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TUMOR CELL RECEPTORS
TUMOR CELL RECEPTORS

... previously harboring or exposed to this tumor, • Individuals with immunodeficiencies show higher frequencies of some tumor types ...
B-cell activation
B-cell activation

... w/ repeating epitopes (lipids, polysaccharides) => No CD4 T helper cells => These lipid & polysaccharide Ags => Tindependent (TI) Ag 4. Heavy chain isotype switching & Hypermutation are often seen in T cell-dependent humoral immune responses. 5. Primary & 2nd Ab responses differ qualitatively & ...
Slide 1
Slide 1

... • Humoral immunity: – is mediated by molecules in the blood and mucosal secretions, called antibodies – against extracellular microbes and their toxins – Antibodies themselves are specialized, (phagocytosis and trigger the release of inflammatory mediators) ...
Immunology Cells and organs of the Immune System
Immunology Cells and organs of the Immune System

... These cytokines further stimulate macrophages to increase phagocytic activity and to in turn produce cytokines that promote inflammation ...
THE IMMUNE SYSTEM
THE IMMUNE SYSTEM

Immunology of Pregnancy 2013 Brochure
Immunology of Pregnancy 2013 Brochure

... abortions. There is also an increasingly stronger series of argument to implicate immunology in preeclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only k ...
Lesson 1
Lesson 1

... to as a phagocyte) All cells have proteins on their cell membranes called ANTIGENS Antigens act as identity markers. Macrophages recognize body cells of the host by its antigens Foreign invaders will have different cell surface antigens which will cue macrophages to get rid of them ...
AP immune
AP immune

... bacteria), and cilia to move pathogens out D. flushing effect – most of these fluids also contain chemical like lysozyme or have a non-neutral pH i. tears, saliva, gastric fluid, urine, etc ...
The Immune System - Anderson School District One
The Immune System - Anderson School District One

... coexists with adaptive immunity mechanisms ◦ 2 are strongly interdependent ◦ basis same as innate immunity in invertebrates but there are additions ...
Presentation
Presentation

... week after an acute viral infection with minimal expansion of cells not specific for the virus (up to 10% of all CD8+ T cells in the blood may be specific for the pathogen) • Some of the progeny of the expanded clone differentiate into effector and memory cells; the majority die by apoptosis ...
Immune
Immune

... What are the mechanisms of innate immunity? 2) Chemical Mechanisms Complement proteins are special globulins that usually exist in an inactive form but can be activated. C3-C7 stimulate phagocytosis, inflammation and chemotaxis C9s form MACs or membrane pores, resulting in cell lysis ...
06-Understanding Stress and Disease
06-Understanding Stress and Disease

... – Caused by the HIV virus • Human Immunodeficiency Virus • Destroys the T-cells in the immune system ...
06-Understanding Stress and Disease
06-Understanding Stress and Disease

... Understanding Stress and Disease ...
The Immune System and Effects of the Active Ingredients in Re:Sist
The Immune System and Effects of the Active Ingredients in Re:Sist

... Vollara believes in scientific research on all our products. Dr. Urso is a Member of our Medical Advisory Board and we commissioned him to provide a presentation on the immune system and the effects of the active ingredients contained in Immunitize. While Dr. Urso has conducted an analysis of the a ...
Chapter 17- Specific Defenses of the Host :The
Chapter 17- Specific Defenses of the Host :The

... -B cell from stem cells in red bone marrow in adults, liver in fetuses, after maturation, mature b cells mirgrate to lymphoid organs ( lymph nodes, spleen), once in organs, B cells recognize by antigen receptors -Apoptosis- rids body of unneeded cells, ex: elimination of activated macrophages termin ...
03. Cell Mediated Immunityx
03. Cell Mediated Immunityx

... activation of the toll like receptor on antigen presenting cell • Foreign antigens such as bacterial proteins induce B7 protein where as self proteins do not ...
Lecture on Innate Immunity and Inflammation
Lecture on Innate Immunity and Inflammation

... • Pro-inflammatory cytokines (TNF, IL-1) signal to endothelial cells to make them: – Leaky to fluid (influx of plasma; containing antibodies, complement components, etc.) – Sticky for leukocytes, leading to influx of neutrophils first, then monocytes, lymphocytes – Systemic effects: fever, acute pha ...
3-CMI Lecture medical2014-10
3-CMI Lecture medical2014-10

... ◦ Many people develop rashes on their skin following contact with certain chemicals such as nickel, certain dyes, and poison ivy plant ◦ The response takes some 24 hours to occur and like DTH, is triggered by CD4+ T cells ...
Humoral Immune Response
Humoral Immune Response

... Helper T-cells interact with antigenic molecule and release substances which stimulate B-cells to produce antibody.  Suppressor T-cells are thought to “turn off” B-cells.  Very fine balance between the action of helper and suppressor T-cells. ...
Allergic reactions
Allergic reactions

... respiratory disease in which the air passage become narrower than normal. ...
Defense against infectious disease
Defense against infectious disease

... Define pathogen. Pathogen: an organism or virus that causes a disease. Explain why antibiotics are effective against bacteria but not against viruses. Antibiotics block specific metabolic pathways found in bacteria. Viruses reproduce using the host cell’s metabolic pathways, which are not affected b ...
Immunological Memory
Immunological Memory

The Lymphatic System and Body Defenses
The Lymphatic System and Body Defenses

...  Our immune cells do not attack our own proteins  Our cells in another person’s body can trigger an immune response because they are foreign  Restricts donors for transplants ...
11 Acut inflammation BA
11 Acut inflammation BA

... • Phagocytic cells • Are not present in healthy tissues • Migration  elimination of pathogens (enzymes, reactive oxygen intermediates) ...


... • activation of TH2 cells specific for the antigen, • production of IgE antibody • binding of the antibody to Fce receptors of mast cells • triggering of the mast cells by re-exposure to the antigen, resulting in the release of mediators from the mast cells and the subsequent pathologic reaction ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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