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1 - Wk 1-2
1 - Wk 1-2

... Active immunization Passive immunization These may be naturally acquired or artificially induced Active Immunity: ...
Foundations in Microbiology
Foundations in Microbiology

... 3. To receive and transmit chemical messages among other cells of the system 4. To aid in cellular development ...
The Babraham Institute
The Babraham Institute

SAFETY IMPLICATIONS FOR BIOTECH PRODUCTS
SAFETY IMPLICATIONS FOR BIOTECH PRODUCTS

Innate Immunity (part II) and Antigen Recognition by Adaptive
Innate Immunity (part II) and Antigen Recognition by Adaptive

... recognition of dsRNA in cytoplasm and inhibits virus replication (also promotes adaptive immunity) •Killing of infected cells is also performed by natural killer cells recognizing stress-induced molecules or loss of MHC class I molecule expression and by cytotoxic T cells which recognize virus antig ...
No Slide Title - Pegasus @ UCF
No Slide Title - Pegasus @ UCF

... A. Humoral Mediated: (B-Cell immunity; Free Ig’s) Antibodies react to bacteria by: 1. Binding directly with bacterial toxins to neutralize them 2. Coat bacteria to enhance the phagocytosis be non-specifics components (monocytes, etc.,). Immunoglobulin subclass: IgG, IgA, IgM, IgD, & IgE ...
HBImmunity
HBImmunity

... Killer T-Cells (or Cytotoxic T-cells, CTL, recognize and attack pathogen-infected cells and are the only T cells that kill. They kill with complement protein or with the porforin protein. Helper T (T4 or CD4) cells must be activated. Once activated they secrete interleukin proteins to promote an imm ...
Press release - Austria Center Vienna
Press release - Austria Center Vienna

... system’s response to cancer cells. Clinical studies have groundbreaking results. This new form of therapy is based on the fact that tumour cells have the capacity to slow the immune system at specific check points. It is possible to disrupt the effect of the tumour on the immune system if the body i ...
Inflammation & the Immune Response Unit VIII
Inflammation & the Immune Response Unit VIII

... their inflammatory response? 4. What are the five physical manifestations of the inflammatory response? 5. Name each distinct phase of the inflammatory response and unique characteristics of each? 6. What are other causes of inflammation besides microorganisms? 7. What are some common diseases of ch ...
Chapter 43: The Immune System- Practice Questions 2) Physical
Chapter 43: The Immune System- Practice Questions 2) Physical

... C) the variable or V regions D) the light chains E) the heavy chains 18) The clonal selection theory implies that A) brothers and sisters have similar immune responses. B) antigens activate specific lymphocytes. C) only certain cells can produce interferon. D) a B cell has multiple types of antigen ...
Chapter 16
Chapter 16

... 10. Describe the structure and functions of the thymus. The thymus is a soft, bilobed structure whose lobes are surrounded by a capsule of connective tissue. It is composed of lymphatic tissue, which is subdivided into lobules by connective tissues. The lobules contain many lymphocytes. It functions ...
Adverse Immune Reactions and Immune Deficiencies
Adverse Immune Reactions and Immune Deficiencies

Edward Jenner, 1796 - University of California, Los Angeles
Edward Jenner, 1796 - University of California, Los Angeles

... All the cellular elements of blood, including the lymphocytes of the adaptive immune system, arise from hematopoietic stem cells in the bone marrow. ...
The Immune System
The Immune System

... reproduction and degrade viral RNA ...
1. Type I allergy
1. Type I allergy

Inflammation – Infection
Inflammation – Infection

19 Physiology of leukocytes
19 Physiology of leukocytes

... called antibodies. These antibodies are produced in response to specific foreign molecules called antigens. An antigen is a polysaccharide or protein which is recognised as foreign by special white blood cells, lymphocytes. These lymphocytes respond by producing specific antibodies for that antigen. ...
Ch. 19: Blood
Ch. 19: Blood

... ▫ “AB” (AB) ...
I. Introduction to class
I. Introduction to class

... Act indirectly by controlling the immune functions of other cells: ...
Tissue effector memory T cells Lymphoid central memory T cells
Tissue effector memory T cells Lymphoid central memory T cells

... • A successful primary immune response eliminates the pathogen and results in long-lasting immunological memory • Antibodies produced during the primary immune response protect against reinfection by neutralization and opsonization. ...
Immune Strategies to Infection
Immune Strategies to Infection

... This occurs as a result of antigen presentation to naïve T cells at the lymph nodes, which get activated and then travel to the site of infection to elicit a response (cell mediated), or antigen may remain in the lymph nodes, activating B cells for antibody production (humoral). What determines whet ...
Lecture 4: Host Response to Infection
Lecture 4: Host Response to Infection

The Case - UBC Wiki
The Case - UBC Wiki

... Combating pathogens: • Fatty acids, sebaceous fluid = inhibit pathogen growth ...
Immunologic Targeting - How to Channel a Minimal Response
Immunologic Targeting - How to Channel a Minimal Response

... 2) role of carriers such as KLH and adjuvants such as QS21 in enhancing immunogenicity and facilitating the immune response. QS21 still remains the best adjuvant through all clinical trials. 3) increasing doses of vaccine do not correlate with augmentation of immunogenicity, ie, lower doses appear t ...
VACCINES - Rovira i Virgili University
VACCINES - Rovira i Virgili University

... Traditional vaccines contain either parts of microbes or whole microbes that have been killed or weakened so that they don’t cause the disease. - take advantage of the body’s to learn how to ...
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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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