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Full chapter notes - lymph system
Full chapter notes - lymph system

... Infectious Mononucleosis •Also called the kissing disease •An acute infectious disease caused by the Epstein-Barr virus •Swollen lymph nodes are a common symptom ...
myeloproliferative
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... It is considered prudent for people who are ill to delay international travel and for people developing symptoms following international travel to seek medical attention, in line with guidance from national authorities. Individuals are advised to wash hands thoroughly with soap and water on a regula ...
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Plague

... millions of deaths in history, plague is still endemic in parts of the world today and thus is still of concern. Infection with Y.pestis causes approximately 3000 deaths per annum globally (World Health Organization figures) and whilst infection rates in Asia have remained steady, the incidence of p ...
Improved Clinical Outcome in Indolent B-Cell
Improved Clinical Outcome in Indolent B-Cell

... histologically distinct NHL cell lines. In contrast, treated lymphoma cells from responders displayed higher amounts of calreticulin and heat shock protein 90 (HSP90) compared with those from nonresponders and boosted the production of specific antibodies when loaded into DCs for vaccination. Accord ...
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206 Malaria.p65

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Stem Cell Research - Evidence for God from Science
Stem Cell Research - Evidence for God from Science

... develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences ...
Induction of tolerance in autoimmune diseases by hematopoietic
Induction of tolerance in autoimmune diseases by hematopoietic

PDF - Bentham Open
PDF - Bentham Open

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Chapter 22 Lympahatic System

... • Immune system can recognize and respond to a billion different epitopes -- even artificially made molecules • Explanation for great diversity of receptors is genetic recombination of few hundred small gene segments • Each B or T cell has its own unique set of gene segments that codes its unique an ...
Establishment of four new mesothelioma cell lines: characterization by ultrastructural and
Establishment of four new mesothelioma cell lines: characterization by ultrastructural and

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hemopoietic stem cells
hemopoietic stem cells

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Application and Advantages of ELISPOT Differences between

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Oxidative Stress in Cardiovascular Inflammation: Its Involvement in
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the attached hematopoiteic cascade
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Chapter 7 Unimpaired immune functions in the absence of Mrp4 (Abcc4)
Chapter 7 Unimpaired immune functions in the absence of Mrp4 (Abcc4)

... response. Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4; ABCC4) is required for the migration of human DC. Since the ABC transporter MRP1 (ABCC1) was previously shown to play a role in both human and mouse DC migration, we here studie ...
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES

... both congenital complement deficiencies (e.g. deficiency of complement component C3) and sustained hypocomplementemia induced by nephritic factor autoantibodies or circulating immune complexes have been associated with MPGN. Antibodies to some unknown protein, called an antigen, get trapped in the f ...
Cellular and Gene Therapy for Major Histocompatibility Complex
Cellular and Gene Therapy for Major Histocompatibility Complex

... hyper-IgM syndrome is another example of an antibody production defect, wherein the B cells are not able to switch from IgM to IgG, IgA, or IgE. The X-linked form of the disease (called HyperIgM-1) is caused by an absence of the CD40 ligand (CD40L) protein. This protein is expressed at the cell surf ...
Cell–Matrix Contact Prevents Recognition and Damage
Cell–Matrix Contact Prevents Recognition and Damage

... antithrombotic to prothrombotic, changes in cytokine production, and upregulation of human leukocyte antigen (HLA) molecules.1 Atherosclerotic disease in general2 as well as a variety of cardiovascular risk factors3–5 and autoimmune diseases6 are associated with circulating anti-EC antibodies that d ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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