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A pharmacologic strategy for the treatment of nicotine addiction
... receptor (Ashby et al., 1999). For the treatment of brain disorders such as drug addiction, Parkinson’s disease, and mental illness, the use of specific suicide inhibitors of an enzyme, like GVG, offers advantages unique to their biochemical mode of action. First, suicide inhibitors are typically lo ...
... receptor (Ashby et al., 1999). For the treatment of brain disorders such as drug addiction, Parkinson’s disease, and mental illness, the use of specific suicide inhibitors of an enzyme, like GVG, offers advantages unique to their biochemical mode of action. First, suicide inhibitors are typically lo ...
Evaluation of Pharmacokinetic Interaction between PA
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
Ceftolozane (as sulfate) / Tazobactam (as sodium salt)
... combined (n = 30). No dose adjustment is recommended based on ethnicity. CLINICAL TRIALS Zerbaxa (ceftolozane/tazobactam) demonstrated clinical and microbiological efficacy against ESBLproducing E. coli (CTX-M-14/15 producing isolates) and K. pneumoniae (CTX-M-15 producing isolates) in two well-cont ...
... combined (n = 30). No dose adjustment is recommended based on ethnicity. CLINICAL TRIALS Zerbaxa (ceftolozane/tazobactam) demonstrated clinical and microbiological efficacy against ESBLproducing E. coli (CTX-M-14/15 producing isolates) and K. pneumoniae (CTX-M-15 producing isolates) in two well-cont ...
Albuterol Sulfate Inhalation Solution 0.5%
... there may be no acceptable alternatives to the use of betaadrenergic blocking agents in patients with asthma. In this setting, cardioselective beta blockers could be considered, although they should be administered with caution. Diuretics: The ECG changes and/or hypokalemia that may result from the ...
... there may be no acceptable alternatives to the use of betaadrenergic blocking agents in patients with asthma. In this setting, cardioselective beta blockers could be considered, although they should be administered with caution. Diuretics: The ECG changes and/or hypokalemia that may result from the ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
Influence of Vesicle Size, Lipid Composition, and
... Tissue Distribution Studies. Doxorubicin, as free drug or in liposomeLiposomal Preparation. Vesicles were prepared by hydrating a lipid encapsulated form, was injected via a tail vein at a dose of 20 mg/kg film (dried down from (ÕKÕ,for 12 h under high vacuum) in the body weight to groups of five ...
... Tissue Distribution Studies. Doxorubicin, as free drug or in liposomeLiposomal Preparation. Vesicles were prepared by hydrating a lipid encapsulated form, was injected via a tail vein at a dose of 20 mg/kg film (dried down from (ÕKÕ,for 12 h under high vacuum) in the body weight to groups of five ...
Buprenorphine and Naloxone: Clinical Pharmacology Abuse Liability
... – Naloxone absorption will be minimal If taken intravenously – Naloxone now100% bioavailable – Precipitated withdrawal occurs Purchasers of Suboxone will find seller and expresses displeasure ...
... – Naloxone absorption will be minimal If taken intravenously – Naloxone now100% bioavailable – Precipitated withdrawal occurs Purchasers of Suboxone will find seller and expresses displeasure ...
Effects of Temperature and Drugs on Frog Heart
... increases in both systolic and diastolic blood pressure. Such doses may have no effect on these parameters in those who consume caffeine regularly. ARRHYTHMIAS At higher concentrations (>10 mg/kg/day) caffeine produces definite tachycardia54; sensitive individuals may experience other arrhythmias55, ...
... increases in both systolic and diastolic blood pressure. Such doses may have no effect on these parameters in those who consume caffeine regularly. ARRHYTHMIAS At higher concentrations (>10 mg/kg/day) caffeine produces definite tachycardia54; sensitive individuals may experience other arrhythmias55, ...
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50
... risk for renal stone formation and associated signs and symptoms such as renal colic, renal pain or flank pain. Risk factors for nephrolithiasis include prior stone formation, a family history or nephrolithiasis and hypercalciuria. None of these risk factors can reliably predict stone formation duri ...
... risk for renal stone formation and associated signs and symptoms such as renal colic, renal pain or flank pain. Risk factors for nephrolithiasis include prior stone formation, a family history or nephrolithiasis and hypercalciuria. None of these risk factors can reliably predict stone formation duri ...
Comprised by BVV Melatonin: Melatonin is a substance produced
... The internal body clock regulates the body hormonal and temperature rhythms. Without melatonin , the internal body clock can change approximately one half hour per day. Thus a hour change in sleep schedule will take approximately two days. This ability to change decreases with age. If not given any ...
... The internal body clock regulates the body hormonal and temperature rhythms. Without melatonin , the internal body clock can change approximately one half hour per day. Thus a hour change in sleep schedule will take approximately two days. This ability to change decreases with age. If not given any ...
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
Evaluation of Diuretic activities of hydro
... In 1553, mercurous chloride (calomel), inorganic mercury, was recorded by Paracelsus to be the first effective diuretic therapy for edema (Marvin et al., 2009; Ellison, 2013). In 1919, the ability of organic mercurial antisyphylitics to affect diuresis was discovered by Vogl, medical student, which ...
... In 1553, mercurous chloride (calomel), inorganic mercury, was recorded by Paracelsus to be the first effective diuretic therapy for edema (Marvin et al., 2009; Ellison, 2013). In 1919, the ability of organic mercurial antisyphylitics to affect diuresis was discovered by Vogl, medical student, which ...
Diamorphine Hydrochloride BP 100 mg Lyophilisate for solution for
... Children and Elderly: Diamorphine has been used in the treatment of terminally ill children. Diamorphine has been administered in reduced doses to children with neoplastic disease when it becomes difficult to give treatment orally. The starting dose should be selected according to age, size, symptom ...
... Children and Elderly: Diamorphine has been used in the treatment of terminally ill children. Diamorphine has been administered in reduced doses to children with neoplastic disease when it becomes difficult to give treatment orally. The starting dose should be selected according to age, size, symptom ...
Claforan - Sanofi Canada
... antibacterial agents, including CLAFORAN. CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea, or symptoms of colitis, pseudomembranous colitis, toxic megacolon, or perforation of colon subsequent to the adm ...
... antibacterial agents, including CLAFORAN. CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea, or symptoms of colitis, pseudomembranous colitis, toxic megacolon, or perforation of colon subsequent to the adm ...
PropoFlo - zoetisUS.com
... doses were similar in sighthounds compared to other animals, however, recoveries were delayed. 9. Cardiac arrhythmias: In one study, propofol increased myocardial sensitivity to the development of epinephrine-induced ventricular arrhythmias in a manner similar to other anesthetics6. In the clinical ...
... doses were similar in sighthounds compared to other animals, however, recoveries were delayed. 9. Cardiac arrhythmias: In one study, propofol increased myocardial sensitivity to the development of epinephrine-induced ventricular arrhythmias in a manner similar to other anesthetics6. In the clinical ...
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
... Suboxone may cause drowsiness, particularly when taken together with alcohol or central nervous system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5). Studies in animals, as well as clinical experience, have demonstrated that buprenorphine may produce dependence but a ...
... Suboxone may cause drowsiness, particularly when taken together with alcohol or central nervous system depressants (such as tranquilisers, sedatives or hypnotics) (see section 4.5). Studies in animals, as well as clinical experience, have demonstrated that buprenorphine may produce dependence but a ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
... be administered with caution to patients who have or may develop prolongation of QTc, including congestive heart failure, bradyarrhythmias or patients taking other medicinal products that lead to either QT prolongation or electrolyte abnormalities (see DRUG INTERACTIONS). Hypokalemia, hypocalcemia, ...
Australian public assessment for Thyroxine Sodium
... Stability data were generated under accelerated and long-term conditions on batches packaged in the proposed container closure system (which includes a child-resistant closure). This would support a shelf life of 2 years when stored below 25ºC with the condition protect from light. The tablets are m ...
... Stability data were generated under accelerated and long-term conditions on batches packaged in the proposed container closure system (which includes a child-resistant closure). This would support a shelf life of 2 years when stored below 25ºC with the condition protect from light. The tablets are m ...
Thyroxine Sodium - Therapeutic Goods Administration
... Stability data were generated under accelerated and long-term conditions on batches packaged in the proposed container closure system (which includes a child-resistant closure). This would support a shelf life of 2 years when stored below 25ºC with the condition protect from light. The tablets are m ...
... Stability data were generated under accelerated and long-term conditions on batches packaged in the proposed container closure system (which includes a child-resistant closure). This would support a shelf life of 2 years when stored below 25ºC with the condition protect from light. The tablets are m ...
HL7 Medication and UKCPRS
... representation of the material defining the prescriber's therapeutic intent, divorced from formulation, dose or strength. ...
... representation of the material defining the prescriber's therapeutic intent, divorced from formulation, dose or strength. ...
Intra-Ventral Tegmental Area Injection of Rat Cocaine and
... 1 h immediately after the microinjection. After these behavioral parameters were recorded, rats were returned to their home cages for a minimum of 48 h before the next testing period. One group of rats (n ⫽ 7) received intra-VTA injections of 0.9% saline and 0.04, 0.2, and 1.0 g CART 55-102 counter ...
... 1 h immediately after the microinjection. After these behavioral parameters were recorded, rats were returned to their home cages for a minimum of 48 h before the next testing period. One group of rats (n ⫽ 7) received intra-VTA injections of 0.9% saline and 0.04, 0.2, and 1.0 g CART 55-102 counter ...
EFFECTS OF COFFEE ON THE CENTRAL NERVOUS SYSTEM
... Figure 2.3. Effects of the administration of increasing doses of caffeine on cerebral metabolism in the brain of rats. On the autoradiograms of coronal rat brain sections taken at selected levels, it appears clearly that glucose metabolism is increased after 1 mg/kg caffeine compared to control leve ...
... Figure 2.3. Effects of the administration of increasing doses of caffeine on cerebral metabolism in the brain of rats. On the autoradiograms of coronal rat brain sections taken at selected levels, it appears clearly that glucose metabolism is increased after 1 mg/kg caffeine compared to control leve ...
Prolonged Attenuation of the Reinforcing Strength of
... evening PR sessions until responding stabilized (3 consecutive days on which the number of injections was within 2 of the 3-day mean, with no upward or downward trend). Subsequently, other doses of cocaine were substituted for the maintenance dose for at least 4 days and until the number of injectio ...
... evening PR sessions until responding stabilized (3 consecutive days on which the number of injections was within 2 of the 3-day mean, with no upward or downward trend). Subsequently, other doses of cocaine were substituted for the maintenance dose for at least 4 days and until the number of injectio ...
... β2-agonists, used by inhalation, have a central role in the treatment of patients with asthma, both as acute and chronic medication. In general, bronchodilation occurs rapidly to inhaled β2-therapy, but with generally used short-acting β2-agonists, such as salbutamol and terbutaline, the duration of ...
HYDROMORPHONE HYDROCHLORIDE TABLETS USP 2 mg, 4
... chewing, snorting, or injecting the dissolved product. These practices pose a significant risk to the abuser that could result in overdose or death (see WARNINGS and DRUG ABUSE AND DEPENDENCE). Concerns about abuse, addiction, and diversion should not prevent the proper management of pain. Healthcar ...
... chewing, snorting, or injecting the dissolved product. These practices pose a significant risk to the abuser that could result in overdose or death (see WARNINGS and DRUG ABUSE AND DEPENDENCE). Concerns about abuse, addiction, and diversion should not prevent the proper management of pain. Healthcar ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.