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15 Blood
15 Blood

...  Having RBC’s with various shapes is called aniscocytosis.  Having RBC’s with various shapes is called poikilocytosis.  In some anemias, such as pernicious anemia, anisocytosis and poikilocytosis causes an increase in the RDW. ...
Lactic acid bacteria for mucosal vaccines and therapy
Lactic acid bacteria for mucosal vaccines and therapy

... intestinal tract where they would have the most potent local effects and/or maximum absorption rates. Studies carried out by a small number of independent laboratories and involving two successive European partnerships has now unequivocally demonstrated that immunisation with L.lactis and certain sp ...
Elements of Adaptive Immunity
Elements of Adaptive Immunity

... Elements of Adaptive Immunity • Immune System Cytokines – Interleukins (ILs) – Signal among leukocytes – Interferons (IFNs) – Antiviral proteins that may act as cytokines – Growth factors – Proteins that stimulate stem cells to divide – Tumor necrosis factor (TNF) – Secreted by macrophages and T ce ...
DOC - ADAM Interactive Anatomy
DOC - ADAM Interactive Anatomy

...  Some bacteria have evolved capsules to avoid phagocytosis. The immune system counters this tactic using opsonins.  Other pathogens avoid digestion in phagosomes and can live and reproduce there. The immune system counters this tactic using T cells to activate macrophages and amplify their killing ...
The biochemistry and genetics of autoimmune disease
The biochemistry and genetics of autoimmune disease

... be modulated by mercury toxicokinetics, but non-H-2 genes may also modulate this response independent of kinetics. AFA and IgE are both important markers for adverse immune reactions after exposure to mercuric chloride, but the responses are probably mechanistically unrelated. Thresholds exist below ...
Innate Host Defenses - Interactive Physiology
Innate Host Defenses - Interactive Physiology

Exam 1 Q2 Review Sheet
Exam 1 Q2 Review Sheet

... hypothyroidism not have cretinism? What happens to adults that develop hypothyroidism and how does this relate to the affects of T3 and T4 on the body. You drink a glass of milk. Explain how your blood calcium will be regulated. Do not stop with the lowering of the calcium concentration, as it will ...
Ontogeny, Phytogeny, and Cellular Cooperation It should not be at
Ontogeny, Phytogeny, and Cellular Cooperation It should not be at

... of anti-hapten response after preimmunization with the same type of erythrocyte used as carrier, but not with a different priming erythrocyte. CRBC and Bufo marinus (TRBC) erythrocytes were used in the four possible combinations of priming erythrocyte type and TNP-conjugate. HRBC and HRBC-TNP assays ...
The protein coexpression Fut u re
The protein coexpression Fut u re

... In an attempt to improve the efficiency of coordinated coexpression, various strategies have been employed: placing multiple genes on the same plasmid DNA, and using multiple divergent or tandem promoters; however, none have proved to be a significant advance. One solution is to concatenate sequence ...
(From the Medicine Branch, National Cancer Institute, Bethesda
(From the Medicine Branch, National Cancer Institute, Bethesda

... (From the Medicine Branch, National Cancer Institute, Bethesda, Maryland, the Department of Haernatology, Postgraduate Medical School, London, the Division of Experimental Biology and Virology, Imperial Cancer Research Fund, and the Immunology Division, National Institute for Medical Research, Mill ...
Blood - El Camino College
Blood - El Camino College

... 1. Type ____ has the A antigen on the RBC 2. Type ____ has the B antigen on the RBC 3. Type ____ has both A and B antigen 4. Type ____ has neither A nor B antigen B. People must receive transfusions of similar blood type because they have ___________ (gamma globulins) against certain RBC antigens, w ...
Sunlight and Reduced Risk of Cancer: Is The Real Story Vitamin D?
Sunlight and Reduced Risk of Cancer: Is The Real Story Vitamin D?

... the benefits of sunlight exposure with respect to the endogenous synthesis of vitamin D. The study by Berwick et al. (3) involved mostly patients with early stage melanoma, and it is plausible that the known antiproliferative and antiangiogenic properties of vitamin D may be inversely associated wi ...
CERVICAL CANCER SCREENING (Pap Test) • Based on
CERVICAL CANCER SCREENING (Pap Test) • Based on

Is there any kind of adaptive immunity in invertebrates?
Is there any kind of adaptive immunity in invertebrates?

... impossibility of vaccine development in invertebrates has been a paradigm for those that assume the non-existence of an adaptive immune response in these animals. As pointed out by Kaattari Ž1994., the arbitrary use of semantic definitions of adaptive immune response leads to potential great errors ...
Induction of antibody response to human tumor antigens by
Induction of antibody response to human tumor antigens by

... to study tumor antigen DNA vaccination primarily because they have been shown to be immunogenic, expressed by a wide variety of human cancers and not expressed by normal tissues.15–17 These are important criteria in the overall design of an effective vaccine against multiple cancers. Studies have de ...
Your Amazing Immune System - how it protects your body
Your Amazing Immune System - how it protects your body

... One type of lymphocyte you’d discover is the B lymphocyte or B cell. B cells produce special weapons called antibodies which stick to a pathogen and help the immune system to destroy it. Other lymphocytes are known as helper T cells and killer T cells. Helper T cells help B cells to produce antibodi ...
Full-Text PDF
Full-Text PDF

... significantly stimulated MNC to produce GM-CSF more than two-fold. However, proteinase K-treated NCPS only increased GM-CSF production by 25%–50%. These observations suggest that proteins contained in NCPS may have a stimulatory effect on GM-CSF secretion. IL-1β is produced from activated macrophage ...
(Delayed or Cell-Mediated) Hypersensitivity
(Delayed or Cell-Mediated) Hypersensitivity

... • Results when cells are destroyed by an immune response • Often the combined activities of complement and antibodies • A component of many autoimmune diseases • Two significant examples ...
Bitter Taste Bodyguards
Bitter Taste Bodyguards

Tumor necrosis factor-alpha in the retina in acquired immune
Tumor necrosis factor-alpha in the retina in acquired immune

... Approximately 58% of patients with acquired immune deficiency syndrome (AIDS) have retinal disease.1 Ischemic lesions are frequent with loss of pericytes, degeneration of endothelial cells, and focal occlusion of small vessels.2 The substantial abnormalities of the retinal microvasculature in AIDS s ...
Chapter 21: Blood Vessels and Circulation
Chapter 21: Blood Vessels and Circulation

... • Formed elements (formed through hematopoiesis) – RBCs (erythrocytes) • Most abundant • Transport O2 and CO2 ...
The immune system - Los Angeles Mission College
The immune system - Los Angeles Mission College

... Includes autonomic responses such as coughing , sneezing , fever ,and species resistance (where each species of living organism is only susceptible to its own set of infections due to body temperature and PH ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
PHS 398 (Rev. 9/04), Biographical Sketch Format Page

... shown that SAP (SLAM-associated protein) plays a central role in CD4 T cell help at the germinal center stage for the development of long term humoral immunity after a viral infection. In this project we study the functional characteristics of CD4 T cells that provide B cell help, and the roles of S ...
Effect of Maitake (Grifola frondosa) D-Fraction on - J
Effect of Maitake (Grifola frondosa) D-Fraction on - J

... enhancement of the activation of CD41 cells. This result suggests an introduction of cellular immunity by the CD41 population. D-Fraction also weakly enhanced CTL activation. This seems to be related to the activation of CTL by the activated CD41 cells. The CD41 T cells are classified into two sub-t ...
A framework for describing infectious diseases
A framework for describing infectious diseases

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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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