![Oxidative stress as an initiator of cytokine release and cell... J.D. Crapo Airway redox balance in health and disease](http://s1.studyres.com/store/data/008916271_1-be959d1edc78ef4919a608ac2010cc19-300x300.png)
Oxidative stress as an initiator of cytokine release and cell... J.D. Crapo Airway redox balance in health and disease
... The challenge to the lung is to process the vast majority of inhaled antigens without inappropriate and potentially damaging inflammatory amplification. Many components of the immune system involving the lung have long been known to have a blunted or subdued response in comparison with the systemic ...
... The challenge to the lung is to process the vast majority of inhaled antigens without inappropriate and potentially damaging inflammatory amplification. Many components of the immune system involving the lung have long been known to have a blunted or subdued response in comparison with the systemic ...
Literature Review on Biological Effects of Gyejibokryeong
... by clearing the endometrial products following menstrual shedding, so decreased NK cell activity and the resulting impaired clearance of endometrium can contribute the development of Interleukin-8 (IL-8), a endometriosis34-36). pro-inflammatory chemokine, initiates many different signalling pathways ...
... by clearing the endometrial products following menstrual shedding, so decreased NK cell activity and the resulting impaired clearance of endometrium can contribute the development of Interleukin-8 (IL-8), a endometriosis34-36). pro-inflammatory chemokine, initiates many different signalling pathways ...
A7 - Ummafrapp
... Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of ...
... Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of ...
Diefenbach, A., and D.H. Raulet. 2003. Innate immune recognition by stimulatory immunoreceptors. Curr Opin Immunol 15:37-44.
... [30,37]. Interestingly, rejection of NKG2D ligandexpressing RMA or RMA-S tumor cells required functional perforin but not IFN-g, suggesting that pore-forming cytotoxic granules, but not IFN-g from NK cells and CD8 T cells, are the main effector mechanism for tumor rejection [37]. Strikingly, mi ...
... [30,37]. Interestingly, rejection of NKG2D ligandexpressing RMA or RMA-S tumor cells required functional perforin but not IFN-g, suggesting that pore-forming cytotoxic granules, but not IFN-g from NK cells and CD8 T cells, are the main effector mechanism for tumor rejection [37]. Strikingly, mi ...
Lymphoid neogenesis in vascular chronic inflammation - HAL
... systemic response and that TLO formation recapitulate organogenesis of SLOs (13). While these data demonstrate that chronic rejection is associated with the development of lymphoid nodular infiltrates within rejected organs, evidence for the involvement of these lymphoid structures in the rejection ...
... systemic response and that TLO formation recapitulate organogenesis of SLOs (13). While these data demonstrate that chronic rejection is associated with the development of lymphoid nodular infiltrates within rejected organs, evidence for the involvement of these lymphoid structures in the rejection ...
Towards a conceptual framework for innate immunity
... cell activation [10]. Most normal tissue cells constitutively express MHC class I molecules, which present intracellular host-derived peptides on the cell surface. Presentation of virus-derived peptides leads to activation of CTL (cytotoxic T lymphocyte) cells and apoptosis in the infected cell thro ...
... cell activation [10]. Most normal tissue cells constitutively express MHC class I molecules, which present intracellular host-derived peptides on the cell surface. Presentation of virus-derived peptides leads to activation of CTL (cytotoxic T lymphocyte) cells and apoptosis in the infected cell thro ...
20 Chapter
... environment to another organism is called an infectious disease. • Infectious diseases are spread by direct contact with the infected organism, through water and air, on food, by contact with contaminated objects, and by disease-carrying organisms called biological vectors. ...
... environment to another organism is called an infectious disease. • Infectious diseases are spread by direct contact with the infected organism, through water and air, on food, by contact with contaminated objects, and by disease-carrying organisms called biological vectors. ...
Slide 1
... environment to another organism is called an infectious disease. • Infectious diseases are spread by direct contact with the infected organism, through water and air, on food, by contact with contaminated objects, and by disease-carrying organisms called biological vectors. ...
... environment to another organism is called an infectious disease. • Infectious diseases are spread by direct contact with the infected organism, through water and air, on food, by contact with contaminated objects, and by disease-carrying organisms called biological vectors. ...
Commentary The Functional Role of CD8 + T Helper Type 2 Cells
... clones from HIV seronegative individuals with or without Job's syndrome or seropositive individuals not afflicted with the Job's type illness were not examined for evidence of reduced cytolytic activity. In a similar study in this issue of TheJournal of Expetimental Medicine, Paganeni et al. (14) st ...
... clones from HIV seronegative individuals with or without Job's syndrome or seropositive individuals not afflicted with the Job's type illness were not examined for evidence of reduced cytolytic activity. In a similar study in this issue of TheJournal of Expetimental Medicine, Paganeni et al. (14) st ...
Chapter 1 – Introduction to the Immune Response
... infection—particular host macromolecules are released into the extracellular milieu or become accessible on the surface of damaged cells or in cellular debris. These molecules are called damage-associated molecular patterns (DAMPs). When a pathogen attacks, it furnishes common molecular structures o ...
... infection—particular host macromolecules are released into the extracellular milieu or become accessible on the surface of damaged cells or in cellular debris. These molecules are called damage-associated molecular patterns (DAMPs). When a pathogen attacks, it furnishes common molecular structures o ...
The Immune System
... Disease D. Memory Cells: cells that are made during an immune response but are kept in storage for a future attack by the same QuickTime™ and a decompressor antigen - these cells are needed to see this picture. contain the “recipe” for making a specific type of antibody ...
... Disease D. Memory Cells: cells that are made during an immune response but are kept in storage for a future attack by the same QuickTime™ and a decompressor antigen - these cells are needed to see this picture. contain the “recipe” for making a specific type of antibody ...
Prevalence of Spotted Fever Rickettsial Antibodies in Dogs and
... Ebetsu 069-8501, Hokkaido, Japan (Received June 30, 2000. Accepted September 7, 2000) ...
... Ebetsu 069-8501, Hokkaido, Japan (Received June 30, 2000. Accepted September 7, 2000) ...
Lupus Erythematosis - University of California, Irvine
... FcγR Iib: Suspected Plasmodium resistance › Ethnicity More prevalent in non-caucasians › Sex More than 90% are female ...
... FcγR Iib: Suspected Plasmodium resistance › Ethnicity More prevalent in non-caucasians › Sex More than 90% are female ...
IMMUNE RESPONSES AGAINST MYCOBACTERIUM
... 1.1 Global and regional facts of tuberculosis ................................................................. 5 II Pathogenesis and immunity of tuberculosis, Chapter 2 ................................................. 8 2.1 Early lines of defense ................................................... ...
... 1.1 Global and regional facts of tuberculosis ................................................................. 5 II Pathogenesis and immunity of tuberculosis, Chapter 2 ................................................. 8 2.1 Early lines of defense ................................................... ...
Syndecan-2 as an emerging target for migration
... Since ABH blood group antigen was found on the surface of red blood cells in 1900, many tissues of human body have been demonstrated to express ABH blood group antigen and their precursors, including skin. In vivo, human skin tissue expresses ABH antigens only in fully differentiated epidermal kerat ...
... Since ABH blood group antigen was found on the surface of red blood cells in 1900, many tissues of human body have been demonstrated to express ABH blood group antigen and their precursors, including skin. In vivo, human skin tissue expresses ABH antigens only in fully differentiated epidermal kerat ...
Evidence for Anti-Inflammatory Effects of Exercise in CKD
... CKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert a ...
... CKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert a ...
Th9 Cells: A Novel CD4 T-cell Subset in the Immune War against
... Purwar and colleagues (13) who inadvertently discovered their role. They observed that RORgt-deficient mice showed reduced tumor growth and presented a high number of IL9-producing CD4 T cells, suggesting that IL9 could play a role in the protective antitumor immunity observed in RORgt-deficient mice. ...
... Purwar and colleagues (13) who inadvertently discovered their role. They observed that RORgt-deficient mice showed reduced tumor growth and presented a high number of IL9-producing CD4 T cells, suggesting that IL9 could play a role in the protective antitumor immunity observed in RORgt-deficient mice. ...
8_tissues and organs h
... - MALT (Mucosal Associated Lymphoid Tissue) GALT (Gut Associated Lymphoid Tissue) BALT (Bronchus Associated Lymphoid Tissue) SALT (Skin Associated Lymphoid Tissue) NALT (Nasal Associated Lymphoid Tissue) ...
... - MALT (Mucosal Associated Lymphoid Tissue) GALT (Gut Associated Lymphoid Tissue) BALT (Bronchus Associated Lymphoid Tissue) SALT (Skin Associated Lymphoid Tissue) NALT (Nasal Associated Lymphoid Tissue) ...
Time course of cigarette smoke-induced pulmonary inflammation in mice
... progressively accumulated both in the airways and lung parenchyma of mice. Furthermore, a clear infiltration of DCs was observed in airways (10-fold increase) and lung parenchyma (1.5-fold increase) of cigarette-exposed mice at 24 weeks. Flow cytometric analysis of bronchoalveolar lavage (BAL) DCs o ...
... progressively accumulated both in the airways and lung parenchyma of mice. Furthermore, a clear infiltration of DCs was observed in airways (10-fold increase) and lung parenchyma (1.5-fold increase) of cigarette-exposed mice at 24 weeks. Flow cytometric analysis of bronchoalveolar lavage (BAL) DCs o ...
Improved Clonal Selection Algorithm (ICLONALG)
... 6) Recognition: of foreigners: the (harmful) molecules that are not native to the body are recognized and eliminated by the immune system. ...
... 6) Recognition: of foreigners: the (harmful) molecules that are not native to the body are recognized and eliminated by the immune system. ...
Bibliographic Vision on Plant Immunity Primary Immune System
... Plants protection occurs through a congenital (innate) system, similar to those described above, specifying that beside the MAMP surface sensors also exist a series of immune receptors in the form of HB -LRR proteins that give an immune response. It follows that after a fight in the surface area, th ...
... Plants protection occurs through a congenital (innate) system, similar to those described above, specifying that beside the MAMP surface sensors also exist a series of immune receptors in the form of HB -LRR proteins that give an immune response. It follows that after a fight in the surface area, th ...
Immunology of Stem Cells and Cancer Stem Cells
... mouse group (33), the ESCs are not stealthy in the heart. In contrast to these findings, recent studies suggest some immune privilege is associated with human ESC-derived tissues (34-36). However, the adaptability of the immune system makes it unlikely that fully differentiated tissues will maintain ...
... mouse group (33), the ESCs are not stealthy in the heart. In contrast to these findings, recent studies suggest some immune privilege is associated with human ESC-derived tissues (34-36). However, the adaptability of the immune system makes it unlikely that fully differentiated tissues will maintain ...
Vitamin D status modulates the immune response to Epstein Barr virus
... cells irrespective of their antigen specificity, and some of these T cells might by chance be autoreactive [13]. (iii) EBV infected B cells may serve as highly efficient antigen presenting cells [14]. (iv) EBV infected B cells express the myelin protein aB-crystalline, and may activate encephalitoge ...
... cells irrespective of their antigen specificity, and some of these T cells might by chance be autoreactive [13]. (iii) EBV infected B cells may serve as highly efficient antigen presenting cells [14]. (iv) EBV infected B cells express the myelin protein aB-crystalline, and may activate encephalitoge ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.