NIH Public Access - Transcell Biologics
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
Peer-reviewed Article PDF
... medium with excess Pi (20 mM), the cells of S. cerevisiae accumulate little Pi (~ 94 µmole P/g dry biomass) and much polyP (~ 658 mole P/g dry biomass) [27]. PolyP with the chain lengths of 3–8 to 200–260 phosphate residues were obtained from yeasts [27]. PolyP has been found in yeasts in the most o ...
... medium with excess Pi (20 mM), the cells of S. cerevisiae accumulate little Pi (~ 94 µmole P/g dry biomass) and much polyP (~ 658 mole P/g dry biomass) [27]. PolyP with the chain lengths of 3–8 to 200–260 phosphate residues were obtained from yeasts [27]. PolyP has been found in yeasts in the most o ...
Phagocytes may counteract the “open window” situation during a
... cells (the first line of cell defense of the organism) may counteract the “open window” situation, as has also been reported previously for intense exercise (Ortega Rincón 1994). Studies performed in our laboratory demonstrated the hypothesis that a stimulated innate immune response mediated by phag ...
... cells (the first line of cell defense of the organism) may counteract the “open window” situation, as has also been reported previously for intense exercise (Ortega Rincón 1994). Studies performed in our laboratory demonstrated the hypothesis that a stimulated innate immune response mediated by phag ...
Trinity™ Multipotential Cellular Bone Matrix
... reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in situ source of osteoprogenitor cells throughout a lifetime.14 Whet ...
... reproductive, and urinary systems. MSCs are developmentally intermediate to embryonic stem cells and terminallydifferentiated adult cells.14,44 It is as a result of their relatively “young” biological age that MSCs can serve as an in situ source of osteoprogenitor cells throughout a lifetime.14 Whet ...
Improved metabolic process control by analysis of genetic clone
... In process development, clones need to be selected. The main selection criteria for this are high titers and high growth kinetics. However high growth kinetics reveal overflow metabolism, such as lactate production [5][6], which is a disadvantageous in respect to metabolic efficiency [7][8] which of ...
... In process development, clones need to be selected. The main selection criteria for this are high titers and high growth kinetics. However high growth kinetics reveal overflow metabolism, such as lactate production [5][6], which is a disadvantageous in respect to metabolic efficiency [7][8] which of ...
A primer on the mouse basal body
... tubes, and the sperm flagellum. While it is unclear whether basal bodies of distinct types of cilia contain sets of proteins unique to that ciliary type, the structure of the cilium itself can vary in ways that may be dependent on the basal body [17]. One example is the transition zone, a region bet ...
... tubes, and the sperm flagellum. While it is unclear whether basal bodies of distinct types of cilia contain sets of proteins unique to that ciliary type, the structure of the cilium itself can vary in ways that may be dependent on the basal body [17]. One example is the transition zone, a region bet ...
ANA – Antinuclear Antibodies
... alternative first line test. Previously, if the IFA failed to demonstrate a clinically significant titer, the entire assay was reported as negative. Beginning 4/15/15, the ANA screen and IFA Hep 2 will be reported separately, regardless of the IFA Hep 2 result. Interpretive comments based on titer r ...
... alternative first line test. Previously, if the IFA failed to demonstrate a clinically significant titer, the entire assay was reported as negative. Beginning 4/15/15, the ANA screen and IFA Hep 2 will be reported separately, regardless of the IFA Hep 2 result. Interpretive comments based on titer r ...
Wellness Foods Based on the Health Benefits of Fruit: Gold Kiwifruit
... Fruits are excellent health foods and ingredients for functional foods. Plant & Food Research is developing new fresh and processed foods to promote gut health and immunity and protect from oxidative stress. The research involves testing using cell-based assays and animal models and validating healt ...
... Fruits are excellent health foods and ingredients for functional foods. Plant & Food Research is developing new fresh and processed foods to promote gut health and immunity and protect from oxidative stress. The research involves testing using cell-based assays and animal models and validating healt ...
MicroRNAs and respiratory diseases REVIEW
... are now recognised, many of which are highly conserved in other organisms, suggesting that they represent a relatively old and important regulatory pathway [7–9]. miRNAs are distinct from the better-known small interfering RNAs (siRNAs) that knock down transcription of single genes, as a single miRN ...
... are now recognised, many of which are highly conserved in other organisms, suggesting that they represent a relatively old and important regulatory pathway [7–9]. miRNAs are distinct from the better-known small interfering RNAs (siRNAs) that knock down transcription of single genes, as a single miRN ...
Full Text PDF
... culture to immortalized, transformed cells undoubtedly accentuates its connection to human cancers [83]. Although EBV may be essential for tumorigenesis, it is not generally sufficient on its own. Other factors such as specific failure of immune recognition, stimulation of B-cell proliferation by ot ...
... culture to immortalized, transformed cells undoubtedly accentuates its connection to human cancers [83]. Although EBV may be essential for tumorigenesis, it is not generally sufficient on its own. Other factors such as specific failure of immune recognition, stimulation of B-cell proliferation by ot ...
METABOLIC ADAPTATION OF CANDIDA
... Candida albicans biofilm, whose importance is attributed to its ability to institute new and reoccurring infections, accounting for about 40% of disseminated candidiasis. The major characteristic of biofilms which differentiates it from planktonic cells is its high tolerance to treatments and the im ...
... Candida albicans biofilm, whose importance is attributed to its ability to institute new and reoccurring infections, accounting for about 40% of disseminated candidiasis. The major characteristic of biofilms which differentiates it from planktonic cells is its high tolerance to treatments and the im ...
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase
... E-mail address: [email protected] (T.S. Heuer). ...
... E-mail address: [email protected] (T.S. Heuer). ...
approach to the patient with lymphadenopathy and splenomegaly
... the primary immune response filter for the blood removing from the circulation senescent red cells, Removing blood cells and other cells coated with immunoglobulins Red pulp occupies more than half the volume of the spleen is the site where senescent red cells are identified and destroyed and red ce ...
... the primary immune response filter for the blood removing from the circulation senescent red cells, Removing blood cells and other cells coated with immunoglobulins Red pulp occupies more than half the volume of the spleen is the site where senescent red cells are identified and destroyed and red ce ...
β2-ADRENERGIC RECEPTOR MODULATION OF MACROPHAGE
... mentioned before, this integrative “cross-talk” is essential to maintaining homeostasis. If any of these pathways are interrupted, serious consequences may evolve. Indeed, disturbances in these routes of communication can directly influence various aspects of disease progression such as course, dura ...
... mentioned before, this integrative “cross-talk” is essential to maintaining homeostasis. If any of these pathways are interrupted, serious consequences may evolve. Indeed, disturbances in these routes of communication can directly influence various aspects of disease progression such as course, dura ...
Metabolic reaction network approach for CHO
... of serum-free media. The new design uses the base media described above with supplementation of different components. Examples of such supplements are: hormones, growth factors, attachment factors, lipids, protease inhibitors, protein hydrolysates and proteins. It is also common to add some amino ac ...
... of serum-free media. The new design uses the base media described above with supplementation of different components. Examples of such supplements are: hormones, growth factors, attachment factors, lipids, protease inhibitors, protein hydrolysates and proteins. It is also common to add some amino ac ...
Transferrin and the Transferrin Receptor: Of Magic Bullets
... reported good lymphocyte proliferation with other iron donors rather than Trf [39] underlying once more the need to examine and evaluate results and conclusions in the context of the experimental protocols used. THE TRANSFERRIN RECEPTOR Iron-bound Trf is internalized by cells expressing receptors sp ...
... reported good lymphocyte proliferation with other iron donors rather than Trf [39] underlying once more the need to examine and evaluate results and conclusions in the context of the experimental protocols used. THE TRANSFERRIN RECEPTOR Iron-bound Trf is internalized by cells expressing receptors sp ...
Inflammatory Bowel Disease Effector Function in a Murine Model of
... types, Th1, Th2, and Th17 cells, depending on the type of cytokines secreted. The fate of T cell differentiation into Th1, Th2, or Th17 type T cells or Tregs is largely regulated by the interaction between naive T cells and dendritic cells (DCs) (15). The recognition of PAMPs by TLRs on DCs promotes ...
... types, Th1, Th2, and Th17 cells, depending on the type of cytokines secreted. The fate of T cell differentiation into Th1, Th2, or Th17 type T cells or Tregs is largely regulated by the interaction between naive T cells and dendritic cells (DCs) (15). The recognition of PAMPs by TLRs on DCs promotes ...
Temeyer 2016 tick salivary cholinesterase
... with resistance for each of the three tick AChEs, and baculoviral expression and biochemical characterization of recombinant AChEs have to date confirmed OP-resistance mutations in at least two of the three tick AChEs (Temeyer et al. 2007, 2009, 2012b, 2013b). The genome of the related hard tick, Ix ...
... with resistance for each of the three tick AChEs, and baculoviral expression and biochemical characterization of recombinant AChEs have to date confirmed OP-resistance mutations in at least two of the three tick AChEs (Temeyer et al. 2007, 2009, 2012b, 2013b). The genome of the related hard tick, Ix ...
COMPARISON OF MAJOR SECONDARY METABOLITES QUANTIFIED IN ELICITED CELL
... Earlier reports show MeJA and chitosan triggering highest total phenolic content in cell cultures [30, 31] whereas in Ocimum, total phenols were observed as the highest in leaves for all the three species and the next highest was observed in the elicited cell cultures. Though it was observed so, tot ...
... Earlier reports show MeJA and chitosan triggering highest total phenolic content in cell cultures [30, 31] whereas in Ocimum, total phenols were observed as the highest in leaves for all the three species and the next highest was observed in the elicited cell cultures. Though it was observed so, tot ...
Tissue adaptation: Implications for gut immunity and tolerance
... Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil ...
... Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil ...
BEL β-trefoil: A novel lectin with antineoplastic properties in king
... Proteins of nonimmune origin that selectively bind and recognize carbohydrates without modifying them enzymatically are called lectins (Sharon 2007). In general, ligand binding precedes the fulfillment of an important biological function, which in some cases is still not known. Some members of this f ...
... Proteins of nonimmune origin that selectively bind and recognize carbohydrates without modifying them enzymatically are called lectins (Sharon 2007). In general, ligand binding precedes the fulfillment of an important biological function, which in some cases is still not known. Some members of this f ...
24.1 Structure and Classification of Lipids
... in unsaturated fatty acids can be hydrogenated by reacting with hydrogen to produce saturated fatty acids. For example, margarine is produced when two thirds of the double bonds present in vegetable oil is hydrogenated. ...
... in unsaturated fatty acids can be hydrogenated by reacting with hydrogen to produce saturated fatty acids. For example, margarine is produced when two thirds of the double bonds present in vegetable oil is hydrogenated. ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.