Progression of cutaneous squamous cell carcinoma
... Again, little data in man is available to date, while in ovine squamous cell carcinoma development, CD3, CD8 and MHC II have been shown to be upregulated during tumour progression 23. Perineoplastic inflammatory infiltrate in squamous cell carcinoma of the skin has been reported to contain 30-40% CD ...
... Again, little data in man is available to date, while in ovine squamous cell carcinoma development, CD3, CD8 and MHC II have been shown to be upregulated during tumour progression 23. Perineoplastic inflammatory infiltrate in squamous cell carcinoma of the skin has been reported to contain 30-40% CD ...
Peptides in Neurons and Microglia Inducing the Synthesis of
... Copyright © 2008 by The American Association of Immunologists, Inc. 0022-1767/08/$2.00 ...
... Copyright © 2008 by The American Association of Immunologists, Inc. 0022-1767/08/$2.00 ...
Subversion of host cellular functions by the
... proteins from the rhoptries and dense granules are involved in development and maintenance of the PVM and PVN. Recently, several of these secreted proteins have been implicated in subversion of host functions to sustain a niche in which the parasite is protected from the host defence mechanisms. Thi ...
... proteins from the rhoptries and dense granules are involved in development and maintenance of the PVM and PVN. Recently, several of these secreted proteins have been implicated in subversion of host functions to sustain a niche in which the parasite is protected from the host defence mechanisms. Thi ...
Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis
... The virus enters the animal via the nose and replicates to high titres in mucous membranes of the upper respiratory tract and in the tonsils. It subsequently disseminates to conjunctivae and by neuronal axonal transport reaches the trigeminal ganglion. After genital infection, BoHV-1 replicates in m ...
... The virus enters the animal via the nose and replicates to high titres in mucous membranes of the upper respiratory tract and in the tonsils. It subsequently disseminates to conjunctivae and by neuronal axonal transport reaches the trigeminal ganglion. After genital infection, BoHV-1 replicates in m ...
Liver immunology and its role in inflammation and
... from blood into hepatocytes and facilitates the removal and degradation of immunogenic molecules (for example, bacterial endotoxin) in the liver (Figure 2). Pattern recognition receptors (PRR) expressed by hepatocytes and liver-resident macrophages (known as Kupffer cells (KC)), bind to microbial as ...
... from blood into hepatocytes and facilitates the removal and degradation of immunogenic molecules (for example, bacterial endotoxin) in the liver (Figure 2). Pattern recognition receptors (PRR) expressed by hepatocytes and liver-resident macrophages (known as Kupffer cells (KC)), bind to microbial as ...
Generation of adenosine tri-phosphate in Leishmania
... from phoshoenolpyruvate. Evidence also suggests that the activity of these enzymes are comparatively higher in the amastigotes. Such a pathway could provide dicarboxylic acids for biosynthetic processes and also contributed to NADP+ recycling. Amastigote cells continuously excrete relatively large q ...
... from phoshoenolpyruvate. Evidence also suggests that the activity of these enzymes are comparatively higher in the amastigotes. Such a pathway could provide dicarboxylic acids for biosynthetic processes and also contributed to NADP+ recycling. Amastigote cells continuously excrete relatively large q ...
Cell death pathways and autophagy in the central nervous system
... through which cell death occurred. ...
... through which cell death occurred. ...
Non-small-cell lung cancers: a heterogeneous set of diseases
... changes, many of which predict sensitivity to clinical inhibitors, jointly account for most cases of lung ADC23–25. For lung SCC, the number of tumours for which whole-exome sequencing is available is lower than for ADC but, so far, potentially targetable mutations in ADC do not seem to be prevalent ...
... changes, many of which predict sensitivity to clinical inhibitors, jointly account for most cases of lung ADC23–25. For lung SCC, the number of tumours for which whole-exome sequencing is available is lower than for ADC but, so far, potentially targetable mutations in ADC do not seem to be prevalent ...
![[NOTE: if using this form [bracketed] text is guidance](http://s1.studyres.com/store/data/007988671_1-14bcfda27166539897509a7a0f8c9da0-300x300.png)
[NOTE: if using this form [bracketed] text is guidance
... ● Oct 1998– Sep 1999: Hitchcock Fellowship Research Grant, Dartmouth Medical School “FcαR signal transduction in membrane rafts” PI: Lang, ML. Direct costs $13,000 (total) Fundable or Scored but Not Awarded ● 2007: NIH, Investigator-Initiated RO3 “CD1d-restricted NKT cells and humoral immunity to ba ...
... ● Oct 1998– Sep 1999: Hitchcock Fellowship Research Grant, Dartmouth Medical School “FcαR signal transduction in membrane rafts” PI: Lang, ML. Direct costs $13,000 (total) Fundable or Scored but Not Awarded ● 2007: NIH, Investigator-Initiated RO3 “CD1d-restricted NKT cells and humoral immunity to ba ...
Tumor Necrosis Factor and Alzheimer`s Disease
... diseases, including AD (20). The immune system comprises a complex interrelated network of cellular, molecular, and chemical mediators that function to protect the body against environmental stress factors. These stressors can be as diverse as microorganisms (viral, bacterial, fungal agents), phys ...
... diseases, including AD (20). The immune system comprises a complex interrelated network of cellular, molecular, and chemical mediators that function to protect the body against environmental stress factors. These stressors can be as diverse as microorganisms (viral, bacterial, fungal agents), phys ...
Thesis final for publication-us-18-7-12 2 - eDiss - Georg
... individuals with and without anti HIV/SIV Noncytolytic activity” "Molecular Medicine" Annual PhD Retreat, September 2011. • Oral Presentation“Differential gene expression pattern of CD8+ T cells from individuals with and without anti HIV/SIV Noncytolytic activity” "Molecular Medicine" Annual PhD Ret ...
... individuals with and without anti HIV/SIV Noncytolytic activity” "Molecular Medicine" Annual PhD Retreat, September 2011. • Oral Presentation“Differential gene expression pattern of CD8+ T cells from individuals with and without anti HIV/SIV Noncytolytic activity” "Molecular Medicine" Annual PhD Ret ...
Cardiovasc. Res. 81197-205 (2009) - digital
... inflammatory foam cells, play an important role in the initiation and progression of ...
... inflammatory foam cells, play an important role in the initiation and progression of ...
Interindividual variations in the efficacy and toxicity of vaccines
... genes and very high levels of antibodies or hyperseropositive responses have been reported. A higher frequency of hyperseropositive responders to measles antigens was observed for individuals carrying the class I HLA-B*07 allele. In contrast, frequencies of HLA-B*44 allele were lower in hyperseropos ...
... genes and very high levels of antibodies or hyperseropositive responses have been reported. A higher frequency of hyperseropositive responders to measles antigens was observed for individuals carrying the class I HLA-B*07 allele. In contrast, frequencies of HLA-B*44 allele were lower in hyperseropos ...
Intestinal mucosal barrier function in health and disease
... equalization of concentrations on both sides of the epithelium. Thus, active transcellular transport depends on the presence of an intact tight junction barrier. The selective permeability of the tight junction barrier also allows transepithelial gradients to drive passive paracellular transport of ...
... equalization of concentrations on both sides of the epithelium. Thus, active transcellular transport depends on the presence of an intact tight junction barrier. The selective permeability of the tight junction barrier also allows transepithelial gradients to drive passive paracellular transport of ...
Major Histocompatibility Antigens
... able to recognize peptides when they are expressed in complexes with MHC Class I molecules. For the TCR to bind a peptide-MHC complex two conditions must be met. Firstly, the TCR must have a structure which allows it to bind the peptide-MHC complex. Secondly, the accessory molecule CD8, must bind to ...
... able to recognize peptides when they are expressed in complexes with MHC Class I molecules. For the TCR to bind a peptide-MHC complex two conditions must be met. Firstly, the TCR must have a structure which allows it to bind the peptide-MHC complex. Secondly, the accessory molecule CD8, must bind to ...
Evolution of an ancient protein function involved in
... For dividing animal cells to generate and maintain organized tissues, the mitotic spindle must be oriented relative to the position of surrounding cells (Morin and Bellaı̈che, 2011; Gillies and Cabernard, 2011; Lu and Johnston, 2013; Cabernard and Doe, 2009; Williams et al., 2011). Cells that orient ...
... For dividing animal cells to generate and maintain organized tissues, the mitotic spindle must be oriented relative to the position of surrounding cells (Morin and Bellaı̈che, 2011; Gillies and Cabernard, 2011; Lu and Johnston, 2013; Cabernard and Doe, 2009; Williams et al., 2011). Cells that orient ...
Apoptosis: Molecular Mechanisms
... p53 loss to worsened prognosis in a large assortment of tumour types. A very important, but incompletely understood, process is the mechanism by which p53 produces apoptosis (versus arrest). A number of transcriptional target genes have been identified, which are capable of triggering death, although ...
... p53 loss to worsened prognosis in a large assortment of tumour types. A very important, but incompletely understood, process is the mechanism by which p53 produces apoptosis (versus arrest). A number of transcriptional target genes have been identified, which are capable of triggering death, although ...
Serodiagnosis of Peste des Petits Ruminants Virus
... of the protective host immune response is raised against the H protein (Renukaradhya et al., 2002). For this reason, and the preponderance of the neutralizing antibodies again the H protein, it has remained under continuous immunological pressure. The H protein is not only involved in cell-tropism b ...
... of the protective host immune response is raised against the H protein (Renukaradhya et al., 2002). For this reason, and the preponderance of the neutralizing antibodies again the H protein, it has remained under continuous immunological pressure. The H protein is not only involved in cell-tropism b ...
T-Cell Subset Analysis of Lewis Lung Carcinoma
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
Carbohydrate profiling reveals a distinctive role for
... Department of Molecular Cell Biology & Immunology and 2Medical Microbiology, VU Medical Center, Amsterdam, the Netherlands ...
... Department of Molecular Cell Biology & Immunology and 2Medical Microbiology, VU Medical Center, Amsterdam, the Netherlands ...
NIH Public Access - Transcell Biologics
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.