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... Natural killer (NK) cells Activating receptor ...
Foundations in Microbiology
Foundations in Microbiology

... • Sensitizing dose – on first contact with allergen, specific B cells form IgE which attache to mast cells and basophils; generally no signs or symptoms • Provocative dose - subsequent exposure with the same allergen binds to the IgE-mast cell complex • Degranulation releases mediators with physiolo ...
The Immune System
The Immune System

... antigens. The actual cause of this disease is unknown and there is a tendency for such diseases to be inherited. MS (multiple sclerosis) is a condition which affects the myelin covering of nerve fibers. Rheumatoid arthritis is a chronic autoimmune disease that affects the bone and tissue of joints i ...
Lecture 14 - Innate Defenses
Lecture 14 - Innate Defenses

... Always have tremendous killing power ...
Defense Systems
Defense Systems

...  does not discriminate between different kinds of threats (pathogens)  no lasting memory of the particular invader 2. Non-specific defenses Table 13.1  species barrier: most pathogens are species specific  physical barriers: skin and mucous membrane  secretions: kills microbes, prevent their en ...
IMMUNOTHERAPY
IMMUNOTHERAPY

antigen
antigen

... WHITE BLOOD CELLS (WBCs) are the main cells of the immune system. These cells are very numerous; of the approximately 100 trillion cells in your body, 2 trillion are white blood cells. The two types essential to immunity are macrophages and lymphocytes. ...
03-Chapter-8-supplement
03-Chapter-8-supplement

... Herpes simplex virus ICP47 protein binds to TAP and prevents translocation of peptides into the lumen of the ER Human cytomegalovirus US6 protein binds to TAP and inhibits ATP binding HCMV US2 and US11, and mouse hepatitis virus mK3 proteins dislocate class I proteins from the ER to the cytoplasm Mu ...
Features of structural change of corticotropic cells of pituitary gland
Features of structural change of corticotropic cells of pituitary gland

... Features of structural change of corticotropic cells of pituitary gland after experimental immunostimulation Bobrysheva I.V. Introduction In the last decade in theoretical medicine and clinical practice there was a new direction – neuroimmunoendocrinology [6, 10, 11, 12]. Now nonspecific regulation ...
Immunity AIM: How does the immune system protect the body
Immunity AIM: How does the immune system protect the body

... examples of these diseasecausing organisms. ...
Immunity and Immune Response
Immunity and Immune Response

... – Each produces a different receptor in the cell membrane – Each receptor is composed of 1 molecule each of two different proteins – Each receptor binds a specific antigen but has only one binding site – Receptor only recognizes antigens which are "presented" to it within another membrane protein of ...
Immune Defense notes part 2 fill-in
Immune Defense notes part 2 fill-in

...  Production or function of immune cells is _________________  May be __________________ or ___________________  Includes AIDS - ________________ Immunodeficiency Syndrome ...
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Studying the Effects of Congaplex® and

lymphocytes
lymphocytes

... • They present the antigen on their surface (APC) for the lymphocytes to identify • Macrophages release chemicals called monokines (a type of cytokine) to attract neutrophils and activate lymphocytes ...
The Lymphatic and System and the Immune System
The Lymphatic and System and the Immune System

... The body's innate defense against disease is natural immunity. The immune system consists of white blood cells, cell products, and other substances. ...
Immune System Information
Immune System Information

... Your first line of defense can also be called your innate or nonspecific immunity. This includes your skin, tears, mucous membranes, nose hair and cilia. These structures perform the following functions to keep you safe from infection:  Act like a barrier against pathogens  Destroy pathogens on co ...
Organs of the Immune System 01/31/06
Organs of the Immune System 01/31/06

...  T cell selection  Based on MHC/Ag complex recognition  Recognize MHC/Non self AG complexes  Recognize MHC/Self Ag complexes  Do not recognize MHC/Ag complexes ...
Cytokines in Cancer Pathogenesis and Cancer Therapy
Cytokines in Cancer Pathogenesis and Cancer Therapy

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L18: Immune System, Part 1

... • Where can pathogens enter the body? • What are the barriers to pathogen entry? ...
Stem cells from fat outperform those from bone marrow Singapore
Stem cells from fat outperform those from bone marrow Singapore

... cells (AT-SCs) to achieve the same effect on the immune cells. When it came to secreting cytokines, the cell signaling molecules that regulate the immune system, the AT-SCs also outperformed the bone marrow-derived cells. The finding could have significant implications in developing new stem-cell-ba ...
Microsoft Word
Microsoft Word

... 20. Suppose a pathogen infects and kills macrophage cells. How will this pathogen affect B Cell activity? T Cell activity? The ability to produce a fever? 21. Of what benefit is a fever during a bacterial infection? 22. Discuss antibodies with respect to each of the following: a. Specificity b. Shap ...
Quiz: Body Defenses
Quiz: Body Defenses

... 20. Suppose a pathogen infects and kills macrophage cells. How will this pathogen affect B Cell activity? T Cell activity? The ability to produce a fever? 21. Of what benefit is a fever during a bacterial infection? 22. Discuss antibodies with respect to each of the following: a. Specificity b. Shap ...
Immunology Introductory course Series of lectures outlining
Immunology Introductory course Series of lectures outlining

... • Neutrophils - live ~ 1 day, migrate into tissues • Lymphocytes - majority short lived - some live for years - constantly circulate ...
Immunology - PharmaEuphoria
Immunology - PharmaEuphoria

... A complete antigen is able to induce antibody formation & produce a specific and observable reaction with the antibody so produced. Haptens are substances which are incapable of inducing antibody formation by themselves, but can be capable of inducing antibodies on combining with larger molecules (n ...
Immunity Talk selected slides
Immunity Talk selected slides

... A substance (usually protein) recognised as 'foreign' that stimulate antibody formation ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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