USMLE Step 1 Web Prep — Transcription and RNA Processing: Part
... There are two kinds of transcription terminators commonly found in prokaryotic genes: 1. Rho-independent termination occurs when the newly formed RNA folds back on itself to form a GC-rich stem-and-loop closely followed by 6–8 U residues. 2. Rho-dependent termination requires participation of rho fa ...
... There are two kinds of transcription terminators commonly found in prokaryotic genes: 1. Rho-independent termination occurs when the newly formed RNA folds back on itself to form a GC-rich stem-and-loop closely followed by 6–8 U residues. 2. Rho-dependent termination requires participation of rho fa ...
Automatic detection of conserved gene clusters in
... considerable amount of juxtaposition of genes, but at the same time there is a tendency for short-range conservation of gene clusters (1–3). The conserved clusters are likely to represent functionally coupled genes, such as those forming operon structures for co-expression and/or those encoding phys ...
... considerable amount of juxtaposition of genes, but at the same time there is a tendency for short-range conservation of gene clusters (1–3). The conserved clusters are likely to represent functionally coupled genes, such as those forming operon structures for co-expression and/or those encoding phys ...
Analyzing stochastic transcription to elucidate the nucleoid`s
... classified as noise and are often discarded. It is presumed – correctly – that the signal does not originate from an "active" or "deterministic" transcription process and that it is therefore non-informative. This conclusion, though, is wrong. The advent of single cell transcription analysis has sho ...
... classified as noise and are often discarded. It is presumed – correctly – that the signal does not originate from an "active" or "deterministic" transcription process and that it is therefore non-informative. This conclusion, though, is wrong. The advent of single cell transcription analysis has sho ...
DNA sequence annotation
... 2. In this project you will work with real data. 3. You will get the DNA sequence by e-mail. The sequence is saved in the text file and it is one long string of characters without spaces or new lines. 4. Please, read the full project description, before you start to write your programs. You don’t ne ...
... 2. In this project you will work with real data. 3. You will get the DNA sequence by e-mail. The sequence is saved in the text file and it is one long string of characters without spaces or new lines. 4. Please, read the full project description, before you start to write your programs. You don’t ne ...
file
... • Use cross validation: partition the data into 5 gene sets, learn the rules based on all but one and test based on the left-out, each time. ...
... • Use cross validation: partition the data into 5 gene sets, learn the rules based on all but one and test based on the left-out, each time. ...
14 PCA and K-Means Decipher Genome
... a hypothesis that this is a result of genomic sequence evolution. This can be explained as follows. Vitality of a bacterium depends on the correct functioning of all biological mechanisms. These mechanisms are encoded in genes, and if something wrong happens with gene sequences (for example there is ...
... a hypothesis that this is a result of genomic sequence evolution. This can be explained as follows. Vitality of a bacterium depends on the correct functioning of all biological mechanisms. These mechanisms are encoded in genes, and if something wrong happens with gene sequences (for example there is ...
7 Genetics - Life Sciences
... enetics is the study of inheritance, the transmission of traits from parent to offspring and the expression of these traits. From earliest times, people have realized that certain traits in both plants and animals are passed on from parents to offspring. Artificial selection was practiced by farmers ...
... enetics is the study of inheritance, the transmission of traits from parent to offspring and the expression of these traits. From earliest times, people have realized that certain traits in both plants and animals are passed on from parents to offspring. Artificial selection was practiced by farmers ...
Begins of the human genome project
... Impact on identification: it is fingerprinting technology, the DNA sequence of each person is specific, people can make use of this property to identify the potential suspects whose DNA may match the evidence left at crime scenes. Moreover, we can make use of DNA fingerprinting to identify the catas ...
... Impact on identification: it is fingerprinting technology, the DNA sequence of each person is specific, people can make use of this property to identify the potential suspects whose DNA may match the evidence left at crime scenes. Moreover, we can make use of DNA fingerprinting to identify the catas ...
Cis-Regulatory Timers for Developmental Gene
... sites they found in early- versus middle-onset CRMs, however, suggesting that differences in site numbers may be the main determinants of different CRM affinities for Bra. This threshold–response model also implies that the availability of Bra protein is limiting for activation of middle-onset CRMs ...
... sites they found in early- versus middle-onset CRMs, however, suggesting that differences in site numbers may be the main determinants of different CRM affinities for Bra. This threshold–response model also implies that the availability of Bra protein is limiting for activation of middle-onset CRMs ...
Lecture 2: Mutation and its effect
... N terminus of a protein contains a free amino group. C terminus of protein contains a free carboxylic acid group. ...
... N terminus of a protein contains a free amino group. C terminus of protein contains a free carboxylic acid group. ...
Press Release: The 1995 Nobel Prize in Physiology or Medicine
... two persons could simultaneously examine the same embryo they analyzed and classified a large number of malformations caused by mutations in genes controlling early embryonic development. For more than a year the two scientists sat opposite each other examining Drosophila embryos resulting from gene ...
... two persons could simultaneously examine the same embryo they analyzed and classified a large number of malformations caused by mutations in genes controlling early embryonic development. For more than a year the two scientists sat opposite each other examining Drosophila embryos resulting from gene ...
L13Generalizations
... 2b) A particular function can be performed by very dissimilar molecules Despite the fundamental unity of life, there are some cases when the same function, either simple or complex, is performed by clearly non-homologous molecules, similar only to the extent dictated by this function. ...
... 2b) A particular function can be performed by very dissimilar molecules Despite the fundamental unity of life, there are some cases when the same function, either simple or complex, is performed by clearly non-homologous molecules, similar only to the extent dictated by this function. ...
Vital Genes in the Heterochromatin of
... Joint efforts are now required to complete the molecular characterization of the heterochromatic genome of D. melanogaster and to extend the work to other Drosophila species. This may allow us to characterize new heterochromatic genes and to learn how they have evolved. An important goal is also to ...
... Joint efforts are now required to complete the molecular characterization of the heterochromatic genome of D. melanogaster and to extend the work to other Drosophila species. This may allow us to characterize new heterochromatic genes and to learn how they have evolved. An important goal is also to ...
Article Comparative Genomics as a Time Machine: How Relative
... WGD (POInT: Polyploidy Orthology Inference Tool; Conant and Wolfe 2008) takes as input an alignment of approximately 4,100 ordered loci (Gordon et al. 2009) in 12 genomes, each duplicated at WGD (fig. 1). Each locus in these data, which were kindly provided by the Yeast Gene Order Browser project (B ...
... WGD (POInT: Polyploidy Orthology Inference Tool; Conant and Wolfe 2008) takes as input an alignment of approximately 4,100 ordered loci (Gordon et al. 2009) in 12 genomes, each duplicated at WGD (fig. 1). Each locus in these data, which were kindly provided by the Yeast Gene Order Browser project (B ...
Welcome to the Broad Institute
... • Detailed descriptions of the analyses, how to run them, and ...
... • Detailed descriptions of the analyses, how to run them, and ...
Pyruvate-Phosphate Dikinase of Oxymonads and
... and parabasalian symbionts. From an EST sequence survey of the eukaryotic fauna from the hindgut of the termite Z. angusticollis, we identified three ESTs matching the PPDK family and other related PEP-utilizing enzymes. Two sequences contained several in-frame, TAA and TAG stop codons, identifying ...
... and parabasalian symbionts. From an EST sequence survey of the eukaryotic fauna from the hindgut of the termite Z. angusticollis, we identified three ESTs matching the PPDK family and other related PEP-utilizing enzymes. Two sequences contained several in-frame, TAA and TAG stop codons, identifying ...
Paper - Ran Blekhman
... clustering multiple TFBSs that regulate the same gene. We find that a relatively high proportion (,37%) of mutations at TFBSs are strongly deleterious, similar to that at a 2-fold degenerate protein-coding site. However, constraint is significantly reduced in human and chimpanzee pCRMS and ChIP-chip ...
... clustering multiple TFBSs that regulate the same gene. We find that a relatively high proportion (,37%) of mutations at TFBSs are strongly deleterious, similar to that at a 2-fold degenerate protein-coding site. However, constraint is significantly reduced in human and chimpanzee pCRMS and ChIP-chip ...
Cocci.GR.letter
... Our questions concern the adaptation of Coccidioides to growth with animals in nature and to pathogenicity of humans. Here, we have compared genomes to find evolutionary evidence to support hypotheses identifying genes involved in these two adaptations. We feel that the gene expansions and contracti ...
... Our questions concern the adaptation of Coccidioides to growth with animals in nature and to pathogenicity of humans. Here, we have compared genomes to find evolutionary evidence to support hypotheses identifying genes involved in these two adaptations. We feel that the gene expansions and contracti ...
ABCA17P - BMC Molecular Biology
... exons that share >70% sequence homology with the ABCA17P exons indicated. The yellow box highlights the alternative exon 1b of the ABCA17P gene. The green box represents a common CpG island at the 5' end of both genes. A metric scale bar is shown. (B) Comparison of the human and mouse ABCA17 – ABCA3 ...
... exons that share >70% sequence homology with the ABCA17P exons indicated. The yellow box highlights the alternative exon 1b of the ABCA17P gene. The green box represents a common CpG island at the 5' end of both genes. A metric scale bar is shown. (B) Comparison of the human and mouse ABCA17 – ABCA3 ...
Metabolic functions of duplicate genes in Saccharomyces cerevisiae
... • Essential reactions are not more likely to be encoded by duplicate genes than by singleton genes. ...
... • Essential reactions are not more likely to be encoded by duplicate genes than by singleton genes. ...
GeneFarm, structural and functional annotation of Arabidopsis gene
... results coming from participant’s laboratories or from publications are given precedence over the results of prediction software. In order to make the loading task easy, robust and traceable, two web submission interfaces were developed for the annotators, one for the gene and a second for the famil ...
... results coming from participant’s laboratories or from publications are given precedence over the results of prediction software. In order to make the loading task easy, robust and traceable, two web submission interfaces were developed for the annotators, one for the gene and a second for the famil ...
Exons and Introns Characterization in Nucleic Acid Sequences by
... transcripts: the basal machinery and gene regulation system. The basal machinery, which is found in all organisms whose genome contains introns, consists of five small nuclear RNA molecules (sRNA) [2]. These molecules, which are formed by few nucleotides, bind to certain proteins to form the "splice ...
... transcripts: the basal machinery and gene regulation system. The basal machinery, which is found in all organisms whose genome contains introns, consists of five small nuclear RNA molecules (sRNA) [2]. These molecules, which are formed by few nucleotides, bind to certain proteins to form the "splice ...
SEGMENTAL VARIATION
... • Depth of coverage in a single patient was compared to average and standard deviation of depth of coverage. • Algorithms were developed for: – Classifying X chromosome as being deleted in males compared with females – Classifying X chromosome as being duplicated in females compared with males S L I ...
... • Depth of coverage in a single patient was compared to average and standard deviation of depth of coverage. • Algorithms were developed for: – Classifying X chromosome as being deleted in males compared with females – Classifying X chromosome as being duplicated in females compared with males S L I ...
Updated map of duplicated regions in the yeast genome
... blocks contain 655 ‘probable’ paralogs (this is not an even number because, as well as simple gene pairs, it includes a few cases where a gene in a block has two tandemly duplicated paralogs in the sister block). For only 11 pairs among these, the transcriptional orientation of one gene appears inve ...
... blocks contain 655 ‘probable’ paralogs (this is not an even number because, as well as simple gene pairs, it includes a few cases where a gene in a block has two tandemly duplicated paralogs in the sister block). For only 11 pairs among these, the transcriptional orientation of one gene appears inve ...
Regulatory sequences
... Scaffold/matrix attached regions (S/MARs) are regions of the DNA strand that are found the basis of chromatin loops. They anchor the DNA to the proteinaceous nuclear matrix. Each loop is considered to be a functional domain. S/MARs genes residual DNA ...
... Scaffold/matrix attached regions (S/MARs) are regions of the DNA strand that are found the basis of chromatin loops. They anchor the DNA to the proteinaceous nuclear matrix. Each loop is considered to be a functional domain. S/MARs genes residual DNA ...
Transposable element
A transposable element (TE or transposon) is a DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell's genome size. Transposition often results in duplication of the TE. Barbara McClintock's discovery of these jumping genes earned her a Nobel prize in 1983.TEs make up a large fraction of the C-value of eukaryotic cells. There are at least two classes of TEs: class I TEs generally function via reverse transcription, while class II TEs encode the protein transposase, which they require for insertion and excision, and some of these TEs also encode other proteins. It has been shown that TEs are important in genome function and evolution. In Oxytricha, which has a unique genetic system, they play a critical role in development. They are also very useful to researchers as a means to alter DNA inside a living organism.