21 - Dr. Jerry Cronin
... – Determine antibody class (IgM, IgA, IgD, IgG, or IgE) – Serve common functions in all antibodies by ...
... – Determine antibody class (IgM, IgA, IgD, IgG, or IgE) – Serve common functions in all antibodies by ...
ch_21_lecture_presentation_b
... – Determine antibody class (IgM, IgA, IgD, IgG, or IgE) – Serve common functions in all antibodies by ...
... – Determine antibody class (IgM, IgA, IgD, IgG, or IgE) – Serve common functions in all antibodies by ...
AIDS 2008 PowerPoint Template
... Susan Zolla-Pazner (USA) “Structural Vaccinology Approach” – cross-clade neutralizing antibodies using a gp120 DNA-based prime followed by a boost with a Env V3 attached to a Cholera Toxin B protein scaffold immunogen. Susan Barnet (USA) – results from the RV144 trial and other studies utilizing non ...
... Susan Zolla-Pazner (USA) “Structural Vaccinology Approach” – cross-clade neutralizing antibodies using a gp120 DNA-based prime followed by a boost with a Env V3 attached to a Cholera Toxin B protein scaffold immunogen. Susan Barnet (USA) – results from the RV144 trial and other studies utilizing non ...
Enlightenments from Immunity on Organizational Theories Yihua
... double-edged sword, its own diseases and disorders are hazardous to human health (Zhang, 2003). The immune system is characterized by a collaboration of various organs, cells, molecules, body fluids with clear division. In addition, immunity is considered as a complex network system able to response ...
... double-edged sword, its own diseases and disorders are hazardous to human health (Zhang, 2003). The immune system is characterized by a collaboration of various organs, cells, molecules, body fluids with clear division. In addition, immunity is considered as a complex network system able to response ...
Overview of Biological Response Modifiers in Infectious Disease
... manifestation have been published, and these will not be dealt with here. It is noteworthy that currently there are more women worldwide who have been infected with HIV than males and females account for nearly half of over 40 million people living with HIV [14]. Women are more vulnerable to HIV inf ...
... manifestation have been published, and these will not be dealt with here. It is noteworthy that currently there are more women worldwide who have been infected with HIV than males and females account for nearly half of over 40 million people living with HIV [14]. Women are more vulnerable to HIV inf ...
The Role of a Cytophilic Factor from Challenged
... are cultured in vitro with these lymphoma cells. This factor renders a monolayer of normal peritoneal C57BL macrophages specifically cytotoxic to the lymphoma cells. Trypsin treatment of macrophages coated with this specific-macrophage-arming factor terminates cytotoxic activity. The factor also bin ...
... are cultured in vitro with these lymphoma cells. This factor renders a monolayer of normal peritoneal C57BL macrophages specifically cytotoxic to the lymphoma cells. Trypsin treatment of macrophages coated with this specific-macrophage-arming factor terminates cytotoxic activity. The factor also bin ...
Lipids rule: resetting lipid metabolism restores T cell function in
... Systemic lupus erythematosus (SLE) is a devastating autoimmune disease characterized by chronic inflammation and systemic destruction of host organs or tissue. A key feature of SLE is T cell dysfunction characterized by hyperresponsive antigen receptor signaling. In this issue of the JCI, McDonald a ...
... Systemic lupus erythematosus (SLE) is a devastating autoimmune disease characterized by chronic inflammation and systemic destruction of host organs or tissue. A key feature of SLE is T cell dysfunction characterized by hyperresponsive antigen receptor signaling. In this issue of the JCI, McDonald a ...
Thyroid Autoimmune Diseases
... • CTLA-4 *gene polymorphism (cytotoxic Tlymphocyte associated protein) result in reduced negative regulation of T-cells. • Most common in middle-aged, starts in adulthood. • Woman to men ratio is 5-10: 1. • Associated with other autoimmune diseases such as: SLE, dermatitis, and scleroderma. ...
... • CTLA-4 *gene polymorphism (cytotoxic Tlymphocyte associated protein) result in reduced negative regulation of T-cells. • Most common in middle-aged, starts in adulthood. • Woman to men ratio is 5-10: 1. • Associated with other autoimmune diseases such as: SLE, dermatitis, and scleroderma. ...
cancer
... The transformation of a normal cell into a cancerous one is called carcinogenesis. Cancer develops through a series of changes that upset normal controls over cell division. ...
... The transformation of a normal cell into a cancerous one is called carcinogenesis. Cancer develops through a series of changes that upset normal controls over cell division. ...
Stem Cell Production
... Stem cells can be cultured ex vivo and their populations expanded and differentiated in either adherent or suspension culture. Since allogenic stem cell therapies are generally meant to treat large patient numbers, this type of therapy may be more cost-effectively produced in bioreactors. Using bior ...
... Stem cells can be cultured ex vivo and their populations expanded and differentiated in either adherent or suspension culture. Since allogenic stem cell therapies are generally meant to treat large patient numbers, this type of therapy may be more cost-effectively produced in bioreactors. Using bior ...
Chaperokine activity of Hsp72
... Initial studies from Gallucci and co-workers demonstrated that dendritic cells (DC) are stimulated by endogenous signals received from stressed, virally infected or necrosis-induced cells, but not by healthy cells or cells undergoing apoptosis (25). The Srivastava group subsequently demonstrated tha ...
... Initial studies from Gallucci and co-workers demonstrated that dendritic cells (DC) are stimulated by endogenous signals received from stressed, virally infected or necrosis-induced cells, but not by healthy cells or cells undergoing apoptosis (25). The Srivastava group subsequently demonstrated tha ...
No Slide Title
... Emergence Complex systems arise from the simple behavior of the individuals that constitute them. The whole is greater than the sum of the parts. Examples of emergent phenomena: •Braess’s Paradox (1968) Adding more lanes to a highway often makes traffic jams worse. •Employee bonuses result in reduc ...
... Emergence Complex systems arise from the simple behavior of the individuals that constitute them. The whole is greater than the sum of the parts. Examples of emergent phenomena: •Braess’s Paradox (1968) Adding more lanes to a highway often makes traffic jams worse. •Employee bonuses result in reduc ...
Infection of Autoreactive B Lymphocytes with EBV
... proliferate and become latently infected memory B cells, which are resistant to the apoptosis that occurs during normal B-cell homeostasis because they express virusencoded anti-apoptotic molecules. Genetic susceptibility to the effects of B-cell infection by EBV leads to an increased number of late ...
... proliferate and become latently infected memory B cells, which are resistant to the apoptosis that occurs during normal B-cell homeostasis because they express virusencoded anti-apoptotic molecules. Genetic susceptibility to the effects of B-cell infection by EBV leads to an increased number of late ...
Behavioral immunization: immunity to self-antigens
... physical injury. We observed significantly improved locomotor activity in rats that were passively transferred with MBP-activated splenocytes derived from CNS-injured rats, compared to injured rats that received splenocytes from an uninjured, naive animal.11 Furthermore, there is a greater survival ...
... physical injury. We observed significantly improved locomotor activity in rats that were passively transferred with MBP-activated splenocytes derived from CNS-injured rats, compared to injured rats that received splenocytes from an uninjured, naive animal.11 Furthermore, there is a greater survival ...
Allergy and Hypersensitivity
... syndrome, hyperacute graft rejection, pemphigus, and antireceptor antibody (Graves, Diabetes). • Anti-receptor antibody may block or enhance the function of the receptor (block recognition site, imitation of the natural ligand, damage of receptor, accelerated degradation and alteration of binding a ...
... syndrome, hyperacute graft rejection, pemphigus, and antireceptor antibody (Graves, Diabetes). • Anti-receptor antibody may block or enhance the function of the receptor (block recognition site, imitation of the natural ligand, damage of receptor, accelerated degradation and alteration of binding a ...
Course Specification of histology for Master of Hepatobiliiary surgery
... Course Title: Histology for master of surgery Code: SURG H 712 Department giving the course: histology department Program(s) on which the course is given: Master of Hepatobiliiary surgery Department(s) offering the Program: Hepatobiliary Surgery department Academic year/level: 1st part Date of appro ...
... Course Title: Histology for master of surgery Code: SURG H 712 Department giving the course: histology department Program(s) on which the course is given: Master of Hepatobiliiary surgery Department(s) offering the Program: Hepatobiliary Surgery department Academic year/level: 1st part Date of appro ...
Chapter 12 Notes B - Herrin High School
... system and provoking an immune response Examples of common antigens Foreign proteins Nucleic acids Large carbohydrates Some lipids Pollen grains ...
... system and provoking an immune response Examples of common antigens Foreign proteins Nucleic acids Large carbohydrates Some lipids Pollen grains ...
Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell
... membrane blebbing is a well-studied phenomenon that occurs during the late stages of programmed cell death, and is the result of caspase-mediated cleavage and consequent activation of ROCK1 [43]. It has been reported that ABs contain nuclear material, which might be functional. However, the results ...
... membrane blebbing is a well-studied phenomenon that occurs during the late stages of programmed cell death, and is the result of caspase-mediated cleavage and consequent activation of ROCK1 [43]. It has been reported that ABs contain nuclear material, which might be functional. However, the results ...
P E R S P E C T I V...
... Fig. 2 Proliferation, cytokine production and phenotyping measured simultaneously in a sinhave responded to stimuli from those gle tube. Peripheral blood mononuclear cells were stained with carboxyfluorescein diacetate that have not done so, to identify other (CFSE) and stimulated with Staphylococcu ...
... Fig. 2 Proliferation, cytokine production and phenotyping measured simultaneously in a sinhave responded to stimuli from those gle tube. Peripheral blood mononuclear cells were stained with carboxyfluorescein diacetate that have not done so, to identify other (CFSE) and stimulated with Staphylococcu ...
Effects of Fibroblastic and Endothelial Extracellular
... human vascular endothelial growth factor (VEGF) in in vitro and in vivo assay systems. It contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. When comparing the sequence of human VEGF protein with that of mouse VEGF protein, we found ...
... human vascular endothelial growth factor (VEGF) in in vitro and in vivo assay systems. It contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. When comparing the sequence of human VEGF protein with that of mouse VEGF protein, we found ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.