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Presentation - people.vcu.edu
Presentation - people.vcu.edu

Gastrointestinal tract barrier function
Gastrointestinal tract barrier function

... Significant progress has been made in understanding the processes by which physiological and pathophysiological stimuli, including cytokines, regulate tight junction function in the GIT. Recent data have emphasized the presence of immune mechanisms that maintain mucosal homeostasis despite barrier d ...
INTEGRATED M.Sc-Ph.D PROGRAM
INTEGRATED M.Sc-Ph.D PROGRAM

... SCMM –Integrated M.Sc-Ph.D Program SCMM is planning to start an integrated M.Sc.-Ph.D. program in the appropriate disciplines of 'Molecular Medicine' as soon as possible subject to the approval of university level academic committee. The goal of this program is to expose and train students in modern ...
Perio and Respiratory Disease
Perio and Respiratory Disease

... airway, pathogenic bacteria that colonize the oral cavity can be aspirated into the lower airway to cause infection. There are four possible mechanisms of the presence of oral bacteria in the pathogenesis of respiratory infections: 1. The oral cavity might be a reservoir for micro-organisms that con ...
Poster
Poster

... statistic, coupled with the common occurrence of heart attacks, demonstrates the importance of blood clot regulation. While these disorders are caused by an excess of clotting, hemophilia and other similar disorders are prime examples of the dangers of too little clotting. As such, it is important f ...
Immunological Tests
Immunological Tests

... Immunological Tests ...
The race between infection and immunity
The race between infection and immunity

... This delay occurs even in vaccinated animals, and the delay in T cell activation coincides with a failure of vaccine-induced cells to control early viral growth [4]. This delay is not limited to HIV, as a similar delay in T cell activation is seen with other slow growing pathogens, such as HBV[13], ...
Gastroenteritis
Gastroenteritis

... – Norovirus epidemics cause 90% of cases – Rotaviruses responsible for 50% infant cases of serious diarrhea • 600,000 worldwide annual fatalities • Oral vaccine available ...
Document
Document

... • The early immune response to SLIT is IL10 secreting regulatory T cells with nonallergen specific T cell suppression. • By one year, regulatory T cells have declined, replaced by allergen-specific T cell suppression and enhanced IFN- ...
HIV/AIDS Pathogenesis 1 PowerPoint Presentation
HIV/AIDS Pathogenesis 1 PowerPoint Presentation

Human Immunodeficiency Virus (HIV)
Human Immunodeficiency Virus (HIV)

... • Upset stomach/bloating/gas/loose stools is also fairly common during the first month and for most patients is fairly mild. • HIV levels in the blood will often drop by > 99% in the first month and the CD4 count (marker of immune system function) will often increase providing protection against AID ...
Lab Spotlight on Odyssey Expert: Dr. Andreas - LI
Lab Spotlight on Odyssey Expert: Dr. Andreas - LI

Vaccinations - e-Bug
Vaccinations - e-Bug

an overview on immunomodulation
an overview on immunomodulation

... they capture antigen or bring it to the lymphoid organs where an immune response is initiated. Unfortunately, one reason we know so little about dendritic cells is that they are extremely hard to isolate, which is often a prerequisite for the study of the functional qualities of specific cell types. ...
Physiology (Immunity) Lec.(5) Dr.Rafah Sami
Physiology (Immunity) Lec.(5) Dr.Rafah Sami

... Formation of Antibodies by Plasma Cells. Before exposure to a specific antigen, the clones of B lymphocytes remain dormant in the lymphoid tissue. On entry of a foreign antigen, macrophages in the lymphoid tissue phagocytize the antigen and then present it to adjacent B lymphocytes. In addition, the ...
Syndecan-2 as an emerging target for migration
Syndecan-2 as an emerging target for migration

... bimodal effect in endothelial cell permeability with a low concentration (pM levels) eliciting a barrier protective and a high concentration (nM levels) eliciting a barrier disruptive response. It is not known whether this PAR-1-dependent activity of thrombin is a unique phenomenon specific for the ...
Principle of the approach Vaccine Preparation
Principle of the approach Vaccine Preparation

... polysaccharide conjugate vaccine first introduced as a 7 valent vaccine now (since 2010) with coverage of 13 serotypes (PCV). Immuno Biology (ImmBio) is developing a new vaccine, based on the over-expression of heat shock proteins (Hsps). Microbial Hsps have been implicated in the induction of both ...
b1-Adrenergic Receptor Function, Autoimmunity, and Pathogenesis
b1-Adrenergic Receptor Function, Autoimmunity, and Pathogenesis

... et al. 2003]). In addition, genetic factors may contribute to the susceptibility to immunologic factors or to the phenotypic expression of the disease (Limas et al. 2004). Irrespective of whether development of DCM is primarily triggered by acute or chronic inflammatory or ischemic myocyte damage, o ...
Targeted therapy in renal cell carcinoma: moving from molecular
Targeted therapy in renal cell carcinoma: moving from molecular

... tumoral, but not healthy tissues while inducing a longlasting memory response against cancer cells. This can only be efficiently achieved by directing these T cells toward target structures specifically expressed or overexpressed in tumor cells. Tumor-associated antigens It is well known that TAAs e ...
HIV Vaccine Research Powerpoint
HIV Vaccine Research Powerpoint

... Final results expected by the end of 2009. “We have a concern about the wisdom of the U.S. government’s sponsoring a recently initiated phase III trial in Thailand…Multiple phase I and II clinical trial have revealed that the ALVAC vector is poorly immunogenic. The gp120 component as now been proven ...
Development of Advanced Adjuvants and Immune Modulators
Development of Advanced Adjuvants and Immune Modulators

Development of an enhanced bovine viral diarrhea virus subunit
Development of an enhanced bovine viral diarrhea virus subunit

... Spain) was used and serum samples from the three experimental groups of bovines were processed following the manufacturer’s instructions at 0, 60, 240 and 360 dpi. Results of VN showed that bovines vaccinated with either 1.5 ␮g of APCH-tE2 or an inactivated BVDV showed geometric mean titers (GMT) >2 ...
Homeostasis in Infected Epithelia: Stem Cells Take
Homeostasis in Infected Epithelia: Stem Cells Take

... In the past few years, the interaction between pathogen growth and host epithelial repair has been an area of intense investigation. In addition, many studies have illustrated the methods that microbes deploy to evade the host immune system. Although many bacterial virulence factors have been identi ...
Toll-like Receptors and Innate Immunity
Toll-like Receptors and Innate Immunity

Biology – The Search for Better Health
Biology – The Search for Better Health

... either DNA or RNA. Viruses that contain RNA are known as retroviruses. Viruses are unable to reproduce on their own and can replicate only inside host cells. The viral protein coat contains chemicals that allow the virus to attach itself to the surface of the host cell. Once the virus attaches itsel ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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