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AB146PSI-AOAPO_KumariP_30092016
AB146PSI-AOAPO_KumariP_30092016

... disease is systemic in nature and predominantly affects bones and cartilage of synovial joints in symmetric fashion. Synovial tissue is the primary target site for inflammation where infiltrated immune cells significantly modify its protective function. Various immune mediators secreted from residen ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
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... II. State whether the following are true or false; if false give reason: (5 x 1= 5 marks) (6) Monocytes are agranulocytes. (7) An individual can inherit a maximum of 12 different MHC II molecules. (8) Autoantibodies to intrinsic factor will lead to Goodpasture’s syndrome. (9) Monoclonal antibodies a ...
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... • Class I molecules “present” peptides from molecules that are made inside the cell (endogenous processing pathway). Viral particles, for example, are made internally. • Together the peptide and MHC form a shape (3-D structure) that may match (complement) the surface of a T cell receptor • MHC Class ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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