Plasmacytoid dendritic cells and dermatological - HAL
... Psoriasis is another inflammatory dermatosis in which hyperproliferation of keratinocytes is observed in response to an environmental aggression on a background of genetic predisposition. Understanding this disease comes down to determining how inflammatory cells of innate and adaptive immunity are ...
... Psoriasis is another inflammatory dermatosis in which hyperproliferation of keratinocytes is observed in response to an environmental aggression on a background of genetic predisposition. Understanding this disease comes down to determining how inflammatory cells of innate and adaptive immunity are ...
Transdermal Delivery of Vaccines and Proteins using a Hand
... than 30 seconds, approximately the same time required for syringe administration. The microstructures are less than 1 mm in length and do not reach the nerve endings in the skin; less than 3 pounds of force is required for insertion. The array is well-tolerated in humans. The immune response generat ...
... than 30 seconds, approximately the same time required for syringe administration. The microstructures are less than 1 mm in length and do not reach the nerve endings in the skin; less than 3 pounds of force is required for insertion. The array is well-tolerated in humans. The immune response generat ...
Role of C-C chemokine receptor type 7 and its ligands during
... Circulation of T cells between peripheral tissues and lymphoid organs is essential for immune surveillance and host defense of non-lymphoid sites. Upon stimulation by their cognate antigen, naive T cells become activated and change their chemokine receptor expression profile to migrate out of the LN ...
... Circulation of T cells between peripheral tissues and lymphoid organs is essential for immune surveillance and host defense of non-lymphoid sites. Upon stimulation by their cognate antigen, naive T cells become activated and change their chemokine receptor expression profile to migrate out of the LN ...
Immunomodulatory Effects of Human Immunodeficiency
... suppress new responses in a cell-cell contact dependent manner. The ability of the HIV-1 primed T cells to proliferate was severely impaired and this condition was reversed after a combined blockade of PD-1, CTLA-4 and TRAIL. Furthermore, more inhibitory molecules TIM-3, LAG-3, CD160, BLIMP-1, and F ...
... suppress new responses in a cell-cell contact dependent manner. The ability of the HIV-1 primed T cells to proliferate was severely impaired and this condition was reversed after a combined blockade of PD-1, CTLA-4 and TRAIL. Furthermore, more inhibitory molecules TIM-3, LAG-3, CD160, BLIMP-1, and F ...
Antibodies and IL-3 support helminth-induced basophil
... the blood, spleen, mesenteric lymph node (MesLN), liver, and bone marrow of C57BL/6, but not AID−/− mice by day 14 postinfection (Fig. 2 A–E). Interestingly, basophil numbers increased within the bone marrow (Fig. 2E) and, to a lesser extent, in the spleen and blood of C57BL/6 mice (Fig. 2 A and B) ...
... the blood, spleen, mesenteric lymph node (MesLN), liver, and bone marrow of C57BL/6, but not AID−/− mice by day 14 postinfection (Fig. 2 A–E). Interestingly, basophil numbers increased within the bone marrow (Fig. 2E) and, to a lesser extent, in the spleen and blood of C57BL/6 mice (Fig. 2 A and B) ...
1 - Webgarden
... E7GGG.GUS-based DNA vaccine might also be efficient against human tumour cells with reduced MHC class I expression. ...
... E7GGG.GUS-based DNA vaccine might also be efficient against human tumour cells with reduced MHC class I expression. ...
Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .
... CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregulates the RAE-1 family of NKG2D ligands, which can provide costimulation for CD8 T cells. We hypothesized that m152/ ...
... CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregulates the RAE-1 family of NKG2D ligands, which can provide costimulation for CD8 T cells. We hypothesized that m152/ ...
Lymphocyte Populations Within the Lamina Propria
... and express CD45RO. The presence of CD45RO+ cells co-expressing high levels of the α4β7 integrin and L-selectinlow near microlymphatics in PPs suggests that these cells are leaving the PPs and are on their way to the lamina propria via the blood. The other site in PPs at which activated T cells are ...
... and express CD45RO. The presence of CD45RO+ cells co-expressing high levels of the α4β7 integrin and L-selectinlow near microlymphatics in PPs suggests that these cells are leaving the PPs and are on their way to the lamina propria via the blood. The other site in PPs at which activated T cells are ...
... is produced by synovial tissues of the joints, in Castelman’s disease with the symptoms of fever, lymph nodes enlargement, anemia, high levels of acute phase proteins. In such pathological conditions the high IL-6 levels were accompanied by high soluble IL-6R levels. In order to block the signal tra ...
NIH Public Access
... Author Manuscript J Dev Orig Health Dis. Author manuscript; available in PMC 2013 December 16. ...
... Author Manuscript J Dev Orig Health Dis. Author manuscript; available in PMC 2013 December 16. ...
Exacerbation of autoantibody-mediated
... antibody-mediated thrombocytopenia was investigated by infecting mice deficient for the receptor of this cytokine (G129). Although the thrombocytopenia induced by the virus alone was not significantly different in these animals and in their normal counterparts, the aggravating effect of LDV on the p ...
... antibody-mediated thrombocytopenia was investigated by infecting mice deficient for the receptor of this cytokine (G129). Although the thrombocytopenia induced by the virus alone was not significantly different in these animals and in their normal counterparts, the aggravating effect of LDV on the p ...
An Essential Role of the Mitochondrial Electron Transport Chain in
... phenformin, were several encoding ETC-related proteins, including complex I subunits (NDUFA11, NDUFB2, NDUFA10, NDUFB9), mitochondrial RNA processing and ubiquinone synthesis enzymes (PDE12 and COQ4), and ETC assembly factors (ACAD9 and SCO2) (Figure 1D, Figure S1B). Unlike genes encoding core ETC c ...
... phenformin, were several encoding ETC-related proteins, including complex I subunits (NDUFA11, NDUFB2, NDUFA10, NDUFB9), mitochondrial RNA processing and ubiquinone synthesis enzymes (PDE12 and COQ4), and ETC assembly factors (ACAD9 and SCO2) (Figure 1D, Figure S1B). Unlike genes encoding core ETC c ...
SERIES ‘‘RARE INTERSTITIAL LUNG DISEASES’’ Number 2 in this Series
... diffuse infiltrating lung disease, surgical lung biopsy showed LCH in ,5% of cases [10]. Over a 6-yr period, COLBY and LOMBARD [11] identified 15 cases of PLCH compared with 274 cases of sarcoidosis among patients evaluated at a referral centre. More recently, in a 5-yr prospective study in 20 pulmo ...
... diffuse infiltrating lung disease, surgical lung biopsy showed LCH in ,5% of cases [10]. Over a 6-yr period, COLBY and LOMBARD [11] identified 15 cases of PLCH compared with 274 cases of sarcoidosis among patients evaluated at a referral centre. More recently, in a 5-yr prospective study in 20 pulmo ...
Ly6Chi Monocytes in the Inflamed Colon Give Rise
... Macrophages are the most abundant mononuclear phagocytes in the steady-state lamina propria of the colon (Figure 1A), characterized by surface expression of the integrins CD11c and CD11b as well as the F4/80 antigen. Intestinal macrophages also express high levels of the chemokine receptor CX3CR1, r ...
... Macrophages are the most abundant mononuclear phagocytes in the steady-state lamina propria of the colon (Figure 1A), characterized by surface expression of the integrins CD11c and CD11b as well as the F4/80 antigen. Intestinal macrophages also express high levels of the chemokine receptor CX3CR1, r ...
Are Expanded at Tumor Sites Regulatory T Cells That + Foxp3 high
... finely tune the immune response. An active role in preventing autoimmune diseases and maintaining immune homeostasis is played by the so-called T regulatory (Treg) cells. Human Treg cells comprise two main groups of CD4+ T cells with different origins: natural occurring Treg cells generated in the t ...
... finely tune the immune response. An active role in preventing autoimmune diseases and maintaining immune homeostasis is played by the so-called T regulatory (Treg) cells. Human Treg cells comprise two main groups of CD4+ T cells with different origins: natural occurring Treg cells generated in the t ...
Papillary Renal Cell Carcinoma Presenting with Hemoptysis
... • Both IL-2 and interferon alpha are important factors in promoting immune responses • IL-2: potent T cell growth factor • Interferon alpha: critical in for anti-viral responses, makes infected cells (or tumors) more susceptible killing by cytotoxic cells (CD8 T cells, and NK cells) ...
... • Both IL-2 and interferon alpha are important factors in promoting immune responses • IL-2: potent T cell growth factor • Interferon alpha: critical in for anti-viral responses, makes infected cells (or tumors) more susceptible killing by cytotoxic cells (CD8 T cells, and NK cells) ...
Investigations on immune sensing of Staphylococcus aureus in
... Sensing bacteria, such as Staphylococcus aureus (S. aureus), is based on the ability to recognize them via special germline encoded pattern recognition receptors (PRRs) of the innate immune system, so called Toll-like receptors (TLRs) and Nucleotide-binding oligomerization domain-containing proteins ...
... Sensing bacteria, such as Staphylococcus aureus (S. aureus), is based on the ability to recognize them via special germline encoded pattern recognition receptors (PRRs) of the innate immune system, so called Toll-like receptors (TLRs) and Nucleotide-binding oligomerization domain-containing proteins ...
Mycobacterium bovis Subsets following Infection with Virulent T Cell
... gd T cells are particularly recognized for their ability to respond to Mycobacterium; both human and murine gd T cells proliferate and secrete cytokines in recall response to protein and nonprotein phosphoantigens of M. tuberculosis (5, 6) and expand significantly in patients with active TB (7–9). M ...
... gd T cells are particularly recognized for their ability to respond to Mycobacterium; both human and murine gd T cells proliferate and secrete cytokines in recall response to protein and nonprotein phosphoantigens of M. tuberculosis (5, 6) and expand significantly in patients with active TB (7–9). M ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.