Transcripts
... a sterile environment. And if you do that, those animals actually do live and can reproduce. However, interestingly enough, those animals grow at a very different rate than normal litter-made animals that would have that bacteria or normal commensal microbiota. So it’s very clear that having those m ...
... a sterile environment. And if you do that, those animals actually do live and can reproduce. However, interestingly enough, those animals grow at a very different rate than normal litter-made animals that would have that bacteria or normal commensal microbiota. So it’s very clear that having those m ...
Systems biology in vaccine design
... is a biological preparation that improves immunity to a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antige ...
... is a biological preparation that improves immunity to a particular disease upon administration to an animal/ human. A vaccine typically contains one or several antigens that resemble a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its derived antige ...
Granzyme A activates another way to die
... mice. Other cytokines implicated in regulating Gzms and PFN are the IL-6 ⁄ IL-12 family (81, 82). Little is known about what transcriptional factors regulate GzmA expression. GzmB has recently been shown to be expressed without PFN in a variety of non-cytolytic cell (especially during inflammation), ...
... mice. Other cytokines implicated in regulating Gzms and PFN are the IL-6 ⁄ IL-12 family (81, 82). Little is known about what transcriptional factors regulate GzmA expression. GzmB has recently been shown to be expressed without PFN in a variety of non-cytolytic cell (especially during inflammation), ...
Cancer Immunotherapy: Whence and Whither
... affinities and with subtly different T-cell–activating outcomes. They both can also interact with CTLA-4 in an inhibitory capacity. The bottom panel shows that antibodies that interrupt the engagement of these surface molecules can reverse their activating or inhibitory functions. ...
... affinities and with subtly different T-cell–activating outcomes. They both can also interact with CTLA-4 in an inhibitory capacity. The bottom panel shows that antibodies that interrupt the engagement of these surface molecules can reverse their activating or inhibitory functions. ...
Licentiate thesis from the Department of Immunology
... Granuloma formation is the hallmark of M. tuberculosis infection. Granulomas are formed in response to chronic local antigenic stimulation, and can be observed in different infectious diseases, including schistosomiasis, leprosy, and leishmaniasis (Reyes-Flores, 1986; Modlin and Rea, 1988; Palma and ...
... Granuloma formation is the hallmark of M. tuberculosis infection. Granulomas are formed in response to chronic local antigenic stimulation, and can be observed in different infectious diseases, including schistosomiasis, leprosy, and leishmaniasis (Reyes-Flores, 1986; Modlin and Rea, 1988; Palma and ...
Innate Immunity: Nonspecific Defenses of the Host
... KEY CONCEPTS The complement system is another way the body fights infection and destroys pathogens. This component of innate immunity “complements” other immune reactions. Complement is a group of over 30 proteins circulating in serum that are activated in a cascade: one complement protein triggers ...
... KEY CONCEPTS The complement system is another way the body fights infection and destroys pathogens. This component of innate immunity “complements” other immune reactions. Complement is a group of over 30 proteins circulating in serum that are activated in a cascade: one complement protein triggers ...
Human embryonic stem cells and therapeutic cloning
... hES cells upon differentiation express the molecules, indicating that immune rejection can be occurred [18]. The strategy being proposed for immunocompatibility of stem cell transplantation is the creation of hES cell bank that will accommodate all different immune types of hES cells for all potenti ...
... hES cells upon differentiation express the molecules, indicating that immune rejection can be occurred [18]. The strategy being proposed for immunocompatibility of stem cell transplantation is the creation of hES cell bank that will accommodate all different immune types of hES cells for all potenti ...
Soluble β-glucan and heparin as modulators of the immune
... monoclonal antibody therapy is therapeutic vaccination. The aim of this treatment strategy is to persuade the immune system to endogenously produce antibodies against tumor-associated antigens, rendering exogenous addition of these “magic bullets” superfluous. Therapeutic vaccination has the potenti ...
... monoclonal antibody therapy is therapeutic vaccination. The aim of this treatment strategy is to persuade the immune system to endogenously produce antibodies against tumor-associated antigens, rendering exogenous addition of these “magic bullets” superfluous. Therapeutic vaccination has the potenti ...
Metals-and-Oxidative-Stress
... low EGF levels which are corrected by Cbl replacement The transcobalamin receptor is upregulated by TNF- ...
... low EGF levels which are corrected by Cbl replacement The transcobalamin receptor is upregulated by TNF- ...
functions occur only through constant mutualism with the INTRODUCTION
... stimulation of Tregs, which are the most important immune T cells aimed at suppressing immune responses to microbetriggered intestinal inflammation. For instance, it has been reported that several species of bacteria such as altered Schaedler flora resulted in a de novo expansion of mucosal Tregs in ...
... stimulation of Tregs, which are the most important immune T cells aimed at suppressing immune responses to microbetriggered intestinal inflammation. For instance, it has been reported that several species of bacteria such as altered Schaedler flora resulted in a de novo expansion of mucosal Tregs in ...
MUCOSAL IMMUNITY IN THE RESPIRATORY TRACT: INTRACELLULAR PATHOGENS
... of recognizing and eliminating a large range of microorganisms (viruses, bacteria and parasites) and other potentially dangerous agents. The immune response has been historically divided in two parts, one is phylogenetically the oldest and is called innate immunity, and the other is called adaptive ...
... of recognizing and eliminating a large range of microorganisms (viruses, bacteria and parasites) and other potentially dangerous agents. The immune response has been historically divided in two parts, one is phylogenetically the oldest and is called innate immunity, and the other is called adaptive ...
Tesi unita 08 - Padua@Research
... hampered by some of its characteristics, which make it difficult to be cultured in vitro. Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In t ...
... hampered by some of its characteristics, which make it difficult to be cultured in vitro. Little is know about how T. pallidum causes the syphilis, and in particular how T. pallidum survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In t ...
Down-regulation of miR-302c and miR
... To explore the potential mechanisms by which 1,25(OH)2D3 enhances the susceptibility of Kasumi-1 and MDA-MB-231 cells to NK92 cells, we screened the miRNAs that were modulated by 1,25(OH)2D3 in Kasumi-1 cells using a miRNA microarray (Fig. 2A). Two highly down-regulated miRNAs, miR-302c and miR-520c ...
... To explore the potential mechanisms by which 1,25(OH)2D3 enhances the susceptibility of Kasumi-1 and MDA-MB-231 cells to NK92 cells, we screened the miRNAs that were modulated by 1,25(OH)2D3 in Kasumi-1 cells using a miRNA microarray (Fig. 2A). Two highly down-regulated miRNAs, miR-302c and miR-520c ...
Trogocytosis-associated cell to cell spread of intracellular bacterial
... Orange arrow- second bacterial transfer event. Movie available as Video 1. (B) The proportion of recipient macrophages infected after a 6 hr coincubation with infected cells of the same type (3 independent experiments performed in triplicate). (C) A representative histogram of the amount of calcein ...
... Orange arrow- second bacterial transfer event. Movie available as Video 1. (B) The proportion of recipient macrophages infected after a 6 hr coincubation with infected cells of the same type (3 independent experiments performed in triplicate). (C) A representative histogram of the amount of calcein ...
Genes that Matter™…
... encoding the IgM heavy chain, λ5, Igα, or BLNK. Mutations in LRRC8 may be autosomal dominant. The autosomal form of agammaglobulinemia affects both males and females.66 HIGM1 is caused by X-linked recessive loss-of-function mutations in CD40LG, which codes for CD40L, and almost exclusively affects m ...
... encoding the IgM heavy chain, λ5, Igα, or BLNK. Mutations in LRRC8 may be autosomal dominant. The autosomal form of agammaglobulinemia affects both males and females.66 HIGM1 is caused by X-linked recessive loss-of-function mutations in CD40LG, which codes for CD40L, and almost exclusively affects m ...
Hematology review Mihaela Mates PGY3 – Internal Medicine
... A monoclonal immunoglobulin in the serum or a single light chain in the urine is found (SPEP, UPEP) and marrow plasmocytosis Hypercalcemia and renal failure are frequent Lytic bone lesions are classical but osteoporosis is more common (alk phos is normal) The blood film shows rouleaux High ESR ...
... A monoclonal immunoglobulin in the serum or a single light chain in the urine is found (SPEP, UPEP) and marrow plasmocytosis Hypercalcemia and renal failure are frequent Lytic bone lesions are classical but osteoporosis is more common (alk phos is normal) The blood film shows rouleaux High ESR ...
Current progress in beta-amyloid immunotherapy
... After immunization with Ab, the peptide is processed by antigen-presenting cells in the periphery and then presented to T and B cells. Epitope mapping of these events following Ab immunization in AD patients indicates that the predominance of T-cell epitopes lies in the central to carboxy-terminal r ...
... After immunization with Ab, the peptide is processed by antigen-presenting cells in the periphery and then presented to T and B cells. Epitope mapping of these events following Ab immunization in AD patients indicates that the predominance of T-cell epitopes lies in the central to carboxy-terminal r ...
International Journal of Antimicrobial Agents Database screening
... catheter at 24 h and 48 h post infection. Mice were euthanised by an overdose of inhaled isoflurane at Days 3 and 14 post infection to quantitate bacterial burdens associated with catheters and the surrounding tissues. Catheters were removed using aseptic technique, immediately placed in 1 mL of PBS ...
... catheter at 24 h and 48 h post infection. Mice were euthanised by an overdose of inhaled isoflurane at Days 3 and 14 post infection to quantitate bacterial burdens associated with catheters and the surrounding tissues. Catheters were removed using aseptic technique, immediately placed in 1 mL of PBS ...
Hematologic Aspects of HIV/AIDS - hem
... presence of the virus.17 This has been further supported by data from other laboratories evaluating the potential for adult human stem cell populations to be directly infected. Weichold and Young found that long term culture initiating cells assays (LTC-IC) were not affected by prior exposure of cel ...
... presence of the virus.17 This has been further supported by data from other laboratories evaluating the potential for adult human stem cell populations to be directly infected. Weichold and Young found that long term culture initiating cells assays (LTC-IC) were not affected by prior exposure of cel ...
Chapter 20
... Lymphatic collecting vessels contain valves that act as smooth muscle pumps to move lymph toward heart. Travel with veins in superficial tissues/arteries in deeper tissues. Have the same three tunics as blood vessels but walls are much thinner and lymph pressure is very low. They also have lymph nod ...
... Lymphatic collecting vessels contain valves that act as smooth muscle pumps to move lymph toward heart. Travel with veins in superficial tissues/arteries in deeper tissues. Have the same three tunics as blood vessels but walls are much thinner and lymph pressure is very low. They also have lymph nod ...