Challenges and strategies: The immune responses in gene therapy
... derived from viral particles, viral genes, and CpG DNA in plasmid. These potential immunostimulants may play important roles in inducing the host immune responses when foreign genes are transferred into the targeted tissues.1 Generally, viral vectors containing the genes of interest are packaged int ...
... derived from viral particles, viral genes, and CpG DNA in plasmid. These potential immunostimulants may play important roles in inducing the host immune responses when foreign genes are transferred into the targeted tissues.1 Generally, viral vectors containing the genes of interest are packaged int ...
Nobel Laureates of AAI - The American Association of Immunologists
... While examining immune reactions in mice infected with lymphocytic choriomeningitis virus (LCMV) from 1973 to 1974, Zinkernagel and Doherty found that virus-killing T lymphocytes taken from one mouse and injected into another could destroy infected cells only if the two mice belonged to the same str ...
... While examining immune reactions in mice infected with lymphocytic choriomeningitis virus (LCMV) from 1973 to 1974, Zinkernagel and Doherty found that virus-killing T lymphocytes taken from one mouse and injected into another could destroy infected cells only if the two mice belonged to the same str ...
Malaria Pigment Enhances Expression of Maturation Markers on the
... present study was designed where APC (mDC and macrophages) were generated from bone marrow of BABL/c mice and subsequently the effect of both sHZ and nHz was investigated on mDC and macrophages. The model deemed suitable, as it was not reported earlier, to answer the unsettled functionality of APC a ...
... present study was designed where APC (mDC and macrophages) were generated from bone marrow of BABL/c mice and subsequently the effect of both sHZ and nHz was investigated on mDC and macrophages. The model deemed suitable, as it was not reported earlier, to answer the unsettled functionality of APC a ...
Read full Publication as PDF here.
... To date, the underlying protective mechanisms of helminth products are being revealed and include the induction of regulatory responses in the host [4], probably via the modulation of dendritic cells (DCs), which are key regulatory players of the adaptive immune response [8]. Our previous work showe ...
... To date, the underlying protective mechanisms of helminth products are being revealed and include the induction of regulatory responses in the host [4], probably via the modulation of dendritic cells (DCs), which are key regulatory players of the adaptive immune response [8]. Our previous work showe ...
Immune control of mammalian gamma- herpesviruses: lessons from
... by murid herpesvirus-4 (MuHV-4) to human infections. The following points emerge: (i) CD8+ T-cell evasion by herpesviruses confers a prominent role in host defence on CD4+ T cells. CD4+ T cells inhibit MuHV-4 lytic gene expression via gamma-interferon (IFN-c). By reducing the lytic secretion of immu ...
... by murid herpesvirus-4 (MuHV-4) to human infections. The following points emerge: (i) CD8+ T-cell evasion by herpesviruses confers a prominent role in host defence on CD4+ T cells. CD4+ T cells inhibit MuHV-4 lytic gene expression via gamma-interferon (IFN-c). By reducing the lytic secretion of immu ...
The Suppression of Immune System Disorders by Passive
... Substituting Eq. 3 into Eq. 1, along with re ~0 yields the stable (dN=dt~0) solution N~k. When re w0 the cells generated by antigenic stimulation bring the total number above the homeostatic equilibrium, Nwk. This reduces the homeostatic renewal, such that f (N)v{rh =k. Except in lymphopenic conditi ...
... Substituting Eq. 3 into Eq. 1, along with re ~0 yields the stable (dN=dt~0) solution N~k. When re w0 the cells generated by antigenic stimulation bring the total number above the homeostatic equilibrium, Nwk. This reduces the homeostatic renewal, such that f (N)v{rh =k. Except in lymphopenic conditi ...
JDRF Cure Research – Halting the autoimmune process and
... National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) to research formulation, dose and the form of delivery for Tregitope. The first target for Tregitope therapy will be T1D. Islet replacement therapy is still in the experimental stage for individuals with advanced disease, but Ep ...
... National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) to research formulation, dose and the form of delivery for Tregitope. The first target for Tregitope therapy will be T1D. Islet replacement therapy is still in the experimental stage for individuals with advanced disease, but Ep ...
frans08efi - HLA Matchmaker
... Acceptable mismatches based on structural epitopes on HLA molecules ...
... Acceptable mismatches based on structural epitopes on HLA molecules ...
Immune privilege induced by regulatory T cells in transplantation
... anti-CD4 blockade (51) and because appropriate CD4þ T-cell clones were already available (52). The resulting A1(M).CBA TCR transgenic mouse behaved appropriately, in that only female mice showed a strong positive selection toward CD4þ T cells with reactivity to the male DBY antigen presented by H-2E ...
... anti-CD4 blockade (51) and because appropriate CD4þ T-cell clones were already available (52). The resulting A1(M).CBA TCR transgenic mouse behaved appropriately, in that only female mice showed a strong positive selection toward CD4þ T cells with reactivity to the male DBY antigen presented by H-2E ...
Achievements in genetic engineering and their influence on
... cloning, DNA injection or transfection, cell fusions, and induction or repres sion of genome expression. This technology is already providing effective measures for achieving greater control of infectious diseases, and work is progressing toward introducing and enhancing desirable characteristics i ...
... cloning, DNA injection or transfection, cell fusions, and induction or repres sion of genome expression. This technology is already providing effective measures for achieving greater control of infectious diseases, and work is progressing toward introducing and enhancing desirable characteristics i ...
The promise of cd T cells and the cd T cell receptor for cancer
... of CD1c-mLPA complex by cd T cells has yet to be demonstrated,42 but recent studies showing that CD1 family members can present self-lipids make these molecules attractive targets for future exploration. cd TCR recognition of general stress ligands cd T cells are known to expand in response to some ...
... of CD1c-mLPA complex by cd T cells has yet to be demonstrated,42 but recent studies showing that CD1 family members can present self-lipids make these molecules attractive targets for future exploration. cd TCR recognition of general stress ligands cd T cells are known to expand in response to some ...
Allergen induced Treg response in the peripheral blood
... sinuses regulated by T cells. Regulatory T (Treg) cells are involved in controlling immune responses and inhibiting the allergen-specific effector cell response. The aim of this study was to evaluate whether NP patients had defects in Treg cells after specific allergen exposure and the possible corr ...
... sinuses regulated by T cells. Regulatory T (Treg) cells are involved in controlling immune responses and inhibiting the allergen-specific effector cell response. The aim of this study was to evaluate whether NP patients had defects in Treg cells after specific allergen exposure and the possible corr ...
Chapter 13 The Lymphatic System and Immunity
... Located in clusters along the pathway of lymphatic vessels (Figures 13-1, 13-5, and 13-6) Lymphoid tissue – mass of lymphocytes and related cells inside a lymphoid organ; provides immune function and development of immune cells Lymph nodes and other lymphoid organs have functions that include defens ...
... Located in clusters along the pathway of lymphatic vessels (Figures 13-1, 13-5, and 13-6) Lymphoid tissue – mass of lymphocytes and related cells inside a lymphoid organ; provides immune function and development of immune cells Lymph nodes and other lymphoid organs have functions that include defens ...
Licentiate thesis from the Department of Immunology,
... the case of B lymphocytes, somatic hypermutation. The initiation of the adaptive response requires the cooperation of antigen-presenting cells (APC) scanning the periphery for pathogens, phagocytosing and processing proteins before migrating to the lymph nodes or spleen where interaction with adapti ...
... the case of B lymphocytes, somatic hypermutation. The initiation of the adaptive response requires the cooperation of antigen-presenting cells (APC) scanning the periphery for pathogens, phagocytosing and processing proteins before migrating to the lymph nodes or spleen where interaction with adapti ...
with Down Syndrome Decreased Naive T Cell Numbers in Children
... Sigrid A. Otto, Jose A. Borghans and Kiki Tesselaar ...
... Sigrid A. Otto, Jose A. Borghans and Kiki Tesselaar ...
Natural killer cell receptors: new biology and
... T-cell–mediated graft-versus-leukemia (GVL) has been shown to be the most efficacious following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions.1,2 Although specific antileukemic responses have been documented, most T-cell–mediated alloreactions are thought to be di ...
... T-cell–mediated graft-versus-leukemia (GVL) has been shown to be the most efficacious following allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions.1,2 Although specific antileukemic responses have been documented, most T-cell–mediated alloreactions are thought to be di ...
CLINICAL FEATURES
... Therapy for Meningitis • In addition, certain patients should receive adjunctive dexamethasone therapy when presenting with suspected or proven bacterial meningitis . • Currently, data support the routine use of adjunctive dexamethasone therapy (0.15mg/kg every 6 hours for 2 to 4 days) in infants a ...
... Therapy for Meningitis • In addition, certain patients should receive adjunctive dexamethasone therapy when presenting with suspected or proven bacterial meningitis . • Currently, data support the routine use of adjunctive dexamethasone therapy (0.15mg/kg every 6 hours for 2 to 4 days) in infants a ...
Immunology and Serology
... microorganisms, mainly bacteria, which together, are called the body’s normal flora or commensals. The term normal flora implies that such microbial inhabitants are harmless For the most part, normal flora microorganisms do not cause disease. ...
... microorganisms, mainly bacteria, which together, are called the body’s normal flora or commensals. The term normal flora implies that such microbial inhabitants are harmless For the most part, normal flora microorganisms do not cause disease. ...
table of contents - Oregon State University
... drugs often broadly suppress the immune system, but it is possible suppression could be targeted with the use of specific Tregs through the AhR. This would allow the body to accept a transplant but also maintain its ability to fight disease, which is hindered by today’s immunosuppressive drugs. If a ...
... drugs often broadly suppress the immune system, but it is possible suppression could be targeted with the use of specific Tregs through the AhR. This would allow the body to accept a transplant but also maintain its ability to fight disease, which is hindered by today’s immunosuppressive drugs. If a ...
