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X Chromosome
X Chromosome

... • The expression of genes on the sex chromosomes differs from the expression of autosomal genes. • Genes located on the sex chromosomes are called sex- linked genes or X-linked genes. • Males express all of the alleles on both sex chromosomes. • In females one of the two X chromosomes is randomly tu ...
Genetic Markers and linkage mapping - genomics-lab
Genetic Markers and linkage mapping - genomics-lab

... hemoglobin is formed from two alpha chains and two beta chains.) The scheme shown was worked out from a comparison of beta-globin genes from many different organisms. For example, the nucleotide sequences of the gammaG and gammaA genes are much more similar to each other than either of them is to th ...
Genomics
Genomics

... • Unlike the human's seemingly random distribution of gene-rich areas, many other organisms' genomes are more uniform, with genes evenly spaced throughout. • Humans have on average three times as many kinds of proteins as the fly or worm because of mRNA transcript "alternative splicing" and chemical ...
Genomics
Genomics

... • Unlike the human's seemingly random distribution of gene-rich areas, many other organisms' genomes are more uniform, with genes evenly spaced throughout. • Humans have on average three times as many kinds of proteins as the fly or worm because of mRNA transcript "alternative splicing" and chemical ...
Chapter 7
Chapter 7

... A gene family consists of related genes that arose by duplication and variation from a single ancestral gene. Duplicated genes may diverge to generate different genes or one copy may become an inactive pseudogene. Translocation Gene cluster ...
基因療法(Gene therapy)的故事
基因療法(Gene therapy)的故事

... • Plasmid is small circle of bacterial DNA • Foreign DNA can be inserted into plasmid – Forms recombinant plasmids – Plasmid is a cloning vector ...
Bioinformatics and Computational Bology notes
Bioinformatics and Computational Bology notes

... officials (could be used for prosecuting poachers) – Detect bacteria and other organisms that may pollute air, water, soil, and food – Match organ donors with recipients in transplant programs – Determine pedigree for seed or livestock breeds – Authenticate consumables such as caviar and wine ...
SilkDB: a knowledgebase for silkworm biology and genomics
SilkDB: a knowledgebase for silkworm biology and genomics

... of all known silkworm genes. The raw sequences were produced by using a whole genome shotgun (WGS) (7) technique and sequence reads were assembled by using an updated version of our RePS software (8). There are 23 156 scaffolds for the 28 chromosomes. The average contig and scaffold sizes, by using ...
Chapter 16: Genome Analysis: DNA Typing, Genomics, and
Chapter 16: Genome Analysis: DNA Typing, Genomics, and

... Three essential features of a gene: • Expression of a product. • Requirement that it be functional. ...
TOC  - Genes | Genomes | Genetics
TOC - Genes | Genomes | Genetics

... Evolution of AMP resistance is considered unlikely or even impossible, yet selection with AMPs leads to resistance in several species of bacteria. Numerous studies have screened for loci that determine AMP susceptibility, but little is known about the genomic changes that accompany resistance evolut ...
speciation (formation of new species)
speciation (formation of new species)

... Prokaryotes reproduce using asexual reproduction e.g. binary fission. They can also transfer genetic material from one cell to another through horizontal gene transfer (HGT). Horizontal gene transfer can occur in three ways: (a) Transformation When cells are destroyed, pieces of their DNA remain and ...
Genetics IB Syllabus
Genetics IB Syllabus

... comparison and at least one species with more genes and one with fewer genes than a human.  The Genbank® database can be used to search for DNA base sequences. The cytochrome C gene sequence is available for many different organisms and is of particular interest because of its use in reclassifying ...
A Statistical Approach to Literature
A Statistical Approach to Literature

... • Each gene is annotated by a set of GO terms • The importance of any term wrt the gene list is measured by the number of genes that are associated with this term • Need to correct for the uneven distribution of GO terms: a hypergeometric test ...
Chapter 18 notes
Chapter 18 notes

... bacteria in any specific way, composite transposons may help bacteria adapt to new environments. • For example, repeated movements of resistance genes by composite transposition may concentrate several genes for antibiotic resistance onto a single R plasmid. • In an antibiotic-rich environment, natu ...
Toward forward genetic screens in malaria-causing
Toward forward genetic screens in malaria-causing

... in which piggyBac has inserted into genes that have a role in blood-stage development. The very essentiality of these genes is of particular interest, as they are likely to be the best targets for future drugs and vaccines. To investigate essential genes will require combining the piggyBac system wi ...
20.1 Structural Genomics Determines the DNA Sequences of Entire
20.1 Structural Genomics Determines the DNA Sequences of Entire

... • A site in the genome where individual members of a species differ in a single base pair • Haplotype: the specific set of SNPs and other genetic variants observed on a chromosome • Linkage disequilibrium • Tag SNPs • Genome-wide association studies ...
PCR analysis
PCR analysis

... The human genome contains small repetitive DNA elements or sequences that have become randomly inserted into it over millions of years. One such repetitive element is called the “Alu sequence” (see Figure 11). This is a DNA sequence about 300 base pairs long that is repeated almost 500,000 times thr ...
doc
doc

... B. Gain a homing endonuclease domain and turn into inteins. C. Subfuctionalization (Both copies retain only part of the original function). D. Neofunctionalization (Acquires a new function). E. Sit around semi-permanently as junk DNA. 15. Which statement is NOT in support of the Duplication-Degenera ...
Ancestral reconstruction and investigations of - GdR BIM
Ancestral reconstruction and investigations of - GdR BIM

... Egel, Richard. "Primal eukaryogenesis: on the communal nature of precellular states, ancestral to modern life." Life 2.1 (2012): 170-212. ...
Lecture Notes - Course Notes
Lecture Notes - Course Notes

... promoter is involved in the attachment of RNA polymerase II to the DNA. Promoters are usually several hundred nucleotides long and contain a consensus sequence (TATA) which binds a series of transcription factors. Not all gene promoters contain these specific sequence elements. In particular, promot ...
Working with enriched gene sets in R
Working with enriched gene sets in R

... • The sum of the values in vector will be 0 • Plot the running sum: ...
BIOL 222 - philipdarrenjones.com
BIOL 222 - philipdarrenjones.com

... A) a base insertion only but ever a deletion B) a base deletion only but never an insertion C) a base substitution only D) deletion of three consecutive bases E) either an insertion or a deletion of a base ...
DNA Technology
DNA Technology

... genome interspersed repetitive DNA (SINEs Short INterspersed Elements) make up 25-40% of mammalian genome  in humans, at least 5% of genome is made of a family of similar sequences called, Alu elements (PV92 anyone?!) ...
lecture 9
lecture 9

... Prediction of protein-protein interaction through detecting domain fusion events ¾ Potential pitfalls for the Rosetta methods: the transitive rule can applied but promiscuous domain should be excluded; ¾ It is better to be combined with other genome context methods. ¾ An example: Peptide methionine ...
Keynote for 2008 Genomics Workshop
Keynote for 2008 Genomics Workshop

... Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073. Kerem B, … Tsui L-C (1989). Identification of the cystic fibrosis gene: genetic analysis. Science ...
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Transposable element



A transposable element (TE or transposon) is a DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell's genome size. Transposition often results in duplication of the TE. Barbara McClintock's discovery of these jumping genes earned her a Nobel prize in 1983.TEs make up a large fraction of the C-value of eukaryotic cells. There are at least two classes of TEs: class I TEs generally function via reverse transcription, while class II TEs encode the protein transposase, which they require for insertion and excision, and some of these TEs also encode other proteins. It has been shown that TEs are important in genome function and evolution. In Oxytricha, which has a unique genetic system, they play a critical role in development. They are also very useful to researchers as a means to alter DNA inside a living organism.
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