Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir
... A new AusPAR will be developed to reflect changes to indications and/or major variations to a prescription medicine subject to evaluation by the TGA. ...
... A new AusPAR will be developed to reflect changes to indications and/or major variations to a prescription medicine subject to evaluation by the TGA. ...
Recommendations for Management of Clinically Significant Drug
... of each agent alone.1 A DDI may result in a change in either drug efficacy or drug toxicity for 1 or both of the interacting medications.2 Pharmacokinetic DDIs result in altered absorption, distribution, metabolism, or excretion of a medication. A pharmacodynamic DDI occurs when 1 medication modifie ...
... of each agent alone.1 A DDI may result in a change in either drug efficacy or drug toxicity for 1 or both of the interacting medications.2 Pharmacokinetic DDIs result in altered absorption, distribution, metabolism, or excretion of a medication. A pharmacodynamic DDI occurs when 1 medication modifie ...
Product Monograph
... DIFLUCAN (fluconazole) is contraindicated in patients who have shown hypersensitivity to fluconazole, to any of its excipients or to related azole compounds. Coadministration of terfenadine is contraindicated in patients receiving DIFLUCAN at multiple doses of 400 mg or higher based upon results of ...
... DIFLUCAN (fluconazole) is contraindicated in patients who have shown hypersensitivity to fluconazole, to any of its excipients or to related azole compounds. Coadministration of terfenadine is contraindicated in patients receiving DIFLUCAN at multiple doses of 400 mg or higher based upon results of ...
PRILOSEC (omeprazole) (omeprazole magnesium) DELAYED-RELEASE CAPSULES
... 80 mg omeprazole reduces the pharmacological activity of clopidogrel, even when administered 12 hours apart. When using PRILOSEC, consider alternative anti-platelet therapy [see Drug Interactions (7.3) and Pharmacokinetics (12.3)]. 5.5 Bone Fracture Several published observational studies suggest th ...
... 80 mg omeprazole reduces the pharmacological activity of clopidogrel, even when administered 12 hours apart. When using PRILOSEC, consider alternative anti-platelet therapy [see Drug Interactions (7.3) and Pharmacokinetics (12.3)]. 5.5 Bone Fracture Several published observational studies suggest th ...
mesna injection, 100 mg/ml
... Clinical studies of mesna did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardia ...
... Clinical studies of mesna did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardia ...
Presentations Indications Dosage and Administration
... respiratory drive and increase the airway resistance to the point of apnoea. Acute abdominal conditions. Methadone may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Plasma amylase and lipase determinations should not be performed within 24 hours after a methad ...
... respiratory drive and increase the airway resistance to the point of apnoea. Acute abdominal conditions. Methadone may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Plasma amylase and lipase determinations should not be performed within 24 hours after a methad ...
Synergistic interactions between Fenfluramine and
... various combinations of the drugs of interest produce the expected reductions in food intake. The results from the Roth and Rowland26 study con®rm a synergism between dexfen and phentermine on food intake in free-feeding rats (see Figure 2). The dose-response curves for dexfen and for phentermine ar ...
... various combinations of the drugs of interest produce the expected reductions in food intake. The results from the Roth and Rowland26 study con®rm a synergism between dexfen and phentermine on food intake in free-feeding rats (see Figure 2). The dose-response curves for dexfen and for phentermine ar ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... similar to the values of racemate induced IKr inhibition obtained from the literature. The model could describe the experimental data only moderately well using this approach, as the reverse rate dependency of the shortening was greater than what could be accounted for by ICaL inhibition. Using the ...
... similar to the values of racemate induced IKr inhibition obtained from the literature. The model could describe the experimental data only moderately well using this approach, as the reverse rate dependency of the shortening was greater than what could be accounted for by ICaL inhibition. Using the ...
View Full Prescribing Information
... anthracis in combination with appropriate antibacterial drugs. ANTHIM is indicated for prophylaxis of inhalational anthrax due to B. anthracis when alternative therapies are not available or not appropriate [see Indications and Usage (1.2)]. 1.2 Limitations of Use ANTHIM should only be used for prop ...
... anthracis in combination with appropriate antibacterial drugs. ANTHIM is indicated for prophylaxis of inhalational anthrax due to B. anthracis when alternative therapies are not available or not appropriate [see Indications and Usage (1.2)]. 1.2 Limitations of Use ANTHIM should only be used for prop ...
Toxicity of Nutmeg (Myristicin): A Review
... nutmeg induces neurotoxicity in human neuroblastoma SKN-SH cells by an apoptotic mechanism. Neurotoxicity can be defined as adverse changes in nervous systems due to the toxic chemical exposure, where can result in traumatic brain damages and other neurological diseases. The term neurotoxicity is sy ...
... nutmeg induces neurotoxicity in human neuroblastoma SKN-SH cells by an apoptotic mechanism. Neurotoxicity can be defined as adverse changes in nervous systems due to the toxic chemical exposure, where can result in traumatic brain damages and other neurological diseases. The term neurotoxicity is sy ...
1. Exposure Data - IARC Monographs
... for deaths from all cancers, which was chiefly due to significantly more deaths from oral cancer (4.2; 95% CI, 1.3–9.7; five cases) and brain tumours (3.7; 95% CI, 1.2–8.6; five cases). The excess risk for death from brain cancer persisted after exclusion of cases prevalent at the time of entry into ...
... for deaths from all cancers, which was chiefly due to significantly more deaths from oral cancer (4.2; 95% CI, 1.3–9.7; five cases) and brain tumours (3.7; 95% CI, 1.2–8.6; five cases). The excess risk for death from brain cancer persisted after exclusion of cases prevalent at the time of entry into ...
1 6111 METRONIDAZOLE VAGINAL GEL, 0.75%
... Other effects that have been reported in association with the use of topical (dermal) formulations of metronidazole include skin irritation, transient skin erythema, and mild skin dryness and burning. None of these adverse events exceeded an incidence of 2% of patients. Oral and Parenteral Formulati ...
... Other effects that have been reported in association with the use of topical (dermal) formulations of metronidazole include skin irritation, transient skin erythema, and mild skin dryness and burning. None of these adverse events exceeded an incidence of 2% of patients. Oral and Parenteral Formulati ...
PHENOLPHTHALEIN 1. Exposure Data
... Kune (1993) analysed data on laxative use reported by 685 subjects with colorectal adenocarcinoma diagnosed in 1980–81 in Melbourne, Australia, and 723 controls frequency matched with cases on age and sex. Laxative use throughout adult life was assessed by interview. The relative risk associated wit ...
... Kune (1993) analysed data on laxative use reported by 685 subjects with colorectal adenocarcinoma diagnosed in 1980–81 in Melbourne, Australia, and 723 controls frequency matched with cases on age and sex. Laxative use throughout adult life was assessed by interview. The relative risk associated wit ...
Cobicistat / Tenofovir disoproxil fumarate / Emtricitabine / Elvitegravir
... to registration of Stribild tablets provided the PI is amended to include the correct pKa values of COBI. Furthermore, it should be a condition of registration that the dissolution test and limits for the product be as originally submitted.2 ...
... to registration of Stribild tablets provided the PI is amended to include the correct pKa values of COBI. Furthermore, it should be a condition of registration that the dissolution test and limits for the product be as originally submitted.2 ...
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... 12.2 Secondary References.............................................................................................. 18 ...
... 12.2 Secondary References.............................................................................................. 18 ...
Safety and Side Effects of CBD
... effects were tiredness, diarrhea and changes of appetite/ weight. In comparison with other medicinal drugs used for the treatment of these medical conditions, CBD has a very favorable side effect profile, which may improve compliance and adherence to treatment. Up until now, CBD was mainly used as a ...
... effects were tiredness, diarrhea and changes of appetite/ weight. In comparison with other medicinal drugs used for the treatment of these medical conditions, CBD has a very favorable side effect profile, which may improve compliance and adherence to treatment. Up until now, CBD was mainly used as a ...
Fortaz - GlaxoSmithKline
... Treatment with antibacterial agents may alter the normal flora of the colon and may permit overgrowth of Clostridium difficile. C. difficile produces toxins A and B, which contribute to the development of CDAD. CDAD may cause significant morbidity and mortality. CDAD can be refractory to antimicrob ...
... Treatment with antibacterial agents may alter the normal flora of the colon and may permit overgrowth of Clostridium difficile. C. difficile produces toxins A and B, which contribute to the development of CDAD. CDAD may cause significant morbidity and mortality. CDAD can be refractory to antimicrob ...
MS_Word ~ 273 KB
... retrospective and actual doses received are difficult to establish. Patients and parents may over or under estimate the ingested dose depending on circumstances (19, 20, 21). ...
... retrospective and actual doses received are difficult to establish. Patients and parents may over or under estimate the ingested dose depending on circumstances (19, 20, 21). ...
Prescribing Information
... twice daily in the 52-week open-label trial did not experience an increase in specific clinically significant adverse events above the number expected based on the medical condition and age of the patients. ...
... twice daily in the 52-week open-label trial did not experience an increase in specific clinically significant adverse events above the number expected based on the medical condition and age of the patients. ...
effect of single oral dose of melatonin on plasma concentration of
... In our study oral melatonin administration caused no significant increase in the Cortisol concentration after 15 minutes of treatment. Melatonin treatment did not modify the Cortisol concentration which was 393.9±41.6 ηg/ml before treatment. Cortisol concentration remains unaffected throughout the s ...
... In our study oral melatonin administration caused no significant increase in the Cortisol concentration after 15 minutes of treatment. Melatonin treatment did not modify the Cortisol concentration which was 393.9±41.6 ηg/ml before treatment. Cortisol concentration remains unaffected throughout the s ...
PRODUCT MONOGRAPH Pilocarpine Hydrochloride Tablets, USP
... Patients with mild and moderate hepatic impairment should begin treatment at a reduced daily dose, gradually increasing the dosage up to 5 mg three to four times daily as safety and tolerability allow. (See DOSAGE AND ADMINISTRATION). No pharmacokinetic data are available for any dose of pilocarpine ...
... Patients with mild and moderate hepatic impairment should begin treatment at a reduced daily dose, gradually increasing the dosage up to 5 mg three to four times daily as safety and tolerability allow. (See DOSAGE AND ADMINISTRATION). No pharmacokinetic data are available for any dose of pilocarpine ...
Chloramphenicol
... months after chloramphenicol treatment has been stopped and there may be a genetic predisposition It is not known whether monitoring the blood counts of patients can prevent the development of aplastic anaemia, but it is recommended that patients have a blood count checked twice weekly while on trea ...
... months after chloramphenicol treatment has been stopped and there may be a genetic predisposition It is not known whether monitoring the blood counts of patients can prevent the development of aplastic anaemia, but it is recommended that patients have a blood count checked twice weekly while on trea ...
Pharmacokinetic and pharmacodynamic drug interactions
... CYP 450 system (CYP1A2, 2C9, 2C19, 2D6, 3A4 and 4A9/11). This indicates that kava has a high potential for causing pharmacokinetic drug interactions with other herbal products or drugs, which are metabolised by the CYP 450 enzymes. In addition, several pharmacodynamic interactions have been postulat ...
... CYP 450 system (CYP1A2, 2C9, 2C19, 2D6, 3A4 and 4A9/11). This indicates that kava has a high potential for causing pharmacokinetic drug interactions with other herbal products or drugs, which are metabolised by the CYP 450 enzymes. In addition, several pharmacodynamic interactions have been postulat ...
... Pa–ET,CO2 difference as small as 0.14 kPa, indicating marginal inhibition of erythrocytic carbonic anhydrase [11, 25]. Based on this finding it was concluded that the effects of acetazolamide could be studied without the complication of significant tissue CO2 retention. The main results of this stud ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.