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Terbutaline Sulfate Tablets
... receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta2-receptors in the human heart, existing in a concentration between 10% to 50%. The precise function of these receptors has not been established (see WARNINGS). In controlled clinical ...
... receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta2-receptors in the human heart, existing in a concentration between 10% to 50%. The precise function of these receptors has not been established (see WARNINGS). In controlled clinical ...
AERIUS® AERIUS KIDS®
... Psychomotor Pharmacodynamics: Clinical trials have demonstrated that there was no difference in the incidence of somnolence in subjects treated with AERIUS (desloratadine) 5 mg as compared to subjects treated with placebo. No significant differences were found in the psychomotor test results betwee ...
... Psychomotor Pharmacodynamics: Clinical trials have demonstrated that there was no difference in the incidence of somnolence in subjects treated with AERIUS (desloratadine) 5 mg as compared to subjects treated with placebo. No significant differences were found in the psychomotor test results betwee ...
butorphanol tartrate injection usp
... Because butorphanol may increase the work of the heart, especially the pulmonary circuit, the use of butorphanol in patients with acute myocardial infarction, ventricular dysfunction, or coronary insufficiency should be limited to those situations where the benefits clearly outweigh the risk (see CL ...
... Because butorphanol may increase the work of the heart, especially the pulmonary circuit, the use of butorphanol in patients with acute myocardial infarction, ventricular dysfunction, or coronary insufficiency should be limited to those situations where the benefits clearly outweigh the risk (see CL ...
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate
... Recognized first-line tests of genotoxicity gave negative results when conducted with CPA. However, further tests showed that CPA was capable of producing adducts with DNA (and an increase in DNA repair activity) in liver cells from rats and monkeys and also in freshly isolated human hepatocytes. Th ...
... Recognized first-line tests of genotoxicity gave negative results when conducted with CPA. However, further tests showed that CPA was capable of producing adducts with DNA (and an increase in DNA repair activity) in liver cells from rats and monkeys and also in freshly isolated human hepatocytes. Th ...
PRODUCT MONOGRAPH METADOL
... arrhythmia (torsades de pointes) have been observed during treatment with methadone. These cases appear to be more commonly associated with, but not limited to, higher dose treatment (>200 mg/day). Most cases involve patients being treated for pain with large, multiple daily doses of methadone, alth ...
... arrhythmia (torsades de pointes) have been observed during treatment with methadone. These cases appear to be more commonly associated with, but not limited to, higher dose treatment (>200 mg/day). Most cases involve patients being treated for pain with large, multiple daily doses of methadone, alth ...
yeast research - Biofarmaka IPB
... and 3. The MICs of xanthorrhizol, ketoconazole, and amphotericin B alone against six Candida species were significantly higher than MICs in combination (xanthorrhizol–ketoconazole or xanthorrhizol–amphotericin B). FICI of xanthorrhizol in combination with ketoconazole against C. albicans, C. glabrat ...
... and 3. The MICs of xanthorrhizol, ketoconazole, and amphotericin B alone against six Candida species were significantly higher than MICs in combination (xanthorrhizol–ketoconazole or xanthorrhizol–amphotericin B). FICI of xanthorrhizol in combination with ketoconazole against C. albicans, C. glabrat ...
Effects of Self-Administered Cocaine on Plasma Adrenocorticotropic
... were reported to be significantly elevated above levels measured before cocaine exposure for all of the doses of cocaine that were tested. However, there was no indication as to whether this increase was dose-dependent in terms of either the dose of cocaine that was available, or the number of infus ...
... were reported to be significantly elevated above levels measured before cocaine exposure for all of the doses of cocaine that were tested. However, there was no indication as to whether this increase was dose-dependent in terms of either the dose of cocaine that was available, or the number of infus ...
the absorption, distribution, metabolism and excretion of rofecoxib, a
... Disposition and metabolism of [14C]rofecoxib in rats and dogs. [14C]Rofecoxib was administered i.v. to rats (n ⫽ 4) by tail vein injection (0.5 ml/kg) at a dose of 2 mg/kg. The oral dose (5 mg/kg) was administered to a second group of animals (n ⫽ 4) by oral gavage (5 ml/kg). In dogs (n ⫽ 4), the i. ...
... Disposition and metabolism of [14C]rofecoxib in rats and dogs. [14C]Rofecoxib was administered i.v. to rats (n ⫽ 4) by tail vein injection (0.5 ml/kg) at a dose of 2 mg/kg. The oral dose (5 mg/kg) was administered to a second group of animals (n ⫽ 4) by oral gavage (5 ml/kg). In dogs (n ⫽ 4), the i. ...
ENCLOSURE 1
... were exposed to ragweed pollen in an environmental exposure unit. In 1 clinical trial conducted with fexofenadine hydrochloride 60 mg capsules, and in 1 clinical trial conducted with fexofenadine hydrochloride and pseudoephedrine 12 Hour extended release tablets, onset of action was seen within 1 to ...
... were exposed to ragweed pollen in an environmental exposure unit. In 1 clinical trial conducted with fexofenadine hydrochloride 60 mg capsules, and in 1 clinical trial conducted with fexofenadine hydrochloride and pseudoephedrine 12 Hour extended release tablets, onset of action was seen within 1 to ...
Sedation and Analgesia in the PICU
... SEDATION and ANALGESIA • Inadequate analgesia and postsurgical stress response is a metabolic, humoral, and hemodynamic response following injury or surgery • This neuroendocrine cascade leads to increased oxygen consumption, increased carbon dioxide production, and a generalized catabolic state wit ...
... SEDATION and ANALGESIA • Inadequate analgesia and postsurgical stress response is a metabolic, humoral, and hemodynamic response following injury or surgery • This neuroendocrine cascade leads to increased oxygen consumption, increased carbon dioxide production, and a generalized catabolic state wit ...
Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline
... Current guidelines for the treatment of asthma recommend short-acting b2-adrenoceptor agonists for symptom relief and long-acting b2-agonists for control [1, 2]. Among the long-acting compounds, salmeterol and formoterol are known to have a similar duration of action in terms of bronchodilation and ...
... Current guidelines for the treatment of asthma recommend short-acting b2-adrenoceptor agonists for symptom relief and long-acting b2-agonists for control [1, 2]. Among the long-acting compounds, salmeterol and formoterol are known to have a similar duration of action in terms of bronchodilation and ...
Comparing Inhaled Corticosteroids
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
Behavioral Profiles in Rats Distinguish Among “Ecstasy
... completely generalize the MDMA cue to amphetamine, but only partially to LSD and DOM (2,5-dimethoxy-4-methylamphetamine, an analogue of DOI), and at disruptive doses of the latter drugs. Conversely, MDMA weakly substituted for amphetamine in not more than 25% of the animals tested (Oberlender & Nich ...
... completely generalize the MDMA cue to amphetamine, but only partially to LSD and DOM (2,5-dimethoxy-4-methylamphetamine, an analogue of DOI), and at disruptive doses of the latter drugs. Conversely, MDMA weakly substituted for amphetamine in not more than 25% of the animals tested (Oberlender & Nich ...
Diltiazem Hydrochloride Extended-Release Capsules, USP
... reactions tended to occur early after therapy initiation (1 to 8 weeks) and have been reversible upon discontinuation of drug therapy. The relationship to diltiazem is uncertain in some cases, but probable in some (see PRECAUTIONS). PRECAUTIONS General Diltiazem hydrochloride is extensively metaboli ...
... reactions tended to occur early after therapy initiation (1 to 8 weeks) and have been reversible upon discontinuation of drug therapy. The relationship to diltiazem is uncertain in some cases, but probable in some (see PRECAUTIONS). PRECAUTIONS General Diltiazem hydrochloride is extensively metaboli ...
Preclinical Absorption, Distribution, Metabolism, and Excretion of an
... Increased survival time with improved quality of life was reported compared to the standard dosing regimen in a Phase II study where gemcitabine was infused over 24 h at a 10-fold lower dose (100 mg/m2) to patients with advanced pancreatic adenocarcinoma [20]. Collectively, these clinical studies in ...
... Increased survival time with improved quality of life was reported compared to the standard dosing regimen in a Phase II study where gemcitabine was infused over 24 h at a 10-fold lower dose (100 mg/m2) to patients with advanced pancreatic adenocarcinoma [20]. Collectively, these clinical studies in ...
Albuterol Sulfate Inhalation Solution 0.083%*
... It has been demonstrated that following oral administration of 4 mg albuterol, the elimination half-life was five to six hours. Animal studies show that albuterol does not pass the blood-brain barrier. Recent studies in laboratory animals (minipigs, rodents, and dogs) recorded the occurrence of card ...
... It has been demonstrated that following oral administration of 4 mg albuterol, the elimination half-life was five to six hours. Animal studies show that albuterol does not pass the blood-brain barrier. Recent studies in laboratory animals (minipigs, rodents, and dogs) recorded the occurrence of card ...
Effects of Acute and Repeated Administration of Oxycodone and
... by oxycodone, continues to increase, producing twice as many overdose deaths as heroin. Surprisingly, preclinical reports relevant to oxycodone’s abuse-related effects are relatively sparse considering its history and patient usage. The goal of this study was to characterize dose- and time-dependent ...
... by oxycodone, continues to increase, producing twice as many overdose deaths as heroin. Surprisingly, preclinical reports relevant to oxycodone’s abuse-related effects are relatively sparse considering its history and patient usage. The goal of this study was to characterize dose- and time-dependent ...
as hydrochloride - Therapeutic Goods Administration
... Olodaterol is a selective long acting beta 2 adrenergic agonist (LABA). Activation of beta 2 receptors in the airways results in stimulation of intracellular adenyl cyclase, which mediates the synthesis of cyclic-3’, 5’ adenosine monophosphate (cAMP). Elevated levels of cAMP in turn induce bronchodi ...
... Olodaterol is a selective long acting beta 2 adrenergic agonist (LABA). Activation of beta 2 receptors in the airways results in stimulation of intracellular adenyl cyclase, which mediates the synthesis of cyclic-3’, 5’ adenosine monophosphate (cAMP). Elevated levels of cAMP in turn induce bronchodi ...
Dopamine and Benzodiazepine-Dependent Mechanisms
... et al (2001) were maintained as separate wild-type and knockout mouse lines by breeding mice of the same genotype. In contrast, the mice of Vicini et al (2001) were always maintained by interbreeding of heterozygotes. Lastly, the mice of Sur et al (2001) were of a mixed C57BL/6J Strain 129/SvEv ge ...
... et al (2001) were maintained as separate wild-type and knockout mouse lines by breeding mice of the same genotype. In contrast, the mice of Vicini et al (2001) were always maintained by interbreeding of heterozygotes. Lastly, the mice of Sur et al (2001) were of a mixed C57BL/6J Strain 129/SvEv ge ...
Central nervous system effects of caffeine and adenosine on fatigue
... Another possibility that has received little scientific attention is that the ergogenic effect of caffeine ingestion occurs primarily through stimulation of the central nervous system (CNS). Caffeine, a potent adenosine antagonist, is a CNS stimulant that easily crosses the blood-brain barrier (BBB) ...
... Another possibility that has received little scientific attention is that the ergogenic effect of caffeine ingestion occurs primarily through stimulation of the central nervous system (CNS). Caffeine, a potent adenosine antagonist, is a CNS stimulant that easily crosses the blood-brain barrier (BBB) ...
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... have a hearing disorder, especially if you are elderly (you may need hearing tests during treatment). ...
... have a hearing disorder, especially if you are elderly (you may need hearing tests during treatment). ...
Product Information - Therapeutic Goods Administration
... binding-adjusted IC95 for wild-type HIV-1 virus). Corresponding steady-state mean Cmax, AUCtau, and Ctrough (mean ± SD) were 1.1 ± 0.40 μg/mL, 8.3 ± 3.8 μg•hr/mL, and 0.05 ± 1.3 μg/mL for cobicistat, 1.9 ± 0.5 μg/mL, 13 ± 4.5 μg•hr/mL, and 0.14 ± 0.25 μg/mL for emtricitabine, and 0.45 ± 0.16 μg/mL, ...
... binding-adjusted IC95 for wild-type HIV-1 virus). Corresponding steady-state mean Cmax, AUCtau, and Ctrough (mean ± SD) were 1.1 ± 0.40 μg/mL, 8.3 ± 3.8 μg•hr/mL, and 0.05 ± 1.3 μg/mL for cobicistat, 1.9 ± 0.5 μg/mL, 13 ± 4.5 μg•hr/mL, and 0.14 ± 0.25 μg/mL for emtricitabine, and 0.45 ± 0.16 μg/mL, ...
1. name of the medicinal product
... There was an increased reporting of lower respiratory tract infections (particularly pneumonia and bronchitis) in the TORCH study in patients with COPD receiving salmeterol/fluticasone propionate 50/500 micrograms twice daily compared with placebo as well as in studies SCO40043 and SCO100250 compari ...
... There was an increased reporting of lower respiratory tract infections (particularly pneumonia and bronchitis) in the TORCH study in patients with COPD receiving salmeterol/fluticasone propionate 50/500 micrograms twice daily compared with placebo as well as in studies SCO40043 and SCO100250 compari ...
Curcumin Analogs as Anticancer Agents
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
Product Information
... Caffeine is a methylxanthine and is structurally related to other methylxanthines such as theophylline. Pharmacodynamics Caffeine is a centrally acting respiratory stimulant. It increases respiratory rate (breaths/minute) significantly in premature infants and significantly reduces the number of sho ...
... Caffeine is a methylxanthine and is structurally related to other methylxanthines such as theophylline. Pharmacodynamics Caffeine is a centrally acting respiratory stimulant. It increases respiratory rate (breaths/minute) significantly in premature infants and significantly reduces the number of sho ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.