a role for mitochondrial enzymes in inherited neoplasia and beyond
... The apparently dominantly inherited tumours are solitary and aggressive, and usually occur early in life (between the ages of 26 and 48 years). A key feature of these tumours is their histopathology — all component renal carcinomas that have been examined have a peculiar papillary histology15,16, wi ...
... The apparently dominantly inherited tumours are solitary and aggressive, and usually occur early in life (between the ages of 26 and 48 years). A key feature of these tumours is their histopathology — all component renal carcinomas that have been examined have a peculiar papillary histology15,16, wi ...
Common Sea Life of Southeastern Alaska
... Alternate life cycles! The un-stalked jellies on this page are the planktonic or medusa stages of hydroids. When looking at the sessile or hydroid phase (see the next page) one might never guess that these medusae come from similar organisms. In fact, many times the hydroid phase has been given a di ...
... Alternate life cycles! The un-stalked jellies on this page are the planktonic or medusa stages of hydroids. When looking at the sessile or hydroid phase (see the next page) one might never guess that these medusae come from similar organisms. In fact, many times the hydroid phase has been given a di ...
DARWIN`S GHOST: THE DARWIN EXHIBIT AT THE AMERICAN
... happen upon a jewel, the very ruby of evolution’s conceptual history – Darwin’s tree of life. There, on display, is that one page from the 1837 B notebook, the first of a series of notebooks on “transmutation”. 6 Indeed, the tree of life is an ancient icon, a perfectly apt and natural symbol, which ...
... happen upon a jewel, the very ruby of evolution’s conceptual history – Darwin’s tree of life. There, on display, is that one page from the 1837 B notebook, the first of a series of notebooks on “transmutation”. 6 Indeed, the tree of life is an ancient icon, a perfectly apt and natural symbol, which ...
The evolution of genomic imprinting and X
... One of the aspects of the PEG10 domain evolution which sets it apart from the other loci was its stepwise evolution. Only PEG10 from this locus was imprinted in marsupials, while the two neighbouring genes from this region, which are imprinted in humans and mice, appeared to be bi-allelically expre ...
... One of the aspects of the PEG10 domain evolution which sets it apart from the other loci was its stepwise evolution. Only PEG10 from this locus was imprinted in marsupials, while the two neighbouring genes from this region, which are imprinted in humans and mice, appeared to be bi-allelically expre ...
Proceedings of the Pittsburgh Workshop in History - Philsci
... discussion of the point we were making quickly. Upon rereading Sober, I’m not sure how he could have been clearer either. Millstein quotes the following sentence from Sober (a sentence we do not quote—we simply refer to pp. 110-115): “When it acts alone, the future frequencies of traits in a populat ...
... discussion of the point we were making quickly. Upon rereading Sober, I’m not sure how he could have been clearer either. Millstein quotes the following sentence from Sober (a sentence we do not quote—we simply refer to pp. 110-115): “When it acts alone, the future frequencies of traits in a populat ...
genetic counselling in psychiatry : scope and challenges.
... neurotransmitter serotonin has at least 14 different known subtypes of receptors. Neurotransmitter receptors initiate complex signaling cascades within nerve cells. These cascades process information, produce immediate outputs, such as a decision to fire, and, at the same time, initiate long-term, a ...
... neurotransmitter serotonin has at least 14 different known subtypes of receptors. Neurotransmitter receptors initiate complex signaling cascades within nerve cells. These cascades process information, produce immediate outputs, such as a decision to fire, and, at the same time, initiate long-term, a ...
A novel mutation of the Keratin 12 gene responsible for a severe
... Irregular astigmatism has been problematic despite the improvement of the recurrent corneal erosions. This rather atypical presentation may reflect the unique Arg430Pro missense mutation, which lies within the helix termination motif of the α-helical rod domain of KRT12 (Figure 4B). The helix-termin ...
... Irregular astigmatism has been problematic despite the improvement of the recurrent corneal erosions. This rather atypical presentation may reflect the unique Arg430Pro missense mutation, which lies within the helix termination motif of the α-helical rod domain of KRT12 (Figure 4B). The helix-termin ...
Superb starlings - Columbia University
... Breeding biology and life history Although superb starlings have been observed nesting in every month of the year at Mpala, the primary breeding season occurs during the long rains from March to June with a secondary breeding season during the short rains in October to November. The mean (± S.D.) nu ...
... Breeding biology and life history Although superb starlings have been observed nesting in every month of the year at Mpala, the primary breeding season occurs during the long rains from March to June with a secondary breeding season during the short rains in October to November. The mean (± S.D.) nu ...
Identification and comparative analysis of accessory gland
... probed the libraries with female cDNA (cDNA from wholebody extracts of Allonemobius and Gryllus females, respectively) to identify and eliminate ‘‘housekeeping’’ genes. To do this we used a plate replicator to spot the library (colonies grown independently in liquid medium) onto nylon membranes plac ...
... probed the libraries with female cDNA (cDNA from wholebody extracts of Allonemobius and Gryllus females, respectively) to identify and eliminate ‘‘housekeeping’’ genes. To do this we used a plate replicator to spot the library (colonies grown independently in liquid medium) onto nylon membranes plac ...
k-selection
... 2) display some phenotypic resemblance to humans 3) engage in courtship behaviours. E.g. send gifts, be willing to take it slow. ...
... 2) display some phenotypic resemblance to humans 3) engage in courtship behaviours. E.g. send gifts, be willing to take it slow. ...
Phylogenetic ANOVA: The Expression Variance and
... Phylogenetic ANOVA: The Expression Variance and Evolution (EVE) model for quantitative trait evolution ...
... Phylogenetic ANOVA: The Expression Variance and Evolution (EVE) model for quantitative trait evolution ...
The making of the Fittest: Natural Selection and Adaptation
... If the offspring is SS, do not place a tally mark in the table; simply return the alleles to the population and mix as you did in simulation 2. The SS genotype represents individuals who have sickle cell disease. Sickle cell disease is a lethal disease caused by a genetic mutation. In East Africa, c ...
... If the offspring is SS, do not place a tally mark in the table; simply return the alleles to the population and mix as you did in simulation 2. The SS genotype represents individuals who have sickle cell disease. Sickle cell disease is a lethal disease caused by a genetic mutation. In East Africa, c ...
35. A History of the Ecological Sciences, Part 35
... was an early naturalist who described using what we now call a plankton net (Wheeler 1968, 1976, Davis 2004, Valier 2004). He was anticipated by John Cranch, who used a similar tow net on James Tuckey’s expedition to the Congo in April 1816 (Wheeler 1976:355). Thompson first used one in 1816, while ...
... was an early naturalist who described using what we now call a plankton net (Wheeler 1968, 1976, Davis 2004, Valier 2004). He was anticipated by John Cranch, who used a similar tow net on James Tuckey’s expedition to the Congo in April 1816 (Wheeler 1976:355). Thompson first used one in 1816, while ...
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
... their offspring account for approximately 10% of the global population. The increased risk for congenital/genetic disorders is most marked for autosomal recessive disorders and depends on the degree of relatedness of the parents. For children of first cousins the increased risk is 2-4%. For individu ...
... their offspring account for approximately 10% of the global population. The increased risk for congenital/genetic disorders is most marked for autosomal recessive disorders and depends on the degree of relatedness of the parents. For children of first cousins the increased risk is 2-4%. For individu ...
02_whole - Massey Research Online
... works, citing two in the first edition and three in the second (Campbell 4). Even more significantly, Darwin was cautious to exclude humans from his discussion of the origins of life, and restricted his analysis to other species exclusively.7 However this was not enough to avoid disparagement from t ...
... works, citing two in the first edition and three in the second (Campbell 4). Even more significantly, Darwin was cautious to exclude humans from his discussion of the origins of life, and restricted his analysis to other species exclusively.7 However this was not enough to avoid disparagement from t ...
Mobility as an Emergent Property of Biological Organization: Insights
... of biological organization, it cannot evolve without changes in a suite of other traits. 2. Evolutionary changes in mobility will result in trade-offs and constraints among associated traits. Because mobility depends on so many traits at various lower levels of biological organization, its independe ...
... of biological organization, it cannot evolve without changes in a suite of other traits. 2. Evolutionary changes in mobility will result in trade-offs and constraints among associated traits. Because mobility depends on so many traits at various lower levels of biological organization, its independe ...
GeNeViSTA Coffin Siris Syndrome: A Disorder of SWI/SNF Pathway
... Two mechanisms of chromosome remodeling by SWI/SNF have been proposed. The rst model involves a unidirectional diffusion of a twist defect in the nucleosomal DNA that starts at the DNA entry site of the nucleosome and results in a corkscrew-like propagation of DNA on the histone octamer surface. The ...
... Two mechanisms of chromosome remodeling by SWI/SNF have been proposed. The rst model involves a unidirectional diffusion of a twist defect in the nucleosomal DNA that starts at the DNA entry site of the nucleosome and results in a corkscrew-like propagation of DNA on the histone octamer surface. The ...
Bean There, Done That: A Hardy-Weinberg
... forces. For the above example, that would mean that after many generations the frequency of AA is still p2 and the frequency of Aa is still 2pq. We can demonstrate this by considering a hypothetical randomly mating population from table above. To do this, first consider all the possible matings from ...
... forces. For the above example, that would mean that after many generations the frequency of AA is still p2 and the frequency of Aa is still 2pq. We can demonstrate this by considering a hypothetical randomly mating population from table above. To do this, first consider all the possible matings from ...
Unit F212 - Molecules, biodiversity, food and health
... B3 DO NOT CREDIT boil / warm B3 DO NOT CREDIT if Benedict’s added to the mixture at the beginning C6 CREDIT description of method ...
... B3 DO NOT CREDIT boil / warm B3 DO NOT CREDIT if Benedict’s added to the mixture at the beginning C6 CREDIT description of method ...
CommercialOutbreds07..
... There is considerable variation in the size of colonies and the way animals are maintained (Table 1). Since unintended directional selection (for example culling small mice) and genetic drift alter genetic diversity, some breeders maintain heterozygosity by periodically crossing the stock to animals ...
... There is considerable variation in the size of colonies and the way animals are maintained (Table 1). Since unintended directional selection (for example culling small mice) and genetic drift alter genetic diversity, some breeders maintain heterozygosity by periodically crossing the stock to animals ...
“Why transgenic animals do not raise the same reactions of people
... Other applications are directed to production of certain medicinal substances for therapeutic needs. It is desirable that the transgenic animal used for pharmaceutical production secretes the desired substance at high levels without endangering its own health and that it passes this ability to its p ...
... Other applications are directed to production of certain medicinal substances for therapeutic needs. It is desirable that the transgenic animal used for pharmaceutical production secretes the desired substance at high levels without endangering its own health and that it passes this ability to its p ...
Induced point mutations in the phytoene synthase 1 gene cause
... To further investigate the colour phenotypes, flesh samples from all fruit were analysed for carotenoid content using HPLC, as described in Materials and Methods (Fig. 4). Four metabolites were measured: phytoene, the direct PSY product; lycopene, the main compound responsible for the red colour of ...
... To further investigate the colour phenotypes, flesh samples from all fruit were analysed for carotenoid content using HPLC, as described in Materials and Methods (Fig. 4). Four metabolites were measured: phytoene, the direct PSY product; lycopene, the main compound responsible for the red colour of ...
AP Biology Exam - Final Checklist
... Practice questions that go to each of these objectives can be found at: http://www.learnerator.com/apbiology?utm_source=sendy&utm_medium=email&utm_campaign=apbiofinalpush Theme 1: Evolution and the Diversity of Life ...
... Practice questions that go to each of these objectives can be found at: http://www.learnerator.com/apbiology?utm_source=sendy&utm_medium=email&utm_campaign=apbiofinalpush Theme 1: Evolution and the Diversity of Life ...
Further Topics in Optimization
... Parent Selection: Roulette wheel selection …contd. These probabilities are represented on a pie chart Then four numbers are randomly generated between 1 and 100 The likeliness of these numbers falling in the region of candidate 2 might be once, whereas for candidate 4 it might be twice and candidat ...
... Parent Selection: Roulette wheel selection …contd. These probabilities are represented on a pie chart Then four numbers are randomly generated between 1 and 100 The likeliness of these numbers falling in the region of candidate 2 might be once, whereas for candidate 4 it might be twice and candidat ...
Koinophilia
Koinophilia is an evolutionary hypothesis concerning sexual selection which proposes that animals seeking mate preferentially choose individuals with a minimum of unusual features. Koinophilia intends to explain the clustering of organisms into species and other issues described by Darwin's Dilemma. The term derives from the Greek, koinos, ""the usual"", and philos, ""fondness"".Natural selection causes beneficial inherited features to become more common and eventually replace their disadvantageous counterparts. A sexually-reproducing animal would be expected to avoid individuals with unusual features, and to prefer to mate with individuals displaying a predominance of common or average features. This means that mates displaying mutant features are also avoided. This is advantageous because most mutations that manifest themselves as changes in appearance, functionality or behavior, are disadvantageous. Because it is impossible to judge whether a new mutation is beneficial or not, koinophilic animals avoid them all, at the cost of avoiding the occasional beneficial mutation. Thus, koinophilia, although not infallible in its ability to distinguish fit from unfit mates, is a good strategy when choosing a mate. A koinophilic choice ensures that offspring are likely to inherit features that have been successful in the past.Koinophilia differs from assortative mating, where ""like prefers like"". If like preferred like, leucistic animals (such as white peacocks) would be sexually attracted to one another, and a leucistic subspecies would come into being. Koinophilia predicts that this is unlikely because leucistic animals are attracted to the average in the same way as other animals. Since non-leucistic animals are not attracted by leucism, few leucistic individuals find mates, and leucistic lineages will rarely form.Koinophilia provides simple explanations for the rarity of speciation (in particular Darwin's Dilemma), evolutionary stasis, punctuated equilibria, and the evolution of cooperation. Koinophilia might also contribute to the maintenance of sexual reproduction, preventing its reversion to the much simpler and inherently more advantageous asexual form of reproduction.The koinophilia hypothesis is supported by research into the physical attractiveness of human faces by Judith Langlois and her co-workers. They found that the average of two human faces was more attractive than either of the faces from which that average was derived. The more faces (of the same gender and age) that were used in the averaging process the more attractive and appealing the average face became. This work into averageness supports koinophilia as an explanation of what constitutes a beautiful face, and how the individuality of a face is recognized.