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March 24 (PP)
March 24 (PP)

... Hypersensitivity – immune responses that causes tissue damage Autoimmune disease – immune responses to self-antigens Immunodeficiency – insufficient immune response ...
your body`s defense against infection lesson 2
your body`s defense against infection lesson 2

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...  Helper cells stimulate B cells to mature into plasma cells, which begin to synthesize and secrete immunoglobulin (proteins with known antibody activity)  Suppressor cells reduce the humoral immunity B. Humoral immunity: also called immunoglobulin-mediated immunity Associated with circulating anti ...
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... them together Neutralize toxins by glomming onto them on the surface of pathogens Stick to surface of pathogen so it can be recognized by phagocytic cells Immunoglobulins are classes of antibodies—each class has more specific immune function ...
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... B and T-lymphocytes recognise specific pathogens that have invaded the body and set in motion mechanisms to destroy them: thus protecting the body from harm. This is known as the immune response. The function of B-lymphocytes B-lymphocytes are involved in the production of antibodies in response to ...
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... thymus removal (thymectomy) to have on the ability of host immunity against infection? Ans: 1. Total lymphocytes are drastically reduced. T cell development was blocked. B cells are also reduced => require T helper cells for their proliferation. LN size is reduced. => Get infections easier. 2. DiGeo ...
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IMMUNITY CELLULAR AND HUMORAL IMMUNITY
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... But early in the process, infected cells display fragments of the viral proteins in their surface class I molecules. CTLs specific for that antigen bind to the infected cell and often will be able to destroy it before it can release a fresh crop of viruses. In general, the role of the T cells is to ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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