psychiatric aspects of marihuana intoxication
... continue their indulgence beyond the point of euphoria, and soon learn to avoid becoming ill by remaining at a pleasurable distance from their maximum capacity for the drug. It may be mentioned that marihuana is no more aphrodisiac than is alcohol. Unlike damiana, yohimbin, testosterone propionate, ...
... continue their indulgence beyond the point of euphoria, and soon learn to avoid becoming ill by remaining at a pleasurable distance from their maximum capacity for the drug. It may be mentioned that marihuana is no more aphrodisiac than is alcohol. Unlike damiana, yohimbin, testosterone propionate, ...
A NEW STABILITY INDICATING VALIDATED METHOD FOR THE DETERMINATION OF
... flow rate of 1mL.min-1. And UV detector at 256 nm. The drug under study was subjected to different conditions like acid, base, alkali, temperature, light and oxidative stress conditions and also examined for solution stability for 48 hours. Results: In the developed method Aripiprazole elutes at a t ...
... flow rate of 1mL.min-1. And UV detector at 256 nm. The drug under study was subjected to different conditions like acid, base, alkali, temperature, light and oxidative stress conditions and also examined for solution stability for 48 hours. Results: In the developed method Aripiprazole elutes at a t ...
Doxylamine Succinate Overdose
... autopsies carried out in the Institute of Legal Medicine at Free University Berlin from 19871997, in two cases (0.30%) doxylamine alone was found. In that study doxylamine blood concentration values was less than 165 mg/l (13). It was reported that lethal dosage of doxylamine was less than 1 g (14, ...
... autopsies carried out in the Institute of Legal Medicine at Free University Berlin from 19871997, in two cases (0.30%) doxylamine alone was found. In that study doxylamine blood concentration values was less than 165 mg/l (13). It was reported that lethal dosage of doxylamine was less than 1 g (14, ...
Penicillins
... Natural resistance to the penicillins occurs in organisms that either lack a peptidoglycan cell wall (for example, mycoplasma) or have cell walls that are impermeable to the drugs. Acquired resistance to the penicillins by plasmid transfer has become a significant clinical problem. Organisms may bec ...
... Natural resistance to the penicillins occurs in organisms that either lack a peptidoglycan cell wall (for example, mycoplasma) or have cell walls that are impermeable to the drugs. Acquired resistance to the penicillins by plasmid transfer has become a significant clinical problem. Organisms may bec ...
![Nefazodone in the rat: mimicry and antagonism of [À]-DOM](http://s1.studyres.com/store/data/007839591_1-ac381daefe7f911d421bf0a90c9e2846-300x300.png)
Nefazodone in the rat: mimicry and antagonism of [À]-DOM
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
HIGHLIGHTS OF PRESCRIBING INFORMATION ----------------------- WARNINGS AND PRECAUTIONS -----------------------
... ----------------------- WARNINGS AND PRECAUTIONS ----------------------• Hepatotoxicity accompanied by severe rash or systemic allergic reaction, including potentially life-threatening events, has been reported. Hepatic laboratory parameters including ALT, AST, and bilirubin should be obtained prior ...
... ----------------------- WARNINGS AND PRECAUTIONS ----------------------• Hepatotoxicity accompanied by severe rash or systemic allergic reaction, including potentially life-threatening events, has been reported. Hepatic laboratory parameters including ALT, AST, and bilirubin should be obtained prior ...
Uptake of Methotrexate, Aminopterin, and
... 1 hr after administration of doses as low as 0.4 mg/kg; however, by contrast with the effects of comparable doses of Mtx, there was no recovery during the 1St 6 hr in mice given MQ. It appeared that MQ might be a more potent inhibitor or ...
... 1 hr after administration of doses as low as 0.4 mg/kg; however, by contrast with the effects of comparable doses of Mtx, there was no recovery during the 1St 6 hr in mice given MQ. It appeared that MQ might be a more potent inhibitor or ...
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... is the determining factor. On the other hand, very high SAC levels can result in extremely defensive actions. Effects/Alcohol and Other Substances Alcohol is very commonly used with other substances. ~~e primary combination, alcohol/marijuana, is more hazardous than using either substance alone, due ...
... is the determining factor. On the other hand, very high SAC levels can result in extremely defensive actions. Effects/Alcohol and Other Substances Alcohol is very commonly used with other substances. ~~e primary combination, alcohol/marijuana, is more hazardous than using either substance alone, due ...
3) Antihypertensive Drugs (Cont`d)
... – Human tPA is an enzyme that promotes conversion of plasminogen to plasmin, an enzyme that digests the fibrin matrix of clots ...
... – Human tPA is an enzyme that promotes conversion of plasminogen to plasmin, an enzyme that digests the fibrin matrix of clots ...
Research Article www.ijrap.net
... concentration range 2-20μg/mL at the λmax 256 nm, 436μg/mL at the λmax 263 nm respectively. The correlation coefficiant (R2) was calculated, where the (R2) value 0.999 for Quercetin and 0.997 for Curcumin indicates the good linearity between the concentration and absorbance. The estimation of Querce ...
... concentration range 2-20μg/mL at the λmax 256 nm, 436μg/mL at the λmax 263 nm respectively. The correlation coefficiant (R2) was calculated, where the (R2) value 0.999 for Quercetin and 0.997 for Curcumin indicates the good linearity between the concentration and absorbance. The estimation of Querce ...
Diuretics for hypertension: Hydrochlorothiazide or chlorthalidone?
... the change in nighttime blood pressure was greater in the chlorthalidone group (–13.5 mm Hg) than in the hydrochlorothiazide group (–6.4 mm Hg; P = .009). These data suggest that at the doses studied, chlorthalidone is more effective than hydrochlorothiazide in lowering systolic blood pressure. Ba ...
... the change in nighttime blood pressure was greater in the chlorthalidone group (–13.5 mm Hg) than in the hydrochlorothiazide group (–6.4 mm Hg; P = .009). These data suggest that at the doses studied, chlorthalidone is more effective than hydrochlorothiazide in lowering systolic blood pressure. Ba ...
Some Neuropharmacological Effects of the Crude Venom Extract of
... + = Mild effect, ++ = Strong effect, - = No Effect. ...
... + = Mild effect, ++ = Strong effect, - = No Effect. ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... breedingof School of medicine at Tabriz University to animals laboratory place of Islamic Azad University of Ahar. To prepare extract of the plant, the petals were used, tothis end1000 grams of dried herb were powdered, and in mixed chloroform: methanol (70:30) was soaked at least for 24 hours, and ...
... breedingof School of medicine at Tabriz University to animals laboratory place of Islamic Azad University of Ahar. To prepare extract of the plant, the petals were used, tothis end1000 grams of dried herb were powdered, and in mixed chloroform: methanol (70:30) was soaked at least for 24 hours, and ...
Alaris Medley Pump Module 8100 Version 7
... facilities that utilize infusion pumps for the delivery of fluids, medications, blood, and blood products using continuous or intermittent delivery through clinically acceptable routes of administration; such as, intravenous (IV), intra-arterial (IA), subcutaneous, epidural, enteral, or irrigation o ...
... facilities that utilize infusion pumps for the delivery of fluids, medications, blood, and blood products using continuous or intermittent delivery through clinically acceptable routes of administration; such as, intravenous (IV), intra-arterial (IA), subcutaneous, epidural, enteral, or irrigation o ...
PDF
... this means that there might be a delay before any effect is seen in terms of transmission from mosquitoto-human. However, ivermectin’s mosquito lethal and sublethal effects can quickly suppress the infectious vector population following MDA and thus immediately reduce mosquito-to-human transmission. ...
... this means that there might be a delay before any effect is seen in terms of transmission from mosquitoto-human. However, ivermectin’s mosquito lethal and sublethal effects can quickly suppress the infectious vector population following MDA and thus immediately reduce mosquito-to-human transmission. ...
4427 Naltrexone/Carers.NSW
... to ensure they are opioid free. If they do have opioids in their body Narcan will immediately bring on withdrawal symptoms which can last approximately one hour. • Certain liver conditions may exclude them from naltrexone treatment. These include acute hepatitis and alcoholic liver disease. The doct ...
... to ensure they are opioid free. If they do have opioids in their body Narcan will immediately bring on withdrawal symptoms which can last approximately one hour. • Certain liver conditions may exclude them from naltrexone treatment. These include acute hepatitis and alcoholic liver disease. The doct ...
PAGE2012 Poster Abstracts - the Population Approach Group in
... II-09 Rik Schoemaker Modelling and simulation of spontaneously reported adverse events after administration of lacosamide ...................................................................................... 123 II-10 Bernard Sebastien Impact of delayed effect in Concentration-QT analyses. ........ ...
... II-09 Rik Schoemaker Modelling and simulation of spontaneously reported adverse events after administration of lacosamide ...................................................................................... 123 II-10 Bernard Sebastien Impact of delayed effect in Concentration-QT analyses. ........ ...
Rifampicin Antagonizes the Effect of Chloroquine on Chloroquine
... of the exact mechanism of resistance, and whether it involves Pgh1, pfcrt, and/or other plasmodial vacuolar transporters, the fact remains that chemosensitizers have been used to excellent effect in reversing CQ resistance, and combinations of such chemosensitizers have been attempted in an effort t ...
... of the exact mechanism of resistance, and whether it involves Pgh1, pfcrt, and/or other plasmodial vacuolar transporters, the fact remains that chemosensitizers have been used to excellent effect in reversing CQ resistance, and combinations of such chemosensitizers have been attempted in an effort t ...
International Editorial Board
... losartan potassium as monotherapy in patients with essential hypertension is 50mg once daily. Some patients may benefit from 100 mg/day. Losartan potassium may be given with or without food.[2] In patients at high risk of hypotension or volume depletion and in those with hepatic dysfunction, the i n ...
... losartan potassium as monotherapy in patients with essential hypertension is 50mg once daily. Some patients may benefit from 100 mg/day. Losartan potassium may be given with or without food.[2] In patients at high risk of hypotension or volume depletion and in those with hepatic dysfunction, the i n ...
Managing Drug Interactions
... enzymes, there is potential for interaction at the site of action, or at sites of major side effects. Propranolol with nifedipine (A-V conduction disturbances and sinus bradycardia U Elkayam et al, Effects of nifedipine on hemodynamics and cardiac function in patients with normal left ventricular ej ...
... enzymes, there is potential for interaction at the site of action, or at sites of major side effects. Propranolol with nifedipine (A-V conduction disturbances and sinus bradycardia U Elkayam et al, Effects of nifedipine on hemodynamics and cardiac function in patients with normal left ventricular ej ...
PDF/153KB - Sumitomo Dainippon Pharma
... Designation from the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) in the treatment of acute myeloid leukemia (AML). National Cancer Institute (NCI) conducted alvocidib’s Phase 2 study（J-1101/NCI-8972, Haematologica 2015;100(9)） comparing ACM regimen (alvocidib, cytarab ...
... Designation from the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) in the treatment of acute myeloid leukemia (AML). National Cancer Institute (NCI) conducted alvocidib’s Phase 2 study（J-1101/NCI-8972, Haematologica 2015;100(9)） comparing ACM regimen (alvocidib, cytarab ...
Antifungal Therapy During Pregnancy
... The azole class of systemic antifungals includes the imidazoles and the more recently introduced triazoles. These drugs have offered a less toxic alternative to amphotericin B for the treatment of many of the fungi that produce deep-seated infection. The azoles are active against a wide array of fun ...
... The azole class of systemic antifungals includes the imidazoles and the more recently introduced triazoles. These drugs have offered a less toxic alternative to amphotericin B for the treatment of many of the fungi that produce deep-seated infection. The azoles are active against a wide array of fun ...
Methamphetamine use in Australia - NCETA
... Methamphetamine belongs to the ‘stimulant’ class of drugs, which also includes amphetamine, ecstasy, and cocaine. These drugs stimulate the brain and central nervous system, resulting in increased alertness and physical activity. ...
... Methamphetamine belongs to the ‘stimulant’ class of drugs, which also includes amphetamine, ecstasy, and cocaine. These drugs stimulate the brain and central nervous system, resulting in increased alertness and physical activity. ...
Essential Tremor
... would be a reasonable alternative to try. Furthermore, reviewing the prescribing information for tranylcypromine, you note that tremor is a rare but potential side effect of this medication. It would be important to review the history of his generalized anxiety and panic disorder and the need for on ...
... would be a reasonable alternative to try. Furthermore, reviewing the prescribing information for tranylcypromine, you note that tremor is a rare but potential side effect of this medication. It would be important to review the history of his generalized anxiety and panic disorder and the need for on ...
rajiv gandhi university of health sciences, karnataka
... prevalence of epilepsy is 0.7 % in India, which is comparable to the U.S. and other developing nations. The estimated incidence rate range from 40 to 60 per 1000,000 population/year. The WHO estimated that approximately 80 % people with epilepsy live in developing countries and most of them do not g ...
... prevalence of epilepsy is 0.7 % in India, which is comparable to the U.S. and other developing nations. The estimated incidence rate range from 40 to 60 per 1000,000 population/year. The WHO estimated that approximately 80 % people with epilepsy live in developing countries and most of them do not g ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.