Document
... ment across a wide concencells specific for MBP(83–99) (triangles) and APL (circles) isolated before (left) and during (right) APL therapy. Regression tration range with both lines demonstrate phenotypic changes of T cells specific for MBP(83–99) (dotted lines) or APL (solid lines). b, Changes in cr ...
... ment across a wide concencells specific for MBP(83–99) (triangles) and APL (circles) isolated before (left) and during (right) APL therapy. Regression tration range with both lines demonstrate phenotypic changes of T cells specific for MBP(83–99) (dotted lines) or APL (solid lines). b, Changes in cr ...
Natural Killer cells in Innate Defense against Infective Pathogens
... NK cell effector functions are stimulated through direct contact with activated dendritic cells (DCs) in vivo [30]. In fact, DC/NK-cell interaction is bi-directional and complex, as it could result not only NK cell activation but also in DC maturation or apoptosis, depending on the activation status ...
... NK cell effector functions are stimulated through direct contact with activated dendritic cells (DCs) in vivo [30]. In fact, DC/NK-cell interaction is bi-directional and complex, as it could result not only NK cell activation but also in DC maturation or apoptosis, depending on the activation status ...
Lennert et al
... Anaplasia larger cell type* * Remain Altercation for adding anaplasia larger cell type HD and omiting Lymphocyte depletion type HD ...
... Anaplasia larger cell type* * Remain Altercation for adding anaplasia larger cell type HD and omiting Lymphocyte depletion type HD ...
Investigation of the humoral and cellular immune responses of
... a time-consuming process, requiring weeks to be fully developed, infections must be initially held in check by the innate immune system, which is the first line of defence against microbial pathogens. The innate immune system slows the rate of multiplication of the pathogens to allow time for the mo ...
... a time-consuming process, requiring weeks to be fully developed, infections must be initially held in check by the innate immune system, which is the first line of defence against microbial pathogens. The innate immune system slows the rate of multiplication of the pathogens to allow time for the mo ...
Interferon gamma and tumor necrosis factor alpha induce Fas
... Our study shows that HSG cells, human salivary intercalated duct cells transformed by irradiation, express Fas antigen after IFN-γ or TNF-α treatment and undergo apoptotic cell death in response to anti-Fas antibody. These results can hopefully serve as the basis for cellular models for future inves ...
... Our study shows that HSG cells, human salivary intercalated duct cells transformed by irradiation, express Fas antigen after IFN-γ or TNF-α treatment and undergo apoptotic cell death in response to anti-Fas antibody. These results can hopefully serve as the basis for cellular models for future inves ...
Mouse and human FcR effector functions
... The ability of FcRs to induce biological functions following interaction with immunoglobulins (i.e. activation, inhibition, internalization, routing, transport) depend on the molecular state of the ligands, whether monomeric, present in an immune complex, or opsonizing cells, viruses, or bacteria. N ...
... The ability of FcRs to induce biological functions following interaction with immunoglobulins (i.e. activation, inhibition, internalization, routing, transport) depend on the molecular state of the ligands, whether monomeric, present in an immune complex, or opsonizing cells, viruses, or bacteria. N ...
Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T
... the inhibition of T-cell-mediated antitumor immune responses (21). However, the mechanisms behind the T-cell inhibition by tumor-associated LECs have not been investigated so far. We hypothesized that tumor-associated LECs might upregulate PDL1 in response to tumor-derived signals, and might thus co ...
... the inhibition of T-cell-mediated antitumor immune responses (21). However, the mechanisms behind the T-cell inhibition by tumor-associated LECs have not been investigated so far. We hypothesized that tumor-associated LECs might upregulate PDL1 in response to tumor-derived signals, and might thus co ...
Toll-like receptors as therapeutic targets in cystic fibrosis.
... between bacteria, inflammatory cells, their secretions and epithelial cells and their receptors. It also represents an inability of the lung’s innate defences to clear the infective causes of inflammation. Historically the lung has been perceived as an organ primarily involved in gas exchange. Howev ...
... between bacteria, inflammatory cells, their secretions and epithelial cells and their receptors. It also represents an inability of the lung’s innate defences to clear the infective causes of inflammation. Historically the lung has been perceived as an organ primarily involved in gas exchange. Howev ...
Micro Chapter 42 [4-20
... o Finding CMV antigen in blood WBCs means actively replicating CMV PCR is great for CMV and EBV Seroconversion – a standard to detect primary infection of CMV and EBV o Finding IgM anitbodies specific for either CMV or EBV suggests a recently acquired infection o Detection of IgG antibodies specific ...
... o Finding CMV antigen in blood WBCs means actively replicating CMV PCR is great for CMV and EBV Seroconversion – a standard to detect primary infection of CMV and EBV o Finding IgM anitbodies specific for either CMV or EBV suggests a recently acquired infection o Detection of IgG antibodies specific ...
Neuroendocrineimmune crosstalk in vertebrates and invertebrates
... that norepinephrine does in vertebrates (see Roeder 2005) and mollusks (Lacoste et al. 2001a). Octopamine is released into the general circulation (i.e. hemolymph) as a neurohormone in response to ‘flight-or-fight’ behaviour (Roeder 2005). Insect hemocytes have receptors for octopamine (R. Easy & S.A. ...
... that norepinephrine does in vertebrates (see Roeder 2005) and mollusks (Lacoste et al. 2001a). Octopamine is released into the general circulation (i.e. hemolymph) as a neurohormone in response to ‘flight-or-fight’ behaviour (Roeder 2005). Insect hemocytes have receptors for octopamine (R. Easy & S.A. ...
INVITED TALK - NK cell Symposium 2017
... thereby contributing to virus persistence. While perforin plays a role in this process, it is not known whether other apoptotic mediators may also contribute to this NK-cell dependent regulation of the CD8+ T cell response. Using a model of virus-induced hepatitis, we found a role for Tnfsf10/Trail ...
... thereby contributing to virus persistence. While perforin plays a role in this process, it is not known whether other apoptotic mediators may also contribute to this NK-cell dependent regulation of the CD8+ T cell response. Using a model of virus-induced hepatitis, we found a role for Tnfsf10/Trail ...
Cytokine responses in human Lyme borreliosis
... tumor-like nodule on the earlobe or the nipple which can arise close to a previous or concurrent EM (Stanek et al. 2003). Lymphocytoma is more frequently seen in children than adults (Stanek et al. 1996). ...
... tumor-like nodule on the earlobe or the nipple which can arise close to a previous or concurrent EM (Stanek et al. 2003). Lymphocytoma is more frequently seen in children than adults (Stanek et al. 1996). ...
International Journal of Antimicrobial Agents Toxin-binding
... MA). It acts by binding to, and subsequently neutralising, C. difficile toxins A and B [20]. It is a high-molecular-weight compound (>400 kDa) with no antimicrobial activity. This latter property was initially appreciated as it does not interfere with the normal intraluminal bacterial flora. Initial a ...
... MA). It acts by binding to, and subsequently neutralising, C. difficile toxins A and B [20]. It is a high-molecular-weight compound (>400 kDa) with no antimicrobial activity. This latter property was initially appreciated as it does not interfere with the normal intraluminal bacterial flora. Initial a ...
Pathophysiologic and Transcriptomic Analyses of
... stained intracellularly with a YFV-specific monoclonal antibody, 3A8.B6 as previously described [23]. ...
... stained intracellularly with a YFV-specific monoclonal antibody, 3A8.B6 as previously described [23]. ...
SITC 2015 Special Edition Immune Monitor – November 2015
... Antibodies targeting immune checkpoint receptors on T cells and their ligands in the tumor microenvironment have shown unprecedented ability to cause durable tumor regression in advanced metastatic cancers refractory to other treatments. Importantly, for a long time, only tumors considered relativel ...
... Antibodies targeting immune checkpoint receptors on T cells and their ligands in the tumor microenvironment have shown unprecedented ability to cause durable tumor regression in advanced metastatic cancers refractory to other treatments. Importantly, for a long time, only tumors considered relativel ...
3. Pathogenesis of giant cell arteritis
... of better therapeutic agents. The association between increased expression of TNFa and persistent disease activity provided support to the performance of clinical trials blocking TNF with infliximab, etanercept or adalimumab which, unfortunately, have proved insufficient to abrogate disease activity ...
... of better therapeutic agents. The association between increased expression of TNFa and persistent disease activity provided support to the performance of clinical trials blocking TNF with infliximab, etanercept or adalimumab which, unfortunately, have proved insufficient to abrogate disease activity ...