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Basic Immunology - Pipestone Veterinary Services
Basic Immunology - Pipestone Veterinary Services

... Clostridia enterotoxemia (overeating) problem. Often we will receive some protection but not as much protection as a lamb that is vaccinated when it is over four weeks of age. Therefore, if the initial Clostridia Type C & D vaccination is given to lambs under four weeks of age, two boosters of the v ...
The Danger Model - Direct-MS
The Danger Model - Direct-MS

... can bind to many different kinds of molecules. How can one receptor--TLR4, for example--be specific for a bacterial LPS, cellular Hsp70 protein, and hyaluron? One possibility is that we may be looking at the PRRs completely backwards (7). Perhaps PRRs have not evolved to bind to pathogens at all. Pe ...
Chapter 8
Chapter 8

... • Exist in inactive state in blood and other fluids • Destroy cells that have been marked for elimination by antibodies • Activation of the system occurs when antibodies bind with antigens on the invading cells • Series of events follow that results in water entering the cells and causing them to bu ...
Synthesis and Characterization of Immunologically Active
Synthesis and Characterization of Immunologically Active

... they are part of certain fat molecules called glycosphingolipids. These molecules are able to activate invariant Natural Killer T-Cells (iNKT cells), white blood cells that mount a dangerous non-specific systemic immune response that can potentially lead to death. However this same immune response, ...
Chapter 13 Physical Activity and the Immune System
Chapter 13 Physical Activity and the Immune System

... Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals (humans included), birds, reptiles, and fish. Monocytes play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under norm ...
PDF - Beachport Liquid Minerals
PDF - Beachport Liquid Minerals

lecture3-host
lecture3-host

... Virulence is measured by the Lethal dose 50 (LD50) which is the number of organisms or mg. of toxins that will kill 50% of susceptible lab. animal – usually mice – when injected into such animal. When the LD 50 is small, the microorganism is considered highly virulent and when it is high the organis ...
Histocompatibility
Histocompatibility

... Class I genes in the H-2K and H-2D, L regions encode cell-surface polypeptides and are found on almost all cell types, are highly polymorphic, and are involved in signaling effector T cells during cell-mediated immunity. Class I genes within the Qa and T1a regions exhibit low polymorphism, encode an ...
Some Differential Characteristics of Procaryotes and Eukaryotes
Some Differential Characteristics of Procaryotes and Eukaryotes

... vitamins K. 2-methyl-3-all trans polyprenol-1, 4-naphatroquinones possessing side chains varying in length from C5 C65. Meanquinoes function as electron carriers ...
Clinical Signs are an Interaction of Host, Agent and the Environment
Clinical Signs are an Interaction of Host, Agent and the Environment

Immune Hemolytic Anemias
Immune Hemolytic Anemias

... http://www.vet.uga.edu/vpp/clerk/hiers/FIG5Slide3.JPG ...
Chapter 5 Gases - LCMR School District
Chapter 5 Gases - LCMR School District

... Take-Home Message: What happens during an ...
Tumor antigens
Tumor antigens

Supplementary Materials and Methods
Supplementary Materials and Methods

... 150 mM NaCl, 1 mM EDTA, 1 mM EGTA, 50 mM Tris-HCl, pH 8.0, containing the above inhibitors. The final pellet was then collected as colonic epithelial cells [purity >80%, shown by staining with antibodies against the epithelial cell marker CK-18 (eBiosciences)], which were stored at -80 °C for protei ...
Bacterial Pathogenesis I
Bacterial Pathogenesis I

... a. Antibiotics are originally from natural products (selected in nature from the competition between microbes, like Penicillin, for example). b. Antibiotics block essential microbial-specific functions (like DNA replication, protein synthesis, cell wall synthesis, etc.). c. Antibiotic resistance com ...
Microbial Interaction with Human
Microbial Interaction with Human

... • Pathogens gain access to host tissues by adherence to mucosal surfaces through interactions between pathogen and host macromolecules. Table 21.3 gives major adherence factors used to facilitate attachment of microbial pathogens to host tissues. ...
Reproductive Immunology Issue One: Cellular and
Reproductive Immunology Issue One: Cellular and

AMA 180 powerpoint
AMA 180 powerpoint

... Plasma: liquid portion of the blood when circulating in the body; carries blood cells through the circulatory system. Composed of water, dissolved proteins, sugar, wastes, salts, hormones, etc. Erythrocytes: red blood cells that contain hemoglobin (protein) that enable them to carry oxygen. ...
Slide 1
Slide 1

... • A target cell puts out outgrowths called filopodia – as one of them approaches a potential presynaptic neuron’s axon, the two cells become linked by cadherins. • In the presynaptic cell, catenins organize a release zone for synaptic vesicles with docking site proteins • In the postsynaptic cell, c ...
B Cells
B Cells

... antigen and then display a fragment of the antigen, bound to a class II MHC molecule, on their membrane. The T cell recognizes and interacts with the antigenclass II MHC molecule complex on the membrane of the antigen presenting cell. An additional co-stimulatory signal is then produced by the antig ...
(Innate) Immunity Lecture
(Innate) Immunity Lecture

Identification of Infectious Disease Processes
Identification of Infectious Disease Processes

... Colonization – organisms in or on a host; growth but no tissue invasion or damage Infection – entry of an infectious agent in tissues of a host; growth and create symptoms Contamination – presence of microorganisms on inanimate objects, skin, or in substances ...
Chapter 14 – Cell-mediated effector responses
Chapter 14 – Cell-mediated effector responses

... receptor (paracrine stimulation) and causes it to proliferate and differentiate into an effector or memory CTL. Memory CTLs have visible granules that contain proteins they will use when they kill. As the amount of antigen in the body is gradually reduced by immune action, the actual effector CTLs a ...
Defense Mechanisms of the Avian Host
Defense Mechanisms of the Avian Host

... to play a distinct role in “genetic” resistance to virusinduced neoplasms. Very recent results show that the avian NK cells are independent of the thymus but have CD3 and CD8 antigens at their surfaces. ...
Telomeres are specialized nucleoprotein structures
Telomeres are specialized nucleoprotein structures

< 1 ... 367 368 369 370 371 372 373 374 375 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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