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The Role of Environmental Triggers in Autoimmunity
The Role of Environmental Triggers in Autoimmunity

... systems in the most remote regions of the world. It has come to the point that all humans are now exposed to synthetic pollutants in their food, drinking water and in the air, as well as in the ordinary things they use in everyday life. Thus, even individuals regarded as nominally healthy have some ...
Innate lymphoid cells: identification of their role in allergic asthma
Innate lymphoid cells: identification of their role in allergic asthma

... Mycoplasma pneumoniae bacteria are common causes of asthma exacerbations. Interestingly, a novel non-T/non-B lymphoid cell population, named group 2 innate lymphocytes (ILC2s), producing high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, ILC2s are not antigenrestricted. ILC2s ...
Immune system - Napa Valley College
Immune system - Napa Valley College

...  What are Natural Killer cells, what do they do  The three types of phagocytes, what are they, what do they do  T cells and B cells – where are the produced, what cells produce them, what they do, where do they mature and where are they found when mature, are they part of the cell mediate or anti ...
Bio-261-Immune-System-part-2
Bio-261-Immune-System-part-2

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... b) Primarily chronic phagocytosis by cells of the innate immune system always begins the destruction of insulin producing cells. c) IgA penetrates the pancreases and mediate complement on beta cells. d) In type 1 diabetes insulin begins to directly attack the pancreas resulting in beta cell destruct ...
Louis Kock - TB-IPCP
Louis Kock - TB-IPCP

...  Also found to have increased levels of interleukin (IL)2, IL-12, IFN-γ, IP-10 and MIG.  Th2 cytokines (IL-4, IL-5, IL-13, and IL-15), were below ...


... or in combination with intra-arterially administered autologous iNKT. These approaches also efficaciously increased iNKT and NK cell responses, as well as antitumor activity, in several patients. Of note, major side effects have not been observed in the trials performed to date (reviewed in ref. 1). ...
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Adaptive Immunity

... A local expansion of blood vessels Carried out by macrophages, neutrophils, and dendritic cells A blood cell having no pigment in the cytoplasm A white blood cell that lives for several months Represented by a macrophage, dendritic cell, or neutrophil A secondary lymphoid tissue (two words) _____ im ...
Inducing tissue specific tolerance in autoimmune disease with
Inducing tissue specific tolerance in autoimmune disease with

... in RA. This approach induces autoantigen-specific regulatory T cells that exert their tissue-specific action through a combination of linked suppression and infectious tolerance, introducing a legacy of targeted, localised immune regulation in the proximity of the lesion. Several trials are in progr ...
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Presentation Title Here Presentation Subtitle Here

... TB Immunopathogenesis The Achilles heel • Increased susceptibility to TB with: ...
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... – Kallikrein converts plasminogen to plasmin • Plasmin digests fibrin, dissolving clot ...
Saskatchewan Immunization Manual
Saskatchewan Immunization Manual

... The immune system depends upon the activities of three categories of white blood cells (WBCs)  that are derived from bone marrow:  1. Phagocytic cells: Macrophages and dendritic cells are phagocytic cells that reside in the blood  and tissues waiting to engulf foreign substances.  2. T cells: After  ...
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... containing digestive enzymes Attack parasitic worms by degranulation Phagocytize immune complexes ...
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eCSI Case Powerpoint

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... of cytokines, costimulation, and/or TCR triggering). As a result, the CTLs could be deficient in effector functions such as cytolytic activity, deleted of high avidity CD8+ cells (15), unable to sustain function in vivo, or programmed to undergo activation-induced cell death (AICD) following target ...
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Immune System

... c.) Hidden in the mess of letters above should be the name of a cancer that targets the white blood cells of the human immune system. Not only does this cancer cause the white blood cells to come out abnormal, but because the cells do not die when they should, they accumulate in large numbers, which ...
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... 3) memory4) toleranceT Cells and Cell-mediated Immunity ▪Key cells in this immunity are cytotoxic T cells, helper T cells, memory T cells, and suppressor T cells. ▪Before an immune response can begin, T cells must be activated by exposure to an antigen, does not occur with direct antigen-lymphocyte ...
Killer Plagues Wksp 2 Articles
Killer Plagues Wksp 2 Articles

... Immunology, the study of the immune system, started long ago--even before people knew there was such a thing as the immune system! By the 1400's there was a primitive form of immunization. A powder made from dried smallpox scabs was inhaled as protection against getting smallpox. Modern immunology r ...
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Immunology

... o Anti-T cell R antibodies Induction of Immunological Tolerance: for example, by use of selective costimulator blockers to prevent T cell sensitization Allogenic Hematopoietic Stem Cell Transplantation: General: usually, the recipient’s immune system is ablated prior to transplantation (ie. by irrad ...
The Innate Immune Response
The Innate Immune Response

... cytokines and proteins that stimulate the microbicidal activities of various cells, notably the phagocytes. Other cellular receptors bind microbes for phagocytosis; these include receptors for mannose residues, which are typical of microbial but not host glycoproteins, and receptors for opsonins suc ...
Path_ggf_8i
Path_ggf_8i

... are induced by various kinds of stress, such as infection and DNA damage. NK cell inhibitory receptors recognize self– class I MHC molecules, which are expressed on all healthy cells. The inhibitory receptors prevent NK cells from killing normal cells. ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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