CD4 T-Cell Th1 Response
... in the cervical transformation zone (Pudney. Biol Reprod. 2005;73:1253) The most likely site of entry of HIV is the transformation zone ...
... in the cervical transformation zone (Pudney. Biol Reprod. 2005;73:1253) The most likely site of entry of HIV is the transformation zone ...
Arabidopsis Sec21p and Sec23p Homologs. Probable Coat Proteins
... both the ER and the Golgi membranes. This could be in agreement with the notion that COPII vesicles are formed at the ER, whereas COPI vesicles can be made by both Golgi and ER membranes. Both AtSec21p and AtSec23p antigens were detected on membranes equilibrating at sucrose densities equivalent to ...
... both the ER and the Golgi membranes. This could be in agreement with the notion that COPII vesicles are formed at the ER, whereas COPI vesicles can be made by both Golgi and ER membranes. Both AtSec21p and AtSec23p antigens were detected on membranes equilibrating at sucrose densities equivalent to ...
Targeting human CD27 with an agonist antibody stimulates T
... This antibody exhibits a high affinity for both the human and macaque variants of CD27, binds to this TNFRSF member expressed on the cell surface, and blocks CD70 binding, suggesting that 1F5 may bind to (or near to) the ligand-binding site of CD27.3 To perform in vivo studies based on the 1F5 antib ...
... This antibody exhibits a high affinity for both the human and macaque variants of CD27, binds to this TNFRSF member expressed on the cell surface, and blocks CD70 binding, suggesting that 1F5 may bind to (or near to) the ligand-binding site of CD27.3 To perform in vivo studies based on the 1F5 antib ...
Policy Forum
... responses to infection are insufficient to prevent these events; what is less clear is whether they have any role in controlling mucosal viral replication, viral evolution, and immune cell depletion [9,11]. A number of studies have identified a paucity in the induction of robust HIV-specific mucosal im ...
... responses to infection are insufficient to prevent these events; what is less clear is whether they have any role in controlling mucosal viral replication, viral evolution, and immune cell depletion [9,11]. A number of studies have identified a paucity in the induction of robust HIV-specific mucosal im ...
Macrophage Polarization at the Crossroad Between HIV
... and other microbial pathogens. In addition, they are likely involved in several steps of cancer development. Circulating monocytes and tissue macrophages are target cells of viral infections, including human cytomegalovirus, human herpes virus 8, and the HIV, and alterations of their functional and ...
... and other microbial pathogens. In addition, they are likely involved in several steps of cancer development. Circulating monocytes and tissue macrophages are target cells of viral infections, including human cytomegalovirus, human herpes virus 8, and the HIV, and alterations of their functional and ...
The MHC complex
... With similar function ensures that each individual produces a number of different MHC molecules ...
... With similar function ensures that each individual produces a number of different MHC molecules ...
Determination of the temporal pattern and importance of BALF1 expression in
... To determine whether BALF1 is necessary for the prevention of apoptosis in EBVinfected cells, we will assay the degree of apoptosis in cells infected with either wild-type EBV or BALF1-knockout EBV. The knockout strain will be constructed by treating wtEBV with appropriate restriction enzymes to re ...
... To determine whether BALF1 is necessary for the prevention of apoptosis in EBVinfected cells, we will assay the degree of apoptosis in cells infected with either wild-type EBV or BALF1-knockout EBV. The knockout strain will be constructed by treating wtEBV with appropriate restriction enzymes to re ...
infected cells expressing H2-D k and CMV - JEM
... and ␣2 from H2-Db were fused with the ␣3, transmembrane (TM), and CT domains of H2-Dk (Db␣1␣2Dk␣3). ␣1, ␣2, and ␣3 from H2-Db were fused with the TM and CT domains of H2-Dk (Db␣1␣2␣3Dk). ␣1 and ␣2 from H2-Dk were fused with the ␣3, TM, and CT domains of H2-Db (Dk␣1␣2 Db␣3). ␣1, ␣2, and ␣3 from H2-Dk ...
... and ␣2 from H2-Db were fused with the ␣3, transmembrane (TM), and CT domains of H2-Dk (Db␣1␣2Dk␣3). ␣1, ␣2, and ␣3 from H2-Db were fused with the TM and CT domains of H2-Dk (Db␣1␣2␣3Dk). ␣1 and ␣2 from H2-Dk were fused with the ␣3, TM, and CT domains of H2-Db (Dk␣1␣2 Db␣3). ␣1, ␣2, and ␣3 from H2-Dk ...
Inflammatory Micro-Environmental Cues of
... In all the AAA tissues analyzed, but none of the control aortas, the immunohistochemical analysis revealed a prototypic organization of the immune infiltrates in the media and the adventitia where massive CD20+ B cell follicles were surrounded by T cells (CD3) (Fig. 1A), suggestive of mature aortic ...
... In all the AAA tissues analyzed, but none of the control aortas, the immunohistochemical analysis revealed a prototypic organization of the immune infiltrates in the media and the adventitia where massive CD20+ B cell follicles were surrounded by T cells (CD3) (Fig. 1A), suggestive of mature aortic ...
Successful Plating Strategies
... clones have already been identified, the cells should be single-cell-cloned as early as possible. This can be performed as early as when the hybridomas are expanded off the fusion plates. Techniques for the freezing and storage of hybridoma cell lines are described in Chapter 8. Often it is difficul ...
... clones have already been identified, the cells should be single-cell-cloned as early as possible. This can be performed as early as when the hybridomas are expanded off the fusion plates. Techniques for the freezing and storage of hybridoma cell lines are described in Chapter 8. Often it is difficul ...
The promise of cd T cells and the cd T cell receptor for cancer
... The adaptive immune compartment comprises of three distinct cell subsets, namely B cells, T cells expressing an ab T cell receptor (TCR) and T cells expressing a cd TCR. These cells generate their defining B cell receptors (BCRs), or TCRs using somatic V(D)J recombination which enables them to recog ...
... The adaptive immune compartment comprises of three distinct cell subsets, namely B cells, T cells expressing an ab T cell receptor (TCR) and T cells expressing a cd TCR. These cells generate their defining B cell receptors (BCRs), or TCRs using somatic V(D)J recombination which enables them to recog ...
Cell-based strategies/therapies for cartilage - HAL
... function of MSCs as well as matrix metalloproteinases (MMPs) and tissue inhibitors of MMP (TIMPs) [25,26], while SDF-1 and Sfrp2 have been identified as anti-apoptotic factors [27,28]. The combination of the different functional roles of secreted factors may be of interest for joint tissue regenerat ...
... function of MSCs as well as matrix metalloproteinases (MMPs) and tissue inhibitors of MMP (TIMPs) [25,26], while SDF-1 and Sfrp2 have been identified as anti-apoptotic factors [27,28]. The combination of the different functional roles of secreted factors may be of interest for joint tissue regenerat ...
BCelsa_WDA
... sufficient representative antibodies and/or sufficient structure/function correlation between modifying the VL or VH regions of their disclosed antibody and the retention of high affinity antagonistic binding to satisfy the WD requirement for claim 2. -result is consistent with Revised Training Mate ...
... sufficient representative antibodies and/or sufficient structure/function correlation between modifying the VL or VH regions of their disclosed antibody and the retention of high affinity antagonistic binding to satisfy the WD requirement for claim 2. -result is consistent with Revised Training Mate ...
Template for PowerPoint Use
... sufficient representative antibodies and/or sufficient structure/function correlation between modifying the VL or VH regions of their disclosed antibody and the retention of high affinity antagonistic binding to satisfy the WD requirement for claim 2. -result is consistent with Revised Training Mate ...
... sufficient representative antibodies and/or sufficient structure/function correlation between modifying the VL or VH regions of their disclosed antibody and the retention of high affinity antagonistic binding to satisfy the WD requirement for claim 2. -result is consistent with Revised Training Mate ...
OX40 ligand newly expressed on bronchiolar progenitors mediates
... are not simply a repeat of what has been published before, which claimed that OX40-OX40L interactions drive an exacerbated T cell response to flu virus that causes pathology (Humphreys et al, JEM, 2003). Although the data as presented look convincing, this experiment was apparently only 1 experiment ...
... are not simply a repeat of what has been published before, which claimed that OX40-OX40L interactions drive an exacerbated T cell response to flu virus that causes pathology (Humphreys et al, JEM, 2003). Although the data as presented look convincing, this experiment was apparently only 1 experiment ...
Dissecting the human immunologic memory for pathogens
... in the blood on day 7, and antibody titers increase concomitantly to reach a plateau on day 10 (25). Intriguingly, we were able to detect rare plasma cells among the newly generated plasma cell pool, which produce antibodies against antigens to which the donor was immune but had not been exposed ove ...
... in the blood on day 7, and antibody titers increase concomitantly to reach a plateau on day 10 (25). Intriguingly, we were able to detect rare plasma cells among the newly generated plasma cell pool, which produce antibodies against antigens to which the donor was immune but had not been exposed ove ...
Complexity of interferon-γ interactions with HSV-1
... persistence are complex. Herpes simplex virus type 1 (HSV-1) uses a variety of receptors to enter cells and is transported to and from the host cell nucleus over the microtubule railroad via retrograde and anterograde transport. IFN-γ exerts dual but conflicting effects on microtubule organization. ...
... persistence are complex. Herpes simplex virus type 1 (HSV-1) uses a variety of receptors to enter cells and is transported to and from the host cell nucleus over the microtubule railroad via retrograde and anterograde transport. IFN-γ exerts dual but conflicting effects on microtubule organization. ...
Immune response to fungal infections
... present early in evolution (innate immunity) to sophisticated adaptive mechanisms that are induced specifically during infection and disease (adaptive immunity). The first-line innate mechanism is the presence of physical barriers in the form of skin and mucous membranes, which is complemented by ce ...
... present early in evolution (innate immunity) to sophisticated adaptive mechanisms that are induced specifically during infection and disease (adaptive immunity). The first-line innate mechanism is the presence of physical barriers in the form of skin and mucous membranes, which is complemented by ce ...