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Transplantation Immunology
Transplantation Immunology

... Transplantation antigens (1) Major Histocompatibility Complex (MHC): – gene complex whose alleles encode polymorphic cell surface glycoproteins involved in antigen recognition and presentation – MHC-matching between transplant donor and recipient greatly reduces likelihood of rejection ...
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... IRIS is a well recognized (but unknown MOA) condition seen in AIDS or other immunosuppressed conditions resulting in an overwhelming response to antigen as the immune system begins to recover Most commonly occurs with TB, M. avium, Cryptococcus, CMV, VZV, EBV, and viral hepatitis Up to 50% of patien ...
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The Immune System - Friedman

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Helper T Cells - My Teacher Pages

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Mediators of Immediate Hypersensitivity

... Immediate, or type I, hypersensitivity is a rapid immunologic reaction occurring in a previously sensitized individual that is triggered by the binding of an antigen to IgE antibody on the surface of mast cells. These reactions are often called allergy , and the antigens that elicit them are allerge ...
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... GITR (Glucocorticoid-Induced TNFR family gene) and its ligand (GITRL) are induced upon activation of a number of immune cell types. GITR is expressed at low levels on resting T cells, but its expression is rapidly increased upon activation. Although constitutively expressed on Foxp3+ regulatory T ce ...
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Maintenance ImmunosuppressionMScFinal6_10_2014

...  Humanised (mouse) monoclonal antibody acts on C5 to inhibit latter part compliment cascade reducing inflammation.  Prevents the generation of the terminal complement membrane attack complex (MAC) (See induction immunosuppression) ...
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Immune Design Announces Treatment of First Patient in Phase 1

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09_Fact_Path_Vir_2_2012_Dent - IS MU

... - starts to operate relatively late, after immune reaction has developed - after repeated contact it acts more quickly and efficiently Tools Antigen-presenting cells (phagocytes) T cells and activated macrophages (cell-mediated immunity) B cells and producers of antibodies (humoral immunity) ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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