SAG-2 oral rabies vaccine A. J. BARRAT
... 10 times greater than that designated for field application was shown to be complete. The short-term innocuity for the red fox of a dose greater than that intended for use in the field was confirmed. Taking these and results obtained in about 20 species with SAG-1 into consideration, it seems unlike ...
... 10 times greater than that designated for field application was shown to be complete. The short-term innocuity for the red fox of a dose greater than that intended for use in the field was confirmed. Taking these and results obtained in about 20 species with SAG-1 into consideration, it seems unlike ...
Activated Monocytes Impacts Presentation by Dendritic Cells and
... during inflammation or infection the distribution of DCs in lymphoid organs changes, and monocytes can also acquire DC-like features, such as expression of CD11c, MHC-II, and costimulatory molecules (20–22). For example, during Listeria infection, monocytes differentiate in the spleen into TNF/induc ...
... during inflammation or infection the distribution of DCs in lymphoid organs changes, and monocytes can also acquire DC-like features, such as expression of CD11c, MHC-II, and costimulatory molecules (20–22). For example, during Listeria infection, monocytes differentiate in the spleen into TNF/induc ...
Expression and V (D) J recombination activity of mutated RAG
... to probe the susceptibility of this region to local alteration. In each case a unique Sail restriction enzyme site (encoding the amino acids valine, aspartic acid) was added to the sequence replacing two residues chosen so that the changes would be fairly conservative. Each insertion was followed by ...
... to probe the susceptibility of this region to local alteration. In each case a unique Sail restriction enzyme site (encoding the amino acids valine, aspartic acid) was added to the sequence replacing two residues chosen so that the changes would be fairly conservative. Each insertion was followed by ...
Molecular And Genetic Properties Of Breast Cancer Associated With
... genes involved in T-cell activation are co-expressed with interferon and NK-cell derived genes, etc. These immune gene signatures represent convenient mRNA expression based surrogates for histological assessment of immune infiltration. The observation that some breast cancers contain a large number ...
... genes involved in T-cell activation are co-expressed with interferon and NK-cell derived genes, etc. These immune gene signatures represent convenient mRNA expression based surrogates for histological assessment of immune infiltration. The observation that some breast cancers contain a large number ...
Chapter 2: Chemistry, Matter, and Life
... • Manufactured by B cells (B lymphocytes) • Must mature in fetal liver or in lymphoid tissue • Provides humoral immunity • Contained in gamma globulin fraction of blood plasma ...
... • Manufactured by B cells (B lymphocytes) • Must mature in fetal liver or in lymphoid tissue • Provides humoral immunity • Contained in gamma globulin fraction of blood plasma ...
Eukaryotic Initiation
... • Initiation factors (IFs in prok; eIFs in euk) – – prokaryotic cells require 3 initiation factors – IF1, IF2, & IF3 bind 30S subunit & help it attach to mRNA – IF2 is GTP-binding, required for adding first aminoacyl-tRNA – IF3 may prevent the large (50S) subunit from joining ...
... • Initiation factors (IFs in prok; eIFs in euk) – – prokaryotic cells require 3 initiation factors – IF1, IF2, & IF3 bind 30S subunit & help it attach to mRNA – IF2 is GTP-binding, required for adding first aminoacyl-tRNA – IF3 may prevent the large (50S) subunit from joining ...
Cloning and characterization of the
... Cloning of S.pombe PUS1 by complementation of the S.cerevisiae los1∆ pus1∆ double disrupted strain The fact that disruption of both LOS1 and PUS1 in the yeast S.cerevisiae causes a synergistic growth arrest at 37°C (4) makes possible the cloning of putative homologs of Los1p or Pus1p from other orga ...
... Cloning of S.pombe PUS1 by complementation of the S.cerevisiae los1∆ pus1∆ double disrupted strain The fact that disruption of both LOS1 and PUS1 in the yeast S.cerevisiae causes a synergistic growth arrest at 37°C (4) makes possible the cloning of putative homologs of Los1p or Pus1p from other orga ...
Publications de l`équipe - Centre de recherche de l`Institut Curie
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
The dynamics of T cells during persistent Staphylococcus aureus
... containment of S. aureus during a persistent infection We (von Köckritz-Blickwede et al, 2008) and others (Mölne et al, 2000; Verdrengh & Tarkowski, 1997) have shown that neutrophil recruitment is critical for effective control of bacterial growth during the acute phase of S. aureus infection. To ...
... containment of S. aureus during a persistent infection We (von Köckritz-Blickwede et al, 2008) and others (Mölne et al, 2000; Verdrengh & Tarkowski, 1997) have shown that neutrophil recruitment is critical for effective control of bacterial growth during the acute phase of S. aureus infection. To ...
Atlantic salmon type I interferons: Protection against virus infection in
... interaction of viruses with the immune system of Atlantic salmon. This doctoral thesis encompasses studies include the function of salmon type I interferon (IFN-I) in vivo, the use of IFN-I in vaccine study. How IFN-I triggering both innate and adaptive immune response gives protection against virus ...
... interaction of viruses with the immune system of Atlantic salmon. This doctoral thesis encompasses studies include the function of salmon type I interferon (IFN-I) in vivo, the use of IFN-I in vaccine study. How IFN-I triggering both innate and adaptive immune response gives protection against virus ...
TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue
... derived cells. Furthermore, it has been demonstrated that bone marrow cells are recruited to sites of axonal degeneration [4,5] or to beta-amyloid depositions in Alzheimer disease animal models [6,7] to become functional microglialike cells. The exact cellular subtype of myeloid precursors developin ...
... derived cells. Furthermore, it has been demonstrated that bone marrow cells are recruited to sites of axonal degeneration [4,5] or to beta-amyloid depositions in Alzheimer disease animal models [6,7] to become functional microglialike cells. The exact cellular subtype of myeloid precursors developin ...
Functional capacities of human IgM memory B cells in early
... receptors and immunomodulatory molecules with higher expression in IgM memory B cells than in IgG memory or naive B cells (Fig. 2A). Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) and chemokine (C-C motif) receptor 2 (CCR2), both molecules that were previously reported to be expressed o ...
... receptors and immunomodulatory molecules with higher expression in IgM memory B cells than in IgG memory or naive B cells (Fig. 2A). Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) and chemokine (C-C motif) receptor 2 (CCR2), both molecules that were previously reported to be expressed o ...
Initial depletion of regulatory T cells: the missing
... obtain adequate numbers of therapeutic cells, T cells need to be cultured and expanded for a sufficient period of time. Because most T lymphocytes are quiescent, it is necessary to activate them to trigger their cycling and proliferation. Furthermore, activation and cell division of the target cells ...
... obtain adequate numbers of therapeutic cells, T cells need to be cultured and expanded for a sufficient period of time. Because most T lymphocytes are quiescent, it is necessary to activate them to trigger their cycling and proliferation. Furthermore, activation and cell division of the target cells ...
Ribosomes in platelets protect the messenger
... risk of tumor necrosis and toxicity resulting from virus reactivation.7 Second, autologous cytotoxic T cells expanded against EBV antigens have been tested, but the very frequent expression of programmed death ligand 1 (PDL1) and immunosuppressive cytokines by NK/T lymphoma cells could inhibit T-cel ...
... risk of tumor necrosis and toxicity resulting from virus reactivation.7 Second, autologous cytotoxic T cells expanded against EBV antigens have been tested, but the very frequent expression of programmed death ligand 1 (PDL1) and immunosuppressive cytokines by NK/T lymphoma cells could inhibit T-cel ...
Human-specific evolution of killer cell immunoglobulin
... interact with the pockets of the HLA class I binding groove [47]. Although not well studied, the peptide sensitivity of KIR binding to HLA class I appears to vary with the KIR. For example, KIR3DL2 binding to HLA-A3 and HLA-A11 appears to be very peptidedependent, because only one peptide (derived f ...
... interact with the pockets of the HLA class I binding groove [47]. Although not well studied, the peptide sensitivity of KIR binding to HLA class I appears to vary with the KIR. For example, KIR3DL2 binding to HLA-A3 and HLA-A11 appears to be very peptidedependent, because only one peptide (derived f ...
TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the
... Detection of microbes through innate immunity is achieved by the use of pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs). PRRs detect foreign substances, but may also detect self-components as danger signals in the presence of infection, inflammation, o ...
... Detection of microbes through innate immunity is achieved by the use of pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs). PRRs detect foreign substances, but may also detect self-components as danger signals in the presence of infection, inflammation, o ...
... infectious diseases. The cells and molecules responsible for immunity constitute the immune system, and their collective and coordinated response after the introduction of foreign substance is the immune response. We now know that many of the mechanisms of resistance to infections also involve the i ...
Granulocyte-Macrophage Colony-Stimulating
... (⫻400) were counted for each well, and the results are depicted on a histogram. The experiment was performed twice will similar results. ...
... (⫻400) were counted for each well, and the results are depicted on a histogram. The experiment was performed twice will similar results. ...
Understanding Autoimmune Disease – a review article for the layman
... which are secreted and circulate in the blood. Surface immunoglobulin is the antigen receptor for B lymphocytes and when it attaches to an antigen the B cell is activated, usually with the help of a TH cell responding to the same antigen. Once the B cell is activated, it undergoes mitotic division t ...
... which are secreted and circulate in the blood. Surface immunoglobulin is the antigen receptor for B lymphocytes and when it attaches to an antigen the B cell is activated, usually with the help of a TH cell responding to the same antigen. Once the B cell is activated, it undergoes mitotic division t ...
Commercial Poultry Production and Feed Additives
... Maintenance of epithelial cells in good condition (skin and the linings of the digestive, reproductive, and respiratory tracts) ...
... Maintenance of epithelial cells in good condition (skin and the linings of the digestive, reproductive, and respiratory tracts) ...
Broad and direct interaction between TLR and Siglec families of
... eLife digest Many living things have an immune system that is able to detect invading bacteria, viruses and other pathogens and trigger a response targeted against the threat before it causes lasting damage. Cells employ a number of different receptors that can detect these pathogens or the molecule ...
... eLife digest Many living things have an immune system that is able to detect invading bacteria, viruses and other pathogens and trigger a response targeted against the threat before it causes lasting damage. Cells employ a number of different receptors that can detect these pathogens or the molecule ...
Plasmacytoid dendritic cells and dermatological - HAL
... Psoriasis is another inflammatory dermatosis in which hyperproliferation of keratinocytes is observed in response to an environmental aggression on a background of genetic predisposition. Understanding this disease comes down to determining how inflammatory cells of innate and adaptive immunity are ...
... Psoriasis is another inflammatory dermatosis in which hyperproliferation of keratinocytes is observed in response to an environmental aggression on a background of genetic predisposition. Understanding this disease comes down to determining how inflammatory cells of innate and adaptive immunity are ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.