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the first chapter - OncologyPRO
the first chapter - OncologyPRO

... not require the presentation of an antigen, and does not lead to immunological memory. Its effector cells are neutrophils, macrophages, and mast cells, reacting within minutes to hours with the help of complement activation and cytokines (CK). ...
White Blood Cells
White Blood Cells

...  Acquired = (developed by exposure to specific invading agents). - humoral ----> circulating antibodies - cellular ----> activated cells ...
The Immune System - Mrs.C's Web Page
The Immune System - Mrs.C's Web Page

... It is centered around lymphocytes which are split into T Cells and B Cells, which act as memory cells that record and store information about various pathogens This is known as immunological memory, which results in an enhanced defense against a ...
Chapter 20- Lymphatic system
Chapter 20- Lymphatic system

... • II. The Immune system- This is a very complex system with multiple layers and forms of defense. In this section we focus on the organs closely associated with cellular response of the immune system. The immune system identifies and attacks specific pathogens. • A. Lymphocytes and other cells of t ...
The Immune System Second Edition
The Immune System Second Edition

... T-cell-mediated autoimmune diseases. Resulting from T cells specific for self antigens- (like type IV hypersensitivity reactions) Multiple sclerosis. Autoimmune response against the myelin sheath of nerve cells. Involves demyelination of central nervous system tissue resulting in sclerotic plaques ...
Microbiology bio 123
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... 2. There are no “all-purpose” antibodies – they can only do one specific thing. 3. All have the same basic structure created from proteins: a. Two heavy chains and two light chains 1. Two heavy chains are forming a Y, with the light chains parallel to the top part of the Y b. All immunoglobulins of ...
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Communicable Diseases

... bacteria is usually centered in the nose/throat which makes it easy to spread Diagnosis is a cotton swab that takes a sample of the fluids at the back of the throat Treatment is a prescription medication that must be taken for at least 10 days after 24 hours the fever will break and you will not be ...
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Molecularly defined vaccines and clinical immunotherapies

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...  Positive selection: recognize MHC survive  Negative selection: react against to self-antigens on MHC killed  2% of initial T-cell precursors  T-cells manage the immune response B-cells: are sorted in the marrow by an incompletely understood process ...
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THE IMMUNE SYSTEM
THE IMMUNE SYSTEM

... Artificial passive immunity Used when a very rapid immune response is needed e.g. after infection with tetanus. Human antibodies are injected. In the case of tetanus these are antitoxin antibodies. Antibodies come from blood donors who have recently had the tetanus vaccination. Only provides short t ...
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... infection, these parasites stay extracellular, exposing them to immune attacks by antibodies and microbicidal compounds released by myeloid cells. However, African trypanosomes have developed mechanisms to escape the immune system, causing chronic infection. Moreover, the immune response elicited to ...
NAME___________________________________TA__________
NAME___________________________________TA__________

... VDJ recombination among multiple regions, terminal transferase creates insertion mutations, unusually high mutation rate at the immunoglobulin loci, and imprecise recombination d) How does the immune system increase receptor avidity after T- and B- cell development? Somatic hypermutation ...
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... that recognize and bind to a particular antigen with very high specificity.  Made in response to exposure to the antigen.  One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind.  Each antibody has at least two identical sites that bind antigen  ...
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... functions related to immune defense 4. Immune clearance. Removes immune complexes from the circulation and deposits them in the liver where they are degraded. C3b facilitates immune complex binding to CR1 on RBCs. In the liver and spleen the complexes are stripped from the RBC and phagocytosed. Comp ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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