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Chemosensory organs as models of neuronal synapses
Chemosensory organs as models of neuronal synapses

... sad‑1 mutants inappropriately accrete presynaptic components in the dendrites of both sensory neurons and motor neurons. These results suggest that the formation of polarized structures that promote receptiveending formation may also be under common control in these two cell types. Trafficking of re ...
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Introduced amino terminal epitopes can reduce surface expression
Introduced amino terminal epitopes can reduce surface expression

Characterization of the Satellite Glial Cell (SGC) in the extrinsic
Characterization of the Satellite Glial Cell (SGC) in the extrinsic

... 4. De Lartigue, G., de la Serre, C. B., Espero, E., Lee, J., & Raybould, H. E. (2011). Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. American Journal of Physiology-Endocrinology and Metabolism, 301(1), E187-E195. 5. De Lartigue, G., De La Serre, C. B., ...
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Identification of the first invertebrate interleukin
Identification of the first invertebrate interleukin

... The evidence presented here indicates that domeless encodes a receptor of the Drosophila JAK/STAT pathway and shows that the pathway is conserved in invertebrates. The previous failure to detect the receptor was due to sequence similarity being restricted to a few critical amino acids in otherwise q ...
The P2Y12 receptor regulates microglial activation by extracellular
The P2Y12 receptor regulates microglial activation by extracellular

... paracrine signaling by these cells6,7. For example, activation of the P2X4 receptor has been implicated in the process whereby nerve damage produces pain hypersensitivity (neuropathic pain), a pathway that may involve nucleotide-evoked release of neurotrophins (BDNF) from microglia8. One hallmark of ...
Anthraquinone emodin inhibits human cancer
Anthraquinone emodin inhibits human cancer

... Adenosine 5ʹ-triphosphate (ATP) is a well-known intracellular source of energy for all forms of living cells. ATP is also released to the extracellular milieu in both physiological and pathological settings, and initiates signaling pathways through activation of membrane receptors. There are two dis ...
Chapter 7 final - Spiral
Chapter 7 final - Spiral

Neuron`s Cell Membrane
Neuron`s Cell Membrane

... channels that regulate the flow of charged ions that are the basis for the neuron’s electrical messages Any time there is a difference in charge, there is the potential for the flow of current or charge from one place to another if a “connection” between the areas is provided. ...
Chapter 9 Lecture Slides - Tanque Verde Unified School District
Chapter 9 Lecture Slides - Tanque Verde Unified School District

... The answer is A. In the Calvin cycle, RuBP bonds to carbon in the first step and is produced in the last step. In the citric acid cycle, oxaloacetic acid reacts in the first step and is recycled in the last step. ...
HL-1 Myocytes Exhibit PKC and K Channel-Dependent Delta Opioid Preconditioning
HL-1 Myocytes Exhibit PKC and K Channel-Dependent Delta Opioid Preconditioning

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Cloning, Expression, and Pharmacological Characterization of a
Cloning, Expression, and Pharmacological Characterization of a

... Alto, CA). PCR was performed using gene specific primers corresponding to the putative coding sequence of the gene from an unfinished genomic sequence (GenBank accession number AC007922), and AP adaptor primers (Clontech). The complete AXOR35 cDNA was isolated from human bone marrow and leukocytes b ...
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Correlations between total cell concentration, total adenosine tri

... 2004; Pepper et al., 2004). It has been discussed previously that HPC results are influenced by various factors such as cultivation media, incubation temperature and the selective culturability of natural bacteria (Hammes et al., 2008; Sartory, 2004). Moreover, the HPC method is time-consuming, requ ...
Gene Section MERTK (c-mer proto-oncogene tyrosine kinase) Atlas of Genetics and Cytogenetics
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... have been identified as the primary sites of autophosphorylation (Ling et al., 1996). These three residues are also conserved in the same sequence context in Axl and Tyro-3. Another residue within the kinase domain, Y872, is part of consensus GRB2 binding site, YXNX, and the corresponding sequence i ...
- Wiley Online Library
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... to the corresponding wildtype based on measurements of specific [3H]-mesulergine binding or flow cytometry analyses. Taken together, these results suggest that K4.45 and S/C7.45 play an important role in the conformational rearrangements leading to agonist-induced activation of 5-HT2 receptors. Keyw ...
Module 13: The Endocrine System: Hormones and Receptors
Module 13: The Endocrine System: Hormones and Receptors

... lower the height of the basket (increase receptor sensitivity) We can also do the opposite to decrease the number of shots that they make by taking a ball and a basket away, and raising the height of the basket. It is not necessary to do all three in order to drastically affect the outcome of the ho ...
Blood 93/6 - Semantic Scholar
Blood 93/6 - Semantic Scholar

Eph signalling and morphogenesis - Development
Eph signalling and morphogenesis - Development

Patrick chapter 19 part 1
Patrick chapter 19 part 1

... • Glaucoma is an eye disease, characterized by increased intraocular pressure. It leads to irreversible loss of vision and is the second leading cause of blindness. • Treatments for glaucoma focus on relieving the pressure. • Carbachol causes miosis (constriction of the pupil), by contracting the c ...
a morphogenetic role for the TNF signalling pathway
a morphogenetic role for the TNF signalling pathway

... One mechanism by which RhoA activity can be regulated is via the RhoGDP dissociation inhibitor (RhoGDI), which can bind to the intracellular domain of p75 (Yamashita and Tohyama, 2003). The binding of RhoGDI to p75 prevents the inhibition of RhoA by RhoGDI, allowing activation of RhoA by an as-yet-u ...
EGF cell surface receptor quantitation on ocular cells by an
EGF cell surface receptor quantitation on ocular cells by an

... cells, endothelial cells, chondrocytes)1'2 by binding to a specific cell surface receptor homogeneously distributed in the plasma membrane. Binding typically triggers, via a cascade effect, cellular oncogene expression and a number of biologic responses in the target cell, including increased glucos ...
Introduction to Endocrinology
Introduction to Endocrinology

... The endocrine hormones are carried by the circulatory system to cells throughout the body, including the nervous system in some cases, where they bind with receptors and initiate many reactions. Some endocrine hormones affect many different types of cells of the body; for example, growth hormone (fr ...
Protein Kinase A Activation Down-Regulates, Whereas Extracellular
Protein Kinase A Activation Down-Regulates, Whereas Extracellular

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Purinergic signalling



Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.The purinergic signalling complex of a cell is sometimes referred to as the “purinome”.
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