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10mb ppt - UCLA.edu
10mb ppt - UCLA.edu

... Digalactose moiety not found in humans and Old World primates due to lack of a1--->3 galactosyl-transferase (a1--->3 GCT) Viruses grown in other mammalian cells can be neutralized by human or old-world primate sera (that have never seen the virus) due to high titer anti- Gal (a1-->3) Gal antibodies ...
Antibiotics
Antibiotics

...  The fever (high temp) kills invaders by inhibiting their growth.  Boosts chemical reactions that are needed to activate the 3 rd line of defense Swelling – caused by fluid moving into damaged area  Fever and swelling can also cause – redness to occur Phagocytosis – done by Macrophages* ...
Defense against disease, immune response
Defense against disease, immune response

... Disease – Terminology 1 Infection - growth of organism within body of host Chronic disease - long-term infection Acute disease - infection occurs suddenly, is short term Parasite - organism living on or in another organism, gains benefit, provides nothing. Not necessarily pathogenic. Carrier - pers ...
Immunology: Introduction and Overview
Immunology: Introduction and Overview

... Stimulants and Effectors ...
PFIZER’S CENTERS FOR THERAPEUTIC INNOVATION (CTI) CTI:
PFIZER’S CENTERS FOR THERAPEUTIC INNOVATION (CTI) CTI:

... either harness the immune system for tumor eradication or, conversely, targeted therapies to provide selective immunosuppression or immunoregulation for autoimmune diseases ...
investigations in uveitis
investigations in uveitis

... Serum C-reactive Protein (SCRP) • The values of SCRP generally parallel that of ESR but the former is not influenced by anemia. • It is a non-specific indicator of inflammatory activity in the body. • It increases earlier and declines faster than ESR at the onset and resolution respectively of ...
the original file
the original file

... 1. What is the evolutionary purpose of having both an innate and adaptive immune system that function as they do in humans? 2. Name 3 different types of barriers (mechanical, chemical, and microbial) that protect us from pathogens and list the key features for each category. 3. A dendritic cell phag ...
Alexo Therapeutics Announces Initiation of Phase 1 Clinical Trial of
Alexo Therapeutics Announces Initiation of Phase 1 Clinical Trial of

... single-agent dose escalation portion followed by a combination therapy portion in which ALX148 will be administered with approved anti-cancer antibodies. The study will enroll patients with advanced/metastatic solid tumors and relapsed or refractory non-Hodgkin lymphoma. For more information, please ...
Chapter 40-2
Chapter 40-2

... that breaks down the cell walls of bacteria  Oil & sweat glands produce an acidic environment on the skin that kills many bacteria  Mucus in mouth & nose help trap pathogens  Stomach acids & digestive enzymes destroy many pathogens that get in your stomach ...
Chapter 16
Chapter 16

PowerPoint to accompany - Current University of Rio Grande
PowerPoint to accompany - Current University of Rio Grande

... tissues and organs • cornea • kidney • liver • pancreas • heart • bone marrow • skin ...
molecular mimicry - Institute of Pathophysiology
molecular mimicry - Institute of Pathophysiology

... erythematodes A frequent and most typical symptom of the disease is a butterfly-shaped erythema on the cheeks. It is caused by photosensitivity. The tissue damage occurs by the type 3 hypersensitivity reaction. The symptoms are very variable, depending where the circulating immune complexes get depo ...
- EBioMedicine
- EBioMedicine

... HPV vaccines are highly effective at preventing anogenital HPV infections and the neoplastic diseases that they cause (Herrero et al., 2015). Like other licensed anti-viral prophylactic vaccines, the HPV vaccines are thought to function primarily by inducing antibodies that bind the virus, thereby p ...
The Immune System - John Burroughs Middle School
The Immune System - John Burroughs Middle School

... chicken pox, the person is not likely to get sick from it again • This is also why we use immunization to prevent getting certain diseases ...
Immune System Lecture_Spring 2002
Immune System Lecture_Spring 2002

... a. B and T Cells that attack self are not eliminated after they are produced b. Appearance of new self proteins/antigens – Possibly due to mutations , or – Bacterial or viral modification of self -proteins ...
Nonspecific vs. Specific Defense Mechanisms
Nonspecific vs. Specific Defense Mechanisms

Immune System Practice Questions 1. T lymphocytes mature in the
Immune System Practice Questions 1. T lymphocytes mature in the

... 24. A B cell does not clone until its antigen is present. A) True B) False 25. When B cells undergo clonal expansion, they produce plasma cells and memory B cells. A) True B) False 26. Defense by T cells is called antibody-mediated immunity. A) True B) False 27. Humoral immunity is so called because ...
The Lymphatic System
The Lymphatic System

III. Immunology and Complement
III. Immunology and Complement

... systems. Proteins - Rh, M, N blood group systems. ...
the-immune-system-part-4-teacher-notes
the-immune-system-part-4-teacher-notes

... - Works against body instead of fights it Allergies - unusually high sensitivity to some substance - Allergen = substance that causes allergic reaction o Foods, pollen, dust, animals  Dust ; feces of dust mites  Cats; saliva dried on their skin flakes ...
Inflammation 1
Inflammation 1

... host cells, blood vessels, proteins and other mediators intended to eliminate the initial cause of cell injury, as well as the necrotic cells and tissues resulting from the original insult, and to initiate the process of repair. ...
11.2 Body`s Lines of Defense
11.2 Body`s Lines of Defense

... Each B cell produces a single type of antibody. Plasma are B cells that produce large amounts of antibodies. (Some plasma cells produce 2000 antibodies/second). ...
Checkpoints in the development of thymic cortical epithelial cells
Checkpoints in the development of thymic cortical epithelial cells

... tissues within the body are also produced. Under normal conditions these are kept in check by “regulatory” cells, however if the balance of “autoimmune” and regulatory cells is altered, it has the potential to trigger auto-immune diseases, such as rheumatoid arthritis and diabetes. Using mouse model ...
Slide 1
Slide 1

... pentoxyfylline (weak TNF inhibitors) – Biologics (e.g., TNF inhibitors, IL-6 inhibitors, anti-IFNa, anti-PD1 ...
Lymphatic system - s3.amazonaws.com
Lymphatic system - s3.amazonaws.com

... transplanted tissue is that the recipient’s cells may recognize the donor’s tissue a foreign and attempt to destroy transplanted tissue  Immunosuppresive drugs are used to reduce rejection of transplanted tissue  Interfere with recipient’s immune response by suppressing formation of antibodies or ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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