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chapter 45 - Biology Junction
chapter 45 - Biology Junction

... signal transduction pathways, and/or different proteins for carrying out the response. Lipid-soluble hormones have intracellular receptors.  Evidence for intracellular receptors for steroid hormones came in the 1960s.  Researchers demonstrated that estrogen and progesterone accumulate within the n ...
Introduction To Endocrinology: The Hypothalamic
Introduction To Endocrinology: The Hypothalamic

... to both the hypothalamus and pituitary, where it acts via specific receptors to inhibit the production and secretion of both its hypothalamic releasing hormone and the regulatory pituitary hormone, thereby tightly regulating target hormone levels. In addition, other brain regions have inputs to the ...
Thyroid Gland - Mr-Js-Science
Thyroid Gland - Mr-Js-Science

... •Thyroid gland enlarges due to lack of iodine •Salt is iodized to prevent goiters •Cretinism •Caused by hyposecretion of thyroxine •Results in dwarfism during childhood ...
Chapter 45 - HCC Southeast Commons
Chapter 45 - HCC Southeast Commons

... Evolution of Hormone Function • Over the course of evolution the function of a given hormone may diverge between species • For example, thyroid hormone plays a role in ...
ch_09_lecture_presentation
ch_09_lecture_presentation

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Hormones and the Endocrine System
Hormones and the Endocrine System

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Human longevity is characterised by high thyroid stimulating
Human longevity is characterised by high thyroid stimulating

... of free T4 (fT4) and free T3 (fT3)7. When offspring were compared to their partners, fT4 levels were similar, whereas TSH was higher and fT3 levels were slightly lower8,9. Moreover studies in the oldest old from the general population also link increased levels of TSH with reduced old age mortality1 ...
Hormonal Responses to Exercise Objectives Objectives
Hormonal Responses to Exercise Objectives Objectives

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The Endocrine System
The Endocrine System

... controlled by nerve fibers from the hypothalamus. In addition to transmitting nerve impulses, however, these specialized nerve fibers seem to also transport “releasing hormones” (e.g. gonadotropin releasing hormone or GnRH) to the pituitary gland. Copyright © 2006 Pearson Education, Inc., publishing ...
CHAPTER 45
CHAPTER 45

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Elective central compartment neck dissection in patients with
Elective central compartment neck dissection in patients with

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Introduction to Endocrinology

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Hashimoto`s Thyroiditis - Thyroid Disease Manager
Hashimoto`s Thyroiditis - Thyroid Disease Manager

... thyroid cells and produce hypothyroidism. It has been proposed that TSBAb bind to epitopes near the carboxyl end of the TSH-R extracellular domain, in contrast to thyroid stimulating antibodies (TSAb), which bind to epitopes near aa 40 at the amino terminus(20). This syndrome occurs in neonates, chi ...
adrenal insufficiency - Hormone Health Network
adrenal insufficiency - Hormone Health Network

... • Primary AI, also called Addison’s disease. In this rare condition, the adrenal glands do not work properly and cannot make enough cortisol (a “stress” hormone). Usually, production of aldosterone and androgens (the other hormones made by the adrenal glands) is also low. • Secondary AI. This far mo ...
Hashimoto`s Thyroiditis
Hashimoto`s Thyroiditis

... HLA-DR alleles for binding of other thyroglobulin peptides. Increased K and NK cell function has been reported in Hashimoto’s thyroiditis(19). Dysfunction of regulatory (or suppressor) CD4+ T cell populations may lead to the development of various organ-specific autoimmune diseases including Hashimo ...
Anterior pituitary hormone effects on hepatic functions in infants with
Anterior pituitary hormone effects on hepatic functions in infants with

... ished serum cortisol levels during stress, particularly during hypoglycemic episodes, would have strongly suggested cortisol deficiency. Cortisol deficiency and hypoglycemia were not initially present in Case 6, but appeared following stress. Low IGF-1, IGFBP-3, and/or GH levels in the presence of h ...
Anterior pituitary hormone effects on hepatic functions
Anterior pituitary hormone effects on hepatic functions

... ished serum cortisol levels during stress, particularly during hypoglycemic episodes, would have strongly suggested cortisol deficiency. Cortisol deficiency and hypoglycemia were not initially present in Case 6, but appeared following stress. Low IGF-1, IGFBP-3, and/or GH levels in the presence of h ...
An Integrative Endocrine Model for the Evolution of
An Integrative Endocrine Model for the Evolution of

... adult metamorphosed amphibians (Darras and Kühn, 1983; Denver, 1988; Jacobs et al., 1988). In contrast, hypothalamic corticotropin-releasing factor (CRF; discussed with corticosteroids below) appears to regulate the release of TSH in larval amphibians (Denver and Licht, 1989; Denver, 1993, 1997, 20 ...
Thierry Hertoghe - Terzo Congresso ImeB
Thierry Hertoghe - Terzo Congresso ImeB

... SUBJECTS: 13 normal volunteers => ate either THERAPY: consumption of 100 or 200 g/day of licorice for 1-4 weeks • > 2x ↑ urine cortisol excretion in 10 of 13 subjects (mean, 33.8 before & 83.3 µg/24 h at 1 week after commencing licorice) => excretion rates similar to Cushing's syndrome in 7 subjects ...
hormones - HCC Learning Web
hormones - HCC Learning Web

... Evolution of Hormone Function • Over the course of evolution the function of a given hormone may diverge between species • For example, thyroid hormone plays a role in ...
Endocrine System
Endocrine System

... Endocrine take longer for effect b/c needs to be made and travels through blood stream throughout body and causes protein synthesis longer lasting because hormones can trigger protein production that lasts long time ...
The Peripheral Endocrine Glands
The Peripheral Endocrine Glands

... Tyrosine-containing Tg produced within the thyroid follicular cells by the endoplasmic reticulum–Golgi complex is transported by exocytosis into the colloid. Iodide is carried by secondary active transport from the blood into the colloid by symporters in the basolateral membrane of the follicular ce ...
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Hyperthyroidism



Hyperthyroidism, also known as over active thyroid and hyperthyreosis, is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism. Some, however, use the terms interchangeably. Signs and symptoms vary between people and may include irritability, muscle weakness, sleeping problems, a fast heartbeat, poor tolerance of heat, diarrhea, enlargement of the thyroid, and weight loss. Symptoms are typically less in the old and during pregnancy. An uncommon complication is thyroid storm in which an event such as an infection results in worsening symptoms such as confusion and a high temperature and often results in death. The opposite is hypothyroidism, when the thyroid gland does not make enough thyroid hormone.Graves' disease is the cause of about 50% to 80% of case of hyperthyroidism in the United States. Other causes include multinodular goiter, toxic adenoma, inflammation of the thyroid, eating too much iodine, and too much synthetic thyroid hormone. A less common cause is a pituitary adenoma. The diagnosis may be suspected based on signs and symptoms and then confirmed with blood tests. Typically blood tests show a low thyroid stimulating hormone (TSH) and raised T3 or T4. Radioiodine uptake by the thyroid, thyroid scan, and TSI antibodies may help determine the cause.Treatment depends partly on the cause and severity of disease. There are three main treatment options: radioiodine therapy, medications, and thyroid surgery. Radioiodine therapy involves taking iodine-131 by mouth which is then concentrated in and destroys the thyroid over weeks to months. The resulting hypothyroidism is treated with synthetic thyroid hormone. Medications such as beta blockers may control the symptoms and anti-thyroid medications such as methimazole may temporarily help people while other treatments are having effect. Surgery to remove the thyroid is another option. This may be used in those with very large thyroids or when cancer is a concern. In the United States hyperthyroidism affects about 1.2% of the population. It occurs between two and ten times more often in women. Onset is commonly between 20 and 50 years of age. Overall the disease is more common in those over the age of 60 years.
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