The Immune System
... 1. B cell response which is a passive, humoral defense that aids in the removal of pathogens 2. T cell response, an active, cell-mediated defense that involves the destruction of pathogens by cytotoxic T cells ...
... 1. B cell response which is a passive, humoral defense that aids in the removal of pathogens 2. T cell response, an active, cell-mediated defense that involves the destruction of pathogens by cytotoxic T cells ...
Immune response part 1
... Specific for particular initiating Ag Adaptive – mechanism of eradication dependent on nature of Ag (bloodborne – by antibodies; intracellular – e.g. viruses – by specific effector cells) Eradicate Ag rapidly and effectively Immunological memory to future infection – to prevent re-infection ...
... Specific for particular initiating Ag Adaptive – mechanism of eradication dependent on nature of Ag (bloodborne – by antibodies; intracellular – e.g. viruses – by specific effector cells) Eradicate Ag rapidly and effectively Immunological memory to future infection – to prevent re-infection ...
Skin as a protection against environmental threats
... • Attachment via P- and E-selectins • Movement to dermis through CXC chemokine gradient ...
... • Attachment via P- and E-selectins • Movement to dermis through CXC chemokine gradient ...
Ub - Ub -Ub- Ub
... ubiquitination of IkB by a ubiquitin ligase (UbL). This produces IkB for degradation by the proteasomes, which then results in the release of NF-kB. The transcription factor is now free to become translocated to the nucleus where it binds to specific DNA elements and activates transcription of NF-kB ...
... ubiquitination of IkB by a ubiquitin ligase (UbL). This produces IkB for degradation by the proteasomes, which then results in the release of NF-kB. The transcription factor is now free to become translocated to the nucleus where it binds to specific DNA elements and activates transcription of NF-kB ...
Myeloma and the Immune System
... cells via a receptor called SLAM F7. This type of antibody is effective in combination with other anti-myeloma therapies. Anti-CD 38 monoclonal antibodies: These monoclonal antibodies target and attach to a specific antigen (CD 38) on the surface of myeloma cells and then signal NK cells to attack ...
... cells via a receptor called SLAM F7. This type of antibody is effective in combination with other anti-myeloma therapies. Anti-CD 38 monoclonal antibodies: These monoclonal antibodies target and attach to a specific antigen (CD 38) on the surface of myeloma cells and then signal NK cells to attack ...
At its Heart, Homeostasis Is About T Cells
... of the type of activating antigen. Therefore, reactive T cells expand clonally in infections and autoimmune diseases, and in response to allogeneic transplants. The activation cascade offers several targets for immunosuppressive therapy. Cyclosporine and ...
... of the type of activating antigen. Therefore, reactive T cells expand clonally in infections and autoimmune diseases, and in response to allogeneic transplants. The activation cascade offers several targets for immunosuppressive therapy. Cyclosporine and ...
Antibodies for MBBS
... presenting cells in association with MHC class II protein. This activates Th cells, which can bind to Ag fragment + MHC II on the B cell surface-leading to B cell activation •Each B cell expresses only one Fab type on its surface Immunoglobulin. •The diversity of these Fab regions is generated durin ...
... presenting cells in association with MHC class II protein. This activates Th cells, which can bind to Ag fragment + MHC II on the B cell surface-leading to B cell activation •Each B cell expresses only one Fab type on its surface Immunoglobulin. •The diversity of these Fab regions is generated durin ...
Document
... (Enzyme Linked Immunosorbent Assay) PBMC co-cultured in vitro with a suitable stimulus, secrete cytokines. Each cytokine can be capture by a specific antibody linked to an enzyme that reacts with a specific substrate and generates a colored product detectable as assorbance ...
... (Enzyme Linked Immunosorbent Assay) PBMC co-cultured in vitro with a suitable stimulus, secrete cytokines. Each cytokine can be capture by a specific antibody linked to an enzyme that reacts with a specific substrate and generates a colored product detectable as assorbance ...
Immunology
... In a class of diseases known as autoimmune disorders, the body's immune system attacks its own tissues ...
... In a class of diseases known as autoimmune disorders, the body's immune system attacks its own tissues ...
immune response
... Saliva, tears, nasal secretions, and perspiration contain lysozyme which damage or kill bacteria. ...
... Saliva, tears, nasal secretions, and perspiration contain lysozyme which damage or kill bacteria. ...
Emotional Behaviors
... Patrol blood and other body fluids for invaders Identifies antigens on intruders and signal attack from immune system Macrophage Surrounds intruder, digests it, and exposes its antigens on its own surface ...
... Patrol blood and other body fluids for invaders Identifies antigens on intruders and signal attack from immune system Macrophage Surrounds intruder, digests it, and exposes its antigens on its own surface ...
Immunological tolerance
... AIRE is responsible for the expression of tissue antigens in the thymus Mutations in AIRE cause an autoimmune polyendocrine syndrome Lack of proper negative selection allows too many self reactive T-cell clones to leave the thymus Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECE ...
... AIRE is responsible for the expression of tissue antigens in the thymus Mutations in AIRE cause an autoimmune polyendocrine syndrome Lack of proper negative selection allows too many self reactive T-cell clones to leave the thymus Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECE ...
Nertila_Ujkaj:Littin_Kandoth_Sandra
... Meresse, B., et al., Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity, 2004. 21(3): p. 357-66. ...
... Meresse, B., et al., Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity, 2004. 21(3): p. 357-66. ...
Current Opinion in Immunology 2009, 21:440–445 Biomarkers of
... longitudinal studies limited to the very elderly have begun to reveal “immune signatures” or biomarkers of immune ageing consisting of several parameters which we have designated the “immune risk profile”, or IRP. Although hinted at many years ago, a marked impact of usually asymptomatic infection w ...
... longitudinal studies limited to the very elderly have begun to reveal “immune signatures” or biomarkers of immune ageing consisting of several parameters which we have designated the “immune risk profile”, or IRP. Although hinted at many years ago, a marked impact of usually asymptomatic infection w ...
Antibody
... they are removed and destroyed immediately after synthesis. • when antibodies to “self” escape the initial screening process, they can attack the body causing autoimmune diseases. ...
... they are removed and destroyed immediately after synthesis. • when antibodies to “self” escape the initial screening process, they can attack the body causing autoimmune diseases. ...
PowerPoint Presentation - I. Introduction to class
... recognise and bind to antigens and protect us against circulating viruses, and bacteria and their toxins (free antigens). As many as 10 million different types of B cell develop in each of us and each one recognises one specific antigen. ...
... recognise and bind to antigens and protect us against circulating viruses, and bacteria and their toxins (free antigens). As many as 10 million different types of B cell develop in each of us and each one recognises one specific antigen. ...
10 Hypersensitivity.
... activation Attempted phagocytosis causes enzyme release and results in tissue damage ...
... activation Attempted phagocytosis causes enzyme release and results in tissue damage ...
Antibodies - UCSF Immunology Program
... Affinity and Avidity II •IgM is produced early in an immune response when the affinity for antigen often is low; as an immune response continues, antibody affinity is improved, this is combined by “class switching” to the use of smaller molecules (IgG, IgE and IgA). The increased affinity compensat ...
... Affinity and Avidity II •IgM is produced early in an immune response when the affinity for antigen often is low; as an immune response continues, antibody affinity is improved, this is combined by “class switching” to the use of smaller molecules (IgG, IgE and IgA). The increased affinity compensat ...
The Role of Regulatory T cell in HIV
... CD4CD25 T cells might be a key factor for the inefficiency of CD8 responses in viral persistence. The mechanisms of this suppression are not elucidated. Generation of CD8 T cell response following viral infection or vaccination is indispensable for infection control. In HIV infection the initial dec ...
... CD4CD25 T cells might be a key factor for the inefficiency of CD8 responses in viral persistence. The mechanisms of this suppression are not elucidated. Generation of CD8 T cell response following viral infection or vaccination is indispensable for infection control. In HIV infection the initial dec ...
Abrams Presentation for 11/22 and 11/29
... activity due to large granular lymphocytes, which comprise 5–10% of PBMC ...
... activity due to large granular lymphocytes, which comprise 5–10% of PBMC ...
The Body`s Defenses
... pathogens when they land on it. Second, as the surface layer of dead skin cells flake off they take many pathogens with them. Finally, the epidermis’s tough layers of dead cells acts like a shield keeping many pathogens out. ...
... pathogens when they land on it. Second, as the surface layer of dead skin cells flake off they take many pathogens with them. Finally, the epidermis’s tough layers of dead cells acts like a shield keeping many pathogens out. ...
chapter 14 cell surface markers of t-cells, b-cells and
... TcR. The T-cell antigen receptor (TcR) is the principle defining marker of all T-cells. This molecule is used by the T-cell for specific recognition of MHC-associated peptide antigens, discussed in Chapter 12. Also associated with the TcR is a complex of proteins known as CD3, which participate in t ...
... TcR. The T-cell antigen receptor (TcR) is the principle defining marker of all T-cells. This molecule is used by the T-cell for specific recognition of MHC-associated peptide antigens, discussed in Chapter 12. Also associated with the TcR is a complex of proteins known as CD3, which participate in t ...
The Immune System
... injected into an animal › Active immunity is aquired by vaccination or by natural infection with a microorganism. Vaccination is the administration of an antigen to stimulate a protective immune response against an infectious agent ...
... injected into an animal › Active immunity is aquired by vaccination or by natural infection with a microorganism. Vaccination is the administration of an antigen to stimulate a protective immune response against an infectious agent ...
What is Immunovet
... Immunovet also has an immune modulating effect by exerting a selective inhibition of MHC-I (major histo-compatibility-I) expression on the surface of tumor cells. Immunovet seems to restore the immune system to its pre-damaged condition. The MHC genes are responsible for regulating antibody recognit ...
... Immunovet also has an immune modulating effect by exerting a selective inhibition of MHC-I (major histo-compatibility-I) expression on the surface of tumor cells. Immunovet seems to restore the immune system to its pre-damaged condition. The MHC genes are responsible for regulating antibody recognit ...