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Comparison of Inhaled Corticosteroids: An Update
... these studies also provide results that vary between laboratories.15,16 The relative binding affinities correlate with relative potencies in carefully controlled clinical trials.17 It is clear from the relative potencies that some drugs (beclomethasone dipropionate, ciclesonide) act as prodrugs and ...
... these studies also provide results that vary between laboratories.15,16 The relative binding affinities correlate with relative potencies in carefully controlled clinical trials.17 It is clear from the relative potencies that some drugs (beclomethasone dipropionate, ciclesonide) act as prodrugs and ...
Title
... on three animal models strychnine and picrotoxin induced convulsions, pentobarbitone sleeping time and exploratory behaviour in animals. The extract protected the animals from strychnine and picrotoxin induced convulsion. A prolongation of pentobarbitone sleeping time as well as suppression of explo ...
... on three animal models strychnine and picrotoxin induced convulsions, pentobarbitone sleeping time and exploratory behaviour in animals. The extract protected the animals from strychnine and picrotoxin induced convulsion. A prolongation of pentobarbitone sleeping time as well as suppression of explo ...
PRODUCT MONOGRAPH OFLOXACIN TABLETS 200, 300 and 400 mg
... Convulsions, increased intracranial pressure, and toxic psychosis have been reported in patients receiving quinolones, including ofloxacin. Quinolones, including ofloxacin, may also cause central nervous system stimulation, which may lead to tremors, restlessness/agitation, nervousness/anxiety, ligh ...
... Convulsions, increased intracranial pressure, and toxic psychosis have been reported in patients receiving quinolones, including ofloxacin. Quinolones, including ofloxacin, may also cause central nervous system stimulation, which may lead to tremors, restlessness/agitation, nervousness/anxiety, ligh ...
Levalbuterol HCl Inhalation Solution 0.31 m Levalbuterol
... Hepatic Impairment: The effect of hepatic impairment on the pharmacokinetics of Levalbuterol HCI Inhalation Solution has not been evaluated. Renal Impairment: The effect of renal impairment on the pharmacokinetics of racemic albuterol was evaluated in 5 subjects with creatinine clearance of 7 to 53 ...
... Hepatic Impairment: The effect of hepatic impairment on the pharmacokinetics of Levalbuterol HCI Inhalation Solution has not been evaluated. Renal Impairment: The effect of renal impairment on the pharmacokinetics of racemic albuterol was evaluated in 5 subjects with creatinine clearance of 7 to 53 ...
avodart - Urological Sciences Research Foundation
... DHT levels. These 5α-reductase deficient males have a small prostate gland throughout life and do not develop BPH. Except for the associated urogenital defects present at birth, no other clinical abnormalities related to 5α-reductase deficiency have been observed in these individuals. Other Effects: ...
... DHT levels. These 5α-reductase deficient males have a small prostate gland throughout life and do not develop BPH. Except for the associated urogenital defects present at birth, no other clinical abnormalities related to 5α-reductase deficiency have been observed in these individuals. Other Effects: ...
Effects of Chronic Methylphenidate on Cocaine Self
... administration, unconditioned effects of MPD were noted on several days indicated with asterisks along the abscissa in Fig. 2, particularly in R-1429. Such effects included self- or experimenter-directed aggression (e.g., threats, picking or biting the leg and/or harness) as well as increased locomo ...
... administration, unconditioned effects of MPD were noted on several days indicated with asterisks along the abscissa in Fig. 2, particularly in R-1429. Such effects included self- or experimenter-directed aggression (e.g., threats, picking or biting the leg and/or harness) as well as increased locomo ...
Clinical Manual Part 2 Drug Infusion Guidelines
... standard 500 mL fluid bags are offered. 500 mL formats are generally for use through an intravenous rate controlling device such as an IVAC infusion pump. Although greater fluid volumes are necessary, there is a greater margin of safety in controlling rates, especially during transport and handover. ...
... standard 500 mL fluid bags are offered. 500 mL formats are generally for use through an intravenous rate controlling device such as an IVAC infusion pump. Although greater fluid volumes are necessary, there is a greater margin of safety in controlling rates, especially during transport and handover. ...
QA_18_6_AmlodipinevsfelodipineAUG_15_FINAL
... efficacy as an antihypertensive when compared with felodipine m/r. However, some smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihyp ...
... efficacy as an antihypertensive when compared with felodipine m/r. However, some smaller studies found them to have similar antihypertensive efficacy. It has been suggested that if patients are intermittently compliant, amlodipine may be more suitable than felodipine m/r. This is because the antihyp ...
Nuedexta Prescribing Information
... mg combination (N=110) compared to placebo (N=109). Approximately 60% of patients had ALS and 40% had MS. Patients were 25 to 80 years of age, with a mean age of approximately 51 years. Three (3) ALS patients in each drug treatment arm and 1 ALS patient in the placebo arm died during the 12-week pla ...
... mg combination (N=110) compared to placebo (N=109). Approximately 60% of patients had ALS and 40% had MS. Patients were 25 to 80 years of age, with a mean age of approximately 51 years. Three (3) ALS patients in each drug treatment arm and 1 ALS patient in the placebo arm died during the 12-week pla ...
Dose uniformity of topical corticosteroid preparations: difluprednate
... generic prednisolone products. Overall, very low concentrations in the generic prednisolone bottle were observed through day 15, while the branded product exhibited overall higher concentrations with much less variability. In most cases, a lower dispensed drug concentration of generic prednisolone w ...
... generic prednisolone products. Overall, very low concentrations in the generic prednisolone bottle were observed through day 15, while the branded product exhibited overall higher concentrations with much less variability. In most cases, a lower dispensed drug concentration of generic prednisolone w ...
Intranasal (IN) Medication Administration MBED Clinical Practice
... INDICATIONS: Dexmedetomidine is indicated for short-term (< 24 hrs) sedation of intubated and mechanically ventilated patients in the intensive care setting. *Currently looking into its off-label use for procedural sedation in pediatrics when used intranasally. CLINICAL PHARMACOLOGY: Dexmedetomidine ...
... INDICATIONS: Dexmedetomidine is indicated for short-term (< 24 hrs) sedation of intubated and mechanically ventilated patients in the intensive care setting. *Currently looking into its off-label use for procedural sedation in pediatrics when used intranasally. CLINICAL PHARMACOLOGY: Dexmedetomidine ...
Actavis v ICOS
... the minimal effective dose for tadalafil and because a 5mg dose would be obvious in any event. Lilly does not agree. It contends that a dose of tadalafil as low as 5mg and the advantages it provides in terms of efficacy and low side effects were not obvious. Even if the skilled team embarked on a cl ...
... the minimal effective dose for tadalafil and because a 5mg dose would be obvious in any event. Lilly does not agree. It contends that a dose of tadalafil as low as 5mg and the advantages it provides in terms of efficacy and low side effects were not obvious. Even if the skilled team embarked on a cl ...
Product Information: Lisdexamfetamine dimesilate
... aged 6 to 12 (N=290) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type). Patients were randomised to fixed dose treatment groups receiving final doses of 30, 50, or 70 mg of VYVANSE or placebo once daily in the morning for four weeks. All subjects receiving ...
... aged 6 to 12 (N=290) who met DSM-IV criteria for ADHD (either the combined type or the hyperactive-impulsive type). Patients were randomised to fixed dose treatment groups receiving final doses of 30, 50, or 70 mg of VYVANSE or placebo once daily in the morning for four weeks. All subjects receiving ...
Multiple mechanisms involved in the large-spectrum
... the production of reactive oxygen species (ROS)-generating NADPH oxidases [47,52– 54]. Moreover, CBD pretreatment attenuated high-glucose-induced mitochondrial superoxide generation and NF-kB activation, along with the expression of adhesion molecules ICAM-1 and VCAM-1 [48]. Together, these results ...
... the production of reactive oxygen species (ROS)-generating NADPH oxidases [47,52– 54]. Moreover, CBD pretreatment attenuated high-glucose-induced mitochondrial superoxide generation and NF-kB activation, along with the expression of adhesion molecules ICAM-1 and VCAM-1 [48]. Together, these results ...
PRODUCT MONOGRAPH Pr PERIDEX ORAL RINSE
... Since the safety and efficacy of Peridex in children has not yet been fully established, the benefits of its use should be weighed against the possible risks. ...
... Since the safety and efficacy of Peridex in children has not yet been fully established, the benefits of its use should be weighed against the possible risks. ...
Venous Relaxation Caused by Acetylcholine Acting on the
... (1.63 ±0.380 g) was obtained in all preparations. Stimulated Preparations.—Figure 1 shows the original record of an experiment in which a single dose of acetylcholine (5xlO~ 8 g/ml) was given during a sustained response to a 2-cps electrical stimulation. Acetylcholine caused a marked relaxation of t ...
... (1.63 ±0.380 g) was obtained in all preparations. Stimulated Preparations.—Figure 1 shows the original record of an experiment in which a single dose of acetylcholine (5xlO~ 8 g/ml) was given during a sustained response to a 2-cps electrical stimulation. Acetylcholine caused a marked relaxation of t ...
Spiractin - Medicines.org.au
... the management of patients subjected to regional or general anaesthesia while they are being treated with spironolactone. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, and mefenamic acid may attenuate the natriuretic efficacy of diuretics due to inhibition of intraren ...
... the management of patients subjected to regional or general anaesthesia while they are being treated with spironolactone. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, and mefenamic acid may attenuate the natriuretic efficacy of diuretics due to inhibition of intraren ...
Guideline on Inhalational medicinal products
... not expected that all described testing would be conducted on all clinical trial batches. However, extensive characterisation of the drug substance and drug product batches used in pivotal clinical trials is necessary to qualify the product proposed for marketing. Only quality aspects specific to in ...
... not expected that all described testing would be conducted on all clinical trial batches. However, extensive characterisation of the drug substance and drug product batches used in pivotal clinical trials is necessary to qualify the product proposed for marketing. Only quality aspects specific to in ...
Chronic l-Alpha Acetylmethadol in Rhesus Monkeys
... dark schedule. Access to food (Teklad monkey food) in the home cage was unrestricted during stimulus-shock termination procedures and restricted during food-maintained responding procedures; in the latter case, monkeys were maintained at no less than 90% of their free-feeding weights. All monkeys we ...
... dark schedule. Access to food (Teklad monkey food) in the home cage was unrestricted during stimulus-shock termination procedures and restricted during food-maintained responding procedures; in the latter case, monkeys were maintained at no less than 90% of their free-feeding weights. All monkeys we ...
Effects of Different Doses of Simvastatin on Lead
... they also have other pleiotropic effects. The aim of this study was to determine the effect of different doses of simvastatin on biochemical and histopathological parameters in mice exposed to lead. Methods: Forty eight adult male mice were randomised into six groups. The control group received no l ...
... they also have other pleiotropic effects. The aim of this study was to determine the effect of different doses of simvastatin on biochemical and histopathological parameters in mice exposed to lead. Methods: Forty eight adult male mice were randomised into six groups. The control group received no l ...
PRODUCT INFORMATION MS Contin® modified release tablets 5
... In the absence of a clear indication for a strong opioid analgesic, drug-seeking behaviour must be suspected and resisted, particularly in individuals with a history of, or propensity for, drug abuse. Withdrawal symptoms may occur following abrupt discontinuation of morphine therapy or upon adminis ...
... In the absence of a clear indication for a strong opioid analgesic, drug-seeking behaviour must be suspected and resisted, particularly in individuals with a history of, or propensity for, drug abuse. Withdrawal symptoms may occur following abrupt discontinuation of morphine therapy or upon adminis ...
Atarax™
... isoforms at concentrations (IC50: 19 to 140 µM; 7 to 52 µg/ml) well above peak plasma concentrations. The metabolite cetirizine at 100 µM has no inhibitory effect on human liver cytochrome P450 (1A2, 2A6, 2C9/C10, 2C19, 2D6, 2E1, and 3A4) and UDP-glucuronyl transferase isoforms. Therefore, hydroxyzi ...
... isoforms at concentrations (IC50: 19 to 140 µM; 7 to 52 µg/ml) well above peak plasma concentrations. The metabolite cetirizine at 100 µM has no inhibitory effect on human liver cytochrome P450 (1A2, 2A6, 2C9/C10, 2C19, 2D6, 2E1, and 3A4) and UDP-glucuronyl transferase isoforms. Therefore, hydroxyzi ...
URO-Jet - Amphastar
... gel 20 mg/ml) were used for lubricating both intranasal and endotracheal tubes. No neonate had plasma levels of lidocaine above 750 mcg/L. Dosages in children should be reduced, commensurate with age, body weight, and physical condition. (See DOSAGE AND ADMINISTRATION.) ADVERSE REACTIONS Adverse exp ...
... gel 20 mg/ml) were used for lubricating both intranasal and endotracheal tubes. No neonate had plasma levels of lidocaine above 750 mcg/L. Dosages in children should be reduced, commensurate with age, body weight, and physical condition. (See DOSAGE AND ADMINISTRATION.) ADVERSE REACTIONS Adverse exp ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... (BZT) possess high affinity for the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects different from those of cocaine. One hypothesis is that muscarinic-M1 receptor actions interfere with cocaine-like effects. Several tropane-nitrogen substitutions of 4⬘,4⬘⬘-diF-BZ ...
... (BZT) possess high affinity for the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects different from those of cocaine. One hypothesis is that muscarinic-M1 receptor actions interfere with cocaine-like effects. Several tropane-nitrogen substitutions of 4⬘,4⬘⬘-diF-BZ ...
Pharmacokinetics, toxicity, and cytochrome P450
... The liver samples were rinsed with ice-cold, 0.9 %NaCl, homogenized in 50 mM sodium phosphate buffer (pH 7.4) containing 0.1 mM EDTA, and centrifuged at 9000 × g for 20 min. The supernatant was ultracentrifuged at 105,000 × g for 60 min, and the resulting microsomal pellets were suspended with ice c ...
... The liver samples were rinsed with ice-cold, 0.9 %NaCl, homogenized in 50 mM sodium phosphate buffer (pH 7.4) containing 0.1 mM EDTA, and centrifuged at 9000 × g for 20 min. The supernatant was ultracentrifuged at 105,000 × g for 60 min, and the resulting microsomal pellets were suspended with ice c ...
Hormesis
Hormesis (from Greek hórmēsis ""rapid motion, eagerness,"" from ancient Greek hormáein ""to set in motion, impel, urge on"") is the term for generally favorable biological responses to low exposures to toxins and other stressors. A pollutant or toxin showing hormesis thus has the opposite effect in small doses as in large doses. A related concept is Mithridatism, which refers to the willful exposure to toxins in an attempt to develop immunity against them. Hormetics is the term proposed for the study and science of hormesis.In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed ""eustress.""The hormesis model of dose response is vigorously debated. The notion that hormesis is important for chemical risks regulations is not widely accepted.The biochemical mechanisms by which hormesis works are not well understood. It is conjectured that low doses of toxins or other stressors might activate the repair mechanisms of the body. The repair process fixes not only the damage caused by the toxin, but also other low-level damage that might have accumulated before without triggering the repair mechanism.