal disease who were on maintenance haemodialysis and were taking 25mg/day sertraline. All 12 showed signs of serotonin syndrome and 11 discontinued within 3 weeks. The Renal Drug Handbook [4] suggests no dose reduction is required with sertraline in ...
... based on a study of 12 patients with end stage renal disease who were on maintenance haemodialysis and were taking 25mg/day sertraline. All 12 showed signs of serotonin syndrome and 11 discontinued within 3 weeks. The Renal Drug Handbook [4] suggests no dose reduction is required with sertraline in ...
DEVELOPMENT AND VALIDATION OF RP-HPLC AND HPTLC METHOD OF ANALYSIS... SIMULTANEOUS ESTIMATION OF AMBROXOL HCL, DEXTROMETHORPHAN HBR AND
... Performance Thin Layer Chromatography (HPTLC) for simultaneous estimation of Ambroxol HCl (AMB), Dextromethorphan HBr (DEX) and Guaifenesin (GUA) in Pharmaceutical Cough Cold Preparation and statistical comparison of both method was done. For RP-HPLC method Hibar RP-C18 (250mm × 4.6mm i.d. with part ...
... Performance Thin Layer Chromatography (HPTLC) for simultaneous estimation of Ambroxol HCl (AMB), Dextromethorphan HBr (DEX) and Guaifenesin (GUA) in Pharmaceutical Cough Cold Preparation and statistical comparison of both method was done. For RP-HPLC method Hibar RP-C18 (250mm × 4.6mm i.d. with part ...
The effects of chlorpromazine and pimozide in reinforcement
... would response rate go down, but reinforcement rate would decrease as well. The reinforcement rate decrease would, in turn, further decrease response rate, and because of this positive feedback loop, reinforcement rate and response rate would in lock-step drive each other ever lower. In support of t ...
... would response rate go down, but reinforcement rate would decrease as well. The reinforcement rate decrease would, in turn, further decrease response rate, and because of this positive feedback loop, reinforcement rate and response rate would in lock-step drive each other ever lower. In support of t ...
O R I G I N A L A R T I C L E
... > tianeptine > moclobemide, cocaine >> lithium, valproate. MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > venlafaxine > amitriptyline > olanzapine > citalopram > desipramine > reboxetine > imipramine > tianeptine > mirtazapine, cocaine >> moclobemide, ...
... > tianeptine > moclobemide, cocaine >> lithium, valproate. MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > venlafaxine > amitriptyline > olanzapine > citalopram > desipramine > reboxetine > imipramine > tianeptine > mirtazapine, cocaine >> moclobemide, ...
PEPZAN - Medsafe
... than 20 mg twice daily in healing oesophageal lesions. In another study however, the results for the 40 mg twice daily group were similar to the results for the 20 mg group. In patients treated for 6 months with famotidine 20 mg twice daily, relapse of oesophageal erosions or ulceration was signific ...
... than 20 mg twice daily in healing oesophageal lesions. In another study however, the results for the 40 mg twice daily group were similar to the results for the 20 mg group. In patients treated for 6 months with famotidine 20 mg twice daily, relapse of oesophageal erosions or ulceration was signific ...
Hyperforin - International Journal of Pharmacy and Pharmaceutical
... On comparing hyperforin rich Hypericum (St. John's wort) extract to the antidepressant drug fluoxetine (Prozac®) and placebo again confirmed the effectiveness of high-quality Hypericum extract for depression. In this randomized, controlled, double-blind trial, the 135 patients with major depressive ...
... On comparing hyperforin rich Hypericum (St. John's wort) extract to the antidepressant drug fluoxetine (Prozac®) and placebo again confirmed the effectiveness of high-quality Hypericum extract for depression. In this randomized, controlled, double-blind trial, the 135 patients with major depressive ...
Tips and Tricks for SG Procedures and GTL for Clinical Graphs
... A forest plot is a graphical display of the relative strength of treatment effects in multiple quantitative scientific studies addressing the same question (Wikipedia). An example of one common display of a Forest Plot is included in the list of Health Care and Life Sciences graph samples in the sup ...
... A forest plot is a graphical display of the relative strength of treatment effects in multiple quantitative scientific studies addressing the same question (Wikipedia). An example of one common display of a Forest Plot is included in the list of Health Care and Life Sciences graph samples in the sup ...
Chapter-3 Drug and excipients profile
... Milk of magnesia is sold for medical use as chewable tablets, capsules, and as liquids having various added flavors. It is primarily used to alleviate constipation, but also to relieve indigestion and heartburn. When taken orally as a laxative, the osmotic force of the magnesia suspension acts to dr ...
... Milk of magnesia is sold for medical use as chewable tablets, capsules, and as liquids having various added flavors. It is primarily used to alleviate constipation, but also to relieve indigestion and heartburn. When taken orally as a laxative, the osmotic force of the magnesia suspension acts to dr ...
Health Services Insights public Health Implications of Household
... data from the National Social life, Health and Aging Project (NSHAP), researchers studied pharmaceutical use among a nationally representative probability sample of community-residing individuals aged 57 through 85 years.10 Key findings from the NSHAP are summarized in Table 1. Among 2,976 individu ...
... data from the National Social life, Health and Aging Project (NSHAP), researchers studied pharmaceutical use among a nationally representative probability sample of community-residing individuals aged 57 through 85 years.10 Key findings from the NSHAP are summarized in Table 1. Among 2,976 individu ...
Document
... eGFR and aGFR in subjects with normal RF (screening eGFRCG $80 mL/min). Cohort 2 was single treatment and open label and aimed to investigate the effects of COBI on eGFR and aGFR in subjects with mild or moderate renal impairment (RI, screening eGFRCG 50–79 mL/min). In cohort 1, 36 healthy male and ...
... eGFR and aGFR in subjects with normal RF (screening eGFRCG $80 mL/min). Cohort 2 was single treatment and open label and aimed to investigate the effects of COBI on eGFR and aGFR in subjects with mild or moderate renal impairment (RI, screening eGFRCG 50–79 mL/min). In cohort 1, 36 healthy male and ...
slides
... States. Astron and Astron Pulsar are trademarks of Biotronik SE & Co. KG. Lifestent and Luminexx are trademarks of C. R. Bard. Zilver and Zilver PTX are trademarks of Cook Medical. Everflex is a trademark of Covidien. S.M.A.R.T. is a trademark of the Cordis Corporation, a Johnson & Johnson company. ...
... States. Astron and Astron Pulsar are trademarks of Biotronik SE & Co. KG. Lifestent and Luminexx are trademarks of C. R. Bard. Zilver and Zilver PTX are trademarks of Cook Medical. Everflex is a trademark of Covidien. S.M.A.R.T. is a trademark of the Cordis Corporation, a Johnson & Johnson company. ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.