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Fermentative Production of Natural and Unnatural Flavonoids by
Fermentative Production of Natural and Unnatural Flavonoids by

... monocytes, and macrophages. In the primary phase of infection, mycobacteria encounter and activate macrophages. Pattern recognition receptors expressed on macrophages and other leukocytes activate signaling cascades that play a fundamental role in phagocytosis and other host defense mechanisms. Toll ...
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... created are capable of producing insulin in a manner similar to that of a normal pancreatic insulinproducing cell. A number of other research groups have genetically altered liver cells from animals so as to produce insulin. These cells are not quite as mature as normal pancreatic insulin-producing ...
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... The Mr of the molecule recognized by the APO1 antibody was reported to be 52 kDa. This Mr was quite different from that initially predicted for the Fas antigen (200 kDa). However, the cloned human Fas cDNA encoded a glycoprotein of 52 kDa. Fas, like APO-1, was found to be expressed in various transf ...
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... functions were examined. In some of the wild-type mice, a neutralizing IFN-␥ monoclonal antibody was administered repeatedly after the viral inoculation. Result. Pulmonary dendritic cells of postinfluenza mice enhanced allergen-specific T-helper (Th)2 responses via an IFN-␥-dependent mechanism. Conc ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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