Immunology of Stem Cells and Cancer Stem Cells
... mouse group (33), the ESCs are not stealthy in the heart. In contrast to these findings, recent studies suggest some immune privilege is associated with human ESC-derived tissues (34-36). However, the adaptability of the immune system makes it unlikely that fully differentiated tissues will maintain ...
... mouse group (33), the ESCs are not stealthy in the heart. In contrast to these findings, recent studies suggest some immune privilege is associated with human ESC-derived tissues (34-36). However, the adaptability of the immune system makes it unlikely that fully differentiated tissues will maintain ...
A Statewide Systems Biology Approach
... • Gallate compounds were more potent than their catecholate analogs in every instance • IC50 values correlated to pKa values of the most acidic phenolic hydrogen for catecholate compounds • Both iron-binding and lipophilicity are important factors: iron binding determines antioxidant activity, while ...
... • Gallate compounds were more potent than their catecholate analogs in every instance • IC50 values correlated to pKa values of the most acidic phenolic hydrogen for catecholate compounds • Both iron-binding and lipophilicity are important factors: iron binding determines antioxidant activity, while ...
Platelets: killers of parasites or patients?
... in killing Plasmodium parasites in infected RBCs.6,7 This current study in Blood took a rigorous in vivo approach to show that although platelets drive an immune response to infection, they are unlikely to have direct protective in vivo parasite-killing functions. There are many potential reasons fo ...
... in killing Plasmodium parasites in infected RBCs.6,7 This current study in Blood took a rigorous in vivo approach to show that although platelets drive an immune response to infection, they are unlikely to have direct protective in vivo parasite-killing functions. There are many potential reasons fo ...
Steel, O`Donoghue et al accepted - Spiral
... evidence that chorioamnionitis is also associated with activation of the fetal immune system; in particular, elevated pro-inflammatory cytokines (such as IL-6) and increased memory T cells in fetal blood, findings that have been linked with the incidence of brain injury in preterm infants (1,2). In ...
... evidence that chorioamnionitis is also associated with activation of the fetal immune system; in particular, elevated pro-inflammatory cytokines (such as IL-6) and increased memory T cells in fetal blood, findings that have been linked with the incidence of brain injury in preterm infants (1,2). In ...
Chapter 1 - University of Amsterdam
... lymphoproliferative response in cytotoxic T cells via activation of interleukin-2 and co-stimulatory receptors like CD40L (Baksh and Burakoff, 2000). Autocrine interaction of interleukin-2 with the interleukin-2 receptor provides lymphocytes with a pro-survival signal that is necessary for a full-bl ...
... lymphoproliferative response in cytotoxic T cells via activation of interleukin-2 and co-stimulatory receptors like CD40L (Baksh and Burakoff, 2000). Autocrine interaction of interleukin-2 with the interleukin-2 receptor provides lymphocytes with a pro-survival signal that is necessary for a full-bl ...
Anatomy Review - ADAM Interactive Anatomy
... • Lymph nodes are secondary lymphoid organs found in clusters along the lymphatic vessels. • Lymph nodes filter the lymph by removing antigens and other debris. • Lymph nodes provide a site for the activation of B and T cells by antigens. Page 11: Lymph Node: Vessels • Afferent lymphatic vessels bri ...
... • Lymph nodes are secondary lymphoid organs found in clusters along the lymphatic vessels. • Lymph nodes filter the lymph by removing antigens and other debris. • Lymph nodes provide a site for the activation of B and T cells by antigens. Page 11: Lymph Node: Vessels • Afferent lymphatic vessels bri ...
DOC - ADAM Interactive Anatomy
... Lymph nodes are secondary lymphoid organs found in clusters along the lymphatic vessels. Lymph nodes filter the lymph by removing antigens and other debris. Lymph nodes provide a site for the activation of B and T cells by antigens. Page 11: Lymph Node: Vessels Afferent lymphatic vessels bri ...
... Lymph nodes are secondary lymphoid organs found in clusters along the lymphatic vessels. Lymph nodes filter the lymph by removing antigens and other debris. Lymph nodes provide a site for the activation of B and T cells by antigens. Page 11: Lymph Node: Vessels Afferent lymphatic vessels bri ...
International team led by Humabs BioMed identifies novel
... and, of even greater concern, congenital birth defects such as microcephaly and other defects in the developing fetus. As of today, there is no preventive vaccine or specific therapy available. The study published in Science reports the first characterization of the human immune response to ZIKV inf ...
... and, of even greater concern, congenital birth defects such as microcephaly and other defects in the developing fetus. As of today, there is no preventive vaccine or specific therapy available. The study published in Science reports the first characterization of the human immune response to ZIKV inf ...
Mature CD11c cells are enhanced in hypersensitivity pneumonitis +
... the lung, these cells have a high phagocytic activity and are specialised in antigen uptake. Following tissue damage or during a lung infection, dendritic cells and macrophages process antigens provoking their maturation, and present antigenic peptides to T-cells. Dendritic cells may also migrate to ...
... the lung, these cells have a high phagocytic activity and are specialised in antigen uptake. Following tissue damage or during a lung infection, dendritic cells and macrophages process antigens provoking their maturation, and present antigenic peptides to T-cells. Dendritic cells may also migrate to ...
Disease
... foreign antigens by specific lymphocytes. - Provide more potent, specific (Ag), & broad protection - Develop immune memory for next exposure - Feedback regulate innate immunity ...
... foreign antigens by specific lymphocytes. - Provide more potent, specific (Ag), & broad protection - Develop immune memory for next exposure - Feedback regulate innate immunity ...
Diagnostic and Clinical Care Guidelines for Primary Immunodeficiency
... antibody deficiency disorder are generally treated on at regular intervals throughout life with replacement IG, either intravenously or subcutaneously. IG therapeutic products are comprised of numerous IgG antibodies purified from blood or plasma donations from approximately 60,000 donors per batch. ...
... antibody deficiency disorder are generally treated on at regular intervals throughout life with replacement IG, either intravenously or subcutaneously. IG therapeutic products are comprised of numerous IgG antibodies purified from blood or plasma donations from approximately 60,000 donors per batch. ...
Glucose metabolism regulates T cell activation, differentiation, and
... mitochondrial TCA cycle (17). The interconversion of metabolites in the TCA cycle generates energy and reducing equivalents, which subsequently enter the oxidative phosphorylation pathway effectively increasing ATP production. The quiescence of naïve T cells is interrupted upon engagement of the T C ...
... mitochondrial TCA cycle (17). The interconversion of metabolites in the TCA cycle generates energy and reducing equivalents, which subsequently enter the oxidative phosphorylation pathway effectively increasing ATP production. The quiescence of naïve T cells is interrupted upon engagement of the T C ...
detailed lecture outline
... antigen. (i.e. Type A blood has Type B antibodies in the plasma; Type B blood has Type A antibodies; Type O blood has both A and B antibodies.) ...
... antigen. (i.e. Type A blood has Type B antibodies in the plasma; Type B blood has Type A antibodies; Type O blood has both A and B antibodies.) ...
Immunology Study Guide Exam I Introduction to Immunology innate
... a) senses MHC class 1 receptors with a ubiquitous molecule (one found everywhere) (1) if the MHC class 1 receptor is not present, then the NK cell with kill it b) kills target cells using perforin and granzyme (1) perforin allows for the transfer of active granzyme into target cells by the creation ...
... a) senses MHC class 1 receptors with a ubiquitous molecule (one found everywhere) (1) if the MHC class 1 receptor is not present, then the NK cell with kill it b) kills target cells using perforin and granzyme (1) perforin allows for the transfer of active granzyme into target cells by the creation ...
Antigen sampling and presentation
... Immunogens refer to antigens that are able to stimulate a specific adaptive immune response when introduced into the body. Not all antigens are immunogens. To be immunogenic, antigens must fulfill certain criteria Hapten are small molecules that need a carrier to be immunogenic ...
... Immunogens refer to antigens that are able to stimulate a specific adaptive immune response when introduced into the body. Not all antigens are immunogens. To be immunogenic, antigens must fulfill certain criteria Hapten are small molecules that need a carrier to be immunogenic ...
Outline/ Active Learning Objectives - Rose
... be transmitted by insect bites, as in the case of malaria, or by sexual encounter, as in the case of the HIV virus. Antigens are substances that bind to receptors on T and B cells or antibodies. Haptens are similar to antigens, but are only immunogenic when linked to a carrier molecule. In addition ...
... be transmitted by insect bites, as in the case of malaria, or by sexual encounter, as in the case of the HIV virus. Antigens are substances that bind to receptors on T and B cells or antibodies. Haptens are similar to antigens, but are only immunogenic when linked to a carrier molecule. In addition ...
Molecular and Cellular Basis of Immune Protection of Mucosal
... Elongated shape and prominent glycocalyx on luminal surface Polarized, with a domed luminal surface separated from the basolateral surface by adherent junctions, but not tight junctions Cells rest on a basal lamina that constitutes the rate-limiting barrier to migrating lymphocytes ...
... Elongated shape and prominent glycocalyx on luminal surface Polarized, with a domed luminal surface separated from the basolateral surface by adherent junctions, but not tight junctions Cells rest on a basal lamina that constitutes the rate-limiting barrier to migrating lymphocytes ...
MicroRNAs of the immune system - Laboratory of Lymphocyte Biology
... be critical for a particular biologic process. Alternatively, there are hints that a particular miRNA may target multiple components that belong to a common regulatory pathway;45 therefore, the impact of miRNA control of a process may be additive and much more important than the moderate effects on ...
... be critical for a particular biologic process. Alternatively, there are hints that a particular miRNA may target multiple components that belong to a common regulatory pathway;45 therefore, the impact of miRNA control of a process may be additive and much more important than the moderate effects on ...
A1981MQ75900001
... in man as it was performed when it was developed and fully established as scientific routine in our laboratory. The first publication on the subject appeared in 1967.1 "At the beginning of the 1960s, immunobiolo-gists hypothesized that cell-mediated immune reactions as known from infectious disease ...
... in man as it was performed when it was developed and fully established as scientific routine in our laboratory. The first publication on the subject appeared in 1967.1 "At the beginning of the 1960s, immunobiolo-gists hypothesized that cell-mediated immune reactions as known from infectious disease ...
Wickenden et al. EHA 2016 PB2040
... PROLIFERATING KI67 EXPRESSING B-CELLS ASSOCIATE WITH CD4+PD1+ T-CELLS IN MARGINAL ZONE LYMPHOMA K Wickenden1,*, N Nawaz1, E Lakidou1, A Wilson1, K Straatman2, S Wagner1, M Ahearne1 1Cancer Studies, 2Biochemistry, University of Leicester, Leicester, United Kingdom Background: Specific microbial antig ...
... PROLIFERATING KI67 EXPRESSING B-CELLS ASSOCIATE WITH CD4+PD1+ T-CELLS IN MARGINAL ZONE LYMPHOMA K Wickenden1,*, N Nawaz1, E Lakidou1, A Wilson1, K Straatman2, S Wagner1, M Ahearne1 1Cancer Studies, 2Biochemistry, University of Leicester, Leicester, United Kingdom Background: Specific microbial antig ...
Immunotherapy of Metastatic Renal Cell Cancer
... The immune perspective of cancer differs somewhat from the perspective centered on the cancer cell itself. From the cancer cell viewpoint, the malignant phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from ...
... The immune perspective of cancer differs somewhat from the perspective centered on the cancer cell itself. From the cancer cell viewpoint, the malignant phenotype is a consequence of genetic instability, resistance to apoptosis, unregulated growth, and the capacity to metastasize. In contrast, from ...
Human Immunodeficiency Virus (HIV)
... • Looks for HIV DNA in the WBCs of a person. • PCR amplifies tiny quantities of the HIV DNA present, each cycle of PCR results in doubling of the DNA sequences present. • The DNA is detected by using radioactive or biotinylated probes. • Once DNA is amplified it is placed on nitrocellulose paper and ...
... • Looks for HIV DNA in the WBCs of a person. • PCR amplifies tiny quantities of the HIV DNA present, each cycle of PCR results in doubling of the DNA sequences present. • The DNA is detected by using radioactive or biotinylated probes. • Once DNA is amplified it is placed on nitrocellulose paper and ...
Establishing Mechanisms of Vitamin D Signaling Pathways
... VDR = Vitamin D Receptor Active vitamin D binds to VDR ...
... VDR = Vitamin D Receptor Active vitamin D binds to VDR ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.