Chapter 21 - El Camino College
... Diffusion barrier – capillaries around the ganglia have reduced permeability as in the blood-brain barrier Integrating center –signals are processed in the ENS and do not go out to the CNS for integration Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings ...
... Diffusion barrier – capillaries around the ganglia have reduced permeability as in the blood-brain barrier Integrating center –signals are processed in the ENS and do not go out to the CNS for integration Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings ...
Cross-Talk between Cancer Cells and the Tumour
... immune and stromal cells within a scaffold of extracellular matrix that a tumour depends upon for sustained growth, invasion and metastasis. Traditionally, anti-cancer drug development has focused on targeting the tumour cell cycle. However, in recent times, there has been a shift in research emphas ...
... immune and stromal cells within a scaffold of extracellular matrix that a tumour depends upon for sustained growth, invasion and metastasis. Traditionally, anti-cancer drug development has focused on targeting the tumour cell cycle. However, in recent times, there has been a shift in research emphas ...
Gaucher iPSC-Derived Macrophages Produce Elevated Levels of
... Gaucher disease (GD) is an autosomal recessive disorder caused by mutations in the acid bglucocerebrosidase (GCase; GBA) gene. The hallmark of GD is the presence of lipid-laden Gaucher macrophages, which infiltrate bone marrow and other organs. These pathological macrophages are believed to be the so ...
... Gaucher disease (GD) is an autosomal recessive disorder caused by mutations in the acid bglucocerebrosidase (GCase; GBA) gene. The hallmark of GD is the presence of lipid-laden Gaucher macrophages, which infiltrate bone marrow and other organs. These pathological macrophages are believed to be the so ...
Role of PD-1 co-inhibitory pathway in HIV Linköping University Post Print
... cells lose the ability to produce cytokines, lyse infected cells and proliferate in a progressive and hierarchical manner. In a mouse model of acute lymphocytic choriomeningitis virus (LCMV-Armstrong) infection, the virusspecific CD8+ T cells expressed lower levels of PD-1 as compared with the clone ...
... cells lose the ability to produce cytokines, lyse infected cells and proliferate in a progressive and hierarchical manner. In a mouse model of acute lymphocytic choriomeningitis virus (LCMV-Armstrong) infection, the virusspecific CD8+ T cells expressed lower levels of PD-1 as compared with the clone ...
Variable expression of immunoreactive surface proteins of
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
Sniðmát meistaraverkefnis HÍ
... lymphocyte in the draining lymph node that has a receptor that can bind to that particular antigen it activates the lymphocyte. The B and T-cells have similar receptors on their surface but they do not recognize or respond to antigens in the same manner. The B-cell receptor is a membrane bound immun ...
... lymphocyte in the draining lymph node that has a receptor that can bind to that particular antigen it activates the lymphocyte. The B and T-cells have similar receptors on their surface but they do not recognize or respond to antigens in the same manner. The B-cell receptor is a membrane bound immun ...
Investigations on immune sensing of Staphylococcus aureus in
... The aim of this work was to elucidate the role of PGN in activating the immune system and to investigate its putative role in diseases, such as atopic dermatitis, Morbus Crohn, ulcerative colitis and food allergies. Therefore, we developed a new method for isolating highly pure PGN in sufficient amo ...
... The aim of this work was to elucidate the role of PGN in activating the immune system and to investigate its putative role in diseases, such as atopic dermatitis, Morbus Crohn, ulcerative colitis and food allergies. Therefore, we developed a new method for isolating highly pure PGN in sufficient amo ...
The Regulation of HPV Late Gene Expression and the Potential
... HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by the immune system, thus acting as a prerequisite for persistence of infection. Therefore, i ...
... HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by the immune system, thus acting as a prerequisite for persistence of infection. Therefore, i ...
Disruption of Dendritic Cell Instruction Virus and Its Avirulent Vaccine
... VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essential to achieve virus control. To promote Th1 responses, DCs must provid ...
... VZV is known to infect monocyte-derived DCs (MDDCs) generated in vitro (10–12). However, no functional defect of immature MDDCs after VZV infection has been defined (10, 11). Powerful Th1-like adaptive immune responses are essential to achieve virus control. To promote Th1 responses, DCs must provid ...
Pathways Molecule-Dependent and
... inhabits JEV endemic areas, and the virus is continuing to spread to previously unaffected regions due to global warming (24 –26). It is estimated that 30,000 –50,000 cases of JEV occur each year, resulting in 10,000 –15,000 deaths, although this number may be underestimated (22, 23). Additionally, ...
... inhabits JEV endemic areas, and the virus is continuing to spread to previously unaffected regions due to global warming (24 –26). It is estimated that 30,000 –50,000 cases of JEV occur each year, resulting in 10,000 –15,000 deaths, although this number may be underestimated (22, 23). Additionally, ...
IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice
... IFNc has been implicated as one of the factors in Lipopolysaccharide (LPS) induced shock so we checked whether IFNc2/2 mice are resistant to SEB induced TSS. Mice were challenged with a lethal dose of SEB and mortality was observed. We observed that IFNc mice were susceptible to SEB induced TSS. Sin ...
... IFNc has been implicated as one of the factors in Lipopolysaccharide (LPS) induced shock so we checked whether IFNc2/2 mice are resistant to SEB induced TSS. Mice were challenged with a lethal dose of SEB and mortality was observed. We observed that IFNc mice were susceptible to SEB induced TSS. Sin ...
Full Meeting Booklet 15.10.15
... When cell death occurs in vivo, cell corpses are not left untreated, but are recognized and engulfed by phagocytes, such as macrophages and dendritic cells. Previously, we reported that CD169+ macrophages in the marginal zone of the spleen capture blood-borne apoptotic cells, and induce dead cell an ...
... When cell death occurs in vivo, cell corpses are not left untreated, but are recognized and engulfed by phagocytes, such as macrophages and dendritic cells. Previously, we reported that CD169+ macrophages in the marginal zone of the spleen capture blood-borne apoptotic cells, and induce dead cell an ...
References
... Between June 2008 and July 2012, 512 eligible HCWs and HHCs with known BCG vaccination status were identified (263 HCWs, 166 HHCs and 83 with unclassified exposure). The exposure classification was assigned through a questionnaire, but this information was not captured in the initial phase of the st ...
... Between June 2008 and July 2012, 512 eligible HCWs and HHCs with known BCG vaccination status were identified (263 HCWs, 166 HHCs and 83 with unclassified exposure). The exposure classification was assigned through a questionnaire, but this information was not captured in the initial phase of the st ...
Soluble Fas and Fas ligand provide new information on metastasis
... induced by an alteration in the expression of a single gene, the soluble Fas level may be an important marker of metastasis of SCLC. In addition to Fas, FasL also exists in soluble form released from cell surfaces after cleavage by metalloproteinases [18,19]. FasL is a type II transmembrane protein ...
... induced by an alteration in the expression of a single gene, the soluble Fas level may be an important marker of metastasis of SCLC. In addition to Fas, FasL also exists in soluble form released from cell surfaces after cleavage by metalloproteinases [18,19]. FasL is a type II transmembrane protein ...
Experimental Biology and Medicine
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
EGFR Kinase Mutations Are Not Affected by Lung Cancer
... Intracellular EGFR mutations were originally described as predictors for response to TKI treatment, but it soon became apparent that they also alter the biology of EGFR. Thus, non-small cell lung cancer (NSCLC) patients with intracellular EGFR mutations had a better prognosis irrespective of their t ...
... Intracellular EGFR mutations were originally described as predictors for response to TKI treatment, but it soon became apparent that they also alter the biology of EGFR. Thus, non-small cell lung cancer (NSCLC) patients with intracellular EGFR mutations had a better prognosis irrespective of their t ...
FVIII Immunity: Early Events and Tolerance Mechanisms to FVIII
... that in vivo, FVIII does not induce the activation and proliferation of hemophilic T cells. Furthermore, infusing FVIII-pulsed immature dendritic cells into hemophilic mice resulted in a long-term reduction in immune reactivity towards FVIII. Also, ...
... that in vivo, FVIII does not induce the activation and proliferation of hemophilic T cells. Furthermore, infusing FVIII-pulsed immature dendritic cells into hemophilic mice resulted in a long-term reduction in immune reactivity towards FVIII. Also, ...
Discoveries in Diabetes Spring 2016
... Long term, Fife aims to develop a way to identify type 1 diabetes in at-risk people, like siblings of people who have the condition, long before it starts destroying the pancreas. Subsequent cell therapy would prevent diabetes from taking root. He also wants to treat people with earlyonset and long- ...
... Long term, Fife aims to develop a way to identify type 1 diabetes in at-risk people, like siblings of people who have the condition, long before it starts destroying the pancreas. Subsequent cell therapy would prevent diabetes from taking root. He also wants to treat people with earlyonset and long- ...
how t-cells use large deviations to recognize foreign
... The above-mentioned article [15] appeared in a biological context (with lots of immunological detail not easily accessible to mathematicians) and therefore put little emphasis on mathematical detail. The aim of the present article is threefold. Firstly, we will make this fascinating piece of theoret ...
... The above-mentioned article [15] appeared in a biological context (with lots of immunological detail not easily accessible to mathematicians) and therefore put little emphasis on mathematical detail. The aim of the present article is threefold. Firstly, we will make this fascinating piece of theoret ...
BioInvent Financial Statement BioInvent issues private placement to
... Chronic lymphatic leukaemia (CLL) is an incurable lymphoma that primarily affects older men. The disease progression is often slow and patients are normally treated with cytostatic drugs, often in combination with monoclonal antibodies. In Europe and North America, around 157,000 people every year a ...
... Chronic lymphatic leukaemia (CLL) is an incurable lymphoma that primarily affects older men. The disease progression is often slow and patients are normally treated with cytostatic drugs, often in combination with monoclonal antibodies. In Europe and North America, around 157,000 people every year a ...