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Slide 1
Slide 1

... Signals - degranulated tissue mast cells and phagocytes, molecules liberated from damaged cells  increased blood vessel permeability  increased endothelial adhesivity, trapping of phagocytes, lymphocytes, penetration into tissues  activation of coagulation, fibrinolytic and complement systems  e ...
The Immune System
The Immune System

... diffused lymphatic tissues found in mucous membranes in the intestine, respiratory, urinary and genital tracts. – The lymph nodes filter the lymph and remove foreign materials from lymph. – The spleen stores blood and destroys damaged RBC’s. – The thymus gland produces T-cells. ...
Immunoglobulins - Khyber Girls Medical College
Immunoglobulins - Khyber Girls Medical College

... Bound IgE serves as a receptor for antigens (allergen) and this antigen-antibody complex triggers allergic responses of the immediate (anaphylactic) type through the release of mediators e.g. histamine Although it is present in trace amounts in normal individuals, its levels are raised in ...
SLE (systemic lupus erythematosus)
SLE (systemic lupus erythematosus)

... binding to complement receptor 1 (CR1) on erythrocytes. ...
II. T cell activation
II. T cell activation

... regulated by cytokines ...
Document
Document

... IgA, IgG, IgD, IgE and IgM The Above Classes Are Called Isotype Each class can have either  or  light chains Minor Differences Led To Sub-classes For IgA and IgG IgA1, IgGA2 and IgG1, IgG2, IgG3, IgG4 ...
immnity organ 3
immnity organ 3

...  In birds →it is 14 lobes  It found from birth & continue to increase in size to full size at puberty, then decrease in size.  The thymus consist of cortex & medulla.  There is thymus barrier between the blood and the T cell unable to react with antigen.  T- lymphocyte → called T cell because i ...
Chapter 15 Cellular Mediated immunity 1. Define immunity providing
Chapter 15 Cellular Mediated immunity 1. Define immunity providing

... a. antibodies against Neisseria gonorrhoeae fimbriae b. antibodies against host cell mannose 16. Explain why a person who recovers from a disease can attend others with the disease without fear of contracting the disease. (4 pts) 17. Pooled human immune serum globulin is sometimes administered to a ...
COMPLEMENT activation - Akademik Ciamik 2010
COMPLEMENT activation - Akademik Ciamik 2010

Haemopoiesis Clinical application
Haemopoiesis Clinical application

...  Liver and spleen  Bone marrow  Gradual replacement of active (red) marrow by inactive (fatty) tissue  Expansion can occur during increased need for cell production ...
Immune System Worksheet
Immune System Worksheet

... 14. Discuss specificity as it relates to acquired immunity. How can this system be so specific in response? Where does the basis for the specificity come from? ...
453.29 Kb PDF
453.29 Kb PDF

... Correlate: An immune response that is responsible for and statistically interrelated with protection Absolute Correlate: A specific level of response highly correlated with protection: a threshold Relative Correlate: Level of response variably correlated with protection Co-Correlate: One of two or m ...
Autoimmunity and immune- mediated inflammatory diseases FOCiS
Autoimmunity and immune- mediated inflammatory diseases FOCiS

... antagonists (block cytokines) ...
lec #1 done by Leen AbdelFattah / Slides #1
lec #1 done by Leen AbdelFattah / Slides #1

... Then T cells will leave the thymus through blood vessels to the secondary organs So: education →segregation→ T4 or T8 *lymph nodes: T and B cells come to different zones in secondary organs (slide 29) -activation of the lymphocytes take place near the HEV. *tonsils : noncapsulated, especially import ...
The Science of Immunity
The Science of Immunity

... was then recognized that both humoral [chemical] molecules and immune cells mediate the host defense. William Cooley in 1891 cured soft tissue malignant sarcomas, using an anti-tumor fraction akin to what we see today as toxic shock. His particular toxin- a polysaccharide released from bacterial mem ...
T cells
T cells

... Table 15-13 Aging-Related Shifts in Antibodies General decrease in humoral responsiveness: Decline in high affinity protective antibody production Increased auto-antibodies: Organ specific and non-organ specific antibodies directed to self Increased serum levels of IgG (i.e. IgG1 and IgG3) and IgA; ...
Document
Document

... that enhance the adaptive immune response when mixed with antigens. Some work by inducing expression of costimulators such as CD80/CD86 ...
L12 nonspecificdefense 7e
L12 nonspecificdefense 7e

... • Cytoplasmic proteins which detect viral RNA in a cell • Activate secretion of interferon and inflammatory response chemicals • Overall goal is to inhibit viral replication ...
Tregs
Tregs

Chapter 43 - The Immune System
Chapter 43 - The Immune System

... ◦ May be caused by failure in regulation of selfreactive lymphocytes ◦ Causes immune system to turn against itself ◦ Ex: Scleroderma, a chronic autoimmune disease that can lead to inflammation and damage of the skin, joints, and internal organs ◦ Ex: Ankylosing spondylitis, a disease that involves i ...
Week 8--2/29
Week 8--2/29

... Why would chronic inflammation lead to cancer? • The pathogen (e.g., virus) carries an oncogene that is inappropriately expressed. • Not all chronic inflammation is due to an infectious agent. For those that are, no oncogenes have been identified. • Infection leads to cell death that requires rapid ...
MICR 201 Microbiology for Health Related Sciences
MICR 201 Microbiology for Health Related Sciences

... ▪ Generation of antibodies for research and diagnostic ▪ Anti-sera ▪ Monoclonal antibodies ...
MICR 201 Microbiology for Health Related Sciences
MICR 201 Microbiology for Health Related Sciences

... ▪ Generation of antibodies for research and diagnostic ▪ Anti-sera ▪ Monoclonal antibodies ...
The Immune System - Ms. Lin`s Science Class
The Immune System - Ms. Lin`s Science Class

... function of the immune system and its major cells including macrophages, antibodies, T-cells, etc. ...
What is the Immune System
What is the Immune System

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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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