Expression of genes involved in the T cell signalling pathway in
... microarray data at 12 MPC but in the qPCR analysis was down-regulated at 12 MPC (p < 0.01), and also had lower expression than controls at 10 and 24 MPC (see Figure 1). Interestingly, PrPc has been found to co-precipitate with the TCR [8,18] and with components of the TCR signaling pathway [9], many ...
... microarray data at 12 MPC but in the qPCR analysis was down-regulated at 12 MPC (p < 0.01), and also had lower expression than controls at 10 and 24 MPC (see Figure 1). Interestingly, PrPc has been found to co-precipitate with the TCR [8,18] and with components of the TCR signaling pathway [9], many ...
Regulation of mucosal immune responses in effector sites
... hypothesised that the changes occur as a result of transient allergic immune responses to novel food or bacteria antigens. The normal mechanism for producing tolerance to food antigens may operate at induction (Peyer’s patches and mesenteric lymph nodes) or at the effector stage (intestinal lamina p ...
... hypothesised that the changes occur as a result of transient allergic immune responses to novel food or bacteria antigens. The normal mechanism for producing tolerance to food antigens may operate at induction (Peyer’s patches and mesenteric lymph nodes) or at the effector stage (intestinal lamina p ...
TRANSPORT
... involving the heart and blood vessels. a. High Blood Pressure- High blood pressure is the most common form of cardiovascular disease characterized by increased arterial pressure. This can be caused by a number of variables including stress, dietary factors, heredity, cigarette smoking, and aging. Hi ...
... involving the heart and blood vessels. a. High Blood Pressure- High blood pressure is the most common form of cardiovascular disease characterized by increased arterial pressure. This can be caused by a number of variables including stress, dietary factors, heredity, cigarette smoking, and aging. Hi ...
The pressure mounts on lung dendritic cells EDITORIAL
... model of PAH, the levels of PAF are greatly increased and a PAF antagonist prevents PAH in this model [14]. It has recently been shown that PAF immobilises DCs in the periphery and is responsible for the accumulation of DCs in the skin and vessel wall of dyslipidaemic ApoE-/- mice, where DCs initiat ...
... model of PAH, the levels of PAF are greatly increased and a PAF antagonist prevents PAH in this model [14]. It has recently been shown that PAF immobilises DCs in the periphery and is responsible for the accumulation of DCs in the skin and vessel wall of dyslipidaemic ApoE-/- mice, where DCs initiat ...
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... mutants in vitro [29], and contributes to bacterial virulence and protection in murine models of the disease [30-33]. Therefore, flagellin may be an attractive vaccine candidate. Flagellin could also serve as a carrier and an adjuvant. The flagellum is a polymer of flagellin and hence acts as a mult ...
... mutants in vitro [29], and contributes to bacterial virulence and protection in murine models of the disease [30-33]. Therefore, flagellin may be an attractive vaccine candidate. Flagellin could also serve as a carrier and an adjuvant. The flagellum is a polymer of flagellin and hence acts as a mult ...
Potential impact of physical activity and sport on the immune system
... much increased because many more cells can be counted. The simplest classification of T cells1'2 identifies helper cells with a characteristic (CD4) surface antigen, the suppressor cells (with a CD8 surface antigen) and cytotoxic T cells (with both CD3 and CD56 antigens). The helper T cells recogniz ...
... much increased because many more cells can be counted. The simplest classification of T cells1'2 identifies helper cells with a characteristic (CD4) surface antigen, the suppressor cells (with a CD8 surface antigen) and cytotoxic T cells (with both CD3 and CD56 antigens). The helper T cells recogniz ...
WRL2903.tmp
... independently of any possible binding to each other. The next question is, where would we expect BB map on this axis? One way of looking at it is to say that AA and BB are both self, so they may be similar to each other, and therefore may map on the same side as each other. On the other hand ...
... independently of any possible binding to each other. The next question is, where would we expect BB map on this axis? One way of looking at it is to say that AA and BB are both self, so they may be similar to each other, and therefore may map on the same side as each other. On the other hand ...
CD1a and MHC Class I Follow a Similar Endocytic
... display an impaired antigen-presenting capacity (9,11,13). In addition, some CD1 proteins possess putative dileucinebased sorting motifs (14), although it has not been shown if these play any role in trafficking or function. Tyrosineand dileucine-based motifs are known to bind adaptor protein (AP) c ...
... display an impaired antigen-presenting capacity (9,11,13). In addition, some CD1 proteins possess putative dileucinebased sorting motifs (14), although it has not been shown if these play any role in trafficking or function. Tyrosineand dileucine-based motifs are known to bind adaptor protein (AP) c ...
The Role of Autoantibodies in Diagnosis of Multiple Sclerosis
... complement. Type III is related to distal oligodendropathy, degenerative changes which occur in distal followed by apoptosis. Type IV results in primary oligodendrocyte damage followed by secondary demyelination. The latter pattern is seen only in a small subset of primary progressive MS patients.[2 ...
... complement. Type III is related to distal oligodendropathy, degenerative changes which occur in distal followed by apoptosis. Type IV results in primary oligodendrocyte damage followed by secondary demyelination. The latter pattern is seen only in a small subset of primary progressive MS patients.[2 ...
Natural killer cell activity in Sjogren`s syndrome and systemic lupus
... Depression of NK cell activity in SLE2 3 may be due to several factors, including a decreased number of active NK cells'3 and an abnormal NK cell function caused by intrinsic cell defects or serum factors.22 Diminished NK cell activity with a normal or reduced number of cells,' 13 23 as well as norm ...
... Depression of NK cell activity in SLE2 3 may be due to several factors, including a decreased number of active NK cells'3 and an abnormal NK cell function caused by intrinsic cell defects or serum factors.22 Diminished NK cell activity with a normal or reduced number of cells,' 13 23 as well as norm ...
PPT Version - OMICS International
... a- subunit vaccines In which microbial polypeptides are isolated from the infective material hepatitis B and influenza viruses B- Recombinant DNA-derived antigen vaccines: In which Ag are synthesizing by inserting the coding genes into E. coli or yeast cell as HBV vaccines C- Recombinant DNA a virul ...
... a- subunit vaccines In which microbial polypeptides are isolated from the infective material hepatitis B and influenza viruses B- Recombinant DNA-derived antigen vaccines: In which Ag are synthesizing by inserting the coding genes into E. coli or yeast cell as HBV vaccines C- Recombinant DNA a virul ...
attention news desk
... The workplace toolkit has been produced by Prostate Scotland and includes information on Benign Prostatic Hyperplasia (BPH, or prostate enlargement), Prostatitis and Prostate Cancer. The target audience is men over 50 years of age, as it is often challenging to get men to talk about urinary symptoms ...
... The workplace toolkit has been produced by Prostate Scotland and includes information on Benign Prostatic Hyperplasia (BPH, or prostate enlargement), Prostatitis and Prostate Cancer. The target audience is men over 50 years of age, as it is often challenging to get men to talk about urinary symptoms ...
Advances and challenges in translating stem cell therapies for
... stem cells could engraft and perhaps regenerate pulmonary epithelium, subsequent studies have indicated that beneficial effects seem to be explained more by paracrine effects rather than by direct cell engraftment in the lung. When mesenchymal stem cells are administered by the intravenous route, mo ...
... stem cells could engraft and perhaps regenerate pulmonary epithelium, subsequent studies have indicated that beneficial effects seem to be explained more by paracrine effects rather than by direct cell engraftment in the lung. When mesenchymal stem cells are administered by the intravenous route, mo ...
COMMON VARIABLE IMMUNODEFICIENCY
... of other disorders characterized by low levels of serum immunoglobulins. In the absence of a significant T-lymphocyte defect or organ damage, immunoglobulin replacement therapy almost always brings improvement of symptoms. Immunoglobulin is extracted from a large pool of human plasma consisting most ...
... of other disorders characterized by low levels of serum immunoglobulins. In the absence of a significant T-lymphocyte defect or organ damage, immunoglobulin replacement therapy almost always brings improvement of symptoms. Immunoglobulin is extracted from a large pool of human plasma consisting most ...
COMMON - Canadian Immunodeficiencies Patient Organization
... of other disorders characterized by low levels of serum immunoglobulins. In the absence of a significant T-lymphocyte defect or organ damage, immunoglobulin replacement therapy almost always brings improvement of symptoms. Immunoglobulin is extracted from a large pool of human plasma consisting most ...
... of other disorders characterized by low levels of serum immunoglobulins. In the absence of a significant T-lymphocyte defect or organ damage, immunoglobulin replacement therapy almost always brings improvement of symptoms. Immunoglobulin is extracted from a large pool of human plasma consisting most ...
Stem Cell Research and Potential Medical Interventions
... have done investigations to find ways to prevent stem cells from being rejected in the body. Bioscience technology website (23) gives information on how immunosuppressant drugs have been used for short term immune responses and how, if these drugs are used over a long period for stem cells, they can ...
... have done investigations to find ways to prevent stem cells from being rejected in the body. Bioscience technology website (23) gives information on how immunosuppressant drugs have been used for short term immune responses and how, if these drugs are used over a long period for stem cells, they can ...
Inflammatory bowel disease related innate immunity and adaptive
... lymphoid tissues, and then activate original T cells to secrete cytokines, thus inducing immune responses. In colitis animal model, DCs from colons were co-cultured with autologous T cells of lamina propria and T cells were stimulated to produce IFN-γ and IL-6, quantity of which was significantly hi ...
... lymphoid tissues, and then activate original T cells to secrete cytokines, thus inducing immune responses. In colitis animal model, DCs from colons were co-cultured with autologous T cells of lamina propria and T cells were stimulated to produce IFN-γ and IL-6, quantity of which was significantly hi ...
The Impact of a Community-Oriented Problem-Based
... Objective: To understand how the different immune correlates (cytokines and cellular subsets) influence parasite dynamics during disease. Design: Active VL patient based cross-sectional study. Setting: VL patients admitted to STM, Kolkata and RMRIMS, Patna. Methodology/ Principal Findings: We examin ...
... Objective: To understand how the different immune correlates (cytokines and cellular subsets) influence parasite dynamics during disease. Design: Active VL patient based cross-sectional study. Setting: VL patients admitted to STM, Kolkata and RMRIMS, Patna. Methodology/ Principal Findings: We examin ...
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients , S. Boniface*,
... resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs ...
... resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs ...
Current Perspective on In Vivo Molecular Imaging of Immune Cells
... cells of the adaptive immune system, predominantly comprising T cells and B cells. Each cell type has a well-defined role in the cascade of events that occurs following encounter with a pathogen or transformed cells. For example, (1) macrophages get rid of cell debris and pathogens; (2) DCs and macr ...
... cells of the adaptive immune system, predominantly comprising T cells and B cells. Each cell type has a well-defined role in the cascade of events that occurs following encounter with a pathogen or transformed cells. For example, (1) macrophages get rid of cell debris and pathogens; (2) DCs and macr ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.