METABOLIC SYNDROME AND THE IMMUNE SYSTEM Authors
... the people who have it. Its pathophysiology has not been fully explained because of complex biological processes and complex cellular interactions. However, epidemiological and clinical evidence suggest a multifactorial disorder resulting from the interaction between genetic, environmental, hormonal ...
... the people who have it. Its pathophysiology has not been fully explained because of complex biological processes and complex cellular interactions. However, epidemiological and clinical evidence suggest a multifactorial disorder resulting from the interaction between genetic, environmental, hormonal ...
The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking
... Around 1960, observations of lymphocytic insulitis and the presence of islet cell autoantibodies in patients with type 1 diabetes led to the concept of type 1 diabetes being an organ-specific autoimmune disease. Much work has since been done to unravel the mechanisms behind the aberrant self-directed ...
... Around 1960, observations of lymphocytic insulitis and the presence of islet cell autoantibodies in patients with type 1 diabetes led to the concept of type 1 diabetes being an organ-specific autoimmune disease. Much work has since been done to unravel the mechanisms behind the aberrant self-directed ...
The promise of nucleic acid vaccines
... used to recruit and mature dendritic cells. The most striking example of this type of cytokine may be granulocyte– monocyte colony-stimulating factor (GM-CSF).21,22 Co-stimulatory molecules are also potentially powerful adjuvants for nucleic acid vaccination. Signaling through the interaction of TCR ...
... used to recruit and mature dendritic cells. The most striking example of this type of cytokine may be granulocyte– monocyte colony-stimulating factor (GM-CSF).21,22 Co-stimulatory molecules are also potentially powerful adjuvants for nucleic acid vaccination. Signaling through the interaction of TCR ...
Immuun nr 3 2015 - Dutch Society for Immunology
... Richard Jaspers PhD of the VU University Amsterdam: “Human Movement Sciences teach cardiology, orthopaedia and exercise physiology. Maastricht also focuses on nutrition and Nijmegen on lung diseases. Immunology has until now remained outside the scope. And if there is some knowledge, this only regar ...
... Richard Jaspers PhD of the VU University Amsterdam: “Human Movement Sciences teach cardiology, orthopaedia and exercise physiology. Maastricht also focuses on nutrition and Nijmegen on lung diseases. Immunology has until now remained outside the scope. And if there is some knowledge, this only regar ...
The lymphoid organs
... The effector functions of these two types of CD4+ T cells are primarily due to the biological activity of the cytokines that they produce. Differentiation of naïve CD4+ T cells into either the Th1 or Th2 phenotype is directed by the cytokines present at the time of antigen-specific activation. ¾ ...
... The effector functions of these two types of CD4+ T cells are primarily due to the biological activity of the cytokines that they produce. Differentiation of naïve CD4+ T cells into either the Th1 or Th2 phenotype is directed by the cytokines present at the time of antigen-specific activation. ¾ ...
Mutant Signal Transducer and Activator of Transcription 5b
... STAT5b(A630P), after stimulation by GH or interferon (IFN)-␥, both of which normally activate the JAK-STAT5b signaling pathways, phospho-STAT5 was not detected, and the STAT5b target gene, IGF-I, clearly was dysregulated (4, 7). The precise explanation for reduced IGF-I gene transcription remained u ...
... STAT5b(A630P), after stimulation by GH or interferon (IFN)-␥, both of which normally activate the JAK-STAT5b signaling pathways, phospho-STAT5 was not detected, and the STAT5b target gene, IGF-I, clearly was dysregulated (4, 7). The precise explanation for reduced IGF-I gene transcription remained u ...
Fact Sheet Fourteen - Naltrexone - Millhouse Integrative Medical
... immune system, and within a year Toll-Like-Receptors (TLR) were also discovered. TLR are found in white blood cells and the cells of various organs where they perform the first line of defense for the innate immune system against microbial invasion. Once TLRs recognise a foreign microorganism, small ...
... immune system, and within a year Toll-Like-Receptors (TLR) were also discovered. TLR are found in white blood cells and the cells of various organs where they perform the first line of defense for the innate immune system against microbial invasion. Once TLRs recognise a foreign microorganism, small ...
슬라이드 1 - Hanyang
... apoptosis and be eliminated - The particular signals that trigger apoptosis in HSCs are as yet unknown. - when used antibodies to disrupt the adhesion of HSCs to the stroma via VLA-4/VCAM-1, the cells were predisposed to apoptosis - stem cells need to get two growth factor signals to continue life a ...
... apoptosis and be eliminated - The particular signals that trigger apoptosis in HSCs are as yet unknown. - when used antibodies to disrupt the adhesion of HSCs to the stroma via VLA-4/VCAM-1, the cells were predisposed to apoptosis - stem cells need to get two growth factor signals to continue life a ...
Inflammation
... • Leukocytes “squeeze” through post-capillary venule endothelial cells • First cells to emigrate are called polymorphonuclear cells (PMC)- include eosinophils and basophils • Second cells to emigrate are called mononuclear cells- include monocytes and macrophages Transmigration (diapedesis) • Occurs ...
... • Leukocytes “squeeze” through post-capillary venule endothelial cells • First cells to emigrate are called polymorphonuclear cells (PMC)- include eosinophils and basophils • Second cells to emigrate are called mononuclear cells- include monocytes and macrophages Transmigration (diapedesis) • Occurs ...
NVC_Bio105_lect16_immune_BLM
... 3. Coats the antigen, making it easier to phagocytize. 4. Binds the antigens, causing them to clump together – this will cause them fall out of solution. ...
... 3. Coats the antigen, making it easier to phagocytize. 4. Binds the antigens, causing them to clump together – this will cause them fall out of solution. ...
Bacterial Pathogenesis
... - Barriers (skin & mucus) – first line - Innate Immune Responses (complement, macrophages & cytokines) – the early stage - Adaptive Immune Responses (Ag-specific B & T cells) – the later stage 2. Susceptibility to bacterial infections depends on the balance between host defenses and bacterial virule ...
... - Barriers (skin & mucus) – first line - Innate Immune Responses (complement, macrophages & cytokines) – the early stage - Adaptive Immune Responses (Ag-specific B & T cells) – the later stage 2. Susceptibility to bacterial infections depends on the balance between host defenses and bacterial virule ...
the invertebrate immune system
... • Structurally resemble bacteria to the immune system – Mimic the microbial cell capsules and cell walls • Stimulate hemocytes to synthesize and release antimicrobial peptides • Probiotic bacteria in feed ...
... • Structurally resemble bacteria to the immune system – Mimic the microbial cell capsules and cell walls • Stimulate hemocytes to synthesize and release antimicrobial peptides • Probiotic bacteria in feed ...
Ocular Autoimmune Disease: An Introduction
... Regardless of the form of autoimmunity, any autoimmune disease affecting the eye will require systemic (e.g., oral as opposed to local, topical, ocular) therapy; the components of the immune system reside not in the eye, but rather are systemic, and therefore, regulation of those components will req ...
... Regardless of the form of autoimmunity, any autoimmune disease affecting the eye will require systemic (e.g., oral as opposed to local, topical, ocular) therapy; the components of the immune system reside not in the eye, but rather are systemic, and therefore, regulation of those components will req ...
BioCentury - Intensity Therapeutics
... month or two, the company will instead choose a candidate for clinical development that includes two chemotherapeutics with different MOAs and an enhancer. Bender said Intensity is positioning its formulations for use in patients with metastatic, inoperable tumors who have failed chemotherapy. Bende ...
... month or two, the company will instead choose a candidate for clinical development that includes two chemotherapeutics with different MOAs and an enhancer. Bender said Intensity is positioning its formulations for use in patients with metastatic, inoperable tumors who have failed chemotherapy. Bende ...
Bioluminescence imaging of lymphocyte trafficking in vivo
... for decades and are thus well characterized and readily applied to a variety of biological questions; this approach has been used to monitor infectious diseases, gene expression patterns, and tumor cell proliferation in vivo [17,30,31]. Luciferases are a family of proteins produced by luminescent or ...
... for decades and are thus well characterized and readily applied to a variety of biological questions; this approach has been used to monitor infectious diseases, gene expression patterns, and tumor cell proliferation in vivo [17,30,31]. Luciferases are a family of proteins produced by luminescent or ...
SKIN
... the extensions elongate if the cells shrink slightly during histologic processing), leading to the appearance of many short “spines” or prickles at the cell surfaces . The epidermis of thick skin subject to continuous friction and pressure (such as the foot soles) has a thicker stratum spinosum with ...
... the extensions elongate if the cells shrink slightly during histologic processing), leading to the appearance of many short “spines” or prickles at the cell surfaces . The epidermis of thick skin subject to continuous friction and pressure (such as the foot soles) has a thicker stratum spinosum with ...
The predominant surface glycoproteins of thymocytes and
... by any other cell type (15). This molecule thus fits with the concept of a uniquely expressed molecule mediating a particular function of a differentiated cell. Histocompatibility antigens function as controlling elements in T-lymphocyte responses (2,3). T lymphocytes appear to recognize foreign ant ...
... by any other cell type (15). This molecule thus fits with the concept of a uniquely expressed molecule mediating a particular function of a differentiated cell. Histocompatibility antigens function as controlling elements in T-lymphocyte responses (2,3). T lymphocytes appear to recognize foreign ant ...
kdfkdfjsdk - Austin Community College
... testing necessary – bone and cornea most common. Transfusion service role Accurate ABO typing of donor Supply blood appropriate blood components. ...
... testing necessary – bone and cornea most common. Transfusion service role Accurate ABO typing of donor Supply blood appropriate blood components. ...
Th1/Th2 paradigm: not seeing the forest for the trees? EDITORIAL
... Th2 balance. Finally, studies regarding this balance in mouse asthma models have failed to provide clear evidence of counter-regulation between the two subtypes. For these latter studies, at least two strategies have been explored: adoptive transfer of in vitro polarised T-cells and treatment with T ...
... Th2 balance. Finally, studies regarding this balance in mouse asthma models have failed to provide clear evidence of counter-regulation between the two subtypes. For these latter studies, at least two strategies have been explored: adoptive transfer of in vitro polarised T-cells and treatment with T ...
THE MEANING OF SELF:
... 3. This reality not only represents his present situation but also acts as a stepping-stone towards his future development. 4. This of course includes some degree of self-regard, for as Horney, 1950 and Rogers, 1951 have indicated, unless an individual loves himself, he will feel a basic hostility t ...
... 3. This reality not only represents his present situation but also acts as a stepping-stone towards his future development. 4. This of course includes some degree of self-regard, for as Horney, 1950 and Rogers, 1951 have indicated, unless an individual loves himself, he will feel a basic hostility t ...
Building on Sipuleucel-T for Immunologic Treatment of Castration-Resistant Prostate Cancer
... Sipuleucel-T was approved by the US Food and Drug Administration (FDA) in 2010 for asymptomatic and minimally symptomatic patients with metastatic castration-resistant prostate cancer (CRPC). Since then, a number of other treatments have been approved for metastatic CRPC. In 2010 and 2011, both abi ...
... Sipuleucel-T was approved by the US Food and Drug Administration (FDA) in 2010 for asymptomatic and minimally symptomatic patients with metastatic castration-resistant prostate cancer (CRPC). Since then, a number of other treatments have been approved for metastatic CRPC. In 2010 and 2011, both abi ...
The Gene Ontology and Immune System Processes
... • Developed for the annotation of gene products, primarily proteins, but also RNAs of various types, to provide a common language for representing protein properties. • Predates BFO and the OBO Foundry, and is still being improved to match recent best practices in ontology building. ...
... • Developed for the annotation of gene products, primarily proteins, but also RNAs of various types, to provide a common language for representing protein properties. • Predates BFO and the OBO Foundry, and is still being improved to match recent best practices in ontology building. ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.