Anaplasma
... inflammation in the eyes called uveitis may occur as a result of the long-term immune stimulation. Neurologic effects may also be seen. Glomerulonephritis, which results in serious urinary protein loss, can also occur. Increased globulin levels are almost always seen in this stage, and albumin is of ...
... inflammation in the eyes called uveitis may occur as a result of the long-term immune stimulation. Neurologic effects may also be seen. Glomerulonephritis, which results in serious urinary protein loss, can also occur. Increased globulin levels are almost always seen in this stage, and albumin is of ...
One way to pathogenesis, many ways to homeostasis
... and Lglas. Pathogenic Th17 cells also downregulate the expression of IL-10, IL9, IL1Rn and Ikzf3, which are upregulated in non-pathogenic Th17 cells. Upregulation of Tbx1 (which encodes transcription factor T-bet) in pathogenic Th17 cells is also well consistent with the essential role of T-bet in t ...
... and Lglas. Pathogenic Th17 cells also downregulate the expression of IL-10, IL9, IL1Rn and Ikzf3, which are upregulated in non-pathogenic Th17 cells. Upregulation of Tbx1 (which encodes transcription factor T-bet) in pathogenic Th17 cells is also well consistent with the essential role of T-bet in t ...
Histology Connective Tissues General Concepts Composition Cells
... the bloodstream and rapidly transform into macrophages that function in phagocytosis, antigen processing, and cytokine secretion. b. Comprise the mononuclear phagocyte system of the body; include Kupffer cells in the liver, alveolar macrophages in the lung, microglia the central nervous system, Lang ...
... the bloodstream and rapidly transform into macrophages that function in phagocytosis, antigen processing, and cytokine secretion. b. Comprise the mononuclear phagocyte system of the body; include Kupffer cells in the liver, alveolar macrophages in the lung, microglia the central nervous system, Lang ...
Nasopharyngeal Carcinoma
... CTL precursor frequency Quality of immune response in cancer patients Homing to mucosal tumor site Tumor milieu T cell infiltrates (lymphoepithelioma) contain suppressive T regulatory cells What are the determinants for clinical efficacy? T cell product ...
... CTL precursor frequency Quality of immune response in cancer patients Homing to mucosal tumor site Tumor milieu T cell infiltrates (lymphoepithelioma) contain suppressive T regulatory cells What are the determinants for clinical efficacy? T cell product ...
Mitochondrial damage-associated molecular patterns and vascular
... The traditional theory of immunological response and tolerance was based on the discrimination between self and non-self, where the immune system was activated by exogenous stimuli (e.g. bacteria, viruses, and fungus). Although this paradigm was acceptable for describing a situation in which the sti ...
... The traditional theory of immunological response and tolerance was based on the discrimination between self and non-self, where the immune system was activated by exogenous stimuli (e.g. bacteria, viruses, and fungus). Although this paradigm was acceptable for describing a situation in which the sti ...
Laughter..the best medicine!
... Available scientific evidence does not support humour as an effective treatment for cancer or any other disease; however, laughter has many benefits, including positive physical changes and an overall sense of well being. The healing power of humour has been long been recognized but only in the past ...
... Available scientific evidence does not support humour as an effective treatment for cancer or any other disease; however, laughter has many benefits, including positive physical changes and an overall sense of well being. The healing power of humour has been long been recognized but only in the past ...
Current subjects of research:
... pleiotropic soluble factors. Functionally, they are implicated in mucosal immunity through the multifaceted innate effector functions of protease inhibition, attenuation of inflammatory responses and microbial clearance. Recently, three of these proteins have been ascribed significant roles in regul ...
... pleiotropic soluble factors. Functionally, they are implicated in mucosal immunity through the multifaceted innate effector functions of protease inhibition, attenuation of inflammatory responses and microbial clearance. Recently, three of these proteins have been ascribed significant roles in regul ...
Chapter 3. Antigens
... Antigen: Substances that can be recognized by the surface antibody (B cells) or by the TCR (T cells) when associated with MHC molecules Immunogenicity VS Antigenicity: Immunogenicity – ability to induce an antibody and/or cell-mediated immune response Antigenicity – ability to combine with the final ...
... Antigen: Substances that can be recognized by the surface antibody (B cells) or by the TCR (T cells) when associated with MHC molecules Immunogenicity VS Antigenicity: Immunogenicity – ability to induce an antibody and/or cell-mediated immune response Antigenicity – ability to combine with the final ...
Roche - FDA approves Roche`s Kadcyla (trastuzumab emtansine
... Like Herceptin, Kadcyla binds to HER2-positive cells and is thought to block out-of-control signals that make the cancer grow while also calling on the body's immune system to attack the cancer cells. Once Kadcyla is taken up by those cells, it is designed to destroy them by releasing the DM1 inside ...
... Like Herceptin, Kadcyla binds to HER2-positive cells and is thought to block out-of-control signals that make the cancer grow while also calling on the body's immune system to attack the cancer cells. Once Kadcyla is taken up by those cells, it is designed to destroy them by releasing the DM1 inside ...
MHC class II Pathway
... cells and dendritic cells, and thymic epithelial cells. In MHC class II phagocytes such as macrophages and immature dendritic cells uptake entities by phagocytosis into phagosomes which fuse with lysosomes whose acidic enzymes cleave the uptaken protein into many different peptides interaction with ...
... cells and dendritic cells, and thymic epithelial cells. In MHC class II phagocytes such as macrophages and immature dendritic cells uptake entities by phagocytosis into phagosomes which fuse with lysosomes whose acidic enzymes cleave the uptaken protein into many different peptides interaction with ...
Mechanism of action of Low Dose Naltrexone (LDN)
... • The effects of LDN are dependent on the OGF-OGFr axis. LDN upregulates OGF-OGFr at the translational ...
... • The effects of LDN are dependent on the OGF-OGFr axis. LDN upregulates OGF-OGFr at the translational ...
video slide
... MHC molecule on the cell surface. A specific helper T cell binds to the displayed complex via its TCR with the aid of CD4. This interaction promotes secretion of cytokines by the dendritic cell. Cytotoxic T cell ...
... MHC molecule on the cell surface. A specific helper T cell binds to the displayed complex via its TCR with the aid of CD4. This interaction promotes secretion of cytokines by the dendritic cell. Cytotoxic T cell ...
Stimulation of TLRs by LMW-HA induces self-defense
... evaluation in the presence of siRNA for TLR2 and TLR4: as shown by Figure 3b, only a slight increase in migrating activity of VK2/E6E7 cells was observed in the presence of LMW-HA in these conditions (P¼0.0098 LMW-HA+siTLR2 and 4 vs LMW-HA, with t¼24 h), characterized by an almost complete inhibitio ...
... evaluation in the presence of siRNA for TLR2 and TLR4: as shown by Figure 3b, only a slight increase in migrating activity of VK2/E6E7 cells was observed in the presence of LMW-HA in these conditions (P¼0.0098 LMW-HA+siTLR2 and 4 vs LMW-HA, with t¼24 h), characterized by an almost complete inhibitio ...
Immunosuppression via TCDD Activation of the Aryl
... Normal (prolonged) immune response: T Cell proliferation TCDD induces CD4+ T Cells to differentiate into CD25 expressing T Regulatory-like cells (Tregs) Tregs inhibit T Cell proliferation, leading to immune suppression ...
... Normal (prolonged) immune response: T Cell proliferation TCDD induces CD4+ T Cells to differentiate into CD25 expressing T Regulatory-like cells (Tregs) Tregs inhibit T Cell proliferation, leading to immune suppression ...
Fetal Cell Detection and Quantification
... 2013 HBF-04 CAP survey, 5% of the 929 participants used flow cytometry to quantify fetal cells, a slight increase from 4.2% in the 2009 survey.6,7 There are several FDA-approved flow cytometry methods that use either anti-HbF or anti-D or a combination of both. These methods have an advantage over t ...
... 2013 HBF-04 CAP survey, 5% of the 929 participants used flow cytometry to quantify fetal cells, a slight increase from 4.2% in the 2009 survey.6,7 There are several FDA-approved flow cytometry methods that use either anti-HbF or anti-D or a combination of both. These methods have an advantage over t ...
Sanofi Pasteur and Immune Design Collaborate on a Vaccine PRESS RELEASE
... development, with Immune Design providing a specific formulation of GLA from the GLAAS platform at its cost through Phase II studies. Immune Design will be eligible to receive future milestone and royalty payments on any product developed from the collaboration; other financial terms of the agreemen ...
... development, with Immune Design providing a specific formulation of GLA from the GLAAS platform at its cost through Phase II studies. Immune Design will be eligible to receive future milestone and royalty payments on any product developed from the collaboration; other financial terms of the agreemen ...
Müller Cell - American Diabetes Association
... of diabetes and a leading cause of vision loss worldwide (1). Unfortunately, there are no treatments targeting early stages of the disease prior to the onset of sight-threatening vascular defects such as macular edema or neovascularization. A better understanding of the etiology of DR is needed to i ...
... of diabetes and a leading cause of vision loss worldwide (1). Unfortunately, there are no treatments targeting early stages of the disease prior to the onset of sight-threatening vascular defects such as macular edema or neovascularization. A better understanding of the etiology of DR is needed to i ...
Jeopardy
... IgG antibodies inactivate microbes by blocking their attachment to host cells in the binding process known as a. neutralization. b. agglutination. c. antibody-dependent cell-mediated cytotoxicity. d. opsonization. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. ...
... IgG antibodies inactivate microbes by blocking their attachment to host cells in the binding process known as a. neutralization. b. agglutination. c. antibody-dependent cell-mediated cytotoxicity. d. opsonization. ANSWER BACK TO GAME © 2013 Pearson Education, Inc. ...
polar bears
... Obtain and use energy and nutrients Polar bears must eat food to have enough energy to survive. Polar bears use energy to keep themselves warm. Polar bears eat meat. It hunts for fish to eat and feed its cubs. If it doesn’t, then it won’t survive or its cubs won’t survive. It will also fight seals ...
... Obtain and use energy and nutrients Polar bears must eat food to have enough energy to survive. Polar bears use energy to keep themselves warm. Polar bears eat meat. It hunts for fish to eat and feed its cubs. If it doesn’t, then it won’t survive or its cubs won’t survive. It will also fight seals ...
THROMBOCYTOPENIA
... presence of immature platelets and abnormalities of the bone marrow (eg. Neoplastic invastion or aplastic anemia). ...
... presence of immature platelets and abnormalities of the bone marrow (eg. Neoplastic invastion or aplastic anemia). ...
Cutting Edge: Recognition of Gram
... This syndrome results from the induction of cytokines and other inflammatory mediators and is characterized by alterations in temperature, pulse, hemodynamic instability, and end organ damage. Conservative estimates suggest that nearly 400,000 Americans develop bacteremia, and that 70,000 of these i ...
... This syndrome results from the induction of cytokines and other inflammatory mediators and is characterized by alterations in temperature, pulse, hemodynamic instability, and end organ damage. Conservative estimates suggest that nearly 400,000 Americans develop bacteremia, and that 70,000 of these i ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.