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Structure and Function of Bacterial Cells Part 1
Structure and Function of Bacterial Cells Part 1

... 1. General properties • Flagella are long whiplike filaments composed of protein that originate in the cell membrane. • Flagella rotate and impart swimming movement on the cells ...
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... 2. TRANSDUCTION – This causes the receptor protein to change shape. Now the signal is changed into another form that the cell can recognize that will cause it to respond in a specific way. – This may occur in multiple steps called a CASCADE. ...
The Immune System
The Immune System

... The actual cause of this disease is unknown and there is a tendency for such diseases to be inherited. MS (multiple sclerosis) is a condition which affects the myelin covering of nerve fibers. Rheumatoid arthritis is a chronic autoimmune disease that affects the bone and tissue of joints in the body ...
Pathogenesis of Bacterial Infections
Pathogenesis of Bacterial Infections

... I. Pathogenicity – The ability of any bacterial species to cause disease in a susceptible human host. II. Pathogen – A bacterial species able to cause such disease when presented with favorable circumstances (for the organism). III. Virulence – A term which presumes pathogenicity but allows expressi ...
Chapter 43:The Body`s Defenses - Volunteer State Community
Chapter 43:The Body`s Defenses - Volunteer State Community

... by the receptors on the surface or by free antibodies that have synthesized & secreted by B cells. • T cell receptors are just as specific but are never secreted. • A single B or T lymphocyte bears about 100,000 antigen receptors, all with exactly the same specificity. ...
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... Short-chain mycolic acid in wall (hint - Mycobacterium) Only B-phage-lysogenized strains are virulent… Tox gene makes A-B exotoxin - 1 of many examples… B = binds host receptor, translocates protein into cell A = catalytic, inactivates EF2 ribosome/translation factor Host receptor = heart and nerve ...
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The Immune System

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Granulocytes: Neutrophils/Eosinophils/Basophils

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... The third line of defense is specific and consists of lymphocytes. There are two typ of lymphocytes, B lymphocytes and T lymphocytes. Both originate in the bc marrow. Once mature, both cell types circulate in the blood, lymph, and lympha tissue: spleen, lymph nodes, tonsils, and adenoids. Both recog ...
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... bind the complex, Interleukin 2 is secreted by the cell which results in proliferation of that class of T-cell. At the same time as this is happening with the T-cell, The B-cells are also engulfing and degrading the antigen, but these cells have an antibody like receptor that recognizes the particul ...
anatomy and physiology answers
anatomy and physiology answers

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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