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Immunological investigation in Czech patients with
Immunological investigation in Czech patients with

... the control of immune recognition. AIRE is expressed in the thymus, lymph node and fetal liver , tissues that have important roles in the maturation of the immune system. AIRE expression was described also in monocytes and dendritic cells. The impaired expression of AIRE in the thymic medulla and an ...
Immunity
Immunity

Hypersensitivity
Hypersensitivity

... When the allergen appears again (usually a few weeks after the first exposure), it cross-links the mIgEs and causes degranulation, releasing granules. Mediators within these granules act on the surrounding tissues such as smooth muscle, small blood vessels, and mucous glands. ...
Foundations in Microbiology
Foundations in Microbiology

... • A substance that provokes an immune response • Foreign cells & large complex molecules over 10,000 MW are most antigenic • Foreign molecules less than 1,000 MW are not antigenic unless attached to a larger carrier • Antigenic determinant or epitope – small molecular group that is recognized by lym ...
Pathogenicity
Pathogenicity

...  Opportunists – don’t usually cause disease, but can when host compromised; examples: S. aureus, S. pneumoniae (meningitis, sepsis, pneumonia, etc.)  Modern medical advances allow these organisms to cause serious infections  Virulence – degree of harm produced by the organism in the host ...
九十九學年度 生技 /生醫系免疫學期中考(II) 姓名: 學號: 周開平副教授
九十九學年度 生技 /生醫系免疫學期中考(II) 姓名: 學號: 周開平副教授

... 姓名: 姓名: ...
INFECTION AND IMMUNITY
INFECTION AND IMMUNITY

... Infectious Diseases Barriers for Defense Against Infection: 1. Skin: ...
Many Gulf War illnesses may be autoimmune disorders caused
Many Gulf War illnesses may be autoimmune disorders caused

... ‘molecular mimicry’, in which a pathogen’s protein is similar enough to a native protein that the immune system mounts an offensive against the foreign protein and later attacks self proteins. A version of this molecular mimicry can be easily envisioned in a case where a native protein is chemically ...
Non specific response to disease - Science Website
Non specific response to disease - Science Website

... Their role is to engulf and destroy pathogens. Step 1 - When the pathogen enters, our body realises it is foreign because it has markers on its outer membrane. These markers are Antigens. (Our own cells have these but our body recognises that they are our own and not a threat) Step 2 - Antibodies in ...
HIV-AIDS
HIV-AIDS

TCR Peptide Therapy
TCR Peptide Therapy

... ANTI-Inflammatory cytokines (IL-10) released:  Suppress neighboring inflammatory cells  Protect lesions from further attack (bystander suppression) ...
Chapter 2: The Immune System
Chapter 2: The Immune System

... swelling and increased blood flow to the area. If there was not this local painful reaction, the infection would not be sealed off and attacked, but could spread throughout the body, with serious results. Similarly, the fever and malaise that are features of the common cold are not caused by the vir ...
Jess - PBL-J-2015
Jess - PBL-J-2015

Comic Strip Immunity Project
Comic Strip Immunity Project

... Using your knowledge of the function of the immune system and the immune response process create a comic strip or storyboard outlining the basic processes involved with the immune response. Be creative! Use analogies, characters, or stories to help you display your information. It is important that ...
Holly gets sick
Holly gets sick

Practice Exam 2 with answers
Practice Exam 2 with answers

... b. These cells accumulate in the lymph nodes c. These cells apoptose d. These cells aggregate around the high endothelial veinules (HEV) e. These cells abrogate TcR/MHC interactions 16. How might you verify that an individual had been successfully vaccinated with the flu vaccine? a. Use RT-PCR to me ...
1. dia - immunology.unideb.hu
1. dia - immunology.unideb.hu

... „yet it was with those who recovered from the disease that the sick and the dying found most compassion……. No fear for themselves; as no man was never attacked twice – never at least fatally” ...
Chapter 15
Chapter 15

... Antigen (Ag)  •  substance that provokes an immune response in  specific lymphocytes  •  perceived as foreign, not a normal constituent of the  body  •  Foreign cells & large complex molecules over 10,000  MW are most antigenic  •  Foreign molecules less than 1,000 MW (haptens) are  not antigenic u ...
CHRONIC LYMPHOCYTIC LEUKAEMIA CLL
CHRONIC LYMPHOCYTIC LEUKAEMIA CLL

... routine physical exam.or by routine CBC. Clinical manifestation develop as the leukemic cell acumalate on lymph nodes ,liver ,spleen & bone marrow . Presenting problems may be anaemia, infections,painless lymphadenopathy, and systemic symptoms such as night sweats or weight loss. However, these more ...
Dental Microbiology #211 IMMUNOLOGY Lecture 3
Dental Microbiology #211 IMMUNOLOGY Lecture 3

... system does not react to antigens expressed by our own tissues and soluble proteins. Our immune system operates through a process of selfnonself discrimination. Both B and T lymphocytes are “educated” to recognize and react only to foreign Ag but not to self (auto) Ag ...
Isotype switching Diversification of Igs after B cells encounter antigens
Isotype switching Diversification of Igs after B cells encounter antigens

... Diversification of Igs after B cells encounter antigens Isotype switching  Isotype switching produces Igs with different C regions but identical antigen specificities.  IgM is the first Ig produced in an antibody response but has limited mechanisms for fighting pathogens.  Antibodies with other ...
Inflammation & the Immune Response Unit VIII
Inflammation & the Immune Response Unit VIII

... An antigen is a substance that elicits an immune response Mostly comprised of protein A foreign substance that invades the body is called an antigen All cells have antigen unique to that individual allowing the body to recognize itself ...
Tuberculosis
Tuberculosis

... These are phagocytes, which respond to invading pathogens in a non-specific manner and provide an initial line of defence. Macrophages and other antigen presenting cells (APCs) recognise and phagocytose the mycobacteria, engulfing them into a phagosome. Typically upon phagocytosis, the bacteria-cont ...
Topics to Review
Topics to Review

Immunity
Immunity

... Not produced by the immune response ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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