- Iranian Journal of Immunology
... allogeneic transplantations. Recently, mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities (1-6). These multi-potent stem cells have self-renewal ability and are capable of migrating and engrafting at the sites of in ...
... allogeneic transplantations. Recently, mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities (1-6). These multi-potent stem cells have self-renewal ability and are capable of migrating and engrafting at the sites of in ...
ASTRAGALUS AND IMMUNITY
... and the overproduction of white blood cells. Astragalus did not increase an abnormal immune response, but instead reduced the autoimmune response just as effectively as prednisone. Perhaps the most important safety finding was that in the prednisone group five patients experienced temporary liver da ...
... and the overproduction of white blood cells. Astragalus did not increase an abnormal immune response, but instead reduced the autoimmune response just as effectively as prednisone. Perhaps the most important safety finding was that in the prednisone group five patients experienced temporary liver da ...
6- review article Tolou.indd
... liver transplantation helped to increase graft and patient survival by treating acute and chronic rejection more effectively. One year survival for liver transplantation in Europe rose progressively from 47% in 1968-1988 to 67 % in 1988-1996. A further advance was the improvement of liver preservati ...
... liver transplantation helped to increase graft and patient survival by treating acute and chronic rejection more effectively. One year survival for liver transplantation in Europe rose progressively from 47% in 1968-1988 to 67 % in 1988-1996. A further advance was the improvement of liver preservati ...
The interleukin-23 axis in intestinal inflammation
... of the gastrointestinal (GI) tract affecting 0.2% of the population. The etiology of IBD is unknown, but results from clinical and experimental studies indicate a breakdown in intestinal homeostasis with the development of aberrant inflammatory responses to intestinal bacteria (1). IBD is a complex ...
... of the gastrointestinal (GI) tract affecting 0.2% of the population. The etiology of IBD is unknown, but results from clinical and experimental studies indicate a breakdown in intestinal homeostasis with the development of aberrant inflammatory responses to intestinal bacteria (1). IBD is a complex ...
Reprogramming of Myeloid Compartments Supporting Tissue
... compartments and the emergence of MDSC during active and resolution phases of inflammation. We show that the immature myeloid compartment expands in bone marrow (BM) specifically at the resolution phase of inflammation during colitis transition to recovery. Additionally, we found enhanced levels of ...
... compartments and the emergence of MDSC during active and resolution phases of inflammation. We show that the immature myeloid compartment expands in bone marrow (BM) specifically at the resolution phase of inflammation during colitis transition to recovery. Additionally, we found enhanced levels of ...
Fontana & Vance (2011) Imm Rev
... ! 2011 John Wiley & Sons A/S • Immunological Reviews 243/2011 ...
... ! 2011 John Wiley & Sons A/S • Immunological Reviews 243/2011 ...
A crucial role for B cells in neuroinvasive scrapie
... After intracerebral (i.c.) challenge with scrapie prions, all immune-deficient mice developed clinical symptoms of scrapie. This was confirmed by histopathological analysis (not shown) and by transmission of disease to indicator tga20 mice, which overexpress the normal prion protein (PrPC) and are h ...
... After intracerebral (i.c.) challenge with scrapie prions, all immune-deficient mice developed clinical symptoms of scrapie. This was confirmed by histopathological analysis (not shown) and by transmission of disease to indicator tga20 mice, which overexpress the normal prion protein (PrPC) and are h ...
CD161 defines the subset of FoxP3+ T cells capable of producing
... In this paper, we have identified the lectin-like receptor, CD161, as the marker of FoxP31 Treg in humans that harbor proinflammatory potential. CD161 expression has previously been linked to Th17 cells,17 but we believe this to be the first report that definitively links CD161 expression to the populat ...
... In this paper, we have identified the lectin-like receptor, CD161, as the marker of FoxP31 Treg in humans that harbor proinflammatory potential. CD161 expression has previously been linked to Th17 cells,17 but we believe this to be the first report that definitively links CD161 expression to the populat ...
Department of Biochemistry and Molecular Biology Honours/Masters
... Mental illness is a large and increasing health and economic burden in Australia and worldwide and more research is urgently required to identify new and innovative therapies. In this regard, neuropeptide GPCRs may be better therapeutic targets than receptors for the ‘primary’ transmitters (amino ac ...
... Mental illness is a large and increasing health and economic burden in Australia and worldwide and more research is urgently required to identify new and innovative therapies. In this regard, neuropeptide GPCRs may be better therapeutic targets than receptors for the ‘primary’ transmitters (amino ac ...
Powerpoint
... Not passing virus onto others Not getting HIV a second time Being considered as a person not infected with HIV ...
... Not passing virus onto others Not getting HIV a second time Being considered as a person not infected with HIV ...
LIPOPOLYSACCHARIDE-MEDIATED REGULATION OF IL-17 RECEPTOR LEVELS IN HUMAN MONOCYTES
... It is now known that when a naïve T cell (T0) first engages an antigen offered by an antigen presenting cell via the T-cell receptor (TCR), it can differentiate either to Th1 or Th2 depending on the cytokine milieu. Interleukin (IL)-12 induces transcription factor Tbet for differentiation to Th1 cel ...
... It is now known that when a naïve T cell (T0) first engages an antigen offered by an antigen presenting cell via the T-cell receptor (TCR), it can differentiate either to Th1 or Th2 depending on the cytokine milieu. Interleukin (IL)-12 induces transcription factor Tbet for differentiation to Th1 cel ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... specific on them. However, the mechanism that induces IL-10 in rheumatoid arthritis synovial is slow unraveled. Lipopolysaccharide (LPS) in vitro is a potent inducer of the secretion of IL-10 by monocytes well, so, the studies prove that IL-1 endogenous tumor necrosis factor (TNF) or downstream of L ...
... specific on them. However, the mechanism that induces IL-10 in rheumatoid arthritis synovial is slow unraveled. Lipopolysaccharide (LPS) in vitro is a potent inducer of the secretion of IL-10 by monocytes well, so, the studies prove that IL-1 endogenous tumor necrosis factor (TNF) or downstream of L ...
Inflammation and Cellular Immune Responses in Abdominal Aortic
... Reactive oxygen species may also contribute to the pathogenesis of AAA. In humans, levels of superoxide anion (O2⫺) significantly increased in AAA lesions compared with tissue from adjacent nonaneurysm or normal control aortas.82 In animal models, reactive oxygen species initiate Th2 type autoimmune ...
... Reactive oxygen species may also contribute to the pathogenesis of AAA. In humans, levels of superoxide anion (O2⫺) significantly increased in AAA lesions compared with tissue from adjacent nonaneurysm or normal control aortas.82 In animal models, reactive oxygen species initiate Th2 type autoimmune ...
Drosophila as a model for the two myeloid blood cell systems in
... Figure 1. Ontogeny of blood cell lineages and regulation of hematopoiesis in Drosophila. (A) Self-renewing tissue hemocytes, which emerge and expand during Drosophila embryonic and larval hematopoiesis. Drosophila tissue hemocytes originate as prohemocyte progenitors (blue) in the head mesoderm at a ...
... Figure 1. Ontogeny of blood cell lineages and regulation of hematopoiesis in Drosophila. (A) Self-renewing tissue hemocytes, which emerge and expand during Drosophila embryonic and larval hematopoiesis. Drosophila tissue hemocytes originate as prohemocyte progenitors (blue) in the head mesoderm at a ...
Neuropathy in a mouse model of CD8+ T cell
... therefore could be expressed by any cell type, histological staining of multiple organs demonstrated that the cellular infiltration in L31 mice is specific to neurological tissue and no tissue destruction of other organs was observed [25]. It has also been shown that I-Aβ -/-, mice in which CD4+ T c ...
... therefore could be expressed by any cell type, histological staining of multiple organs demonstrated that the cellular infiltration in L31 mice is specific to neurological tissue and no tissue destruction of other organs was observed [25]. It has also been shown that I-Aβ -/-, mice in which CD4+ T c ...
Connective Tissue - Nutley Public Schools
... Figure 4.12. Tissue repair of a nonextensive skin wound: regeneration and fibrosis. ...
... Figure 4.12. Tissue repair of a nonextensive skin wound: regeneration and fibrosis. ...
Is Fever Beneficial to the Host: A Clinical Perspective
... antiviral properties of interferon at febrile temperatures. At 390C, interferon completely blocked the generation of suppressor cells in vitro and, in vivo, augmented both delayed-type hypersensitivity and antibody responses [16]. Additionally, fibroblasts treated with interferon at febrile temperat ...
... antiviral properties of interferon at febrile temperatures. At 390C, interferon completely blocked the generation of suppressor cells in vitro and, in vivo, augmented both delayed-type hypersensitivity and antibody responses [16]. Additionally, fibroblasts treated with interferon at febrile temperat ...
Complex Correlates of Protection After Vaccination
... An even greater surprise came from a trial of a canarypox-HIV envelope vector prime followed by an envelope gp 120 protein boost that showed 31% efficacy against infection [101]. Protection correlated with the induction of nonneutralizing antibody directed against the V2 loop of the envelope [102]. A ...
... An even greater surprise came from a trial of a canarypox-HIV envelope vector prime followed by an envelope gp 120 protein boost that showed 31% efficacy against infection [101]. Protection correlated with the induction of nonneutralizing antibody directed against the V2 loop of the envelope [102]. A ...
Immune Response by Chikungunya Virus Triggers an Innate Active
... Detection of CHIKV Ag in HEK 293T cells, monocytes, and CHIKVinfected patients’ PBMCs were carried out in a two-step indirect intracellular staining process. An additional surface staining step was performed on patients’ PBMCs to discriminate between the different cell types present in PBMCs. Abs we ...
... Detection of CHIKV Ag in HEK 293T cells, monocytes, and CHIKVinfected patients’ PBMCs were carried out in a two-step indirect intracellular staining process. An additional surface staining step was performed on patients’ PBMCs to discriminate between the different cell types present in PBMCs. Abs we ...
Arthritis Res. Ther. 13:R129 - Centre for Microbial Diseases and
... chemokine responses. IDR-1002 altered the IL-1b-induced proteome primarily by altering the expression of members of nuclear factor kappa-B (NF-B) and c-Jun N-terminal kinase (JNK) pathways. The proteomics data also suggested that IDR-1002 was altering the transcription factor HNF-4a-mediated respon ...
... chemokine responses. IDR-1002 altered the IL-1b-induced proteome primarily by altering the expression of members of nuclear factor kappa-B (NF-B) and c-Jun N-terminal kinase (JNK) pathways. The proteomics data also suggested that IDR-1002 was altering the transcription factor HNF-4a-mediated respon ...
Dendritic cells in progressive renal disease: some answers, many
... cells in lymphoid organs, we are not sure yet whether local DCs are required for the localization and effector function of antigen-specific CD4+ cells within glomeruli. Studies using bone marrow chimeric mice and mice with lineage-specific MHC II deficiency suggest that antigen recognition and T-cell a ...
... cells in lymphoid organs, we are not sure yet whether local DCs are required for the localization and effector function of antigen-specific CD4+ cells within glomeruli. Studies using bone marrow chimeric mice and mice with lineage-specific MHC II deficiency suggest that antigen recognition and T-cell a ...