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The immune system - Los Angeles Mission College
The immune system - Los Angeles Mission College

... Collecting ducts: formed by the convergence of larger lymphatic vessels called lymphatic trunks. Two collecting ducts drain all lymph fluid back to the blood – thoracic duct returns lymph form the body to the left subclavian vein, and right lymphatic duct returns lymph from the upper body to the rig ...
TBL Module: Blood and Lymphoid Tissue
TBL Module: Blood and Lymphoid Tissue

... importance of erythrocyte cell-surface antigens, and how different kinds of anemia affect erythrocyte size and shape. • Describe the microscopic appearance of the different white blood cells, their relative proportions, how they function, and the unique cellular features that characterize each type, ...
T CELLS - TeacherWeb
T CELLS - TeacherWeb

... *(antibodies react against the antigen that stimulated their production!)…more on this later 4) some activated B cells differentiate into MEMORY B CELLS (respond to subsequent exposures) ...
Cytotoxic Hypersensitivity
Cytotoxic Hypersensitivity

... Clinically, the most important form of DTH, since it causes many of the pathological effects in diseases which involve T cell-mediated immunity Maximal at 14 days Continual release of cytokines Leads to accumulation of large numbers of macrophages Granulomas can also arise from persistence of “indig ...
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cause

... Clinically, the most important form of DTH, since it causes many of the pathological effects in diseases which involve T cell-mediated immunity Maximal at 14 days Continual release of cytokines Leads to accumulation of large numbers of macrophages Granulomas can also arise from persistence of “indig ...
innate immunity
innate immunity

10_12_immuno~2
10_12_immuno~2

... European history) is by Thucydides (460-404 BC, Athens), who described the great pestilence of 430-429 BC in Athens, during the second year of the Peloponnesian War, an outbreak that killed more than 30,000 people (out of a population of 172,000) – Thucydides noted that those who had recovered would ...
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Viruses

... Cytotoxic T Cells – Cells that make poison granules to kill the virus/pathogen Natural Killer Cells - Cells that kill any infected or out of control (cancer) cells ...
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Invariant NKT cells

... multi-functional responses have been shown to enhance microbial and tumour immunity as well as suppressing autoimmune disease and promoting tolerance. However, iNKTs have also been shown to exacerbate certain other diseases such as allergy. There are many ongoing clinical studies that hope to exploi ...
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... multi-functional responses have been shown to enhance microbial and tumour immunity as well as suppressing autoimmune disease and promoting tolerance. However, iNKTs have also been shown to exacerbate certain other diseases such as allergy. There are many ongoing clinical studies that hope to exploi ...
Chapter 5 Gases - LCMR School District
Chapter 5 Gases - LCMR School District

... • Effector B cells that form during an antibody-mediated immune response make and secrete antibodies that recognize and bind antigen-bearing particles in blood or tissue fluids. Antibody binding can neutralize a pathogen or toxin and facilitate its elimination from the body. ...
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... can prevent future disease. The United States is committed to immunizing all children against the common types of childhood disease Immunization involves the use of vaccines, substances that contain an ...
Unit 4 - Immunology and Public Health
Unit 4 - Immunology and Public Health

< 1 ... 324 325 326 327 328 329 330 331 332 ... 422 >

Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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