New advances in the pathogenesis and treatment of ITP 2014 ASH
... B cell depleting therapy and CD8 Tregs • Results – B cell depletion upregulates CD8+CD25highFoxp3+ T cells and CD8+CD11c+ DC cells. – B cell depletion downregulates CD8+ T cell proliferation. – B cell depletion prevents cell-mediated ITP. ...
... B cell depleting therapy and CD8 Tregs • Results – B cell depletion upregulates CD8+CD25highFoxp3+ T cells and CD8+CD11c+ DC cells. – B cell depletion downregulates CD8+ T cell proliferation. – B cell depletion prevents cell-mediated ITP. ...
The Complement system
... • The complement works as a cascade system. – Cascade is when one reaction triggers another reaction which trigger others and so on. These types of systems can grow exponentially very fast. ...
... • The complement works as a cascade system. – Cascade is when one reaction triggers another reaction which trigger others and so on. These types of systems can grow exponentially very fast. ...
A role for antigen in the maintenance of immunological memory
... deleted in a process that has been termed ‘attrition’11, and represents homeostatic deletion (FIG. 2a). Which memory cells are deleted and why is, at present, unclear. However, maintaining the cells that have been activated by antigen in the recent past would ensure responsiveness to antigens that h ...
... deleted in a process that has been termed ‘attrition’11, and represents homeostatic deletion (FIG. 2a). Which memory cells are deleted and why is, at present, unclear. However, maintaining the cells that have been activated by antigen in the recent past would ensure responsiveness to antigens that h ...
Immunology. A Comprehensive Review Brochure
... Immunology: A Comprehensive Review will help readers grasp this difficult and important subject. ...
... Immunology: A Comprehensive Review will help readers grasp this difficult and important subject. ...
AP Biology Outline for Human Systems
... Many physiological changes occur during exercise. (a) Design a controlled experiment to test the hypothesis that an exercise session causes short-term increases in heart rate and breathing rate in humans. (b) Explain how at least three organ systems are affected by this increased physical activity a ...
... Many physiological changes occur during exercise. (a) Design a controlled experiment to test the hypothesis that an exercise session causes short-term increases in heart rate and breathing rate in humans. (b) Explain how at least three organ systems are affected by this increased physical activity a ...
Prognostic Significance of Absolute Lymphocyte Count and
... (Schulenburg et al., 2005). Faster recovery of IgM levels was observed after non-myeloablative transplantation and a delayed recovery of IgA levels was observed in both groups. In patients receiving rituximab 1–12 months before allogeneic stem cell transplantation B-cell counts and immunoglobulin le ...
... (Schulenburg et al., 2005). Faster recovery of IgM levels was observed after non-myeloablative transplantation and a delayed recovery of IgA levels was observed in both groups. In patients receiving rituximab 1–12 months before allogeneic stem cell transplantation B-cell counts and immunoglobulin le ...
The Global Leader in Liver Cell Therapies
... The Global Leader in Liver Cell Therapies Breakthrough immunomodulation & anti-fibrotic treatments for devastating immune-mediated liver diseases Short Briefing January 2017 John Tchelingerian, PhD CEO ...
... The Global Leader in Liver Cell Therapies Breakthrough immunomodulation & anti-fibrotic treatments for devastating immune-mediated liver diseases Short Briefing January 2017 John Tchelingerian, PhD CEO ...
HIV/AIDS: The Status of the Epidemic Today
... •Phagocytes active in the innate immune system display some of the proteins from the pathogen on their surfaces, “advertising” that the pathogen is present. ...
... •Phagocytes active in the innate immune system display some of the proteins from the pathogen on their surfaces, “advertising” that the pathogen is present. ...
CD8 Positive T Cells Influence Antigen
... 11, 13). Human SDF-1a, MIP-1a, MCP-1, and RANTES have been reported to be active in mouse cells (14). The mouse homologue of human IL-8 has not been found; however, human IL-8 has been reported to have activity on mouse cells as a subset of the receptors for IL-8 is expressed on mouse cells (14). Th ...
... 11, 13). Human SDF-1a, MIP-1a, MCP-1, and RANTES have been reported to be active in mouse cells (14). The mouse homologue of human IL-8 has not been found; however, human IL-8 has been reported to have activity on mouse cells as a subset of the receptors for IL-8 is expressed on mouse cells (14). Th ...
The immune system as the sixth sense
... operating? Two observations seem to have set the stage for solving the mystery. First, it was established that peripheral immune responses could alter the firing rate of neurones in the CNS [58]. Thus, information can flow not only from the CNS to the immune system but also in the opposite direction ...
... operating? Two observations seem to have set the stage for solving the mystery. First, it was established that peripheral immune responses could alter the firing rate of neurones in the CNS [58]. Thus, information can flow not only from the CNS to the immune system but also in the opposite direction ...
Modulation of the Immune System: Treatment Options
... previously been intolerant of systemic therapy The mode of action of DMF is not fully understood Problem: tolerability, GI irritation and flush, skin irritation Problem: Papilloma / carcinoma in forestomach rats Biogen Idec has developed a novel micro-tablet formulation (immediate release) and teste ...
... previously been intolerant of systemic therapy The mode of action of DMF is not fully understood Problem: tolerability, GI irritation and flush, skin irritation Problem: Papilloma / carcinoma in forestomach rats Biogen Idec has developed a novel micro-tablet formulation (immediate release) and teste ...
Oncomedicine Immunological Role of Vitamin D in Skin Diseases
... stimulated immunoglobulin production in B cells of active lupus patients. [13] A subpopulation of T lymphocytes, regulatory T cells (Foxp3+ Tregs) maintain immune tolerance and safeguard against autoimmune reactions by removing self-reactive T cells. Tregs may be naturally produced or induced by che ...
... stimulated immunoglobulin production in B cells of active lupus patients. [13] A subpopulation of T lymphocytes, regulatory T cells (Foxp3+ Tregs) maintain immune tolerance and safeguard against autoimmune reactions by removing self-reactive T cells. Tregs may be naturally produced or induced by che ...
Defense against the dark arts
... T cells (80% of circulating lymphocytes) » Cell-mediated immunity B cells (10%–15% of circulating lymphocytes) » Antibody-mediated immunity NK cells (5%–10% of circulating lymphocytes) » Immunological surveillance ...
... T cells (80% of circulating lymphocytes) » Cell-mediated immunity B cells (10%–15% of circulating lymphocytes) » Antibody-mediated immunity NK cells (5%–10% of circulating lymphocytes) » Immunological surveillance ...
Lesson Overview - Southgate Schools
... HIV destroys T cells, crippling the ability of the immune system to fight HIV and other pathogens. Monitoring progression of HIV by counting helper T cells. The fewer helper T cells, the more susceptible to other diseases. When an HIV-infected person’s T cell count reaches about 1/6 the normal level ...
... HIV destroys T cells, crippling the ability of the immune system to fight HIV and other pathogens. Monitoring progression of HIV by counting helper T cells. The fewer helper T cells, the more susceptible to other diseases. When an HIV-infected person’s T cell count reaches about 1/6 the normal level ...
Autoimmune Diseases
... -circulating Ab’s to the GABA-synthesizing enzyme glutamic acid decarboxylase in 60% -patient sera can inhibit enzyme activity in vitro ...
... -circulating Ab’s to the GABA-synthesizing enzyme glutamic acid decarboxylase in 60% -patient sera can inhibit enzyme activity in vitro ...
division of immunology and serology
... prescribed format. The results were sent to QASI. QASI analyzed the result in context with the results obtained from all participating laboratories and the reports were sent back to NARI. The reports were analyzed for the performance of each center and distributed to individual centers. The findings ...
... prescribed format. The results were sent to QASI. QASI analyzed the result in context with the results obtained from all participating laboratories and the reports were sent back to NARI. The reports were analyzed for the performance of each center and distributed to individual centers. The findings ...
Transplantation Immunology
... the antibodies and T cells that react against these antigens are said to be alloreactive and xenoreactive, respectively. allorecognition direct indirect ...
... the antibodies and T cells that react against these antigens are said to be alloreactive and xenoreactive, respectively. allorecognition direct indirect ...
keyhole limpet haemocyanin, KLH
... peptide. Presence of anti-KLH antibodies in serum may cause non-specific background in immunohistochemical staining of tissues from some plant species. Passing serum through HiTrap™ NHS-activated column or a column with CNBr-activated Sepharose™ 4B coupled with KLH, will efficiently remove anti-KLH ...
... peptide. Presence of anti-KLH antibodies in serum may cause non-specific background in immunohistochemical staining of tissues from some plant species. Passing serum through HiTrap™ NHS-activated column or a column with CNBr-activated Sepharose™ 4B coupled with KLH, will efficiently remove anti-KLH ...
Briefformular INSTITUT Word
... developed during the past few years based on experimental and clinical data (1). In principle, this hypothesis states that the earliest stages of atherosclerosis are due to an attack of the innate and adaptive immune system on arterial endothelial cells (ECs) that simultaneously express the stress p ...
... developed during the past few years based on experimental and clinical data (1). In principle, this hypothesis states that the earliest stages of atherosclerosis are due to an attack of the innate and adaptive immune system on arterial endothelial cells (ECs) that simultaneously express the stress p ...
Stomach, Glandular Stomach – Infiltration, Cellular
... Focal collections of mast cells can occasionally be found in the submucosa of the stomach. Mast cells have been shown to contribute importantly to acute allergic reactions, late-phase reactions, and chronic allergic inflammation. Focal accumulations of mast cells in the submucosa of the gastrointest ...
... Focal collections of mast cells can occasionally be found in the submucosa of the stomach. Mast cells have been shown to contribute importantly to acute allergic reactions, late-phase reactions, and chronic allergic inflammation. Focal accumulations of mast cells in the submucosa of the gastrointest ...
Oxidative stress as an initiator of cytokine release and cell... J.D. Crapo Airway redox balance in health and disease
... The challenge to the lung is to process the vast majority of inhaled antigens without inappropriate and potentially damaging inflammatory amplification. Many components of the immune system involving the lung have long been known to have a blunted or subdued response in comparison with the systemic ...
... The challenge to the lung is to process the vast majority of inhaled antigens without inappropriate and potentially damaging inflammatory amplification. Many components of the immune system involving the lung have long been known to have a blunted or subdued response in comparison with the systemic ...
Overview of the Immune System
... immunized to bacteria could transfer the immune state to unimmunized animals g-globulin (gG) immunoglobulin (Ig) antibody (Ab, 相對於 antigen [Ag]) Because immunity was mediated by antibodies contained in body fluid (known as humors), it was called humoral immunity. ...
... immunized to bacteria could transfer the immune state to unimmunized animals g-globulin (gG) immunoglobulin (Ig) antibody (Ab, 相對於 antigen [Ag]) Because immunity was mediated by antibodies contained in body fluid (known as humors), it was called humoral immunity. ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.