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IL-33: an alarmin cytokine with crucial roles in
IL-33: an alarmin cytokine with crucial roles in

... function as a novel alarmin (intracellular alarm signal released upon cell injury) to alert the immune system of tissue damage following trauma or infection [36,37,45,46]. IL-33 is likely to be a very good alarm signal because, due to its constitutive expression in normal tissues, it is ready to be ...
Q&A: What is a pathogen? A question that begs
Q&A: What is a pathogen? A question that begs

... host cannot be identified for many microbes. Second, properties conferring pathogenicity depend as much on the host as they do on the microorganism: encapsulated bacteria are pathogenic because they have a polysac­ charide coat that prevents phagocytic cells from seeing them, and thereby avoid immed ...
HERPESVIRIDAE i - Evergreen State College Archives
HERPESVIRIDAE i - Evergreen State College Archives

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MyD88 Dependent Neisserial Porins Is Toll

... B cells were performed by incubating the cells with N. meningitidis LPS, which could not induce expression of B7-2 or class II MHC in MyD88-deficient B cells (Fig. 2A). Similar results were obtained using purified Escherichia coli LPS (data not shown). These data demonstrate that B cell activation b ...
The role of released ATP in killingCandida albicansand other
The role of released ATP in killingCandida albicansand other

Cellular and Antibody Mediated Graft Rejection
Cellular and Antibody Mediated Graft Rejection

Coagulase-negative Staphylococcus Species Information Sheet
Coagulase-negative Staphylococcus Species Information Sheet

... are subclinical and the clinical cases are normally mild and transient. SCCs will elevate to no more than 500,000 cells/ml and rarely impact milk production. However, there are some species of CNS that can be more pathogenic and can cause a decrease in milk production. Since CNS are part of the norm ...
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... consensus motif. The specificity of DNA binding was assessed by preincubating extracts with unlabeled specific NF-ƙB or unspecific (AP-1) competitor oligonucleotide. ...
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Lesson Plan - The Vaccine Makers Project
Lesson Plan - The Vaccine Makers Project

... This activity represents the adaptive immune system because the letter on the P players’ cards represents surface antigens. The letter on the IM player’s cards represents antibodies that recognize the surface antigens. In each round, the IM player takes two more cards, enabling the IM player to reco ...
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03.Lecture (3) Lymphoid system Hazem KSU 2008

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How HIV Causes AIDS: Is HIV an Inflammatory Disease?

... • Key is treating the underlying infection to decrease antigen load • Continue ART in all cases • Most cases are self-limited • However, CNS IRIS (crypto and PML) can be lethal and may require intensive management of ICP and/or steroids • Steroids can be used, but should be reserved for severe cases ...
Alveolar macrophages (AMs)
Alveolar macrophages (AMs)

... immunity v. S.pneumoniae • Antibody via improved alveolar macrophage and neutrophil phagocytosis v. important • Th-17 mechanisms also could be helpful • Natural adaptive immune responses can be directed against protein antigens • Need to aim for vaccination strategy that: - boosts S. pneumoniae clea ...
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... ARCHITECT HIV Ag/Ab Combo assay is intended to be used as an aid in the diagnosis of HIV-1/HIV-2 infection, including acute or primary HIV-1 infection. The assay may also be used as an aid in the diagnosis of HIV-1/HIV-2 infection in pediatric subjects (i.e., children as young as two years of age) a ...
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Uptake of Autologous and Allogenic Tumor Cell Antigens by

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Low CD4+ T Cell Nadir Is an Independent Predictor of Lower HIV

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00 (Jouranl of fish~).hwp

... samples from fish and shellfish, and, after concentration by filter-feeding shellfish such as oysters, may ...
Single‐cell technologies to study the immune system
Single‐cell technologies to study the immune system

Slide 1
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... CP005/5A efficacy and treatment duration study: Phase IIb Randomized, double-blind, placebo-controlled parallel group trial with Environmental Exposure Chamber (EEC) ...
Mesenchymal stem cells: harnessing cell plasticity to
Mesenchymal stem cells: harnessing cell plasticity to

... been derived from humans and thus are available for human experimentation, they pose several disadvantages: Primarily, in the mouse, these cells have been found to cause the formation of teratomas and teratocarcinomas, even when induced to differentiate, due to few residual cells that remain as stem ...
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Peptide-Binding Specificity Molecule, Defines a New Supertype of

The Lymphatic and Immune Systems
The Lymphatic and Immune Systems

... Infectious Mononucleosis •Also called the kissing disease •An acute infectious disease caused by the Epstein-Barr virus •Swollen lymph nodes are a common symptom ...
Why drink a protein shake for breakfast? Protein is essential to our
Why drink a protein shake for breakfast? Protein is essential to our

... If your body gets the carbs/glucose it needs in a nice steady stream (no sugar rush), your body is jump-started and ready for the day: Your metabolism gets going converting glucose and fat to energy instead of storing your toast or breakfast cereal as fat, you feel full not hungry and are less likel ...
ANTIVIRAL ANTIBODY-PRODUCING CELLS IN
ANTIVIRAL ANTIBODY-PRODUCING CELLS IN

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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