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Cannabinoid receptors in microglia of the central nervous system
Cannabinoid receptors in microglia of the central nervous system

... migrate and proliferate during and after injury and inflammation [22–25]. Once activated, they produce various cytokines including interleukin-1 (IL-1), IL-6, and tumor necrosis factor-␣ (TNF-␣) and express major histocompatibility complex classes I and II antigens and the complement receptor, CR3. ...
β2-ADRENERGIC RECEPTOR MODULATION OF MACROPHAGE
β2-ADRENERGIC RECEPTOR MODULATION OF MACROPHAGE

... As the field progressed, increasing amounts of evidence demonstrated that inflammatory mediators, such as cytokines, prostaglandins and chemokines, released by immunocompetent cells are able to influence various activities of the nervous system [7, 8, 10, 14, 61]. This collection of work established ...
HMGB1-promoted and TLR2/4-dependent NK cell maturation and
HMGB1-promoted and TLR2/4-dependent NK cell maturation and

... previous findings have reinforced the notion that BA is a virus-induced and immune ...
Neonatal Chlamydial Infection Induces Mixed T-Cell
Neonatal Chlamydial Infection Induces Mixed T-Cell

Free PDF
Free PDF

... primary pathogenic cause. In others, such as in liver cirrhosis, it would lead to the translocation of microbial antigens into the entero-hepatic circulation with the consequent exacerbation of liver fibrosis and of portal hypertension, and a further increase in permeability1. Whether the alteration ...
Cytomegalovirus Tegument Proteins and the
Cytomegalovirus Tegument Proteins and the

... 4.1. pp65 A good tegument protein to target would be pp65, since it is the most abundant tegu‐ ment protein [67]. pp65 is implicated in counteracting both innate and adaptive immune responses during CMV infections. It invokes humoral and cellular immunity and is the dominant target antigen of cytoto ...
Lectins, Mitogens and Agglutinins
Lectins, Mitogens and Agglutinins

... typically contains high titre anti-banana lectin (BanLec-1) IgG4. Lectins can modulate IgE responses to other antigens [hG3 also does this, and there is some evidence that CD23 (the low-affinity IgE receptor) is in itself a C-type lectin.] Dietary lectins can induce the release of IL-4 and IL-13 fro ...
O A RIGINAL RTICLES
O A RIGINAL RTICLES

... pneumonia at the time of hospital admission were highest and lowest in patients with non-bacteraemic and bacteraemic disease respectively.20 More recently, Huo et al. reported that in a small group of patients with documented pneumococcal disease, the concentrations of circulating IgG antibodies to ...
The Origins, Specificity, and Potential Biological
The Origins, Specificity, and Potential Biological

CD161 defines the subset of FoxP3+ T cells capable of producing
CD161 defines the subset of FoxP3+ T cells capable of producing

Nutrition in the surgical patient
Nutrition in the surgical patient

... Oxygen consumption may be increased 50-100%. This metabolic activity is needed to maintain high cardiac output and ventilatory needs, liver acute phase response and increased immunological activity for healing. ...
- Wiley Online Library
- Wiley Online Library

expresses surface proteins that closely resemble those from
expresses surface proteins that closely resemble those from

Chapter 21 - Dr. Gerry Cronin
Chapter 21 - Dr. Gerry Cronin

... • The thymus slightly protrudes from the mediastinum into the lower neck. • It is a palpable 70g in infants, atrophies by puberty, and is ...
Newborns Develop a Th1-Type Immune Response to
Newborns Develop a Th1-Type Immune Response to

... Copyright © 1999 by The American Association of Immunologists All rights reserved. ...
the role of the c5a receptor in host defense against listeria
the role of the c5a receptor in host defense against listeria

microbiology - UtechDMD2015
microbiology - UtechDMD2015

... • Obligate parasite in humans • Spread from person to person via air droplets or direct contact with Skin or Fomites • Pharyngitis most common in Winter & Spring • Highest incidence in Adolescents • Contaminated Milk & Eggs causes for foodborne epidemics • Impetigo-like Skin infection mostly in summ ...
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item[`#file`]

... o Acute – more common in children, preceded by viral infection; generally self-limited o Chronic – commonly seen in women 20-40y, a chronic disorder, have normal bone marrow  Tx – give immunosuppressives, reduce platelet removal by macrophages o Secondary – associated with disordered lymphoid funct ...
Uveitis in horses - case of
Uveitis in horses - case of

... – Infectious agents may only activate ERU. Lepto antigen and horses. – Self-antigens perpetuate the disease. Bystander activation Epitope (a single antigenic site on a protein against which an antibody reacts) spreading – Shifts in immunoreactivity may cause the waxing/waning character of ERU – Shif ...
Phenotype
Phenotype

... bacteria and the differentiation of lactose fermenting from lactose non-fermenting gram-negative bacteria. It has also become common to use the media to differentiate bacteria by their abilities to ferment sugars other than lactose. In these cases lactose is replaced in the medium by another sugar. ...
Pathogenesis of Bronchial Asthma
Pathogenesis of Bronchial Asthma

... Pathogenesis of Atopic Asthma Late phase reaction Recruitment of leukocytes mediated by product of mast cells: 1. Eosinophil and neutophil chemotactic factors 2. IL-4 & IL-5 and induceTH2 subset ofCD4+ T cells 3. Platelet-activating factor 4. Tumor necrosis factor. ...
Biological Activities of Royal Jelly - Review
Biological Activities of Royal Jelly - Review

... there has been an increase in plaque-forming splenocytes, in the weight of the inguinal lymph node and in the number of peripheral lymphocytes [71]. In tumor bearing mice RJ administration increased the survival period of and proved myeloprotection through positive effects on stem cells of bone marr ...
Negative regulation of SEK1 signaling by serum and
Negative regulation of SEK1 signaling by serum and

... ally identified as the product of a gene whose transcription was controlled by serum and glucocorticoids in rat mammary tumor cells (Webster et al, 1993a). SGK1 is implicated in a variety of cellular activities including the regulation of ion channel conductance, cell volume, and cell survival (Brune ...
Evolution of the innate immune system: the worm perspective
Evolution of the innate immune system: the worm perspective

... In such habitats, frequent encounters with pathogens are expected, such that the nematode should have evolved a multifaceted immune response. In consideration of its natural ecology and its advantages for genetic analysis, C. elegans should prove extremely valuable for deciphering the molecular gene ...
Mast cell-orchestrated immunity to pathogens
Mast cell-orchestrated immunity to pathogens

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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